F4HPN2
Gene name |
IRE4 |
Protein name |
Probable serine/threonine protein kinase IRE4 |
Names |
AtIRE4 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G45160 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
850-860 (Activation loop from InterPro)
Target domain |
670-955 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
810-820 (Activation loop from InterPro)
Target domain |
670-955 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for F4HPN2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4HPN2-F1 | Predicted | AlphaFoldDB |
106 variants for F4HPN2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_17090265_T_C | 5 | N>D | No | 1000Genomes | |
| ENSVATH00081597 | 16 | A>S | No | 1000Genomes | |
| ENSVATH01295623 | 16 | A>V | No | 1000Genomes | |
| ENSVATH14230011 | 25 | K>Q | No | 1000Genomes | |
| ENSVATH04875683 | 25 | K>R | No | 1000Genomes | |
| ENSVATH01295622 | 33 | P>L | No | 1000Genomes | |
| ENSVATH13380474 | 34 | R>K | No | 1000Genomes | |
| ENSVATH14230010 | 44 | K>* | No | 1000Genomes | |
| ENSVATH00081596 | 53 | T>I | No | 1000Genomes | |
| tmp_1_17090118_T_G | 54 | I>L | No | 1000Genomes | |
| tmp_1_17090073_C_T | 69 | E>K | No | 1000Genomes | |
| tmp_1_17089769_G_A | 76 | S>L | No | 1000Genomes | |
| tmp_1_17089719_A_G | 93 | Y>H | No | 1000Genomes | |
| ENSVATH04875676 | 98 | T>K | No | 1000Genomes | |
| tmp_1_17089190_C_A | 165 | G>V | No | 1000Genomes | |
| ENSVATH04875671 | 168 | H>L | No | 1000Genomes | |
| tmp_1_17089078_T_A | 202 | E>D | No | 1000Genomes | |
| ENSVATH04875670 | 203 | D>V | No | 1000Genomes | |
| tmp_1_17089030_C_T | 218 | M>I | No | 1000Genomes | |
| tmp_1_17089001_G_T | 228 | T>N | No | 1000Genomes | |
| tmp_1_17088883_C_G | 267 | M>I | No | 1000Genomes | |
| tmp_1_17088853_C_G | 277 | E>D | No | 1000Genomes | |
| ENSVATH13380453 | 303 | V>F | No | 1000Genomes | |
| tmp_1_17088764_C_T | 307 | G>D | No | 1000Genomes | |
| ENSVATH00081592 | 309 | G>S | No | 1000Genomes | |
| ENSVATH13380447 | 311 | P>S | No | 1000Genomes | |
| ENSVATH01295614 | 314 | Q>P | No | 1000Genomes | |
| ENSVATH04875669 | 318 | A>S | No | 1000Genomes | |
| ENSVATH01295613 | 322 | F>L | No | 1000Genomes | |
| tmp_1_17088719_A_G | 322 | F>S | No | 1000Genomes | |
| tmp_1_17088715_T_A | 323 | K>N | No | 1000Genomes | |
| tmp_1_17088687_C_T | 333 | E>K | No | 1000Genomes | |
| ENSVATH14230005 | 338 | Y>N | No | 1000Genomes | |
| ENSVATH04875668 | 342 | N>D | No | 1000Genomes | |
| ENSVATH04875667 | 356 | A>T | No | 1000Genomes | |
| tmp_1_17088603_G_A | 361 | P>S | No | 1000Genomes | |
| tmp_1_17088582_C_T | 368 | D>N | No | 1000Genomes | |
| tmp_1_17088566_T_C | 373 | E>G | No | 1000Genomes | |
| tmp_1_17088548_C_A | 379 | S>I | No | 1000Genomes | |
| tmp_1_17088546_C_T | 380 | D>N | No | 1000Genomes | |
| ENSVATH00081591 | 412 | F>S | No | 1000Genomes | |
| ENSVATH04875665 | 437 | R>G | No | 1000Genomes | |
| ENSVATH04875664 | 450 | D>E | No | 1000Genomes | |
| ENSVATH14229993 | 453 | S>C | No | 1000Genomes | |
