G5EF60
SS
Gene name |
stim-1 (Y55B1BM.1) |
Protein name |
Stromal interaction molecule 1 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_Y55B1BM.1 |
EC number |
|
Protein Class |
|
Descriptions
STIM2 plays a role in mediating store-operated Ca2+ entry (SOCE), a Ca2+ influx following depletion of intracellular Ca2+ stores and functions as a highly sensitive Ca2+ sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca2+-influx. EF-SAM in STIM2 regulates CRAC channels through a divergent balance between EF-hand Ca2+ affinity and SAM domain stability. The Ca2+-binding EF-hand and SAM domain are major contributors to the autoinhibition of oligomerization in each respective isoform.
Autoinhibitory domains (AIDs)
Target domain |
283-386 (SOAR domain) |
Relief mechanism |
Others |
Assay |
|
Accessory elements
No accessory elements
References
- Zheng L et al. (2011) "Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry", Proceedings of the National Academy of Sciences of the United States of America, 108, 1337-42
- Korzeniowski MK et al. (2010) "Activation of STIM1-Orai1 involves an intramolecular switching mechanism", Science signaling, 3, ra82
- Stathopulos PB et al. (2008) "Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry", Cell, 135, 110-22
Autoinhibited structure
Activated structure
3 structures for G5EF60
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3TER | X-ray | 255 A | A/B | 256-391 | PDB |
| 6PW7 | X-ray | 189 A | A/B | 25-185 | PDB |
| AF-G5EF60-F1 | Predicted | AlphaFoldDB |
No variants for G5EF60
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for G5EF60 | |||||
No associated diseases with G5EF60
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| intracellular organelle | Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| calcium channel regulator activity | Modulates the activity of a calcium channel. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| identical protein binding | Binding to an identical protein or proteins. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular calcium ion homeostasis | A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. |
| ovulation | The release of a mature ovum/oocyte from an ovary. |
| positive regulation of engulfment of apoptotic cell | Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell. |
| positive regulation of smooth muscle contraction | Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. |
| reproduction | The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. |
| store-operated calcium entry | A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q58CP9 | STIM1 | Stromal interaction molecule 1 | Bos taurus (Bovine) | SS |
| P83094 | Stim | Stromal interaction molecule homolog | Drosophila melanogaster (Fruit fly) | SS |
| Q13586 | STIM1 | Stromal interaction molecule 1 | Homo sapiens (Human) | EV |
| Q9P246 | STIM2 | Stromal interaction molecule 2 | Homo sapiens (Human) | EV |
| P70302 | Stim1 | Stromal interaction molecule 1 | Mus musculus (Mouse) | SS |
| P83093 | Stim2 | Stromal interaction molecule 2 | Mus musculus (Mouse) | SS |
| P84903 | Stim1 | Stromal interaction molecule 1 | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGRVSWIIAL | YLTINVVIVV | NGDRVTRNVE | VTAEEEKIRD | KLGYEAIRDI | HRDMDDDHSG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SIDRNESTGF | MKEDMQMRGS | ERTRRENKFH | GDDDAITVDD | LWEAWFESIE | RTWTNERLVE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WLINDVNLPS | IVEAVKAKKI | DGKILPRFAS | PNSDFLNKEL | GIKSSVYRQK | LRLNSLDVVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FGYKDNNNRT | KDILLAFLAL | LLTSLIFLYV | RQKQKAQQKV | NELSNKLTEL | KCMETEFEDV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QKMLNDERSK | RSISDGVVNH | TEMENLRVQL | EEAERRLEAN | SNGSQAPLAL | QPLLRRTCEN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EMAFLEKQRQ | DCFKEMKEAI | EMVDRLQKKQ | GSVLSSLKLA | TGAASTSDQV | DSKIFALKSR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MEKIHTLTRE | TQERWLQIES | LCGFPLLYLN | ETEHINRSIA | SSHFYNKSHE | GSSSSGSISN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AHSNPNAVNS | NFVKKVSPPI | PPSQQTANLR | FVPTEQSDSI | HSEDTSPIVE | DVAISRSLTQ |
| 490 | 500 | 510 | 520 | ||
| DLAEADMQSI | VSGSTNGSGS | VAALKKRKGI | FPKLFRRNTS | KSSSLGGTSN |