F6PHZ6

PR
Gene name
FKBP6 (FKBP36)
Protein name
Inactive peptidyl-prolyl cis-trans isomerase FKBP6
Names
Inactive PPIase FKBP6, 36 kDa FK506-binding protein, FK506-binding protein 6, FKBP-6, Immunophilin FKBP36
Species
Equus caballus (Horse)
KEGG Pathway
ecb:100061393
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F6PHZ6

Entry ID Method Resolution Chain Position Source
AF-F6PHZ6-F1 Predicted AlphaFoldDB

2 variants for F6PHZ6

Variant ID(s) Position Change Description Diseaes Association Provenance
174 H>N associated with the impaired acrosomal reaction phenotype [UniProt] No
229 C>R No

No associated diseases with F6PHZ6

3 regional properties for F6PHZ6

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 255 IPR000719
active_site Serine/threonine-protein kinase, active site 120 - 132 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
synaptonemal complex A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element.

1 GO annotations of molecular function

Name Definition
Hsp90 protein binding Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.

7 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
DNA methylation involved in gamete generation The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.
gene silencing by RNA A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
piRNA metabolic process The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QQ71 FKBP6 Inactive peptidyl-prolyl cis-trans isomerase FKBP6 Bos taurus (Bovine) PR
Q9W1I9 shu Inactive peptidyl-prolyl cis-trans isomerase shutdown Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MGGSAPGQSP YQRLSQRMLD ISGDRGVLKD VIREGAGELV TPDASVLVKY SGYLEHMDKP
70 80 90 100 110 120
FDSNCFRKTP RLMKLGEDIT LWGMELGLLS MRRGELARFL FKPTYAYGTL GCPPLIPPNT
130 140 150 160 170 180
TVLFEIELLD FLDSAESDKF CALSAEQQDQ FPLQKVLKVA ATEREFGNYL FRQHRFYDAK
190 200 210 220 230 240
VRYKRALLLL HRRSAPPEEQ HLVEAAKLLV LLNLSFTYLK LERPTTALCY GEQALVIDQK
250 260 270 280 290 300
NAKALFRCGQ ACLLMTEYQK ARDFLVQAQK AQPFNHDINN ELKKLASCYK DYTDKEKEMC
310
HRMFAPCDDD SAVGEN