| tmp_1_17088320_T_C | 455 | N>S | No | 1000Genomes | |
| ENSVATH00081590 | 458 | T>P | No | 1000Genomes | |
| ENSVATH00081589 | 459 | Q>P | No | 1000Genomes | |
| tmp_1_17088282_G_T | 468 | L>M | No | 1000Genomes | |
| ENSVATH01295610 | 471 | S>A | No | 1000Genomes | |
| tmp_1_17088183_C_T | 501 | D>N | No | 1000Genomes | |
| tmp_1_17088159_A_C,G | 509 | Y>D | No | 1000Genomes | |
| tmp_1_17088159_A_C,G | 509 | Y>H | No | 1000Genomes | |
| ENSVATH04875663 | 513 | I>S | No | 1000Genomes | |
| ENSVATH13380430 | 521 | A>G | No | 1000Genomes | |
| ENSVATH14229992 | 526 | H>R | No | 1000Genomes | |
| tmp_1_17088040_G_C | 548 | H>Q | No | 1000Genomes | |
| ENSVATH04875660 | 558 | C>S | No | 1000Genomes | |
| ENSVATH00081588 | 565 | R>Q | No | 1000Genomes | |
| tmp_1_17087253_C_T | 630 | A>T | No | 1000Genomes | |
| tmp_1_17087247_C_G | 632 | E>Q | No | 1000Genomes | |
| tmp_1_17087234_T_C | 636 | D>G | No | 1000Genomes | |
| tmp_1_17087235_C_T | 636 | D>N | No | 1000Genomes | |
| ENSVATH00081587 | 643 | I>V | No | 1000Genomes | |
| tmp_1_17087180_G_A | 654 | S>L | No | 1000Genomes | |
| tmp_1_17087139_C_T | 668 | D>N | No | 1000Genomes | |
| ENSVATH00081585 | 677 | S>G | No | 1000Genomes | |
| ENSVATH04875648 | 695 | F>I | No | 1000Genomes | |
| ENSVATH14229985 | 826 | L>F | No | 1000Genomes | |
| tmp_1_17085857_T_A | 829 | H>L | No | 1000Genomes | |
| ENSVATH04875634 | 831 | S>T | No | 1000Genomes | |
| tmp_1_17085848_T_G | 832 | D>A | No | 1000Genomes | |
| ENSVATH01295594 | 836 | R>K | No | 1000Genomes | |
| tmp_1_17085834_T_C | 837 | T>A | No | 1000Genomes | |
| ENSVATH01295593 | 839 | S>P | No | 1000Genomes | |
| ENSVATH01295593 | 839 | S>T | No | 1000Genomes | |
| ENSVATH01295592 | 847 | E>G | No | 1000Genomes | |
| tmp_1_17085798_C_G | 849 | E>Q | No | 1000Genomes | |
| tmp_1_17085735_T_A | 870 | T>S | No | 1000Genomes | |
| ENSVATH00081578 | 874 | Y>F | No | 1000Genomes | |
| tmp_1_17085644_C_A | 875 | A>S | No | 1000Genomes | |
| tmp_1_17085626_C_A | 881 | A>S | No | 1000Genomes | |
| ENSVATH00081577 | 881 | A>V | No | 1000Genomes | |
| tmp_1_17085619_A_G | 883 | I>T | No | 1000Genomes | |
| tmp_1_17085596_C_T | 891 | G>R | No | 1000Genomes | |
| ENSVATH00081576 | 898 | S>A | No | 1000Genomes | |
| ENSVATH00081574 | 919 | G>C | No | 1000Genomes | |
| tmp_1_17085078_C_T | 927 | D>N | No | 1000Genomes | |
| tmp_1_17084767_G_A | 937 | P>L | No | 1000Genomes | |
| ENSVATH00081571 | 944 | N>I | No | 1000Genomes | |
| tmp_1_17084599_A_T | 952 | H>Q | No | 1000Genomes | |
| tmp_1_17084338_G_A | 969 | A>V | No | 1000Genomes | |
| tmp_1_17084255_T_C | 997 | T>A | No | 1000Genomes | |
| tmp_1_17084197_A_T | 1016 | L>H | No | 1000Genomes | |
| ENSVATH04875608 | 1018 | P>S | No | 1000Genomes | |
| tmp_1_17084186_G_C | 1020 | L>V | No | 1000Genomes | |
| ENSVATH00081566 | 1024 | S>T | No | 1000Genomes | |
| ENSVATH04875607 | 1025 | I>T | No | 1000Genomes | |
| ENSVATH04875606 | 1026 | C>F | No | 1000Genomes | |
| ENSVATH04875606 | 1026 | C>Y | No | 1000Genomes | |
