F4I114
Gene name |
At1g09600 (F14J9.26) |
Protein name |
Probable serine/threonine-protein kinase At1g09600 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G09600 |
EC number |
|
Protein Class |
|

Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
304-328 (Activation loop from InterPro)
Target domain |
163-447 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure

Activated structure

1 structures for F4I114
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-F4I114-F1 | Predicted | AlphaFoldDB |
76 variants for F4I114
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
ENSVATH04545397 | 8 | G>R | No | 1000Genomes | |
ENSVATH01028287 | 12 | D>N | No | 1000Genomes | |
ENSVATH00013765 | 13 | N>D | No | 1000Genomes | |
tmp_1_3108660_A_G | 15 | N>S | No | 1000Genomes | |
tmp_1_3108684_T_A | 23 | V>D | No | 1000Genomes | |
ENSVATH00013766 | 23 | V>F | No | 1000Genomes | |
ENSVATH00013766 | 23 | V>I | No | 1000Genomes | |
ENSVATH04545398 | 32 | R>G | No | 1000Genomes | |
ENSVATH01028292 | 58 | F>L | No | 1000Genomes | |
ENSVATH01028291 | 58 | F>S | No | 1000Genomes | |
tmp_1_3108797_C_G | 61 | R>G | No | 1000Genomes | |
ENSVATH10850021 | 63 | N>S | No | 1000Genomes | |
ENSVATH04545399 | 64 | D>G | No | 1000Genomes | |
ENSVATH10850022 | 67 | E>Q | No | 1000Genomes | |
tmp_1_3108818_G_A | 68 | A>T | No | 1000Genomes | |
ENSVATH10850023 | 72 | L>V | No | 1000Genomes | |
ENSVATH04545401 | 77 | D>A | No | 1000Genomes | |
ENSVATH10850024 | 78 | A>V | No | 1000Genomes | |
tmp_1_3108888_A_C | 91 | E>A | No | 1000Genomes | |
ENSVATH04545402 | 104 | T>A | No | 1000Genomes | |
tmp_1_3109032_G_T | 139 | G>V | No | 1000Genomes | |
ENSVATH04545404 | 164 | E>K | No | 1000Genomes | |
tmp_1_3109116_A_G | 167 | E>G | No | 1000Genomes | |
ENSVATH04545409 | 199 | M>I | No | 1000Genomes | |
tmp_1_3109309_G_T | 202 | D>Y | No | 1000Genomes | |
tmp_1_3109351_A_T | 216 | R>W | No | 1000Genomes | |
ENSVATH01028293 | 217 | L>I | No | 1000Genomes | |
tmp_1_3109369_G_A | 222 | V>I | No | 1000Genomes | |
tmp_1_3109413_T_A | 236 | S>R | No | 1000Genomes | |
tmp_1_3109453_G_T | 250 | G>C | No | 1000Genomes | |
tmp_1_3109471_G_A | 256 | G>R | No | 1000Genomes | |
ENSVATH01028294 | 272 | L>F | No | 1000Genomes | |
tmp_1_3109607_G_A | 276 | E>K | No | 1000Genomes | |
ENSVATH04545411 | 282 | G>D | No | 1000Genomes | |
ENSVATH10850145 | 299 | N>K | No | 1000Genomes | |
tmp_1_3109687_A_T | 302 | K>N | No | 1000Genomes | |
tmp_1_3109749_G_A | 323 | R>H | No | 1000Genomes | |
tmp_1_3109782_T_A | 334 | L>Q | No | 1000Genomes | |
tmp_1_3109860_G_C | 360 | G>A | No | 1000Genomes | |
ENSVATH04545414 | 366 | G>S | No | 1000Genomes | |
tmp_1_3109916_C_A | 379 | L>I | No | 1000Genomes | |
tmp_1_3109986_A_C | 402 | Q>P | No | 1000Genomes | |
tmp_1_3110051_G_A | 424 | V>I | No | 1000Genomes | |
ENSVATH04545418 | 434 | A>T | No | 1000Genomes | |
tmp_1_3110265_C_T | 457 | S>L | No | 1000Genomes | |
ENSVATH00013768 | 463 | Q>L | No | 1000Genomes | |
tmp_1_3110496_C_T | 502 | A>V | No | 1000Genomes | |
ENSVATH04545423 | 504 | D>E | No | 1000Genomes | |
ENSVATH04545424 | 506 | N>Y | No | 1000Genomes | |
tmp_1_3110533_A_T | 514 | Q>H | No | 1000Genomes | |
ENSVATH13870431 | 514 | Q>K | No | 1000Genomes | |
ENSVATH00013771 | 520 | H>N | No | 1000Genomes | |
ENSVATH04545427 | 552 | H>N | No | 1000Genomes | |
tmp_1_3110746_A_G | 555 | Y>C | No | 1000Genomes | |
ENSVATH13870432 | 560 | V>A | No | 1000Genomes | |
ENSVATH00013772 | 573 | R>Q | No | 1000Genomes | |
ENSVATH01028296 | 584 | S>F | No | 1000Genomes | |
ENSVATH13870433 | 599 | S>T | No | 1000Genomes | |
ENSVATH04545430 | 601 | A>T | No | 1000Genomes | |
ENSVATH04545431 | 618 | D>E | No | 1000Genomes | |
ENSVATH04545432 | 621 | N>K | No | 1000Genomes | |
tmp_1_3110986_G_A | 635 | R>H | No | 1000Genomes | |
ENSVATH04545433 | 640 | H>P | No | 1000Genomes | |
ENSVATH10850152 | 643 | F>L | No | 1000Genomes | |
tmp_1_3111019_A_C | 646 | H>P | No | 1000Genomes | |
tmp_1_3111138_A_C | 655 | E>D | No | 1000Genomes | |
