F4I114

PR
Gene name
At1g09600 (F14J9.26)
Protein name
Probable serine/threonine-protein kinase At1g09600
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G09600
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-172 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

304-328 (Activation loop from InterPro)

Target domain

163-447 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for F4I114

Entry ID Method Resolution Chain Position Source
AF-F4I114-F1 Predicted AlphaFoldDB

76 variants for F4I114

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04545397 8 G>R No 1000Genomes
ENSVATH01028287 12 D>N No 1000Genomes
ENSVATH00013765 13 N>D No 1000Genomes
tmp_1_3108660_A_G 15 N>S No 1000Genomes
tmp_1_3108684_T_A 23 V>D No 1000Genomes
ENSVATH00013766 23 V>F No 1000Genomes
ENSVATH00013766 23 V>I No 1000Genomes
ENSVATH04545398 32 R>G No 1000Genomes
ENSVATH01028292 58 F>L No 1000Genomes
ENSVATH01028291 58 F>S No 1000Genomes
tmp_1_3108797_C_G 61 R>G No 1000Genomes
ENSVATH10850021 63 N>S No 1000Genomes
ENSVATH04545399 64 D>G No 1000Genomes
ENSVATH10850022 67 E>Q No 1000Genomes
tmp_1_3108818_G_A 68 A>T No 1000Genomes
ENSVATH10850023 72 L>V No 1000Genomes
ENSVATH04545401 77 D>A No 1000Genomes
ENSVATH10850024 78 A>V No 1000Genomes
tmp_1_3108888_A_C 91 E>A No 1000Genomes
ENSVATH04545402 104 T>A No 1000Genomes
tmp_1_3109032_G_T 139 G>V No 1000Genomes
ENSVATH04545404 164 E>K No 1000Genomes
tmp_1_3109116_A_G 167 E>G No 1000Genomes
ENSVATH04545409 199 M>I No 1000Genomes
tmp_1_3109309_G_T 202 D>Y No 1000Genomes
tmp_1_3109351_A_T 216 R>W No 1000Genomes
ENSVATH01028293 217 L>I No 1000Genomes
tmp_1_3109369_G_A 222 V>I No 1000Genomes
tmp_1_3109413_T_A 236 S>R No 1000Genomes
tmp_1_3109453_G_T 250 G>C No 1000Genomes
tmp_1_3109471_G_A 256 G>R No 1000Genomes
ENSVATH01028294 272 L>F No 1000Genomes
tmp_1_3109607_G_A 276 E>K No 1000Genomes
ENSVATH04545411 282 G>D No 1000Genomes
ENSVATH10850145 299 N>K No 1000Genomes
tmp_1_3109687_A_T 302 K>N No 1000Genomes
tmp_1_3109749_G_A 323 R>H No 1000Genomes
tmp_1_3109782_T_A 334 L>Q No 1000Genomes
tmp_1_3109860_G_C 360 G>A No 1000Genomes
ENSVATH04545414 366 G>S No 1000Genomes
tmp_1_3109916_C_A 379 L>I No 1000Genomes
tmp_1_3109986_A_C 402 Q>P No 1000Genomes
tmp_1_3110051_G_A 424 V>I No 1000Genomes
ENSVATH04545418 434 A>T No 1000Genomes
tmp_1_3110265_C_T 457 S>L No 1000Genomes
ENSVATH00013768 463 Q>L No 1000Genomes
tmp_1_3110496_C_T 502 A>V No 1000Genomes
ENSVATH04545423 504 D>E No 1000Genomes
ENSVATH04545424 506 N>Y No 1000Genomes
tmp_1_3110533_A_T 514 Q>H No 1000Genomes
ENSVATH13870431 514 Q>K No 1000Genomes
ENSVATH00013771 520 H>N No 1000Genomes
ENSVATH04545427 552 H>N No 1000Genomes
tmp_1_3110746_A_G 555 Y>C No 1000Genomes
ENSVATH13870432 560 V>A No 1000Genomes
ENSVATH00013772 573 R>Q No 1000Genomes
ENSVATH01028296 584 S>F No 1000Genomes
ENSVATH13870433 599 S>T No 1000Genomes
ENSVATH04545430 601 A>T No 1000Genomes
ENSVATH04545431 618 D>E No 1000Genomes
ENSVATH04545432 621 N>K No 1000Genomes
tmp_1_3110986_G_A 635 R>H No 1000Genomes
ENSVATH04545433 640 H>P No 1000Genomes
ENSVATH10850152 643 F>L No 1000Genomes
tmp_1_3111019_A_C 646 H>P No 1000Genomes
tmp_1_3111138_A_C 655 E>D No 1000Genomes
ENSVATH04545438 668 S>F No 1000Genomes
tmp_1_3111193_G_A 674 D>N No 1000Genomes
ENSVATH13870434 686 L>F No 1000Genomes
ENSVATH13870455 689 R>H No 1000Genomes
ENSVATH01028299 692 R>Q No 1000Genomes
ENSVATH10850153 693 V>L No 1000Genomes
ENSVATH01028300 697 T>K No 1000Genomes
ENSVATH01028300 697 T>M No 1000Genomes
tmp_1_3111262_A_T 697 T>S No 1000Genomes
ENSVATH04545439 704 Q>* No 1000Genomes