| ENSVATH13380368 | 1029 | R>P | No | 1000Genomes | |
| tmp_1_17084151_A_T | 1031 | Y>* | No | 1000Genomes | |
| tmp_1_17084150_G_A,T | 1032 | R>C | No | 1000Genomes | |
| tmp_1_17084150_G_A,T | 1032 | R>S | No | 1000Genomes | |
| ENSVATH00081565 | 1034 | L>* | No | 1000Genomes | |
| tmp_1_17084125_C_T | 1040 | C>Y | No | 1000Genomes | |
| ENSVATH15133756 | 1043 | F>S | No | 1000Genomes |
No associated diseases with F4HPN2
3 regional properties for F4HPN2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclin, N-terminal | 37 - 148 | IPR006671 |
| domain | Cyclin-like domain | 46 - 144 | IPR013763-1 |
| domain | Cyclin-like domain | 161 - 236 | IPR013763-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q4V3C8 | PDPK2 | 3-phosphoinositide-dependent protein kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEENRKDRG | VSSTVAIPSG | LNRIKTRLAS | SGPRPEDSSD | TVLKPPFNRN | QKTIVPRGHG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RTTGSSKQER | KGTKLSRWLA | SYKPKYSCHP | PKYACSSTTS | SEEIKLRGKN | SGKDEEKMIK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ISETNPPCSK | SMGIKSFSHE | LGPRGGVQTP | YPRPHSYNDL | KELLGSLHSR | FDVAKETVDK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLDVFVRDVK | EAMEKMDPSC | PEDREMAEQL | LDVARACMEM | TSAQLRATCE | SIVQDLTRKR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KQCQAGLVKW | LFSQLLFILT | HCTRVVMFQK | ETEPIDESSF | RKFKECLERI | PALETDWGST |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PRVDDSGSGY | PEYQRNEAGQ | KFKRRDKESL | ESETALDYVV | PNDHGNNAAR | EGYAAAKQEF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PSHEPQFDSK | VVEQRFYLSD | EYEDKMSNEP | GKELGGSDYV | ICRICEEEVP | LFHLEPHSYI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CAYADKCEIN | CVDVDERLLK | LEEILEQIID | SRSLNSFTQA | GGLENSVLRK | SGVASEGCSP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KINEWRNKGL | EGMFEDLHEM | DTAFIDESYT | YPIHLKSHVG | AKFCHHATSS | STGSITSVSS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TNTPRTSHFD | SYWLERHCPE | QEDLRLMMDL | SDIARCGAST | DFSKEGSCDY | IMACMQDIQA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VLKQGKLKAL | VIDTFGGRIE | KLLCEKYLHA | RELTADKSSV | GNIKESEDVL | EHASATPQLL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LKDRISIDDF | EIIKPISRGA | FGKVFLARKR | TTGDFFAIKV | LKKLDMIRKN | DIERILQERN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ILITVRYPFL | VRFFYSFTCR | DNLYLVMEYL | NGGDLYSLLQ | KVGCLDEEIA | RIYIAELVLA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LEYLHSLKIV | HRDLKPDNLL | IAYNGHIKLT | DFGLSKIGLI | NNTIDLSGHE | SDVSPRTNSH |
| 850 | 860 | 870 | 880 | 890 | 900 |
| HFQKNQEEER | IRHSAVGTPD | YLAPEILLGT | EHGYAADWWS | AGIVLFELLT | GIPPFTASRP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EKIFDNILNG | KMPWPDVPGE | MSYEAQDLIN | RLLVHEPEKR | LGANGAAEVK | SHPFFQGVDW |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| ENLALQKAAF | VPQPESINDT | SYFVSRFSES | SCSDTETGNN | SGSNPDSGDE | VGIWKLHPFL |
| 1030 | 1040 | ||||
| SRYSICNHRI | YRKLFFLLLC | VF |