F1N9Y5

SS
Gene name
SYK (RCJMB04_19o18)
Protein name
Tyrosine-protein kinase SYK
Names
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:427272
EC number
Protein Class

Descriptions

Syk is non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Upon BCR crosslinking, Syk is recruited via its tandem SH2 domain to tyrosine-phosphorylated Ig-α/Ig-β constituting components of BCR, and intimately cooperates with the signaling subunits of the BCR and plays a central role in the amplification and diversification of BCR signals. Syk has two linkers called interdomains that regulate conformations of SYK: interdomain A (SH2-SH2), interdomain B (SH2-Protein Kinase). The interdomain interaction of A and B maintains the kinase domain inactive.

Autoinhibitory domains (AIDs)

107-166 (Interdomain A) SS

Target domain

349-613 (Protein kinase domain)

Relief mechanism

Partner binding, PTM

Assay

259-348 (Interdomain B) SS

Target domain

349-613 (Protein kinase domain)

Relief mechanism

Partner binding, PTM

Assay

Accessory elements

489-515 (Activation loop from InterPro)

Target domain

349-613 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for F1N9Y5

Entry ID Method Resolution Chain Position Source
AF-F1N9Y5-F1 Predicted AlphaFoldDB

No variants for F1N9Y5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for F1N9Y5

No associated diseases with F1N9Y5

8 regional properties for F1N9Y5

Type Name Position InterPro Accession
domain Protein kinase domain 349 - 613 IPR000719
domain SH2 domain 12 - 106 IPR000980-1
domain SH2 domain 165 - 258 IPR000980-2
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 354 - 601 IPR001245
active_site Tyrosine-protein kinase, active site 468 - 480 IPR008266
binding_site Protein kinase, ATP binding site 355 - 380 IPR017441
domain Tyrosine-protein kinase, catalytic domain 349 - 604 IPR020635
domain SYK/ZAP-70, N-terminal SH2 domain 12 - 115 IPR035838

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early phagosome A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

31 GO annotations of biological process

Name Definition
adaptive immune response An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
B cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
blood vessel morphogenesis The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cellular response to hydrogen peroxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
cellular response to molecule of fungal origin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
integrin-mediated signaling pathway The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
leukocyte activation involved in immune response A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
leukocyte cell-cell adhesion The attachment of a leukocyte to another cell via adhesion molecules.
lymph vessel development The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.
macrophage activation involved in immune response A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
neutrophil activation involved in immune response The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
neutrophil chemotaxis The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
peptidyl-tyrosine phosphorylation The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
positive regulation of alpha-beta T cell proliferation Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.
positive regulation of B cell differentiation Any process that activates or increases the frequency, rate or extent of B cell differentiation.
positive regulation of bone resorption Any process that activates or increases the frequency, rate or extent of bone resorption.
positive regulation of cell adhesion mediated by integrin Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.
positive regulation of mast cell degranulation Any process that activates or increases the frequency, rate or extent of mast cell degranulation.
regulation of arachidonic acid secretion Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.
regulation of ERK1 and ERK2 cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
regulation of neutrophil degranulation Any process that modulates the frequency, rate, or extent of neutrophil degranulation.
regulation of phagocytosis Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.
regulation of platelet activation Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
regulation of platelet aggregation Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
regulation of superoxide anion generation Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell.
serotonin secretion by platelet The regulated release of serotonin by a platelet or group of platelets.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P00523 SRC Proto-oncogene tyrosine-protein kinase Src Gallus gallus (Chicken) EV
Q02977 YRK Proto-oncogene tyrosine-protein kinase Yrk Gallus gallus (Chicken) SS
P09324 YES1 Tyrosine-protein kinase Yes Gallus gallus (Chicken) SS
P41239 CSK Tyrosine-protein kinase CSK Gallus gallus (Chicken) SS
Q00944 PTK2 Focal adhesion kinase 1 Gallus gallus (Chicken) EV
P42683 LCK Proto-oncogene tyrosine-protein kinase LCK Gallus gallus (Chicken) SS
Q8JH64 BTK Tyrosine-protein kinase BTK Gallus gallus (Chicken) SS
Q05876 FYN Tyrosine-protein kinase Fyn Gallus gallus (Chicken) SS
P43403 ZAP70 Tyrosine-protein kinase ZAP-70 Homo sapiens (Human) EV
P43405 SYK Tyrosine-protein kinase SYK Homo sapiens (Human) EV
P43404 Zap70 Tyrosine-protein kinase ZAP-70 Mus musculus (Mouse) SS
P48025 Syk Tyrosine-protein kinase SYK Mus musculus (Mouse) SS
Q00655 SYK Tyrosine-protein kinase SYK Sus scrofa (Pig) SS
Q64725 Syk Tyrosine-protein kinase SYK Rattus norvegicus (Rat) SS
Q9SYA0 At1g61500 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FG33 LECRKS5 Probable L-type lectin-domain containing receptor kinase S.5 Arabidopsis thaliana (Mouse-ear cress) PR
O22558 STY8 Serine/threonine-protein kinase STY8 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWL6 STY17 Serine/threonine-protein kinase STY17 Arabidopsis thaliana (Mouse-ear cress) PR
F4JTP5 STY46 Serine/threonine-protein kinase STY46 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASNMANPAN HLPYFFGNIT REEAEEYLMQ GGMSDGLYLL RQSRNYLGGF ALSLAYGRKV
70 80 90 100 110 120
HHYTIERELS GTYAIAGGKS HASPAELINY HSEEADGLIC LLRKSFNRPP GVEPKTGPFE
130 140 150 160 170 180
DLKENLIREY VKQTWNLQGH ALEQAIISQK PQLEKLIATT AHEKMPWFHG RISREESEHR
190 200 210 220 230 240
ILIGSRNNGK FLIRERDSNG SYALCLLNDG KVLHYRIDRD KTGKLSIPDG KRFDTLWQLV
250 260 270 280 290 300
EHYSYKPDGL LRVLSIPCPR HGSESDNVVF DTRPLPGTPS KLQTPIGAPS DDQTPFNPYV
310 320 330 340 350 360
LQRARGLIGA EKGDQREALP MDTEVYESPY ADPDEIKPKN VTLDRKLLTL EEGELGSGNF
370 380 390 400 410 420
GTVKKGFYKM KKGAKPVAVK ILKNESNDPA IKDELLREAN VMQQLDNPYI VRMIGICEAE
430 440 450 460 470 480
AWMLVMEMAE LGPLNKFLQK NRHVTEKNIT ELVHQVSMGM KYLEENNFVH RDLAARNVLL
490 500 510 520 530 540
VTQHYAKISD FGLSKALSAD ENYYKAQSHG KWPVKWYAPE CMNFYKFSSK SDVWSFGVLM
550 560 570 580 590 600
WEAFSYGQKP YKGMKGGEVA QMIERGERME CPEACPVEVY DLMKLCWTYN VDDRPGFVAV
610
ELRLRNYYYD ISH