G5EBU4
Gene name |
zag-1 |
Protein name |
Zinc finger E-box-binding homeobox protein zag-1 |
Names |
Zinc finger involved in axon guidance 1, ZAG-1 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F28F9.1 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for G5EBU4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-G5EBU4-F1 | Predicted | AlphaFoldDB |
No variants for G5EBU4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for G5EBU4 | |||||
No associated diseases with G5EBU4
7 regional properties for G5EBU4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Homeobox domain | 221 - 285 | IPR001356 |
| domain | Zinc finger C2H2-type | 24 - 51 | IPR013087-1 |
| domain | Zinc finger C2H2-type | 52 - 72 | IPR013087-2 |
| domain | Zinc finger C2H2-type | 481 - 508 | IPR013087-3 |
| domain | Zinc finger C2H2-type | 509 - 536 | IPR013087-4 |
| domain | Zinc finger C2H2-type | 537 - 565 | IPR013087-5 |
| conserved_site | Homeobox, conserved site | 256 - 279 | IPR017970 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| metal ion binding | Binding to a metal ion. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| anatomical structure development | The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| dendrite development | The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. |
| larval development | The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| neuron fate specification | The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. |
| positive regulation of axon extension | Any process that activates or increases the frequency, rate or extent of axon extension. |
| regulation of neuron differentiation | Any process that modulates the frequency, rate or extent of neuron differentiation. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVDIAEAMPT | TASSLPSDEA | LRKFKCPECT | KAFKFKHHLK | EHIRIHSGEK | PFECQQCHKR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FSHSGSYSSH | MSSKKCVQQA | SPSMVTPFNP | YQLMMYRNIM | LQLQTPQVSF | LPSTAANNMD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YMSLLQANLF | QSLENGTSPT | PTQEPSAPAS | PEPKIEVVDE | PEVSSEVKTE | VKTEVKTEDS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VPEESITPAV | SMSLSPAPEQ | NGNESMNNGG | SGSDGKSSPD | WRPLRSRSFL | NDSQVAVLQN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HFKRNPFPSK | YELSAVAEQI | GVNKRVVQVW | FQNTRAKERR | SNRLPSMPRG | SVASAAAAAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TSPTVWQTPV | QLMAAWASQF | SNGNNSLTAS | QDERNNENTD | EVMDHDGLKD | GKETPLDLTL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| STDDTEPEWS | PEKLIGFLDQ | TGGVIQELLR | QAGNGFVTNQ | EDEEEKPIKA | EESPVSSGSS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SIWPSFIGQY | PSILDSASLS | VLEKALDQQK | SSEDDASSLC | SNESKLLKFP | TTPLKEEEGL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FSCDQCDKVF | GKQSSLARHK | YEHSGQRPYK | CDICEKAFKH | KHHLTEHKRL | HSGEKPFQCD |
| 550 | 560 | 570 | 580 | 590 | |
| KCLKRFSHSG | SYSQHMNHRY | SYCKPYREQP | ASPSDVLNGG | SVTVSPSSSN | TPPPST |