F7BJB9
SS
Gene name |
Morc3 (Nxp2, Zcwcc3) |
Protein name |
MORC family CW-type zinc finger protein 3 |
Names |
Nuclear matrix protein 2 , Zinc finger CW-type coiled-coil domain protein 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:338467 |
EC number |
|
Protein Class |
|
Descriptions
Microrchidia 3 is a human protein linked to autoimmune disorders, Down syndrome, and cancer. The extensive ATPase:CW interface stabilizes the protein fold and inhibits the catalytic activity of MORC3. The CW domain sterically impedes binding of the ATPase domain to DNA. MORC3 autoinhibition is released by disrupting the intramolecular ATPase:DW coupling through the competitive interaction of CW with histone H3 tail. Binding of CW to H3 leads to a marked rearrangement in the ATPase-CW cassette, which frees the DNA-binding site in active MORC3.
Autoinhibitory domains (AIDs)
Target domain |
17-290 (C-terminal ATPase domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Zhang Y et al. (2019) "Mechanism for autoinhibition and activation of the MORC3 ATPase", Proceedings of the National Academy of Sciences of the United States of America, 116, 6111-6119
- Zhang Y et al. (2019) "MORC3 Is a Target of the Influenza A Viral Protein NS1", Structure (London, England : 1993), 27, 1029-1033.e3
- Zhang Y et al. (2019) "MORC3 Forms Nuclear Condensates through Phase Separation", iScience, 17, 182-189
Autoinhibited structure
Activated structure
3 structures for F7BJB9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5IX1 | X-ray | 260 A | A/B | 7-456 | PDB |
| 5IX2 | X-ray | 290 A | A/B | 7-456 | PDB |
| AF-F7BJB9-F1 | Predicted | AlphaFoldDB |
47 variants for F7BJB9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3406400039 | 2 | A>T | No | EVA | |
| rs3389427214 | 38 | D>E | No | EVA | |
| rs1133568892 | 86 | S>R | No | EVA | |
| rs1132506974 | 90 | T>N | No | EVA | |
| rs1133370237 | 91 | M>V | No | EVA | |
| rs3389419658 | 147 | I>F | No | EVA | |
| rs3389426630 | 174 | L>R | No | EVA | |
| rs217542071 | 176 | S>P | No | EVA | |
| rs3389417077 | 221 | I>T | No | EVA | |
| rs3389443631 | 240 | M>V | No | EVA | |
| rs3389433797 | 286 | E>* | No | EVA | |
| rs3389417133 | 294 | F>I | No | EVA | |
| rs3389418521 | 331 | G>* | No | EVA | |
| rs3389443625 | 352 | L>F | No | EVA | |
| rs3389422135 | 374 | L>P | No | EVA | |
| rs3389443597 | 377 | K>M | No | EVA | |
| rs3389422154 | 392 | E>K | No | EVA | |
| rs3389437052 | 458 | V>M | No | EVA | |
| rs3389443679 | 481 | I>N | No | EVA | |
| rs3389425505 | 495 | Y>F | No | EVA | |
| rs47825490 | 511 | V>I | No | EVA | |
| rs3389427197 | 515 | H>Q | No | EVA | |
| rs3389418554 | 526 | R>K | No | EVA | |
| rs49028347 | 536 | A>T | No | EVA | |
| rs50696691 | 548 | L>F | No | EVA | |
| rs3389425556 | 561 | R>K | No | EVA | |
| rs213293367 | 567 | V>I | No | EVA | |
| rs235019914 | 576 | D>E | No | EVA | |
| rs3389425551 | 590 | K>N | No | EVA | |
| rs222635589 | 593 | V>L | No | EVA | |
| rs3389430485 | 607 | Q>K | No | EVA | |
| rs3389419671 | 612 | Q>K | No | EVA | |
| rs51163235 | 616 | H>Q | No | EVA | |
| rs50041464 | 630 | S>T | No | EVA | |
| rs3389341266 | 650 | D>V | No | EVA | |
| rs3389418499 | 657 | K>I | No | EVA | |
| rs32831025 | 679 | G>S | No | EVA | |
| rs3389396012 | 684 | V>L | No | EVA | |
| rs241142641 | 696 | S>G | No | EVA | |
| rs3389437038 | 714 | D>Y | No | EVA | |
| rs3389425554 | 751 | T>A | No | EVA | |
| rs229373999 | 788 | R>K | No | EVA | |
| rs3389419664 | 796 | V>M | No | EVA | |
| rs3389430456 | 838 | N>Y | No | EVA | |
| rs3389437116 | 854 | C>Y | No | EVA | |
| rs220447420 | 872 | A>G | No | EVA | |
| rs3389396025 | 874 | D>Y | No | EVA |
No associated diseases with F7BJB9
6 regional properties for F7BJB9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 644 - 769 | IPR000008 |
| domain | Phosphatidylinositol-specific phospholipase C, X domain | 337 - 483 | IPR000909 |
| domain | Phospholipase C, phosphatidylinositol-specific, Y domain | 528 - 644 | IPR001711 |
