Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for F4IFF3

Entry ID Method Resolution Chain Position Source
AF-F4IFF3-F1 Predicted AlphaFoldDB

80 variants for F4IFF3

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH13054618 3 S>L No 1000Genomes
ENSVATH01775566 8 S>A No 1000Genomes
ENSVATH09452602 9 E>D No 1000Genomes
ENSVATH01775568 9 E>V No 1000Genomes
ENSVATH01775569 10 H>Y No 1000Genomes
ENSVATH00227694 13 S>P No 1000Genomes
ENSVATH01775570 14 M>V No 1000Genomes
tmp_2_5909302_C_G 21 H>Q No 1000Genomes
ENSVATH01775571 23 P>S No 1000Genomes
tmp_2_5909319_G_A 27 R>H No 1000Genomes
tmp_2_5909321_G_A 28 E>K No 1000Genomes
ENSVATH13054620 42 F>S No 1000Genomes
ENSVATH00227695 43 I>L No 1000Genomes
ENSVATH05449637 44 E>V No 1000Genomes
ENSVATH00227696 54 S>P No 1000Genomes
ENSVATH01775574 58 Q>R No 1000Genomes
tmp_2_5909418_T_A 60 F>Y No 1000Genomes
ENSVATH00227698 62 D>N No 1000Genomes
tmp_2_5909436_A_C 66 Y>S No 1000Genomes
ENSVATH01775577 72 D>E No 1000Genomes
ENSVATH14422579 85 M>T No 1000Genomes
tmp_2_5909569_T_A 88 F>Y No 1000Genomes
ENSVATH01775582 89 E>K No 1000Genomes
ENSVATH14422580 90 E>D No 1000Genomes
ENSVATH01775583 90 E>K No 1000Genomes
ENSVATH05449642 92 I>T No 1000Genomes
tmp_2_5909587_T_G 94 I>S No 1000Genomes
ENSVATH05449643 95 E>D No 1000Genomes
ENSVATH01775584 99 I>V No 1000Genomes
tmp_2_5909632_C_A 109 P>H No 1000Genomes
ENSVATH14422581 114 P>L No 1000Genomes
ENSVATH05449646 144 V>M No 1000Genomes
tmp_2_5909832_G_T 152 M>I No 1000Genomes
tmp_2_5910164_G_T 190 G>C No 1000Genomes
ENSVATH05449651 192 N>K No 1000Genomes
tmp_2_5910200_C_T 202 R>C No 1000Genomes
tmp_2_5910237_C_G 214 T>S No 1000Genomes
ENSVATH13054681 229 V>I No 1000Genomes
tmp_2_5910296_C_T 234 L>F No 1000Genomes
ENSVATH05449652 237 N>K No 1000Genomes
ENSVATH05449653 240 A>G No 1000Genomes
ENSVATH05449662 277 T>I No 1000Genomes
ENSVATH05449663 279 E>K No 1000Genomes
ENSVATH14422709 295 K>Q No 1000Genomes
tmp_2_5910864_A_T 300 H>L No 1000Genomes
tmp_2_5910867_T_A 301 F>Y No 1000Genomes
ENSVATH01775665 302 R>K No 1000Genomes
ENSVATH05449664 304 T>S No 1000Genomes
tmp_2_5911218_C_A 339 Q>K No 1000Genomes
ENSVATH05449672 344 S>T No 1000Genomes
ENSVATH01775729 376 N>T No 1000Genomes
ENSVATH01775730 377 R>K No 1000Genomes
tmp_2_5911778_A_T 424 S>C No 1000Genomes
ENSVATH13054835 458 I>M No 1000Genomes
ENSVATH13054814 458 I>T No 1000Genomes
ENSVATH05449692 493 L>I No 1000Genomes
tmp_2_5912691_G_A 507 V>I No 1000Genomes
ENSVATH13054844 520 D>E No 1000Genomes
ENSVATH01775809 520 D>G No 1000Genomes
ENSVATH13054865 524 D>V No 1000Genomes
ENSVATH05449693 533 P>L No 1000Genomes
ENSVATH13054867 534 M>L No 1000Genomes
ENSVATH01775826 539 I>V No 1000Genomes
tmp_2_5913080_A_G,C 545 N>D No 1000Genomes
tmp_2_5913080_A_G,C 545 N>H No 1000Genomes
ENSVATH01775827 547 R>K No 1000Genomes
tmp_2_5913110_G_A 555 E>K No 1000Genomes
ENSVATH14422948 569 S>L No 1000Genomes
ENSVATH05449709 593 R>T No 1000Genomes
tmp_2_5913673_G_C 599 E>D No 1000Genomes
tmp_2_5913702_T_C 609 I>T No 1000Genomes
ENSVATH05449711 612 I>V No 1000Genomes
ENSVATH05449712 613 E>K No 1000Genomes
tmp_2_5913751_G_T 625 M>I No 1000Genomes
ENSVATH14422952 635 E>Q No 1000Genomes
tmp_2_5913780_A_T 635 E>V No 1000Genomes
ENSVATH05449714 638 D>N No 1000Genomes
ENSVATH05449716 643 L>H No 1000Genomes
ENSVATH13054901 644 F>L No 1000Genomes
ENSVATH01775873 647 H>Y No 1000Genomes

