G5ECY0
Gene name |
dlg-1 (C25F6.2, CELE_C25F6.2) |
Protein name |
Disks large homolog 1 |
Names |
MAGUK protein DLG-1 , SAP97-like protein DLG-1 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_C25F6.2 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
749-948 (GK domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Target domain |
749-948 (GK domain) |
Relief mechanism |
Partner binding, Others |
Assay |
|
Accessory elements
No accessory elements
References
- Qian Y et al. (2006) "Interdomain interactions in the tumor suppressor discs large regulate binding to the synaptic protein GukHolder", The Journal of biological chemistry, 281, 35757-63
- McGee AW et al. (1999) "Identification of an intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95", The Journal of biological chemistry, 274, 17431-6
Autoinhibited structure
Activated structure
1 structures for G5ECY0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-G5ECY0-F1 | Predicted | AlphaFoldDB |
No variants for G5ECY0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for G5ECY0 | |||||
No associated diseases with G5ECY0
9 regional properties for G5ECY0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH3 domain | 619 - 690 | IPR001452 |
| domain | PDZ domain | 202 - 289 | IPR001478-1 |
| domain | PDZ domain | 361 - 448 | IPR001478-2 |
| domain | PDZ domain | 508 - 591 | IPR001478-3 |
| domain | L27 domain | 5 - 68 | IPR004172 |
| domain | Guanylate kinase-like domain | 769 - 955 | IPR008144 |
| domain | Guanylate kinase/L-type calcium channel beta subunit | 768 - 944 | IPR008145 |
| domain | L27-1 | 9 - 65 | IPR015143 |
| conserved_site | Guanylate kinase, conserved site | 801 - 818 | IPR020590 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| apical junction complex | A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. |
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| lateral plasma membrane | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| postsynaptic density membrane | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanylate kinase activity | Catalysis of the reaction |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-cell adhesion | The attachment of one cell to another cell via adhesion molecules. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| embryo development ending in birth or egg hatching | The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. |
| establishment or maintenance of epithelial cell apical/basal polarity | Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. |
| receptor clustering | The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. |
| receptor localization to synapse | Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. |
| zonula adherens assembly | Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P31007 | dlg1 | Disks large 1 tumor suppressor protein | Drosophila melanogaster (Fruit fly) | EV |
| Q9BXL7 | CARD11 | Caspase recruitment domain-containing protein 11 | Homo sapiens (Human) | EV |
| Q92796 | DLG3 | Disks large homolog 3 | Homo sapiens (Human) | SS |
| Q12959 | DLG1 | Disks large homolog 1 | Homo sapiens (Human) | SS |
| P78352 | DLG4 | Disks large homolog 4 | Homo sapiens (Human) | SS |
| Q15700 | DLG2 | Disks large homolog 2 | Homo sapiens (Human) | SS |
| Q8CIS0 | Card11 | Caspase recruitment domain-containing protein 11 | Mus musculus (Mouse) | SS |
| Q99KF0 | Card14 | Caspase recruitment domain-containing protein 14 | Mus musculus (Mouse) | PR |
| P70175 | Dlg3 | Disks large homolog 3 | Mus musculus (Mouse) | SS |
| Q811D0 | Dlg1 | Disks large homolog 1 | Mus musculus (Mouse) | SS |
| Q62108 | Dlg4 | Disks large homolog 4 | Mus musculus (Mouse) | SS |
| Q91XM9 | Dlg2 | Disks large homolog 2 | Mus musculus (Mouse) | SS |
| Q62936 | Dlg3 | Disks large homolog 3 | Rattus norvegicus (Rat) | SS |
| Q62696 | Dlg1 | Disks large homolog 1 | Rattus norvegicus (Rat) | SS |
| P31016 | Dlg4 | Disks large homolog 4 | Rattus norvegicus (Rat) | SS |
| Q63622 | Dlg2 | Disks large homolog 2 | Rattus norvegicus (Rat) | EV |
| Q28C55 | dlg1 | Disks large homolog 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q5PYH5 | dlg1l | Discs large homolog 1-like protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5PYH7 | dlg2 | Disks large homolog 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6R005 | dlg4 | Disks large homolog 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSHESSEKAH | KAIENVEDYC | QTLTRHGNEE | LRTNLERVIT | TFKSNLMHSL | LDIHDLYEQT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLSERKSDAE | KNMEVRRVIE | RLEGGPHSYN | SRPAATTSTS | NYNLSSTTPL | ISDLRDRGGF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SYLNGGGLGN | GLGNGLGNGL | LSSPYNSSST | HYLHERQRQT | SHDGTWRETT | TRTVDTPSGL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ERRVVEHTGV | IDDHGRKWEL | ENIVLEKGHT | GLGFSITGGM | DQPTEDGDTS | IYVTNIIEGG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AALADGRMRK | NDIITAVNNT | NCENVKHEVA | VNALKSSGNV | VSLSLKRRKD | EAFLPIGGNF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GGSTSYLRSG | VTPSVSAGNL | QHAIHSPSAP | IHPPPPPPVH | HGSLSQLSVG | QYRSTRPNTS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VIDLVKGARG | LGFSIAGGQG | NEHVKGDTDI | YVTKIIEEGA | AELDGRLRVG | DKILEVDHHS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LINTTHENAV | NVLKNTGNRV | RLLIQQGTGA | IFNDSASQQF | MPTTPILRPS | SVQDYNRSQM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GSQSHLSYGG | PLNTSYSSQA | PIAIPLEPRP | VQLVKGQNGL | GFNIVGGEDN | EPIYISFVLP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GGVADLSGNV | KTGDVLLEVN | GVVLRNATHK | EAAEALRNAG | NPVYLTLQYR | PQEYQIFESK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IEKLRNDVIA | QSRMGTLSRK | SEYVRALFDY | DPSRENSVAP | HRSMGFNYGD | ILHIINSSDD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EWWTARKVHE | NGEETAEGVI | PSKKRVEKRE | RLRRKQVNFN | SGSQSLGRNS | STTGLENRRG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SRSQLSFSRK | FPFVKSTDRL | NDLNEESSNV | AEEPVWSYQA | VEQQAINYVR | PVIILGALKD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RINDELVNRD | PSKFSSCVPH | TSRPPREGEV | NGRDYYFVNK | HNMEEDVKNN | LFIEAGQFQN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| NLYGTSIQSV | RDVANQGRHC | ILDVSGNAIR | RLQSNANIQP | ISIFIKPSSA | QQILELDSQL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ATNRQDDRAM | SGEEAQAQYS | RCHRIEQTFG | DLFTQEISNV | HSANDVLSKV | YSIISRESQT |
| PIWVPRH |