G5EDF7
Gene name |
sek-1 |
Protein name |
Dual specificity mitogen-activated protein kinase kinase sek-1 |
Names |
MAP kinase kinase sek-1 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_R03G5.2 |
EC number |
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
193-215 (Activation loop from InterPro)
Target domain |
50-311 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for G5EDF7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-G5EDF7-F1 | Predicted | AlphaFoldDB |
No variants for G5EDF7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for G5EDF7 | |||||
No associated diseases with G5EDF7
12 regional properties for G5EDF7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPS motif | 697 - 749 | IPR000203 |
| domain | Cysteine-rich flanking region, C-terminal | 187 - 236 | IPR000483 |
| repeat | Leucine-rich repeat | 85 - 141 | IPR001611 |
| domain | GPCR, family 2, extracellular hormone receptor domain | 323 - 418 | IPR001879 |
| repeat | Leucine-rich repeat, typical subtype | 79 - 103 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 104 - 127 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 128 - 151 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 152 - 175 | IPR003591-4 |
| domain | Immunoglobulin subtype | 249 - 342 | IPR003599 |
| domain | Immunoglobulin-like domain | 242 - 340 | IPR007110 |
| domain | Immunoglobulin I-set | 247 - 340 | IPR013098 |
| domain | GPCR, family 2-like, transmembrane domain | 756 - 1050 | IPR017981 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.12.2 | Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase kinase activity | Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. |
| metal ion binding | Binding to a metal ion. |
| mitogen-activated protein kinase kinase kinase binding | Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
21 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to fungus | Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. |
| defense response to Gram-negative bacterium | Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. |
| defense response to Gram-positive bacterium | Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. |
| determination of left/right asymmetry in nervous system | The establishment of the nervous system with respect to the left and right halves. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| negative regulation of neuron death | Any process that stops, prevents or reduces the frequency, rate or extent of neuron death. |
| p38MAPK cascade | An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of oviposition | Any process that activates or increases the frequency, rate or extent of oviposition. |
| positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium | Any positive regulation of transcription from RNA polymerase II promoter that is involved in defense response to Gram-negative bacterium. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of oviposition | Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium. |
| response to nematicide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nematicide stimulus. Nematicides are chemicals used to kill nematodes. |
| response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
| response to reactive oxygen species | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. |
| response to superoxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. |
| response to toxic substance | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. |
| stress-activated MAPK cascade | The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. |
| turning behavior involved in mating | The sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9X2 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | Bos taurus (Bovine) | EV |
| P46734 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | Homo sapiens (Human) | SS |
| P52564 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | Homo sapiens (Human) | EV |
| O14733 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | Homo sapiens (Human) | PR |
| P45985 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | Homo sapiens (Human) | EV |
| P70236 | Map2k6 | Dual specificity mitogen-activated protein kinase kinase 6 | Mus musculus (Mouse) | EV |
| O09110 | Map2k3 | Dual specificity mitogen-activated protein kinase kinase 3 | Mus musculus (Mouse) | PR |
| Q8CE90 | Map2k7 | Dual specificity mitogen-activated protein kinase kinase 7 | Mus musculus (Mouse) | PR |
| P47809 | Map2k4 | Dual specificity mitogen-activated protein kinase kinase 4 | Mus musculus (Mouse) | EV |
| G5EDT6 | jkk-1 | Dual specificity mitogen-activated protein kinase kinase jkk-1 | Caenorhabditis elegans | PR |
| Q10664 | mek-2 | Dual specificity mitogen-activated protein kinase kinase mek-2 | Caenorhabditis elegans | PR |
| Q21307 | mek-1 | Dual specificity mitogen-activated protein kinase kinase mek-1 | Caenorhabditis elegans | PR |
| Q9DGE0 | map2k6 | Dual specificity mitogen-activated protein kinase kinase 6 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERKGRERKL | PGMKIVMPTP | VETPTMNLED | RCLIKLTNES | EEIEIAATDL | VVLEELGKGG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YGIVEKMQHR | QSGIIMAVKR | IKSSINDQSQ | KQMLNELDAC | RRSDCCPQMV | RFYGAMFREG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DVWICMEVMD | TSLDKFYRHA | YKIGKHIPEP | FIGKMALSVI | EGLNFMKEQL | NLIHRDVKPS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NILLNRHGQV | KICDFGISGH | LTNSMAKTVQ | AGCKPYMPPE | RIDGETKSAY | DVRADVWSLG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ITIIEIAVGT | HPYANWKTPF | EQLKQVVKEP | PPKLPMESGF | SVDCQYFVKR | CLEKDYNERP |
| 310 | 320 | 330 | |||
| KYPELLAMPF | MEQARNEKQF | SMARFINEIL | DTVWRR |