G5EBT1
SS
Gene name |
sma-5 (W06B3.2) |
Protein name |
Mitogen-activated protein kinase sma-5 |
Names |
EC 2.7.11.24 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_W06B3.2 |
EC number |
2.7.11.24: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
MAPK1 encodes Mitogen-activated protein kinase 1, and is involved in diverse cellular responses by phosphorylating cytoplasmic and nuclear proteins. Unlike other MAP kinases, MAPK1 activates via dual phosphorylation of Thr-186 and Tyr-193 within the activation lip, and mutations at Q105 alone were sufficient for autoactivation. Additionally, in the inactive form, L76, Q10 and I87 form a structural unit that restrains intramolecular autophosphorylation by preventing interactions between activation lip residues and the catalytic base (D149) needed for phosphoryl transfer. Mutations at L76, I87 and additionally S153 increased basal specific activity via autophosphorylation of Thr-186 and Tyr-193.
Autoinhibitory domains (AIDs)
Target domain |
105-411 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
248-280 (Activation loop from InterPro)
Target domain |
105-417 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Emrick MA et al. (2006) "The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity", Proceedings of the National Academy of Sciences of the United States of America, 103, 18101-6
- Emrick MA et al. (2001) "Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations", The Journal of biological chemistry, 276, 46469-79
Autoinhibited structure
Activated structure
1 structures for G5EBT1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-G5EBT1-F1 | Predicted | AlphaFoldDB |
No variants for G5EBT1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for G5EBT1 | |||||
No associated diseases with G5EBT1
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.24 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase activity | Catalysis of the reaction |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| cell population proliferation | The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
| dauer larval development | The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. |
| determination of adult lifespan | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| nematode larval development | The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. |
| organelle localization | Any process in which an organelle is transported to, and/or maintained in, a specific location. |
| parturition | The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of cell growth | Any process that activates or increases the frequency, rate, extent or direction of cell growth. |
| positive regulation of cell size | Any process that increases cell size. |
| positive regulation of multicellular organism growth | Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. |
| post-embryonic development | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. |
| regulation of multicellular organism growth | Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. |
88 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41808 | SMK1 | Sporulation-specific mitogen-activated protein kinase SMK1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q00772 | SLT2 | Mitogen-activated protein kinase SLT2/MPK1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3T0N5 | MAPK13 | Mitogen-activated protein kinase 13 | Bos taurus (Bovine) | SS |
| P46196 | MAPK1 | Mitogen-activated protein kinase 1 | Bos taurus (Bovine) | SS |
| A5PKJ4 | MAPK7 | Mitogen-activated protein kinase 7 | Bos taurus (Bovine) | SS |
| Q5F3W3 | MAPK6 | Mitogen-activated protein kinase 6 | Gallus gallus (Chicken) | SS |
| Q95NE7 | MAPK14 | Mitogen-activated protein kinase 14 | Pan troglodytes (Chimpanzee) | SS |
| Q9N272 | MAPK13 | Mitogen-activated protein kinase 13 | Pan troglodytes (Chimpanzee) | SS |
| Q9W354 | Erk7 | Extracellular signal-regulated kinase 7 | Drosophila melanogaster (Fruit fly) | SS |
| O61443 | p38b | Mitogen-activated protein kinase p38b | Drosophila melanogaster (Fruit fly) | SS |
| O62618 | p38a | Mitogen-activated protein kinase p38a | Drosophila melanogaster (Fruit fly) | SS |
