G5EGK5

SS
Gene name
cam-1 (kin-8, C01G6.8)
Protein name
Tyrosine-protein kinase receptor cam-1
Names
EC 2.7.10.1
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C01G6.8
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

Tyrosine-protein kinase receptor cam-1 (cam-1) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of cam-1.

Autoinhibitory domains (AIDs)

Accessory elements

743-750 (Activation loop from InterPro)

Target domain

590-870 (Protein kinase domain)

Relief mechanism

Assay

762-768 (Activation loop from InterPro)

Target domain

590-870 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for G5EGK5

Entry ID Method Resolution Chain Position Source
AF-G5EGK5-F1 Predicted AlphaFoldDB

No variants for G5EGK5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for G5EGK5

No associated diseases with G5EGK5

13 regional properties for G5EGK5

Type Name Position InterPro Accession
domain Kringle 351 - 431 IPR000001
domain Protein kinase domain 590 - 870 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 591 - 857 IPR001245
domain Immunoglobulin subtype 2 50 - 117 IPR003598
domain Immunoglobulin subtype 44 - 128 IPR003599
domain Immunoglobulin-like domain 36 - 126 IPR007110
active_site Tyrosine-protein kinase, active site 722 - 734 IPR008266
domain Immunoglobulin I-set 40 - 127 IPR013098
binding_site Protein kinase, ATP binding site 596 - 625 IPR017441
conserved_site Kringle, conserved site 400 - 413 IPR018056
domain Frizzled domain 200 - 332 IPR020067
domain Tyrosine-protein kinase, catalytic domain 590 - 857 IPR020635
domain Ror-like, cysteine-rich domain 203 - 335 IPR041775

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Cell projection, axon
  • Cell projection, dendrite
  • Perikaryon
  • Synapse
  • Localizes in punctate structures along neuronal processes where it partially colocalizes with synaptic vesicle marker snb-1 (PubMed:15944127)
  • Localizes in punctate structures in the axons forming the nerve ring and in proximal AIM neurites destined for elimination (PubMed:19561603)
  • Enriched at the distal tips of muscle arms where they interact with ventral nerve cord (PubMed:15944127)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body membrane The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
frizzled binding Binding to a frizzled (fz) receptor.
metal ion binding Binding to a metal ion.
neurotrophin binding Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
neurotrophin receptor activity Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction
Wnt-protein binding Binding to a Wnt-protein, a secreted growth factor involved in signaling.

13 GO annotations of biological process

Name Definition
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.
cellular response to nerve growth factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
establishment of neuroblast polarity The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.
interneuron migration The orderly movement of an interneuron from one site to another.
motor neuron migration The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.
neuroblast migration The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.
neuron migration The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
sensory neuron migration The orderly movement of a sensory neuron from one site to another.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

