F1Q8X5
SS
Gene name |
fermt2 |
Protein name |
Fermitin family homolog 2 |
Names |
Kindlin-2 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:553051 |
EC number |
|
Protein Class |
|
Descriptions
Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. kindlin-3 is maintained in a homotrimer state, which is different from the monomer that binds integrin β cytoplasmic tails. The trimer formation of kindlin-3 results in an autoinhibited state, as the integrin-binding pocket is blocked by the pleckstrin homology (PH) domain of another protomer. Mutations disrupting the trimer interface (Q471A, A475F, S478A) lead to increased integrin-mediated cell adhesion and spreading, indicating relief from autoinhibition. This autoinhibition regulates kindlin-3’s role in integrin activation and signaling, with implications for diseases like leukocyte adhesion deficiency (LAD) III and cancer.
Autoinhibitory domains (AIDs)
Target domain |
588-684 (F3 subdomain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for F1Q8X5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| No available structures | |||||
No variants for F1Q8X5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for F1Q8X5 | |||||
No associated diseases with F1Q8X5
5 regional properties for F1Q8X5
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| I band | A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. |
| intercalated disc | A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. |
| lamellipodium membrane | The portion of the plasma membrane surrounding a lamellipodium. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| stress fiber | A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| integrin binding | Binding to an integrin. |
| lipid binding | Binding to a lipid. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| cardiac muscle tissue morphogenesis | The process in which the anatomical structures of cardiac muscle tissue are generated and organized. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. |
| cell-matrix adhesion | The binding of a cell to the extracellular matrix via adhesion molecules. |
| cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| integrin-mediated signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q32LP0 | FERMT3 | Fermitin family homolog 3 | Bos taurus (Bovine) | SS |
| Q9VZI3 | Fit1 | Unc-112-related protein | Drosophila melanogaster (Fruit fly) | SS |
| Q86UX7 | FERMT3 | Fermitin family homolog 3 | Homo sapiens (Human) | EV |
| Q9BQL6 | FERMT1 | Fermitin family homolog 1 | Homo sapiens (Human) | SS |
| Q96AC1 | FERMT2 | Fermitin family homolog 2 | Homo sapiens (Human) | SS |
| Q9Y4G6 | TLN2 | Talin-2 | Homo sapiens (Human) | SS |
| Q9Y490 | TLN1 | Talin-1 | Homo sapiens (Human) | EV |
| P59113 | Fermt1 | Fermitin family homolog 1 | Mus musculus (Mouse) | SS |
| Q8CIB5 | Fermt2 | Fermitin family homolog 2 | Mus musculus (Mouse) | SS |
| Q8K1B8 | Fermt3 | Fermitin family homolog 3 | Mus musculus (Mouse) | SS |
| P26039 | Tln1 | Talin-1 | Mus musculus (Mouse) | EV |
| Q18685 | unc-112 | Protein unc-112 | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALDGIRMPD | GCYADGTWEL | KMHVTDLNRD | VSLRVTGEIH | IGGVMLKLVE | KLDVKKDWSD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HALWWEKKKT | WLLKTHWTLD | KYGIQADARL | LFTPQHKLLR | LQLPNMKHMR | VKVNFSDRVF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KAVSDICKTF | NIRHPEELSL | LRKPRDPKKK | KKKLEDAEEE | TLELEGPLLT | PGSGSIYSSP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GLYSKTMTPT | YDSRDGSPLS | PTSAWFGDSP | LSEGNPSILA | VSQPITSPDI | LVKMYKPQSL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDKAKINQGW | LDSSRSLMEQ | DVKENEVLLL | RFKYHSFFDL | NPKYDAIRVN | QLYEQAKWAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LLEEIECTEE | EMMMFAALQY | HINKLSIMSS | DNHMNNSEKE | VDEVDAALSD | LEITLEGGKT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SNTLGDITSI | PELADYVKVF | KPKKLTLKGY | KQYWCTFKDI | TISCYKSREE | AHGTPAHQMN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LRGCEVTPDV | NISGQKFNIK | LLIPVADGMN | EIWLRCDTEK | QYAQWMAACR | LASKGKTMAD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SSYNLEVQNI | LSFLKMQHMN | PDPQIIEPIT | TDINPECLVS | PRYLKKYKNK | QPGFVRDLIS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ARILEAHQNV | AQMSLIEAKM | RFIQAWQSLP | EFGITHFLAK | FQGGKKDELI | GITYNRLIRM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DAGTGDAIKT | WRFSNMKQWN | VNWEIKMVTV | EFADEPSLAF | ICAEVDCKVV | HEFIGGYIFL |
| 670 | 680 | ||||
| STRAKDQNES | LDEEMFYKLT | SGWV |