G5EFF5
PR
Gene name |
daf-12 |
Protein name |
Nuclear hormone receptor family member daf-12 |
Names |
Abnormal dauer formation protein 12 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F11A1.3 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for G5EFF5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-G5EFF5-F1 | Predicted | AlphaFoldDB |
No variants for G5EFF5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for G5EFF5 | |||||
No associated diseases with G5EFF5
Functions
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| (25S)-Delta(4)-dafachronate binding | Binding to (25S)-Delta(4)-dafachronate. |
| (25S)-Delta(7)-dafachronate binding | Binding to (25S)-Delta(7)-dafachronate. |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| nuclear receptor activity | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| zinc ion binding | Binding to a zinc ion (Zn). |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| aging | A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| dauer larval development | The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. |
| determination of adult lifespan | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. |
| heat acclimation | Any process that increases heat tolerance of an organism in response to high temperatures. |
| male mating behavior | The specific behavior of a male organism that is associated with reproduction. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of dauer larval development | Any process that increases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of dauer larval development | Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. |
| regulation of development, heterochronic | Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. |
| regulation of pharyngeal pumping | Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes. |
28 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9TTR7 | NR2F2 | COUP transcription factor 2 | Bos taurus (Bovine) | PR |
| O18971 | PPARG | Peroxisome proliferator-activated receptor gamma | Bos taurus (Bovine) | PR |
| Q90733 | NR2F2 | COUP transcription factor 2 | Gallus gallus (Chicken) | PR |
| P68306 | THRB | Thyroid hormone receptor beta | Gallus gallus (Chicken) | PR |
| A7X8B3 | PGR | Progesterone receptor | Pan troglodytes (Chimpanzee) | SS |
| P37231 | PPARG | Peroxisome proliferator-activated receptor gamma | Homo sapiens (Human) | PR |
| P10588 | NR2F6 | Nuclear receptor subfamily 2 group F member 6 | Homo sapiens (Human) | PR |
| P06401 | PGR | Progesterone receptor | Homo sapiens (Human) | EV |
| P10589 | NR2F1 | COUP transcription factor 1 | Homo sapiens (Human) | PR |
| P24468 | NR2F2 | COUP transcription factor 2 | Homo sapiens (Human) | PR |
| P49116 | NR2C2 | Nuclear receptor subfamily 2 group C member 2 | Homo sapiens (Human) | PR |
| O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (Human) | PR |
| P35396 | Ppard | Peroxisome proliferator-activated receptor delta | Mus musculus (Mouse) | PR |
| P43136 | Nr2f6 | Nuclear receptor subfamily 2 group F member 6 | Mus musculus (Mouse) | PR |
| P43135 | Nr2f2 | COUP transcription factor 2 | Mus musculus (Mouse) | PR |
| Q00175 | Pgr | Progesterone receptor | Mus musculus (Mouse) | SS |
| Q9Z0Y9 | Nr1h3 | Oxysterols receptor LXR-alpha | Mus musculus (Mouse) | PR |
| O62807 | PPARG | Peroxisome proliferator-activated receptor gamma | Sus scrofa (Pig) | PR |
| O09018 | Nr2f2 | COUP transcription factor 2 | Rattus norvegicus (Rat) | PR |
| Q63449 | Pgr | Progesterone receptor | Rattus norvegicus (Rat) | SS |
| Q8SQ01 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | Macaca mulatta (Rhesus macaque) | PR |
| O45460 | nhr-54 | Nuclear hormone receptor family member nhr-54 | Caenorhabditis elegans | PR |
| Q21006 | nhr-34 | Nuclear hormone receptor family member nhr-34 | Caenorhabditis elegans | PR |
| O17928 | nhr-52 | Nuclear hormone receptor family member nhr-52 | Caenorhabditis elegans | PR |
| Q21878 | nhr-1 | Nuclear hormone receptor family member nhr-1 | Caenorhabditis elegans | PR |
| O18141 | nhr-79 | Nuclear hormone receptor family member nhr-79 | Caenorhabditis elegans | PR |
| Q20765 | nhr-7 | Nuclear hormone receptor family member nhr-7 | Caenorhabditis elegans | PR |
| Q6PH18 | nr2f1b | Nuclear receptor subfamily 2 group F member 1-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGTNGGVIAE | QSMEIETNEN | PDKVEEPVVR | RKRVTRRRHR | RIHSKNNCLT | PPNSDDDPQM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| STPDDPVIHS | PPSIGAAPGM | NGYHGSGVKL | EESSGACGSP | DDGLLDSSEE | SRRRQKTCRV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CGDHATGYNF | NVITCESCKA | FFRRNALRPK | EFKCPYSEDC | EINSVSRRFC | QKCRLRKCFT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VGMKKEWILN | EEQLRRRKNS | RLNNTGTCNK | RSQPGNQQSP | QGPNQQPHLS | PHHPGVAIYP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PQPQRPLTIN | PMDNQMMHHM | QANRPNAMPQ | LISPPGAQPY | PLTSPVGSSA | SDSPPNRSLT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MMHNGEKSPD | GYDPNIMAHR | APPPSFNNRP | KMDSGQVVLS | TEEYKQLLSR | IPGAQVPGLM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NEEEPINKRA | AYNCNGHPMP | AETTPPYSAP | MSDMSLSRHN | STSSGTEKNH | MTHSTVSAIP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GNSAQNHFDI | ASFGMGIVTA | TGGGDAAEEM | YKRMNMFYEN | CIQSALDSPE | NQEPKPQEAM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IPKEEYMTPT | HGFQYQSDPY | QVPPAERNIN | YQLNAAELKA | LDAVREAFYG | MDDPMEQGRQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MQSFLKANKT | PADIMNIMDV | TMRRFVKVAK | GVPAFREVSQ | EGKFSLLKGG | MIEMLTVRGV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TRYDASTNSF | KTPTIKGQNV | SVNVDDMFAK | LNANAQAQKA | KCLEFFGFFD | EEIKKNELAV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YLVMLAVLFS | VRSDPPMNEN | DVRIVTERHN | HFMSLLNRYL | ESLFGEQARR | IFERIPKALG |
| 730 | 740 | 750 | |||
| LLNEIARNAG | MLFMGTVRSG | EAEELPGEFF | KIK |