No associated diseases with F4I114

3 regional properties for F4I114

Type Name Position InterPro Accession
domain Protein kinase domain 163 - 447 IPR000719
active_site Serine/threonine-protein kinase, active site 283 - 295 IPR008271
binding_site Protein kinase, ATP binding site 169 - 192 IPR017441

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

3 GO annotations of biological process

Name Definition
phosphorylation of RNA polymerase II C-terminal domain The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
positive regulation of transcription elongation by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
protein phosphorylation The process of introducing a phosphate group on to a protein.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q03957 CTK1 CTD kinase subunit alpha Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q5EAB2 CDK9 Cyclin-dependent kinase 9 Bos taurus (Bovine) PR
Q2TBL8 CDK10 Cyclin-dependent kinase 10 Bos taurus (Bovine) PR
Q5ZKN1 CDK9 Cyclin-dependent kinase 9 Gallus gallus (Chicken) PR
P50750 CDK9 Cyclin-dependent kinase 9 Homo sapiens (Human) PR
Q15131 CDK10 Cyclin-dependent kinase 10 Homo sapiens (Human) PR
Q99J95 Cdk9 Cyclin-dependent kinase 9 Mus musculus (Mouse) PR
Q3UMM4 Cdk10 Cyclin-dependent kinase 10 Mus musculus (Mouse) PR
Q641Z4 Cdk9 Cyclin-dependent kinase 9 Rattus norvegicus (Rat) PR
P46551 cdk-12 Cyclin-dependent kinase 12 Caenorhabditis elegans PR
Q9C9U2 CDKD-1 Cyclin-dependent kinase D-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMT0 CDKD-3 Cyclin-dependent kinase D-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZVM9 At1g54610 Probable serine/threonine-protein kinase At1g54610 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FGW5 CDKG1 Cyclin-dependent kinase G1 Arabidopsis thaliana (Mouse-ear cress) PR
Q6GLD8 cdk9 Cyclin-dependent kinase 9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MGCNCTKGTR PDNDNVDNSN SIVSNVNVKE RRSKPKKTPK KKKKSKSASS SKDNNVGFEE
70 80 90 100 110 120
RSNDNKEASL TLLIPIDAKK DDESEKKVNL ERKSSRLVFQ RRPTGIEVGA NNIGTLQQPK
130 140 150 160 170 180
MTRICSVSNG ERGAQVMAGW PSWLASVAGE AINGWIPRKA DSFEKLEKIG QGTYSSVYKA
190 200 210 220 230 240
RDLETNQLVA LKKVRFANMD PDSVRFMARE IIILRRLDHP NVMKLEGLIT SRVSGSMYLI
250 260 270 280 290 300
FEYMEHDLAG LASTPGINFS EAQIKCYMKQ LLHGLEHCHS RGVLHRDIKG SNLLLDHNNN
310 320 330 340 350 360
LKIGDFGLAN FYQGHQKQPL TSRVVTLWYR PPELLLGSTD YGVTVDLWST GCILAELFTG
370 380 390 400 410 420
KPIMPGRTEV EQLHKIFKLC GSPSEEYWKI SKLPHATIFK PQQPYKRCVA ETFKSLPSSA
430 440 450 460 470 480
LALVEVLLAV EPDARGTTAS ALESEFFTTS PLASDPSSLP KYQPRKEIDV KAQEEEAKRK
490 500 510 520 530 540
KDTSSKQNDS KQVSRESKAV PAPDSNAESL TSIQKRQGQH NQVSNSDKFN PGEDAASFRI
550 560 570 580 590 600
EPLKSGTAKD GHTRYGVSSV NRNGENVMMG SSRSPRKELR TQRSFVQRGT AQLSRFSNSV
610 620 630 640 650 660
AARDGSHFAI ANPRWFEDSY NNNNGRQNGG AWSQRLVVKH KEFTKHKESI TVNGEKKERM
670 680 690 700 710
HCSGPLVSAG GNLDEMLKEH ERQIQLAVRK ARVDKKTNRG DNRQTQAFLA ANGR