F1Q4R9
PR
Gene name |
meox1 |
Protein name |
Homeobox protein MOX-1 |
Names |
Mesenchyme homeobox 1, Protein choker |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:436723 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F1Q4R9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F1Q4R9-F1 | Predicted | AlphaFoldDB |
No variants for F1Q4R9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for F1Q4R9 | |||||
No associated diseases with F1Q4R9
4 regional properties for F1Q4R9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Homeobox domain | 168 - 232 | IPR001356 |
| conserved_site | Homeobox, conserved site | 203 - 226 | IPR017970 |
| domain | Homeobox domain, metazoa | 192 - 203 | IPR020479-1 |
| domain | Homeobox domain, metazoa | 207 - 226 | IPR020479-2 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| developmental pigmentation | The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. |
| hematopoietic stem cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. |
| hemopoiesis | The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. |
| muscle cell development | The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| sclerotome development | The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. |
| skeletal system development | The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). |
| somite development | The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P23459 | HOXD8 | Homeobox protein Hox-D8 | Gallus gallus (Chicken) | PR |
| A2T6Z0 | HOXB1 | Homeobox protein Hox-B1 | Pan troglodytes (Chimpanzee) | SS |
| P10105 | lab | Homeotic protein labial | Drosophila melanogaster (Fruit fly) | EV |
| P31268 | HOXA7 | Homeobox protein Hox-A7 | Homo sapiens (Human) | SS |
| P49639 | HOXA1 | Homeobox protein Hox-A1 | Homo sapiens (Human) | SS |
| P14653 | HOXB1 | Homeobox protein Hox-B1 | Homo sapiens (Human) | SS |
| P09022 | Hoxa1 | Homeobox protein Hox-A1 | Mus musculus (Mouse) | SS |
| O08656 | Hoxa1 | Homeobox protein Hox-A1 | Rattus norvegicus (Rat) | SS |
| A2D649 | HOXB1 | Homeobox protein Hox-B1 | Macaca mulatta (Rhesus macaque) | SS |
| Q28IU6 | hoxd1 | Homeobox protein Hox-D1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q8JH55 | hoxb8b | Homeobox protein Hox-B8b | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEQSASSCMR | SPHTGGALWG | CVRSPHSGGS | GAGIQPYQQA | PFALHQKHDF | LAYTDFSSSC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVPAPHAYPR | EDRLYPETHS | GYQRTEWQFS | PCEPRGRGQE | PCQGAAEAVG | AEMDSAGGDR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LAGAVTGCLE | GDYSPQSVPA | VDTEKKSSKR | KREVTDIQDS | SFKADSNCKA | RKERTAFTKE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QLRELEAEFT | HHNYLTRLRR | YEIAVNLDLT | ERQVKVWFQN | RRMKWKRVKG | GQPASPHDLE |
| 250 | |||||
| ADELDSAASP | SSE |