G2XKQ0

SS
Gene name
SUMO1P1 (SUMO5, UBL2, UBL6)
Protein name
Small ubiquitin-related modifier 5
Names
SUMO-5 , SUMO1 pseudogene 1 , Ubiquitin-like 2 , Ubiquitin-like 6
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The N-terminal region of SUMO1 functions as an autoinhibition domain by blocking its binding to the phosphorylated SIMs of PML and Daxx. This autoinhibition is relieved by zinc, which stabilizes the complex between SUMO1 and a phospho-mimetic form of the SIM of PML, suggesting a paralog specific function of SUMO1 in regulating SUMO1-SIM interactions required for PML-NB formation and function.

Autoinhibitory domains (AIDs)

17-97 (N-terminal region) SS

Target domain

20-97 (Ubiquitin-like domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for G2XKQ0

Entry ID Method Resolution Chain Position Source
6IAM X-ray 151 A C 5-8 PDB
AF-G2XKQ0-F1 Predicted AlphaFoldDB

No variants for G2XKQ0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for G2XKQ0

No associated diseases with G2XKQ0

5 regional properties for G2XKQ0

Type Name Position InterPro Accession
domain IBR domain 194 - 255 IPR002867-1
domain IBR domain 263 - 327 IPR002867-2
domain TRIAD supradomain 124 - 331 IPR044066
domain Ariadne domain 341 - 453 IPR045840
domain E3 ubiquitin-protein ligase ARIH1-like, UBA-like domain 61 - 100 IPR048962

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Forms prominent non-membrane-bound structures in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
PML body A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.

4 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
protein tag activity A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation.
transcription factor binding Binding to a transcription factor, a protein required to initiate or regulate transcription.
ubiquitin-like protein ligase binding Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase.

2 GO annotations of biological process

Name Definition
PML body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia).
protein sumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12306 SMT3 Ubiquitin-like protein SMT3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
Q5E9D1 SUMO1 Small ubiquitin-related modifier 1 Bos taurus (Bovine) SS
Q8QGH2 SUMO1 Small ubiquitin-related modifier 1 Gallus gallus (Chicken) SS
P61956 SUMO2 Small ubiquitin-related modifier 2 Homo sapiens (Human) SS
Q6EEV6 SUMO4 Small ubiquitin-related modifier 4 Homo sapiens (Human) SS
P55854 SUMO3 Small ubiquitin-related modifier 3 Homo sapiens (Human) SS
P63165 SUMO1 Small ubiquitin-related modifier 1 Homo sapiens (Human) EV
P63166 Sumo1 Small ubiquitin-related modifier 1 Mus musculus (Mouse) SS
A7WLH8 SUMO1 Small ubiquitin-related modifier 1 Sus scrofa (Pig) SS
Q5I0H3 Sumo1 Small ubiquitin-related modifier 1 Rattus norvegicus (Rat) SS
P55857 SUMO1 Small ubiquitin-related modifier 1 Oryza sativa subsp. japonica (Rice) SS
P55853 smo-1 Small ubiquitin-related modifier Caenorhabditis elegans SS
Q9FKC5 SUMO4 Putative small ubiquitin-related modifier 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FLP5 SUMO3 Small ubiquitin-related modifier 3 Arabidopsis thaliana (Mouse-ear cress) SS
P55852 SUMO1 Small ubiquitin-related modifier 1 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FLP6 SUMO2 Small ubiquitin-related modifier 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q8VZI7 SUMO5 Small ubiquitin-related modifier 5 Arabidopsis thaliana (Mouse-ear cress) SS
B3H5R8 SUMO8 Putative small ubiquitin-related modifier 8 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E8A8 SUMO7 Putative small ubiquitin-related modifier 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q6DEP7 sumo1 Small ubiquitin-related modifier 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q7SZR5 sumo1 Small ubiquitin-related modifier 1 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MSDLEAKPST EHLGDKIKDE DIKLRVIGQD SSEIHFKVKM TTPLKKLKKS YCQRQGVPVN
70 80 90 100
SLRFLFEGQR IADNHTPEEL GMEEEDVIEV YQEQIGGHST V