G3X9K3
PR
Gene name |
Arfgef1 |
Protein name |
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 |
Names |
BIG1, Brefeldin A-inhibited GEP 1, ADP-ribosylation factor guanine nucleotide-exchange factor 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:211673 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for G3X9K3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-G3X9K3-F1 | Predicted | AlphaFoldDB |
77 variants for G3X9K3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388458389 | 45 | K>I | No | EVA | |
| rs3388458176 | 46 | V>I | No | EVA | |
| rs3388458548 | 148 | Q>L | No | EVA | |
| rs3388456645 | 263 | G>A | No | EVA | |
| rs3388457730 | 266 | E>K | No | EVA | |
| rs3388457874 | 267 | P>T | No | EVA | |
| rs1133297506 | 311 | D>E | No | EVA | |
| rs1134028249 | 314 | Y>* | No | EVA | |
| rs1133435516 | 317 | D>N | No | EVA | |
| rs1134763054 | 319 | E>Q | No | EVA | |
| rs1134163842 | 320 | E>K | No | EVA | |
| rs1131761456 | 320 | E>V | No | EVA | |
| rs3388458554 | 326 | V>I | No | EVA | |
| rs3388458883 | 332 | E>A | No | EVA | |
| rs3388458525 | 415 | I>N | No | EVA | |
| rs3388457759 | 416 | L>F | No | EVA | |
| rs3388457588 | 506 | L>P | No | EVA | |
| rs3388458934 | 519 | Q>* | No | EVA | |
| rs3388457883 | 538 | S>L | No | EVA | |
| rs3388456628 | 558 | S>* | No | EVA | |
| rs3388458421 | 560 | V>E | No | EVA | |
| rs3388456657 | 560 | V>R | No | EVA | |
| rs3388456625 | 583 | L>P | No | EVA | |
| rs3388457957 | 584 | S>P | No | EVA | |
| rs3388457573 | 604 | S>C | No | EVA | |
| rs3388457959 | 606 | R>* | No | EVA | |
| rs3388457560 | 607 | K>R | No | EVA | |
| rs3388457583 | 701 | Q>* | No | EVA | |
| rs3388458324 | 723 | L>F | No | EVA | |
| rs3388458532 | 725 | T>S | No | EVA | |
| rs3388457561 | 746 | G>S | No | EVA | |
| rs3388456631 | 748 | F>* | No | EVA | |
| rs3388458545 | 748 | F>L | No | EVA | |
| rs3388458330 | 749 | L>R | No | EVA | |
| rs3388457526 | 786 | R>G | No | EVA | |
| rs3388458339 | 792 | Q>H | No | EVA | |
| rs3388457909 | 795 | D>E | No | EVA | |
| rs3388458734 | 796 | R>* | No | EVA | |
| rs3388458901 | 804 | R>* | No | EVA | |
| rs3388457569 | 933 | F>Y | No | EVA | |
| rs3388458924 | 947 | K>* | No | EVA | |
| rs3388456644 | 949 | A>D | No | EVA | |
| rs3388458926 | 1078 | T>N | No | EVA | |
| rs3388458283 | 1123 | D>N | No | EVA | |
| rs3388457980 | 1220 | E>V | No | EVA | |
| rs3388457974 | 1241 | M>T | No | EVA | |
| rs3388456731 | 1281 | L>V | No | EVA | |
| rs3388457700 | 1283 | A>T | No | EVA | |
| rs1134759192 | 1335 | D>E | No | EVA | |
| rs1133706329 | 1336 | T>K | No | EVA | |
| rs1133170231 | 1337 | S>R | No | EVA | |
| rs1134350551 | 1342 | R>Q | No | EVA | |
| rs1131896567 | 1347 | C>Y | No | EVA | |
| rs3388457371 | 1357 | A>S | No | EVA | |
| rs3388457613 | 1359 | K>N | No | EVA | |
| rs3388457841 | 1375 | W>* | No | EVA | |
| rs3388458897 | 1396 | D>Y | No | EVA | |
| rs3413024385 | 1398 | R>K | No | EVA | |
| rs3388456626 | 1425 | F>S | No | EVA | |
| rs3388457852 | 1434 | N>I | No | EVA | |
| rs3388457684 | 1464 | T>I | No | EVA | |
| rs3388458595 | 1471 | S>R | No | EVA | |
| rs3388458899 | 1512 | F>Y | No | EVA | |
| rs3388458939 | 1608 | Q>* | No | EVA | |
| rs3388458935 | 1617 | K>N | No | EVA | |
| rs3388456563 | 1639 | K>E | No | EVA | |
| rs3388456590 | 1642 | D>N | No | EVA | |
| rs3388458671 | 1651 | R>I | No | EVA | |
| rs3388456558 | 1667 | M>I | No | EVA | |
| rs3388457584 | 1671 | L>* | No | EVA | |
| rs3389644154 | 1682 | C>S | No | EVA | |
| rs3388456584 | 1691 | K>* | No | EVA | |
| rs3388458311 | 1696 | N>D | No | EVA | |
| rs47170348 | 1754 | V>I | No | EVA | |
| rs3388457579 | 1764 | T>I | No | EVA | |
| rs46017648 | 1791 | S>N | No | EVA | |