| domain | Pleckstrin homology domain | 65 - 174 | IPR001849 |
| binding_site | EF-Hand 1, calcium-binding site | 231 - 243 | IPR018247 |
| domain | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3, EF hand domain | 186 - 324 | IPR039504 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nuclear matrix | The dense fibrillar network lying on the inner side of the nuclear membrane. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| PML body | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP hydrolysis activity | Catalysis of the reaction |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| methylated histone binding | Binding to a histone in which a residue has been modified by methylation. |
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| zinc ion binding | Binding to a zinc ion (Zn). |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| antiviral innate immune response | A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. |
| maintenance of protein location in nucleus | Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. |
| negative regulation of fibroblast proliferation | Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. |
| negative regulation of interferon-beta production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of cellular senescence | Any process that activates or increases the frequency, rate or extent of cellular senescence. |
| post-embryonic development | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8TE76 | MORC4 | MORC family CW-type zinc finger protein 4 | Homo sapiens (Human) | SS |
| Q9Y6X9 | MORC2 | ATPase MORC2 | Homo sapiens (Human) | PR |
| Q14149 | MORC3 | MORC family CW-type zinc finger protein 3 | Homo sapiens (Human) | EV |
| Q69ZX6 | Morc2a | ATPase MORC2A | Mus musculus (Mouse) | PR |
| Q8C5W4 | Morc2b | ATPase MORC2B | Mus musculus (Mouse) | PR |
| Q8BMD7 | Morc4 | MORC family CW-type zinc finger protein 4 | Mus musculus (Mouse) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAQPPTGIR | LSALCPKFLH | TNSTSHTWPF | SAVAELIDNA | YDPDVNAKQI | WIDKTVISDH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ICLTFTDNGN | GMTADKLHKM | LSFGFSDKVT | MNGHVPVGLY | GNGFKSGSMR | LGKDAMVFTK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NGETMSVGFL | SQTYLEVIKA | EHVVVPIVTF | NKHRQMINLT | ESKASLAAIL | EHSLFSTEQK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLAELNAIMG | KKGTRIIIWN | LRSYKNATEF | DFEKDKYDIR | IPEDLDETAG | RKGYKKQERM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DQIAPESDYS | LRAYCSILYL | KPRMQIIIRG | QKVKTQLVSK | SLAYIERDVY | RPKFLTRTVR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ITFGFNCRNK | DHYGIMMYHK | NRLIKAYEKV | GCQLKANNMG | VGVVGIIECN | FLKPTHNKQD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FDYTNEYRLT | ILALGEKLND | YWNEMKVKKN | AEYPVNLPVE | DIQKRPDQTW | VQCDACLKWR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KLPDGIDQLP | EKWYCSNNPD | PQFRNCEVPE | EPEDEDLVHP | TYEKTYKKTS | KERFRIRQPE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ILPRILPQIN | PELLYQTSVS | SQSFSPVKES | VPRPHLSEVT | SPFAARIINL | NLASPASEPE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NSSMKRKLGV | HSSILNAKTR | RLSNPPVENS | SYKNDDDEDV | IILEENSTPK | PAVDLEVKSD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IEVKSEQSHT | EQSGIHVDLV | SSPKPCVQAS | STSTSTSRSD | PGITVSTQTD | APGLTVKKEE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SMEEDMGVRN | GTATLSCVGT | EAKVQETSAE | SVDATSHQLQ | ELRSELLVVT | QERDDYKRQC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QMFTDQIQVL | QQRLLEMNDK | CVKKEKCHQS | TETDAVFLLD | SVNGQAESLD | HLGSQYQQAL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QEIERLKRQC | SALQQVKSEC | SQASCTESKS | EVDEMAVQLD | DVFRQLDKCT | IERDQYKNEV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| QLLEIEKSHI | HSQCEELQTE | VEQLKSTGQQ | AAADGSTASN | AEEPVSYVDG | ESLKLRSLRV |
| 910 | 920 | 930 | 940 | ||
| NVGQLLAMIV | PDLDLQQVNY | DVDVVDEILG | QVVEQMSEIS | ST |