F4IFF3
PR
Gene name |
MCM9 (At2g14050, F9B22) |
Protein name |
Probable DNA helicase MCM9 |
Names |
Minichromosome maintenance 9, AtMCM9 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G14050 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4IFF3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4IFF3-F1 | Predicted | AlphaFoldDB |
80 variants for F4IFF3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH13054618 | 3 | S>L | No | 1000Genomes | |
| ENSVATH01775566 | 8 | S>A | No | 1000Genomes | |
| ENSVATH09452602 | 9 | E>D | No | 1000Genomes | |
| ENSVATH01775568 | 9 | E>V | No | 1000Genomes | |
| ENSVATH01775569 | 10 | H>Y | No | 1000Genomes | |
| ENSVATH00227694 | 13 | S>P | No | 1000Genomes | |
| ENSVATH01775570 | 14 | M>V | No | 1000Genomes | |
| tmp_2_5909302_C_G | 21 | H>Q | No | 1000Genomes | |
| ENSVATH01775571 | 23 | P>S | No | 1000Genomes | |
| tmp_2_5909319_G_A | 27 | R>H | No | 1000Genomes | |
| tmp_2_5909321_G_A | 28 | E>K | No | 1000Genomes | |
| ENSVATH13054620 | 42 | F>S | No | 1000Genomes | |
| ENSVATH00227695 | 43 | I>L | No | 1000Genomes | |
| ENSVATH05449637 | 44 | E>V | No | 1000Genomes | |
| ENSVATH00227696 | 54 | S>P | No | 1000Genomes | |
| ENSVATH01775574 | 58 | Q>R | No | 1000Genomes | |
| tmp_2_5909418_T_A | 60 | F>Y | No | 1000Genomes | |
| ENSVATH00227698 | 62 | D>N | No | 1000Genomes | |
| tmp_2_5909436_A_C | 66 | Y>S | No | 1000Genomes | |
| ENSVATH01775577 | 72 | D>E | No | 1000Genomes | |
| ENSVATH14422579 | 85 | M>T | No | 1000Genomes | |
| tmp_2_5909569_T_A | 88 | F>Y | No | 1000Genomes | |
| ENSVATH01775582 | 89 | E>K | No | 1000Genomes | |
| ENSVATH14422580 | 90 | E>D | No | 1000Genomes | |
| ENSVATH01775583 | 90 | E>K | No | 1000Genomes | |
| ENSVATH05449642 | 92 | I>T | No | 1000Genomes | |
| tmp_2_5909587_T_G | 94 | I>S | No | 1000Genomes | |
| ENSVATH05449643 | 95 | E>D | No | 1000Genomes | |
| ENSVATH01775584 | 99 | I>V | No | 1000Genomes | |
| tmp_2_5909632_C_A | 109 | P>H | No | 1000Genomes | |
| ENSVATH14422581 | 114 | P>L | No | 1000Genomes | |
| ENSVATH05449646 | 144 | V>M | No | 1000Genomes | |
| tmp_2_5909832_G_T | 152 | M>I | No | 1000Genomes | |
| tmp_2_5910164_G_T | 190 | G>C | No | 1000Genomes | |
| ENSVATH05449651 | 192 | N>K | No | 1000Genomes | |
| tmp_2_5910200_C_T | 202 | R>C | No | 1000Genomes | |
| tmp_2_5910237_C_G | 214 | T>S | No | 1000Genomes | |
| ENSVATH13054681 | 229 | V>I | No | 1000Genomes | |
| tmp_2_5910296_C_T | 234 | L>F | No | 1000Genomes | |
| ENSVATH05449652 | 237 | N>K | No | 1000Genomes | |
| ENSVATH05449653 | 240 | A>G | No | 1000Genomes | |
| ENSVATH05449662 | 277 | T>I | No | 1000Genomes | |
| ENSVATH05449663 | 279 | E>K | No | 1000Genomes | |
| ENSVATH14422709 | 295 | K>Q | No | 1000Genomes | |
| tmp_2_5910864_A_T | 300 | H>L | No | 1000Genomes | |
| tmp_2_5910867_T_A | 301 | F>Y | No | 1000Genomes | |
| ENSVATH01775665 | 302 | R>K | No | 1000Genomes | |
| ENSVATH05449664 | 304 | T>S | No | 1000Genomes | |
| tmp_2_5911218_C_A | 339 | Q>K | No | 1000Genomes | |
| ENSVATH05449672 | 344 | S>T | No | 1000Genomes | |
| ENSVATH01775729 | 376 | N>T | No | 1000Genomes | |
| ENSVATH01775730 | 377 | R>K | No | 1000Genomes | |
| tmp_2_5911778_A_T | 424 | S>C | No | 1000Genomes | |
| ENSVATH13054835 | 458 | I>M | No | 1000Genomes | |
| ENSVATH13054814 | 458 | I>T | No | 1000Genomes | |
| ENSVATH05449692 | 493 | L>I | No | 1000Genomes | |
