F4JJE0

SS
Gene name
CCT2 (At4g15130, dl3610w, FCAALL.209)
Protein name
Choline-phosphate cytidylyltransferase 2
Names
AtCCT2 , EC 2.7.7.15 , CTP:phosphocholine cytidylyltransferase 2 , Phosphorylcholine transferase 2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G15130
EC number
2.7.7.15: Nucleotidyltransferases
Protein Class

Descriptions

Phosphocholine cytidylyltransferase (CCT) interconverts between an inactive soluble and active membrane-bound form in response to changes in membrane lipid composition. Activation involves disruption of an inhibitory interaction between the alphaE helices at the base of the active site and an autoinhibitory (AI) segment in the regulatory M domain and membrane insertion of the M domain as an amphipathic helix.

Autoinhibitory domains (AIDs)

216-236 (autoinhibitory segment in the M domain) SS

Target domain

148-169 (alphaE helices within the catalytic domain)

Relief mechanism

Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F4JJE0

Entry ID Method Resolution Chain Position Source
AF-F4JJE0-F1 Predicted AlphaFoldDB

No variants for F4JJE0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for F4JJE0

No associated diseases with F4JJE0

2 regional properties for F4JJE0

Type Name Position InterPro Accession
domain Cytidyltransferase-like domain 22 - 153 IPR004821
domain CTP:phosphocholine cytidylyltransferase domain 19 - 170 IPR041723

Functions

Description
EC Number 2.7.7.15 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
choline-phosphate cytidylyltransferase activity Catalysis of the reaction
phosphatidylcholine binding Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline.

1 GO annotations of biological process

Name Definition
phosphatidylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P49585 PCYT1A Choline-phosphate cytidylyltransferase A Homo sapiens (Human) SS
Q9Y5K3 PCYT1B Choline-phosphate cytidylyltransferase B Homo sapiens (Human) PR
P49586 Pcyt1a Choline-phosphate cytidylyltransferase A Mus musculus (Mouse) SS
Q811Q9 Pcyt1b Choline-phosphate cytidylyltransferase B Mus musculus (Mouse) SS
P19836 Pcyt1a Choline-phosphate cytidylyltransferase A Rattus norvegicus (Rat) EV
Q9QZC4 Pcyt1b Choline-phosphate cytidylyltransferase B Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MSVNGENKVS GGDSSSSDRP VRVYADGIFD LFHFGHARAI EQAKKSFPNT YLLVGCCNDE
70 80 90 100 110 120
ITNKFKGKTV MTESERYESL RHCKWVDEVI PDAPWVLTTE FLDKHKIDYV AHDALPYADT
130 140 150 160 170 180
SGAGNDVYEF VKSIGKFKET KRTEGISTSD IIMRIVKDYN QYVLRNLDRG YSREELGVSF
190 200 210 220 230 240
EEKRLRVNMR LKKLQEKVKE QQEKIQTVAK TAGMHHDEWL ENADRWVAGF LEMFEEGCHK
250 260 270 280 290 300
MGTAIRDGIQ QRLMRQESEE NRRLLQNGLT ISKDNDDEQM SDDNEFAEED CVNVSNKGIE
TVKK