G5EFM9
Gene name |
nekl-3 |
Protein name |
Serine/threonine-protein kinase nekl-3 |
Names |
Molting protein MLT-1, Never in mitosis A kinase-like 3, NimA kinase-like 3 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F19H6.1 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
167-190 (Activation loop from InterPro)
Target domain |
23-288 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for G5EFM9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-G5EFM9-F1 | Predicted | AlphaFoldDB |
No variants for G5EFM9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for G5EFM9 | |||||
No associated diseases with G5EFM9
4 regional properties for G5EFM9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Tyrosine-specific protein phosphatase, PTPase domain | 159 - 415 | IPR000242 |
| domain | Tyrosine-specific protein phosphatases domain | 332 - 404 | IPR000387 |
| domain | Protein-tyrosine phosphatase, catalytic | 313 - 412 | IPR003595 |
| active_site | Protein-tyrosine phosphatase, active site | 352 - 362 | IPR016130 |
Functions
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| gonad development | The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. |
| molting cycle | The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc. |
| multicellular organism growth | The increase in size or mass of an entire multicellular organism, as opposed to cell growth. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9HC98 | NEK6 | Serine/threonine-protein kinase Nek6 | Homo sapiens (Human) | EV |
| Q8TDX7 | NEK7 | Serine/threonine-protein kinase Nek7 | Homo sapiens (Human) | EV |
| Q9ES70 | Nek6 | Serine/threonine-protein kinase Nek6 | Mus musculus (Mouse) | SS |
| Q9ES74 | Nek7 | Serine/threonine-protein kinase Nek7 | Mus musculus (Mouse) | SS |
| A2BD05 | NEK6 | Serine/threonine-protein kinase Nek6 | Sus scrofa (Pig) | SS |
| D3ZBE5 | Nek7 | Serine/threonine-protein kinase Nek7 | Rattus norvegicus (Rat) | SS |
| P59895 | Nek6 | Serine/threonine-protein kinase Nek6 | Rattus norvegicus (Rat) | SS |
| Q9LVL5 | WNK4 | Probable serine/threonine-protein kinase WNK4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STK6 | WNK3 | Probable serine/threonine-protein kinase WNK3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDKISNIYNF | DDPPPDKLSL | ELFIIEKKIG | KGQFSEVFRA | QCTWVDLHVA | LKKIQVFEMV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DQKARQDCLK | EIDLLKQLNH | VNVIRYYASF | IDNNQLNIVL | ELAEAGDMSR | MIKHFKKGGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LIPEKTIWKY | FVQLARALAH | MHSKRIMHRD | IKPANVFITG | NGIVKLGDLG | LGRFFSSKTT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AAHSLVGTPY | YMSPERIQES | GYNFKSDLWS | TGCLLYEMAA | LQSPFYGDKM | NLYSLCKKIE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NCEYPPLPAD | IYSTQLRDLV | SRCILPEASK | RPETSEVLQV | AEHMNNYFSP | SGDQSTTPST |
| QF |