| rs3388458687 | 1829 | I>M | No | EVA |
No associated diseases with G3X9K3
9 regional properties for G3X9K3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | 326 - 853 | IPR001394 |
| domain | Zinc finger, UBP-type | 175 - 283 | IPR001607 |
| domain | Ubiquitin-associated domain | 654 - 695 | IPR015940-1 |
| domain | Ubiquitin-associated domain | 722 - 762 | IPR015940-2 |
| conserved_site | Ubiquitin specific protease, conserved site | 327 - 342 | IPR018200-1 |
| conserved_site | Ubiquitin specific protease, conserved site | 801 - 819 | IPR018200-2 |
| domain | Ubiquitin specific protease domain | 326 - 856 | IPR028889 |
| domain | Ubiquitinyl hydrolase, variant UBP zinc finger | 16 - 78 | IPR041432 |
| domain | Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain | 655 - 702 | IPR041812 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| nuclear matrix | The dense fibrillar network lying on the inner side of the nuclear membrane. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| small nuclear ribonucleoprotein complex | A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| myosin binding | Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. |
| protein kinase A regulatory subunit binding | Binding to one or both of the regulatory subunits of protein kinase A. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| endomembrane system organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. |
| Golgi organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
| negative regulation of actin filament polymerization | Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization. |
| negative regulation of GTPase activity | Any process that stops or reduces the rate of GTP hydrolysis by a GTPase. |
| neuron projection development | The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| positive regulation of protein kinase B signaling | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| positive regulation of wound healing | Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of ARF protein signal transduction | Any process that modulates the frequency, rate or extent of ARF protein signal transduction. |
| regulation of establishment of cell polarity | Any process that modulates the frequency, rate or extent of establishment of cell polarity. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O46382 | ARFGEF1 | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 | Bos taurus (Bovine) | PR |
| Q9Y6D5 | ARFGEF2 | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 | Homo sapiens (Human) | PR |
| Q9Y6D6 | ARFGEF1 | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 | Homo sapiens (Human) | PR |
| A2A5R2 | Arfgef2 | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 | Mus musculus (Mouse) | PR |
| Q3TES0 | Iqsec3 | IQ motif and SEC7 domain-containing protein 3 | Mus musculus (Mouse) | SS |
| Q80YW0 | Cyth4 | Cytohesin-4 | Mus musculus (Mouse) | SS |
| O08967 | Cyth3 | Cytohesin-3 | Mus musculus (Mouse) | EV |
| Q8R0S2 | Iqsec1 | IQ motif and SEC7 domain-containing protein 1 | Mus musculus (Mouse) | SS |
| P63034 | Cyth2 | Cytohesin-2 | Mus musculus (Mouse) | SS |
| Q9QX11 | Cyth1 | Cytohesin-1 | Mus musculus (Mouse) | SS |
| Q5DU25 | Iqsec2 | IQ motif and SEC7 domain-containing protein 2 | Mus musculus (Mouse) | SS |
| D4A631 | Arfgef1 | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 | Rattus norvegicus (Rat) | PR |