32 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q91044 NTRK3 NT-3 growth factor receptor Gallus gallus (Chicken) SS
Q91987 NTRK2 BDNF/NT-3 growth factors receptor Gallus gallus (Chicken) SS
Q91009 NTRK1 High affinity nerve growth factor receptor Gallus gallus (Chicken) SS
Q8AXY6 MUSK Muscle, skeletal receptor tyrosine protein kinase Gallus gallus (Chicken) SS
Q5IS37 NTRK3 NT-3 growth factor receptor Pan troglodytes (Chimpanzee) SS
Q9V6K3 Nrk Tyrosine-protein kinase transmembrane receptor Ror2 Drosophila melanogaster (Fruit fly) SS
Q24488 Ror Tyrosine-protein kinase transmembrane receptor Ror Drosophila melanogaster (Fruit fly) SS
Q16620 NTRK2 BDNF/NT-3 growth factors receptor Homo sapiens (Human) EV
Q16288 NTRK3 NT-3 growth factor receptor Homo sapiens (Human) SS
O15146 MUSK Muscle, skeletal receptor tyrosine-protein kinase Homo sapiens (Human) EV
P04629 NTRK1 High affinity nerve growth factor receptor Homo sapiens (Human) EV
Q01973 ROR1 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Homo sapiens (Human) PR
Q01974 ROR2 Tyrosine-protein kinase transmembrane receptor ROR2 Homo sapiens (Human) EV
Q3UFB7 Ntrk1 High affinity nerve growth factor receptor Mus musculus (Mouse) SS
Q6VNS1 Ntrk3 NT-3 growth factor receptor Mus musculus (Mouse) SS
P15209 Ntrk2 BDNF/NT-3 growth factors receptor Mus musculus (Mouse) SS
Q61006 Musk Muscle, skeletal receptor tyrosine-protein kinase Mus musculus (Mouse) SS
Q9Z139 Ror1 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Mus musculus (Mouse) PR
Q9Z138 Ror2 Tyrosine-protein kinase transmembrane receptor ROR2 Mus musculus (Mouse) SS
P24786 NTRK3 NT-3 growth factor receptor Sus scrofa (Pig) SS
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
Q62838 Musk Muscle, skeletal receptor tyrosine protein kinase Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
O61460 vab-1 Ephrin receptor 1 Caenorhabditis elegans SS
H2KZU7 svh-2 Tyrosine-protein kinase receptor svh-2 Caenorhabditis elegans SS
Q95ZV7 ddr-2 Discoidin domain-containing receptor tyrosine kinase B Caenorhabditis elegans PR
Q17833 old-1 Tyrosine-protein kinase receptor old-1 Caenorhabditis elegans PR
P34892 kin-16 Receptor-like tyrosine-protein kinase kin-16 Caenorhabditis elegans PR
G5ED65 ver-1 Protein ver-1 Caenorhabditis elegans PR
Q19238 F09A5.2 Putative tyrosine-protein kinase F09A5.2 Caenorhabditis elegans SS
Q10656 egl-15 Myoblast growth factor receptor egl-15 Caenorhabditis elegans PR
10 20 30 40 50 60
MSPRPEDDDL VIEPADDEGL HYGNASMEGT STGQRPYIRL TSQLRNATKS SGDEVRFKCE
70 80 90 100 110 120
ALGTPPLKFI WLKNNGPVEK TKRVKIRDKE NSSRLVITQL DVLDSGYYQC IVSNPAASVN
130 140 150 160 170 180
TTSVLRVNNV PDAVKLSQKK GSHHSTKHIA FDEYEDYEMM DRGRLPDEED ADLYRVPDSA
190 200 210 220 230 240
AGSNYAPVAV SERWLDGIKY RVGDCVQYRG EACRQYLSNK FVMMTNESRE EMYDIDRNLR
250 260 270 280 290 300
AAMLFINGAP TISQKCRQLS QAVACHHMYK VCESDSNNQI VSICKHDCDV IQNDECPSEL
310 320 330 340 350 360
ALAAQHELVG DTPKALFPLC SRLSSTSNCI PVMSTALQSS PVAEVNRGHL THWCYVNSGT
370 380 390 400 410 420
QYEGTVAQTS SGKQCAPWID STSRDFNVHR FPELMNSKNY CRNPGGKKSR PWCYSKPMGQ
430 440 450 460 470 480
EEYCDVPQCP SDMYPHLNDK KVEGSTKGGV SESVTALWDS LDPTMQVALV GGGVFFSLLL
490 500 510 520 530 540
LLLFCCACCC RAKKKSQKTR HQNAHCSSAP SVINSAANSA YYRKLNGTST PIMGRVPPHV
550 560 570 580 590 600
EMTSLLPSAQ HLGPPPYPMD QHLQQARRFP SQEPIDDNSY KVFEITPSQL SVREKIGEGQ
610 620 630 640 650 660
FGVVHSGIYT SGLFAPEPMA VAVKKCRHDA TNAERAQLEQ EIRAVATFDH PNVIKLIGVC
670 680 690 700 710 720
YMDNSLLAVF EYMVHGDLHE LLKVRVPPAD HDMGGITEAN AEFLYIATQI ALGMEYLASM
730 740 750 760 770 780
SFVHRDLATR NCLVGDTRTI KIADFGLMRT SYGSDYYKML HRSWMPVRWM SKEAIEQGRF
790 800 810 820 830 840
SEASDVWSFG VTLWEIWSFG RQPYEGASNQ QVIELVANRH LLECPHNCPT NIYSLMVECW
850 860 870 880 890 900
HENIERRPTF SEIRSRLQSW SLASPAHSIL QQHNNRAGSH SGSSGAGRPP THQRGYPSQK
910 920
LHRRVEGASP LMKRHDANYA YSEDGDSD