F4K128
PR
Gene name |
CHR23 |
Protein name |
Probable ATP-dependent DNA helicase CHR23 |
Names |
Protein CHROMATIN REMODELING 23, AtCHR23, Protein MINUSCULE 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G19310 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4K128
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4K128-F1 | Predicted | AlphaFoldDB |
61 variants for F4K128
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH10859659 | 13 | P>S | No | 1000Genomes | |
| tmp_5_6498980_C_T,A | 25 | N>K | No | 1000Genomes | |
| ENSVATH03080611 | 39 | A>D | No | 1000Genomes | |
| tmp_5_6499020_G_A | 39 | A>T | No | 1000Genomes | |
| tmp_5_6499026_G_A | 41 | V>I | No | 1000Genomes | |
| tmp_5_6499041_C_T,A | 46 | H>N | No | 1000Genomes | |
| tmp_5_6499041_C_T,A | 46 | H>Y | No | 1000Genomes | |
| ENSVATH00631956 | 47 | A>G | No | 1000Genomes | |
| ENSVATH10859660 | 50 | S>F | No | 1000Genomes | |
| ENSVATH03080615 | 55 | S>P | No | 1000Genomes | |
| ENSVATH03080617 | 68 | G>V | No | 1000Genomes | |
| tmp_5_6499307_G_C | 75 | E>Q | No | 1000Genomes | |
| ENSVATH00631958 | 85 | Y>C | No | 1000Genomes | |
| ENSVATH06995133 | 87 | S>L | No | 1000Genomes | |
| ENSVATH00631959 | 99 | Y>F | No | 1000Genomes | |
| ENSVATH03080618 | 101 | N>S | No | 1000Genomes | |
| ENSVATH00631960 | 109 | Q>E | No | 1000Genomes | |
| tmp_5_6499418_G_A | 112 | G>R | No | 1000Genomes | |
| ENSVATH06995141 | 123 | E>G | No | 1000Genomes | |
| ENSVATH03080623 | 127 | L>F | No | 1000Genomes | |
| ENSVATH00631962 | 140 | R>K | No | 1000Genomes | |
| ENSVATH00631962 | 140 | R>M | No | 1000Genomes | |
| tmp_5_6499713_G_T | 143 | G>V | No | 1000Genomes | |
| ENSVATH10859701 | 146 | S>R | No | 1000Genomes | |
| tmp_5_6499764_G_C | 160 | R>T | No | 1000Genomes | |
| tmp_5_6499769_C_A | 162 | L>I | No | 1000Genomes | |
| tmp_5_6499807_G_A | 174 | M>I | No | 1000Genomes | |
| ENSVATH03080628 | 180 | S>P | No | 1000Genomes | |
| ENSVATH14094075 | 193 | R>H | No | 1000Genomes | |
| tmp_5_6500142_A_G | 231 | I>V | No | 1000Genomes | |
| tmp_5_6500173_G_A | 241 | R>K | No | 1000Genomes | |
| tmp_5_6500335_G_T | 248 | W>L | No | 1000Genomes | |
| ENSVATH10859703 | 328 | S>F | No | 1000Genomes | |
| ENSVATH06995158 | 406 | N>S | No | 1000Genomes | |
| ENSVATH06995162 | 524 | A>V | No | 1000Genomes | |
| tmp_5_6501333_A_G | 528 | T>A | No | 1000Genomes | |
| ENSVATH06995168 | 581 | E>D | No | 1000Genomes | |
| tmp_5_6501857_A_G | 603 | I>M | No | 1000Genomes | |
| ENSVATH06995173 | 645 | V>I | No | 1000Genomes | |
| ENSVATH06995174 | 718 | S>T | No | 1000Genomes | |
| ENSVATH14094078 | 727 | L>F | No | 1000Genomes | |
| tmp_5_6502352_A_G | 734 | N>D | No | 1000Genomes | |
| tmp_5_6502355_G_A | 735 | D>N | No | 1000Genomes | |
| tmp_5_6502383_G_A | 744 | S>N | No | 1000Genomes | |
| tmp_5_6502431_C_T | 760 | P>L | No | 1000Genomes | |
| tmp_5_6502670_G_A | 840 | D>N | No | 1000Genomes | |
| ENSVATH06995176 | 905 | R>C | No | 1000Genomes | |
| tmp_5_6503023_C_T | 929 | T>I | No | 1000Genomes | |
| tmp_5_6503052_C_T | 939 | H>Y | No | 1000Genomes | |
| ENSVATH14094079 | 945 | G>S | No | 1000Genomes | |
| tmp_5_6503167_T_A | 977 | V>D | No | 1000Genomes | |
| tmp_5_6503166_G_T | 977 | V>F | No | 1000Genomes | |
| tmp_5_6503178_C_T | 981 | R>* | No | 1000Genomes | |
| ENSVATH00631973 | 988 | T>A | Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| ENSVATH06995178 | 994 | S>L | No | 1000Genomes | |
| tmp_5_6503232_G_C | 999 | V>L | No | 1000Genomes | |
| ENSVATH06995179 | 1019 | G>E | No | 1000Genomes | |
| tmp_5_6503296_A_G | 1020 | K>R | No | 1000Genomes | |
| ENSVATH03080639 | 1035 | T>S | No | 1000Genomes | |