| Q7TSU1 | Arfgef2 | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYEGKKTKNM | FLTRALEKIL | ADKEVKKAHH | SQLRKACEVA | LEEIKVETEK | QSPPHGEAKA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GSGTLPPVKS | KTNFIEADKY | FLPFELACQS | KCPRIVSTSL | DCLQKLIAYG | HLTGRAPDST |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TPGKKLIDRI | IETICGCFQG | PQTDEGVQLQ | IIKALLTAVT | SQHIEIHEGT | VLQAVRTCYN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IYLASKNLIN | QTTAKATLTQ | MLNVIFARME | NQALQEAKQM | ERERHRQQQH | LLQSPVSHHE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PESPHLRYLP | PQTVDHINQE | HEGDLEPQTH | DVDKSLQDDT | EPENGSDISS | AENEQTEADQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ATAAETLSKN | DILYDGDYEE | KPLDIVQSIV | EEMVNIIVGD | MGEGMAISAS | TEGNTGTVED |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GSDSENIQAN | GIPGTPISVA | YTPSLPDDRL | SVSSNDTQES | GNSSGPSPGA | KFSHILQKDA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FLVFRSLCKL | SMKPLSDGPP | DPKSHELRSK | ILSLQLLLSI | LQNAGPVFRT | NEMFINAIKQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YLCVALSKNG | VSSVPEVFEL | SLSIFLTLLS | NFKTHLKMQI | EVFFKEIFLY | ILETSTSSFD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HKWMVIQTLT | RICADAQSVV | DIYVNYDCDL | NAANIFERLV | NDLSKIAQGR | GSQELGMSNV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QELSLRKKGL | ECLVSILKCM | VEWSKDQYVN | PNSQTTLGQE | KPSEQEISEV | KHPETINRYG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SLNSLESTSS | SGIGSYSTQM | SGTDNPEQFE | VLKQQKEIIE | QGIDLFNKKP | KRGIQYLQEQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GMLGTTPEDI | AQFLHQEERL | DSTQVGEFLG | DNDKFNKEVM | YAYVDQHDFS | GKDFVSALRL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FLEGFRLPGE | AQKIDRLMEK | FAARYLECNQ | GQTLFASADT | AYVLAYSIIM | LTTDLHSPQV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KNKMTKEQYI | KMNRGINDSK | DLPEEYLSAI | YNEIAGKKIS | MKETKELTIP | TKSTKQNVAS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EKQRRLLYNL | EMEQMAKTAK | ALMEAVSHVQ | APFTSATHLE | HVRPMFKLAW | TPFLAAFSVG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LQDCDDTEVA | SLCLEGIRCA | IRIACIFSIQ | LERDAYVQAL | ARFTLLTVSS | GITEMKQKNI |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| DTIKTLITVA | HTDGNYLGNS | WHEILKCISQ | LELAQLIGTG | VKPRYISGTV | RGREGSLTGT |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KDQAPDEFVG | LGLVGGNVDW | KQIASIQESI | GETSSQSVVV | AVDRIFTGST | RLDGNAIVDF |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| VRWLCAVSMD | ELLSTTHPRM | FSLQKIVEIS | YYNMGRIRLQ | WSRIWEVIGD | HFNKVGCNPN |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| EDVAIFAVDS | LRQLSMKFLE | KGELANFRFQ | KDFLRPFEHI | MKRNRSPTIR | DMVVRCIAQM |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| VNSQAANIRS | GWKNIFSVFH | LAASDQDESI | VELAFQTTGH | IVTLVFEKHF | PATIDSFQDA |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| VKCLSEFACN | AAFPDTSMEA | IRLIRHCAKY | VSDRPQAFKE | YTSDDMSVAP | EDRVWVRGWF |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| PILFELSCII | NRCKLDVRTR | GLTVMFEIMK | TYGHTYEKHW | WQDLFRIVFR | IFDNMKLPEQ |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| QTEKAEWMTT | TCNHALYAIC | DVFTQYLEVL | SDVLLDDIFA | QLYWCVQQDN | EQLARSGTNC |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| LENVVILNGE | KFTLEIWDKT | CNCTLDIFKT | TIPHALLTWR | PTSGEAEPPS | PSAVSEKPLD |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| AISQKSVDIH | DSIQPRSSDN | RQQAPLVSVS | TVSEEVSKVK | STAKFPEQKL | FAALLIKCVV |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| QLELIQTIDN | IVFFPATSKK | EDAENLAAAQ | RDAVDFDVRV | DTQDQGMYRF | LTSQQLFKLL |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| DCLLESHRFA | KAFNSNNEQR | TALWKAGFKG | KSKPNLLKQE | TSSLACGLRI | LFRMYMDESR |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| VSAWEEVQQR | LLNVCREALS | YFLTLTSESH | REAWTNLLLL | FLTKVLKISD | SRFKAHASFY |
| 1810 | 1820 | 1830 | 1840 | ||
| YPLLCEIMQF | DLIPELRAVL | RRFFLRIGIV | FQISQPPEQE | LGINRQ |