G1KGI8

SS
Gene name
MDM4
Protein name
Protein Mdm4
Names
Species
Anolis carolinensis (Green anole) (American chameleon)
KEGG Pathway
EC number
Protein Class

Descriptions

MDM4 is a homologous protein that binds to p53 and regulates its activity. Intrinsically disordered region constitute an inhibitory module. It competes with the p53TAD for binding to the NTD of MDM4, thus lowering the affinity of MDMX for p53. Efficient binding of MDM4 to p53 requires a mechanism to relieve the allosteric self-inhibition.

Autoinhibitory domains (AIDs)

177-197 (Tryptohpan-rich segment) SS

Target domain

24-107 (SWIB/MDM2 domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for G1KGI8

Entry ID Method Resolution Chain Position Source
AF-G1KGI8-F1 Predicted AlphaFoldDB

No variants for G1KGI8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for G1KGI8

No associated diseases with G1KGI8

2 regional properties for G1KGI8

Type Name Position InterPro Accession
domain Zinc finger, RanBP2-type 286 - 315 IPR001876
domain SWIB/MDM2 domain 24 - 107 IPR003121

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription repressor complex A protein complex that possesses activity that prevents or downregulates transcription.

3 GO annotations of molecular function

Name Definition
enzyme binding Binding to an enzyme, a protein with catalytic activity.
metal ion binding Binding to a metal ion.
p53 binding Binding to one of the p53 family of proteins.

9 GO annotations of biological process

Name Definition
cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
DNA damage response, signal transduction by p53 class mediator A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
protein-containing complex assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSSTSAQFP LHEKACRTSS ERITQVRPKL PLLRILQTAG AQGETFTLKQ IIHYLGEYIV
70 80 90 100 110 120
LKQLYDKEEQ HMVYCEGDQL GDLLGRESFS VRDPSPVYDM LKRNVTPASV TDAAQTHALA
130 140 150 160 170 180
KDQSVDNPSQ DQLKSSTERS SSIEYKEETS IWYTSKSGCI EDTDNPSKEQ TSLDSVLEEW
190 200 210 220 230 240
DVPGLPWWFL GNLRNNYKSR SNGSTDIQTS QDVDTAVVSD TTDDLWFLSE AVSEQLGVTV
250 260 270 280 290 300
PMKTIDCEHA NEDGKENNKM VSEVTSSDDF EDSQSLSDDT DNDIAPEDGW QCTKCKKFNS
310 320 330 340 350 360
PIKRYCLRCW ALRKDWFFDC PKLKHSVSTS NIASLQSTDE AEGMDVPDCR RTVSAPVVRP
370 380 390 400 410 420
KDLCSSDVTC SSSPKSSMDS LDVSQLCEQR KPVLQLGKRK EKEEEEAQSL ETCKELLKPC
430 440 450 460 470
PLCRKRPRNG NIVHGKTAHL VACFPCARML KKTRSPCPLC KKQIQVVIKT YIS