ENSVATH04545438 | 668 | S>F | No | 1000Genomes | |
tmp_1_3111193_G_A | 674 | D>N | No | 1000Genomes | |
ENSVATH13870434 | 686 | L>F | No | 1000Genomes | |
ENSVATH13870455 | 689 | R>H | No | 1000Genomes | |
ENSVATH01028299 | 692 | R>Q | No | 1000Genomes | |
ENSVATH10850153 | 693 | V>L | No | 1000Genomes | |
ENSVATH01028300 | 697 | T>K | No | 1000Genomes | |
ENSVATH01028300 | 697 | T>M | No | 1000Genomes | |
tmp_1_3111262_A_T | 697 | T>S | No | 1000Genomes | |
ENSVATH04545439 | 704 | Q>* | No | 1000Genomes |
No associated diseases with F4I114
2 GO annotations of cellular component
Name | Definition |
---|---|
cyclin-dependent protein kinase holoenzyme complex | Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. |
nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
Name | Definition |
---|---|
ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
RNA polymerase II CTD heptapeptide repeat kinase activity | Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II. |
3 GO annotations of biological process
Name | Definition |
---|---|
phosphorylation of RNA polymerase II C-terminal domain | The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex. |
positive regulation of transcription elongation by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. |
protein phosphorylation | The process of introducing a phosphate group on to a protein. |
15 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
Q03957 | CTK1 | CTD kinase subunit alpha | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
Q5EAB2 | CDK9 | Cyclin-dependent kinase 9 | Bos taurus (Bovine) | PR |
Q2TBL8 | CDK10 | Cyclin-dependent kinase 10 | Bos taurus (Bovine) | PR |
Q5ZKN1 | CDK9 | Cyclin-dependent kinase 9 | Gallus gallus (Chicken) | PR |
P50750 | CDK9 | Cyclin-dependent kinase 9 | Homo sapiens (Human) | PR |
Q15131 | CDK10 | Cyclin-dependent kinase 10 | Homo sapiens (Human) | PR |
Q99J95 | Cdk9 | Cyclin-dependent kinase 9 | Mus musculus (Mouse) | PR |
Q3UMM4 | Cdk10 | Cyclin-dependent kinase 10 | Mus musculus (Mouse) | PR |
Q641Z4 | Cdk9 | Cyclin-dependent kinase 9 | Rattus norvegicus (Rat) | PR |
P46551 | cdk-12 | Cyclin-dependent kinase 12 | Caenorhabditis elegans | PR |
Q9C9U2 | CDKD-1 | Cyclin-dependent kinase D-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
Q9LMT0 | CDKD-3 | Cyclin-dependent kinase D-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
Q9ZVM9 | At1g54610 | Probable serine/threonine-protein kinase At1g54610 | Arabidopsis thaliana (Mouse-ear cress) | PR |
Q9FGW5 | CDKG1 | Cyclin-dependent kinase G1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
Q6GLD8 | cdk9 | Cyclin-dependent kinase 9 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MGCNCTKGTR | PDNDNVDNSN | SIVSNVNVKE | RRSKPKKTPK | KKKKSKSASS | SKDNNVGFEE |
70 | 80 | 90 | 100 | 110 | 120 |
RSNDNKEASL | TLLIPIDAKK | DDESEKKVNL | ERKSSRLVFQ | RRPTGIEVGA | NNIGTLQQPK |
130 | 140 | 150 | 160 | 170 | 180 |
MTRICSVSNG | ERGAQVMAGW | PSWLASVAGE | AINGWIPRKA | DSFEKLEKIG | QGTYSSVYKA |
190 | 200 | 210 | 220 | 230 | 240 |
RDLETNQLVA | LKKVRFANMD | PDSVRFMARE | IIILRRLDHP | NVMKLEGLIT | SRVSGSMYLI |
250 | 260 | 270 | 280 | 290 | 300 |
FEYMEHDLAG | LASTPGINFS | EAQIKCYMKQ | LLHGLEHCHS | RGVLHRDIKG | SNLLLDHNNN |
310 | 320 | 330 | 340 | 350 | 360 |
LKIGDFGLAN | FYQGHQKQPL | TSRVVTLWYR | PPELLLGSTD | YGVTVDLWST | GCILAELFTG |
370 | 380 | 390 | 400 | 410 | 420 |
KPIMPGRTEV | EQLHKIFKLC | GSPSEEYWKI | SKLPHATIFK | PQQPYKRCVA | ETFKSLPSSA |
430 | 440 | 450 | 460 | 470 | 480 |
LALVEVLLAV | EPDARGTTAS | ALESEFFTTS | PLASDPSSLP | KYQPRKEIDV | KAQEEEAKRK |
490 | 500 | 510 | 520 | 530 | 540 |
KDTSSKQNDS | KQVSRESKAV | PAPDSNAESL | TSIQKRQGQH | NQVSNSDKFN | PGEDAASFRI |
550 | 560 | 570 | 580 | 590 | 600 |
EPLKSGTAKD | GHTRYGVSSV | NRNGENVMMG | SSRSPRKELR | TQRSFVQRGT | AQLSRFSNSV |
610 | 620 | 630 | 640 | 650 | 660 |
AARDGSHFAI | ANPRWFEDSY | NNNNGRQNGG | AWSQRLVVKH | KEFTKHKESI | TVNGEKKERM |
670 | 680 | 690 | 700 | 710 | |
HCSGPLVSAG | GNLDEMLKEH | ERQIQLAVRK | ARVDKKTNRG | DNRQTQAFLA | ANGR |