| tmp_2_5912691_G_A | 507 | V>I | No | 1000Genomes | |
| ENSVATH13054844 | 520 | D>E | No | 1000Genomes | |
| ENSVATH01775809 | 520 | D>G | No | 1000Genomes | |
| ENSVATH13054865 | 524 | D>V | No | 1000Genomes | |
| ENSVATH05449693 | 533 | P>L | No | 1000Genomes | |
| ENSVATH13054867 | 534 | M>L | No | 1000Genomes | |
| ENSVATH01775826 | 539 | I>V | No | 1000Genomes | |
| tmp_2_5913080_A_G,C | 545 | N>D | No | 1000Genomes | |
| tmp_2_5913080_A_G,C | 545 | N>H | No | 1000Genomes | |
| ENSVATH01775827 | 547 | R>K | No | 1000Genomes | |
| tmp_2_5913110_G_A | 555 | E>K | No | 1000Genomes | |
| ENSVATH14422948 | 569 | S>L | No | 1000Genomes | |
| ENSVATH05449709 | 593 | R>T | No | 1000Genomes | |
| tmp_2_5913673_G_C | 599 | E>D | No | 1000Genomes | |
| tmp_2_5913702_T_C | 609 | I>T | No | 1000Genomes | |
| ENSVATH05449711 | 612 | I>V | No | 1000Genomes | |
| ENSVATH05449712 | 613 | E>K | No | 1000Genomes | |
| tmp_2_5913751_G_T | 625 | M>I | No | 1000Genomes | |
| ENSVATH14422952 | 635 | E>Q | No | 1000Genomes | |
| tmp_2_5913780_A_T | 635 | E>V | No | 1000Genomes | |
| ENSVATH05449714 | 638 | D>N | No | 1000Genomes | |
| ENSVATH05449716 | 643 | L>H | No | 1000Genomes | |
| ENSVATH13054901 | 644 | F>L | No | 1000Genomes | |
| ENSVATH01775873 | 647 | H>Y | No | 1000Genomes |
No associated diseases with F4IFF3
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| MCM complex | A hexameric protein complex required for the initiation and regulation of DNA replication. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| metal ion binding | Binding to a metal ion. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| double-strand break repair via homologous recombination | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P49736 | MCM2 | DNA replication licensing factor MCM2 | Homo sapiens (Human) | PR |
| P97310 | Mcm2 | DNA replication licensing factor MCM2 | Mus musculus (Mouse) | PR |
| Q69QA6 | MCM9 | Probable DNA helicase MCM9 | Oryza sativa subsp japonica (Rice) | PR |
| Q9SF37 | MCM8 | Probable DNA helicase MCM8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESPTQTSEH | IESMTEFLVK | HYPDQLREIS | LSSDPKLHYP | LFIEYAELVD | DNPSLARQVF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SDPEHYLRQF | DDSAILAHKI | ALEHMKKFEE | KIGIEKRFIH | VRINTSGSPL | ERSPETFPSI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GRVRVKHRGI | LMMLKGTVIR | SGAVKMYEGE | KMYRCRKCKH | MFPIFPELES | INSIVKPPFC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PSQRSKACEG | TNFDPVDDTV | TRHDYQEIKI | QENTQVLGVG | VIPRSILVVL | KDDLVDNVKA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GDDVVVSGIL | TSKWSHDLKD | VRCDLEPMLI | ANHVRRTNEL | KSEIDISDDL | IEKFKNFWSH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FRDTPLKGRN | AILRGICPQV | FGLFTVKLAV | ALTLIGGVQH | VDASGTKVRG | ESHLLLIGDP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GTGKSQFLKF | AAKLSNRAVI | TTGLGSTSAG | LTVTAVKDGG | EWMLEAGALV | LADGGLCCID |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EFDSMREHDR | ATIHEAMEQQ | SISVAKAGLV | TTLSTKTIVF | GATNPKGQYD | PDQSLSVNTA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LSGPLLSRFD | IVLVLLDTKN | PEWDAVVSSH | ILAEVQIEQD | REVDDLTTIW | PLPMLQRYIQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FVKKNFRPVL | SKEAEEIISS | YYRLQRRSST | HNAARTTVRM | LESLIRLAQA | HARLMFRNEV |
| 610 | 620 | 630 | 640 | ||
| TRLDAITAIL | CIESSMTISA | IVDSMGNALH | SNFSEEPDQE | CILFRH |