No associated diseases with F4IFF3

4 regional properties for F4IFF3

Type Name Position InterPro Accession
domain MCM domain 308 - 513 IPR001208
domain AAA+ ATPase domain 350 - 499 IPR003593
domain MCM OB domain 123 - 251 IPR033762
domain MCM, AAA-lid domain 534 - 615 IPR041562

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
MCM complex A hexameric protein complex required for the initiation and regulation of DNA replication.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
metal ion binding Binding to a metal ion.
single-stranded DNA binding Binding to single-stranded DNA.

2 GO annotations of biological process

Name Definition
double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P49736 MCM2 DNA replication licensing factor MCM2 Homo sapiens (Human) PR
P97310 Mcm2 DNA replication licensing factor MCM2 Mus musculus (Mouse) PR
Q69QA6 MCM9 Probable DNA helicase MCM9 Oryza sativa subsp japonica (Rice) PR
Q9SF37 MCM8 Probable DNA helicase MCM8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MESPTQTSEH IESMTEFLVK HYPDQLREIS LSSDPKLHYP LFIEYAELVD DNPSLARQVF
70 80 90 100 110 120
SDPEHYLRQF DDSAILAHKI ALEHMKKFEE KIGIEKRFIH VRINTSGSPL ERSPETFPSI
130 140 150 160 170 180
GRVRVKHRGI LMMLKGTVIR SGAVKMYEGE KMYRCRKCKH MFPIFPELES INSIVKPPFC
190 200 210 220 230 240
PSQRSKACEG TNFDPVDDTV TRHDYQEIKI QENTQVLGVG VIPRSILVVL KDDLVDNVKA
250 260 270 280 290 300
GDDVVVSGIL TSKWSHDLKD VRCDLEPMLI ANHVRRTNEL KSEIDISDDL IEKFKNFWSH
310 320 330 340 350 360
FRDTPLKGRN AILRGICPQV FGLFTVKLAV ALTLIGGVQH VDASGTKVRG ESHLLLIGDP
370 380 390 400 410 420
GTGKSQFLKF AAKLSNRAVI TTGLGSTSAG LTVTAVKDGG EWMLEAGALV LADGGLCCID
430 440 450 460 470 480
EFDSMREHDR ATIHEAMEQQ SISVAKAGLV TTLSTKTIVF GATNPKGQYD PDQSLSVNTA
490 500 510 520 530 540
LSGPLLSRFD IVLVLLDTKN PEWDAVVSSH ILAEVQIEQD REVDDLTTIW PLPMLQRYIQ
550 560 570 580 590 600
FVKKNFRPVL SKEAEEIISS YYRLQRRSST HNAARTTVRM LESLIRLAQA HARLMFRNEV
610 620 630 640
TRLDAITAIL CIESSMTISA IVDSMGNALH SNFSEEPDQE CILFRH