Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F1NEA7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F1NEA7-F1 | Predicted | AlphaFoldDB |
20 variants for F1NEA7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs736979191 | 6 | V>G | No | Ensembl | |
| rs734972874 | 68 | H>P | No | Ensembl | |
| rs732628993 | 71 | Q>K | No | Ensembl | |
| rs316510453 | 83 | L>R | No | Ensembl | |
| rs739803795 | 126 | F>S | No | Ensembl | |
| rs736440528 | 133 | L>P | No | Ensembl | |
| rs735793041 | 217 | S>R | No | Ensembl | |
| rs740869992 | 238 | I>T | No | Ensembl | |
| rs734750799 | 253 | T>P | No | Ensembl | |
| rs740645970 | 256 | Y>S | No | Ensembl | |
| rs734527800 | 258 | S>P | No | Ensembl | |
| rs732506834 | 259 | S>P | No | Ensembl | |
| rs733936732 | 270 | F>S | No | Ensembl | |
| rs736385664 | 280 | L>F | No | Ensembl | |
| rs739231470 | 288 | M>R | No | Ensembl | |
| rs740364508 | 294 | M>I | No | Ensembl | |
| rs735539404 | 294 | M>L | No | Ensembl | |
| rs738349313 | 299 | M>R | No | Ensembl | |
| rs739455381 | 308 | S>P | No | Ensembl | |
| rs738792349 | 318 | L>P | No | Ensembl |
No associated diseases with F1NEA7
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
25 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A0JNI8 | LHX9 | LIM/homeobox protein Lhx9 | Bos taurus (Bovine) | PR |
| Q90881 | LHX9 | LIM/homeobox protein Lhx9 | Gallus gallus (Chicken) | PR |
| Q90963 | PRRX2 | Paired mesoderm homeobox protein 2 | Gallus gallus (Chicken) | PR |
| Q8IRC7 | Awh | LIM/homeobox protein Awh | Drosophila melanogaster (Fruit fly) | PR |
| Q8NHV9 | RHOXF1 | Rhox homeobox family member 1 | Homo sapiens (Human) | PR |
| Q9NQ69 | LHX9 | LIM/homeobox protein Lhx9 | Homo sapiens (Human) | PR |
| O95076 | ALX3 | Homeobox protein aristaless-like 3 | Homo sapiens (Human) | PR |
| Q9BQY4 | RHOXF2 | Rhox homeobox family member 2 | Homo sapiens (Human) | PR |
| Q99811 | PRRX2 | Paired mesoderm homeobox protein 2 | Homo sapiens (Human) | PR |
| P50458 | LHX2 | LIM/homeobox protein Lhx2 | Homo sapiens (Human) | PR |
| O15266 | SHOX | Short stature homeobox protein | Homo sapiens (Human) | PR |
| P63013 | Prrx1 | Paired mesoderm homeobox protein 1 | Mus musculus (Mouse) | PR |
| Q8VIH1 | Nobox | Homeobox protein NOBOX | Mus musculus (Mouse) | PR |
| Q06348 | Prrx2 | Paired mesoderm homeobox protein 2 | Mus musculus (Mouse) | PR |
| O88933 | Esx1 | Extraembryonic, spermatogenesis, homeobox 1 (Homeobox protein SPX1) (Homeodomain protein EPX) | Mus musculus (Mouse) | EV |
| Q9WUH2 | Lhx9 | LIM/homeobox protein Lhx9 | Mus musculus (Mouse) | PR |
| Q80W90 | Lhx9 | LIM/homeobox protein Lhx9 | Rattus norvegicus (Rat) | PR |
| P36198 | Lhx2 | LIM/homeobox protein Lhx2 | Rattus norvegicus (Rat) | PR |
| Q6H6S3 | HOX24 | Homeobox-leucine zipper protein HOX24 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XUJ5 | HOX22 | Homeobox-leucine zipper protein HOX22 | Oryza sativa subsp japonica (Rice) | PR |
| A3BYC1 | HOX25 | Homeobox-leucine zipper protein HOX25 | Oryza sativa subsp japonica (Rice) | PR |
| Q9M276 | ATHB-12 | Homeobox-leucine zipper protein ATHB-12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q28G02 | siamois | Homeobox protein siamois | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q1LWV4 | lhx9 | LIM/homeobox protein Lhx9 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q566X8 | dmbx1b | Diencephalon/mesencephalon homeobox protein 1-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQHYGVNGYS | LHAMNSLSAM | YNLHQQAAQQ | AQHAPDYRPS | VHALTLAERL | AGCTFQDIIL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EARYGSQHRK | QRRSRTAFTA | QQLEALEKTF | QKTHYPDVVM | RERLAMCTNL | PEARVQVWFK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NRRAKFRKKQ | RSLQKEQLQK | QKDCESSHSE | GKTEPPVLET | QSTIPDTEKT | QSIPSEVSTD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LNLTLSEQSA | SESAPEDQTD | REEEFKSTLD | EAKVDKSPGV | DGKALNCKRA | SPKSESPISA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TVTPSSSSGL | AQTHSYSSSP | LSLFRLQEQF | RQHMAATNNL | VHYSSFEMGT | PSAMPYLGMN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VNMAPLSSLH | CQSYYQSLSH | AQQVWSSPIL | QASSSLPSLN | SKTTSIENLR | LRAKQHAASL |
| GLDTLPN |