| P83100 | p38c | Putative mitogen-activated protein kinase 14C | Drosophila melanogaster (Fruit fly) | SS |
| P40417 | rl | Mitogen-activated protein kinase ERK-A | Drosophila melanogaster (Fruit fly) | SS |
| O15264 | MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens (Human) | SS |
| P53778 | MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens (Human) | SS |
| P28482 | MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens (Human) | EV |
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens (Human) | SS |
| Q16659 | MAPK6 | Mitogen-activated protein kinase 6 | Homo sapiens (Human) | SS |
| P27361 | MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens (Human) | SS |
| Q15759 | MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens (Human) | SS |
| Q8TD08 | MAPK15 | Mitogen-activated protein kinase 15 | Homo sapiens (Human) | SS |
| P31152 | MAPK4 | Mitogen-activated protein kinase 4 | Homo sapiens (Human) | SS |
| Q13164 | MAPK7 | Mitogen-activated protein kinase 7 | Homo sapiens (Human) | SS |
| Q9Z1B7 | Mapk13 | Mitogen-activated protein kinase 13 | Mus musculus (Mouse) | SS |
| P47811 | Mapk14 | Mitogen-activated protein kinase 14 | Mus musculus (Mouse) | SS |
| Q61532 | Mapk6 | Mitogen-activated protein kinase 6 | Mus musculus (Mouse) | SS |
| Q63844 | Mapk3 | Mitogen-activated protein kinase 3 | Mus musculus (Mouse) | SS |
| P63085 | Mapk1 | Mitogen-activated protein kinase 1 | Mus musculus (Mouse) | SS |
| Q9WUI1 | Mapk11 | Mitogen-activated protein kinase 11 | Mus musculus (Mouse) | SS |
| O08911 | Mapk12 | Mitogen-activated protein kinase 12 | Mus musculus (Mouse) | SS |
| Q80Y86 | Mapk15 | Mitogen-activated protein kinase 15 | Mus musculus (Mouse) | SS |
| Q6P5G0 | Mapk4 | Mitogen-activated protein kinase 4 | Mus musculus (Mouse) | SS |
| Q9WVS8 | Mapk7 | Mitogen-activated protein kinase 7 | Mus musculus (Mouse) | SS |
| P70618 | Mapk14 | Mitogen-activated protein kinase 14 | Rattus norvegicus (Rat) | SS |
| Q9WTY9 | Mapk13 | Mitogen-activated protein kinase 13 | Rattus norvegicus (Rat) | SS |
| P63086 | Mapk1 | Mitogen-activated protein kinase 1 | Rattus norvegicus (Rat) | SS |
| Q9Z2A6 | Mapk15 | Mitogen-activated protein kinase 15 | Rattus norvegicus (Rat) | SS |
| P27704 | Mapk6 | Mitogen-activated protein kinase 6 | Rattus norvegicus (Rat) | SS |
| P21708 | Mapk3 | Mitogen-activated protein kinase 3 | Rattus norvegicus (Rat) | SS |
| Q63538 | Mapk12 | Mitogen-activated protein kinase 12 | Rattus norvegicus (Rat) | SS |
| Q63454 | Mapk4 | Mitogen-activated protein kinase 4 | Rattus norvegicus (Rat) | SS |
| P0C865 | Mapk7 | Mitogen-activated protein kinase 7 | Rattus norvegicus (Rat) | SS |
| Q10N20 | MPK5 | Mitogen-activated protein kinase 5 | Oryza sativa subsp. japonica (Rice) | SS |
| Q84UI5 | MPK1 | Mitogen-activated protein kinase 1 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5J4W4 | MPK2 | Mitogen-activated protein kinase 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q336X9 | MPK6 | Mitogen-activated protein kinase 6 | Oryza sativa subsp. japonica (Rice) | SS |
| Q53N72 | MPK15 | Mitogen-activated protein kinase 15 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5VN19 | MPK11 | Mitogen-activated protein kinase 11 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5VP69 | MPK16 | Mitogen-activated protein kinase 16 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5Z859 | MPK4 | Mitogen-activated protein kinase 4 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5Z9J0 | MPK12 | Mitogen-activated protein kinase 12 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5ZCI1 | MPK10 | Mitogen-activated protein kinase 10 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6L5F7 | MPK17 | Mitogen-activated protein kinase 17 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6Z437 | MPK3 | Mitogen-activated protein kinase 3 | Oryza sativa subsp. japonica (Rice) | SS |
| Q75KK8 | MPK14 | Mitogen-activated protein kinase 14 | Oryza sativa subsp. japonica (Rice) | SS |