| tmp_5_6503383_C_A | 1049 | S>* | No | 1000Genomes | |
| ENSVATH14094080 | 1063 | R>Q | No | 1000Genomes |
No associated diseases with F4K128
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent activity, acting on DNA | Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. |
| ATP-dependent chromatin remodeler activity | An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. |
| chromatin DNA binding | Binding to DNA that is assembled into chromatin. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| maintenance of root meristem identity | The process in which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. |
| maintenance of seed dormancy | Any process that maintains a seed in a dormant state. |
| maintenance of shoot apical meristem identity | The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| unidimensional cell growth | The process in which a cell irreversibly increases in size in one |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32597 | STH1 | Nuclear protein STH1/NPS1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| F4J9M5 | CHR12 | Probable ATP-dependent DNA helicase CHR12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9XFH4 | DDM1 | ATP-dependent DNA helicase DDM1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWY3 | CHR11 | ISWI chromatin-remodeling complex ATPase CHR11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVKQLQEQEE | NDPVEKTKSL | ISALNYLSRD | LLLPSHLYAS | VSSIYHASVS | DLSPSPPLRG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NSYTPNRGDL | MSEFEDALLQ | QRLNYESGSR | LAELKETRYK | NRIHNRLSQL | EGLPSNRGED |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LQEKCLLELY | GLKLQELQCR | VRGEVSAEYW | LRLNCADPER | QLYDWGMMRL | PRRMYGVGDS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FVMEADDQFR | NKRDAERLLR | LEEEEKNLIE | TTQRKFFAEV | LNAVREFQLQ | IQASHRRCKQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RNDGVQAWHG | KQRQRATRAE | KLRIMALKSD | DQEEYMKLAK | ESKNEKLTLF | LEETNKIFVS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGAAVQRQKD | AKLSENTKLL | KGSESDLSDV | DAPEDVLPAQ | DIEIIDSDNN | DDSNDLLEGE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RQFNLAIHSI | QEKVTKQPSL | LQGGELRSYQ | LEGLQWMVSL | YNNDYNGILA | DEMGLGKTIQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TIALIAYLLE | SKDLHGPHLI | LAPKAVLPNW | ENEFALWAPS | ISAFLYDGSK | EKRTEIRARI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AGGKFNVLIT | HYDLIMRDKA | FLKKIDWNYM | IVDEGHRLKN | HECALAKTLG | TGYRIKRRLL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LTGTPIQNSL | QELWSLLNFL | LPHIFNSIHN | FEEWFNTPFA | ECGSASLTDE | EELLIINRLH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HVIRPFLLRR | KKSEVEKFLP | GKTQVILKCD | MSAWQKLYYK | QVTDVGRVGL | HSGNGKSKSL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QNLTMQLRKC | CNHPYLFVGA | DYNMCKKPEI | VRASGKFELL | DRLLPKLKKA | GHRILLFSQM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TRLIDLLEIY | LSLNDYMYLR | LDGSTKTDQR | GILLKQFNEP | DSPYFMFLLS | TRAGGLGLNL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QTADTIIIFD | SDWNPQMDQQ | AEDRAHRIGQ | KKEVRVFVLV | SIGSIEEVIL | ERAKQKMGID |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AKVIQAGLFN | TTSTAQDRRE | MLEEIMSKGT | SSLGEDVPSE | REINRLAART | EEEFWMFEQM |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DEERRKKENY | KTRLMEEKEV | PEWAYTSETQ | EDKTNAKNHF | GSLTGKRKRK | EAVYSDSLSD |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LQWMKAMESE | DEDASKVSQK | RKRTDTKTRM | SNGSKAEAVL | SESDEEKEEE | EEERKEESGK |
| 1030 | 1040 | 1050 | 1060 | ||
| ESEEENEKPL | HSWKTNKKKR | SRYPVMTSSP | NSRGKGSSKG | SKRN |