F8VPU2

SS
Gene name
Farp1
Protein name
FERM, ARHGEF and pleckstrin domain-containing protein 1
Names
FERM, RhoGEF and pleckstrin domain-containing protein 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:223254
EC number
Protein Class

Descriptions

Farp1 is a guanine nucleotide exchange factor for RAC1. Farp1 contains a FERM domain, a Dbl-homology (DH) domain and two pleckstrin homology (PH) domains. In a structural study with mouse Farp2 (Q91VS8), the GEF substrate-binding site is blocked collectively by the last helix (Helix α6) in the DH domain and the two PH domains.

Autoinhibitory domains (AIDs)

731-749 (C-terminal portion of Helix α6 in DH domain) SS

Target domain

542-733 (DH domain)

Relief mechanism

PTM

Assay

762-1032 (PH domains) SS

Target domain

542-733 (DH domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F8VPU2

Entry ID Method Resolution Chain Position Source
AF-F8VPU2-F1 Predicted AlphaFoldDB

10 variants for F8VPU2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs215597022 195 R>K No Ensembl
rs225066043 198 E>G No Ensembl
rs244392008 204 V>I No Ensembl
rs245902180 405 G>D No Ensembl
rs48774662 417 A>V No Ensembl
rs46014814 619 V>I No Ensembl
rs252225615 623 Y>N No Ensembl
rs50748534 663 R>W No Ensembl
rs30242657 751 I>V No Ensembl
rs30629338 758 T>I No Ensembl

No associated diseases with F8VPU2

6 regional properties for F8VPU2

Type Name Position InterPro Accession
domain Protein kinase domain 53 - 304 IPR000719
domain Kinase associated domain 1 (KA1) 727 - 776 IPR001772
active_site Serine/threonine-protein kinase, active site 171 - 183 IPR008271
domain Ubiquitin-associated domain 323 - 362 IPR015940
binding_site Protein kinase, ATP binding site 59 - 82 IPR017441
domain Serine/threonine-protein kinase MARK 1-4, catalytic domain 52 - 304 IPR049508

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Synapse
  • Synapse, synaptosome
  • Cytoplasm, cytosol
  • Cell projection, filopodium
  • Cell projection, dendrite
  • Cell projection, dendritic spine
  • Recruited to the cell membrane via interaction with CADM1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
extrinsic component of postsynaptic membrane The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.

3 GO annotations of molecular function

Name Definition
cytoskeletal protein binding Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
small GTPase binding Binding to a small monomeric GTPase.

5 GO annotations of biological process

Name Definition
dendrite morphogenesis The process in which the anatomical structures of a dendrite are generated and organized.
postsynaptic actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
regulation of presynapse assembly Any process that modulates the frequency, rate or extent of presynapse assembly.
retrograde trans-synaptic signaling by trans-synaptic protein complex Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex.
synapse assembly The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
F1P065 FARP1 FERM, ARHGEF and pleckstrin domain-containing protein 1 Gallus gallus (Chicken) SS
O94887 FARP2 FERM, ARHGEF and pleckstrin domain-containing protein 2 Homo sapiens (Human) SS
Q9Y4F1 FARP1 FERM, ARHGEF and pleckstrin domain-containing protein 1 Homo sapiens (Human) SS
A2AD83 Frmd7 FERM domain-containing protein 7 Mus musculus (Mouse) PR
Q91VS8 Farp2 FERM, ARHGEF and pleckstrin domain-containing protein 2 Mus musculus (Mouse) EV
F1LYQ8 Farp1 FERM, ARHGEF and pleckstrin domain-containing protein 1 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MGEIEQKPTP ASRLGAPENS GISTLERGQK PPPTPSGKLM TVKIQMLDDT QEAFEVPQRA
70 80 90 100 110 120
PGKVLFDAVC NHLNLVEGDY FGLEFPDHRK IVVWLDLLKP IVKQIRRPKH VVVKFVVKFF
130 140 150 160 170 180
PPDHTQLQEE LTRYLFALQV KQDLAQGRLT CNDTSAALLI SHIVQSEIGD FDEALDREHL
190 200 210 220 230 240
AKNKYVPQQD ALEDRIMEFH HSHVGQTPAE SDFQLLEVAR RLEMYGIRLH PAKDREGTKI
250 260 270 280 290 300
NLAVANTGIL VFQGFTKINA FNWAKVRKLS FKRKRFLIKL RPDVNSSYQD TLEFLMAGRD
310 320 330 340 350 360
FCKSFWKICV EHHAFFRLFE EPKPKPKPVL FSRGSSFRFS GRTQKQVLDY VKEGGHKKVQ
370 380 390 400 410 420
FERKHSKIHS TRSLVSQPTA PNSEVPKQSP QSASLTFGEG TESPGGQSCQ QAKETKACTL
430 440 450 460 470 480
ELGPHQSPAL PKSPPGSKAA DGTTVVPPEE EEEEEGGKDG IRPSNPQPPQ PSTGSLTGSP
490 500 510 520 530 540
HLSELSINSQ GGAAPANVTL SPNLSPDNKQ ASPLISPLLN DQACPRTDDE EEGRRKRFPT
550 560 570 580 590 600
DKAYYIAKEV STTERTYLKD LEVIASWFQS TVSKEDSMPE ALKSLIFPNF EPLHKFHTNF
610 620 630 640 650 660
LKEIEQRLAL WEGRSNAHVR GDYQRIGDVM LKNIQGMKHL AAHLWKHSEA LEALETSIKG
670 680 690 700 710 720
SRRLEHFCRD FELQKVCYLP LNTFLLRPLH RLMHYKHVLE RLCKHHPPNH ADFRDCRAAL
730 740 750 760 770 780
AEITEMVAQL HGTMIKMENF QKLHELKKDL IGIDNLVTPG REFIRLGSLS KLSGKGLQQR
790 800 810 820 830 840
MFFLFNDVLL YTSRGLTASN QFKVHGQLPL YGMTIEESEE EWGVPHCLTL RGQRQSIIVA
850 860 870 880 890 900
ASSRSEMEKW MEDIQMAIDL AEKSNGPTPE LLASSPPDNK SPDEATAADQ ESEDDLSASR
910 920 930 940 950 960
TSLERQAPHR GNTMVHVCWH RSTSVSMVDF SIAVENQLSG NLLRKFKNSN GWQKLWVVFT
970 980 990 1000 1010 1020
NFCLFFYKSH QDSHPLASLP LLGYSLTIPS ESENIHKDYV FKLHFKSHVY YFRAESEYTF
1030 1040
ERWMEVIRSA TSSASRAHIL SHKESHLY