| Q0E459 | MPK13 | Mitogen-activated protein kinase 13 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5SN53 | MPK8 | Mitogen-activated protein kinase 8 | Oryza sativa subsp. japonica (Rice) | SS |
| Q67C40 | MPK7 | Mitogen-activated protein kinase 7 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6L5D4 | MPK9 | Mitogen-activated protein kinase 9 | Oryza sativa subsp japonica (Rice) | PR |
| O44514 | pmk-3 | Mitogen-activated protein kinase pmk-3 | Caenorhabditis elegans | PR |
| P39745 | mpk-1 | Mitogen-activated protein kinase mpk-1 | Caenorhabditis elegans | SS |
| Q11179 | mapk-15 | Mitogen-activated protein kinase 15 | Caenorhabditis elegans | SS |
| Q17446 | pmk-1 | Mitogen-activated protein kinase pmk-1 | Caenorhabditis elegans | SS |
| Q8MXI4 | pmk-2 | Mitogen-activated protein kinase pmk-2 | Caenorhabditis elegans | SS |
| O44408 | kgb-1 | GLH-binding kinase 1 | Caenorhabditis elegans | PR |
| Q9LMM5 | MPK11 | Mitogen-activated protein kinase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LQQ9 | MPK13 | Mitogen-activated protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39026 | MPK6 | Mitogen-activated protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GYQ5 | MPK12 | Mitogen-activated protein kinase 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39023 | MPK3 | Mitogen-activated protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M1Z5 | MPK10 | Mitogen-activated protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39024 | MPK4 | Mitogen-activated protein kinase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39025 | MPK5 | Mitogen-activated protein kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23236 | MPK14 | Mitogen-activated protein kinase 14 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39021 | MPK1 | Mitogen-activated protein kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39022 | MPK2 | Mitogen-activated protein kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39027 | MPK7 | Mitogen-activated protein kinase 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84M93 | MPK17 | Mitogen-activated protein kinase 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8W4J2 | MPK16 | Mitogen-activated protein kinase 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C5C0 | MPK18 | Mitogen-activated protein kinase 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C9U4 | MPK15 | Mitogen-activated protein kinase 15 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LM33 | MPK8 | Mitogen-activated protein kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LUC3 | MPK19 | Mitogen-activated protein kinase 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LV37 | MPK9 | Mitogen-activated protein kinase 9 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SJG9 | MPK20 | Mitogen-activated protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O42376 | mapk12 | Mitogen-activated protein kinase 12 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DGE1 | mapk14b | Mitogen-activated protein kinase 14B | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DGE2 | mapk14a | Mitogen-activated protein kinase 14A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVFADFLEKI | KSLFAKTKDP | ITSMSPPQEN | RSPKAEYLNN | FFNTNPTNGK | SRGSQEAPRK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PLGQTNLNVQ | GSMPAKKEGF | NRVLDGLKKR | QLQHDFKLER | AAETYEPTQN | IGSGAFGIVC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EAVETSSNQK | VAIKKVAHAS | ATPTLARRTL | REIRVLRYIN | HPNIVPLRDI | FRTKGPLGID |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VFLVMDLMQN | NLHHIIYGNE | DPLEEHYINA | FLGQLLRGLE | YLHAACIAHR | DLKPSNLLVN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QDGTLRIADF | GMAKCADNSS | KKHDDEEHCY | YMTQHVATLP | YRAPELLFVL | PEHSTAVDMW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AVGCIFGEMV | IRNEILPGRS | VQGQIKMLLT | MLGQPPQEVI | NEVRCDRTRK | LIQDFGRKAD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AEWDDIMFCK | ARGDDQIVRG | NCDTIDFVKQ | LFQYDAQKRI | NIQDALLHPY | IQRVIPAEAP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QKKCPFRVKK | DMMQVEDLNH | QELISMMKQD | VRSAENPITY | SELHSGDSTG | STSDMSTNTS |
| 490 | 500 | ||||
| GEYSPIAQHE | QLLEDVATQI | SICEPTCDL |