E9Q634
PR
Gene name |
Myo1e (Myr3) |
Protein name |
Unconventional myosin-Ie |
Names |
Unconventional myosin 1E |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:71602 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for E9Q634
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2XMF | X-ray | 150 A | A | 1053-1107 | PDB |
| AF-E9Q634-F1 | Predicted | AlphaFoldDB |
58 variants for E9Q634
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389057594 | 22 | D>E | No | EVA | |
| rs3389063642 | 38 | N>D | No | EVA | |
| rs3400116016 | 65 | M>I | No | EVA | |
| rs3389053845 | 71 | K>* | No | EVA | |
| rs30226946 | 73 | V>I | No | EVA | |
| rs3389064766 | 95 | M>I | No | EVA | |
| rs3389058835 | 97 | R>I | No | EVA | |
| rs3389031899 | 112 | G>D | No | EVA | |
| rs3389031898 | 130 | S>P | No | EVA | |
| rs3389058805 | 134 | G>V | No | EVA | |
| rs3389060857 | 186 | G>A | No | EVA | |
| rs3389044010 | 187 | G>A | No | EVA | |
| rs3389056721 | 203 | N>K | No | EVA | |
| rs3389060854 | 222 | E>* | No | EVA | |
| rs3412781131 | 227 | L>I | No | EVA | |
| rs3389058857 | 239 | S>N | No | EVA | |
| rs3389063667 | 244 | Y>C | No | EVA | |
| rs3389057588 | 289 | S>R | No | EVA | |
| rs253920649 | 289 | S>T | No | EVA | |
| rs3389024122 | 314 | I>L | No | EVA | |
| rs3400356459 | 315 | N>Y | No | EVA | |
| rs3389057609 | 335 | K>Q | No | EVA | |
| rs3389024097 | 433 | I>V | No | EVA | |
| rs3389036037 | 434 | R>S | No | EVA | |
| rs3389058850 | 508 | A>D | No | EVA | |
| rs3389064761 | 517 | G>D | No | EVA | |
| rs3389056719 | 525 | V>L | No | EVA | |
| rs3389063621 | 562 | G>R | No | EVA | |
| rs3389060828 | 577 | M>L | No | EVA | |
| rs250141840 | 650 | D>E | No | EVA | |
| rs3389003358 | 663 | N>Y | No | EVA | |
| rs3389058830 | 666 | S>G | No | EVA | |
| rs3389055101 | 693 | R>K | No | EVA | |
| rs3389044008 | 714 | K>I | No | EVA | |
| rs3389049832 | 718 | M>T | No | EVA | |
| rs3389055112 | 752 | P>Q | No | EVA | |
| rs3389056663 | 782 | R>L | No | EVA | |
| rs3389036010 | 789 | K>N | No | EVA | |
| rs3389063661 | 789 | K>T | No | EVA | |
| rs3389049802 | 807 | V>I | No | EVA | |
| rs3389063671 | 822 | L>M | No | EVA | |
| rs3389063626 | 828 | T>I | No | EVA | |
| rs3389003298 | 845 | L>R | No | EVA | |
| rs3389036027 | 866 | Q>* | No | EVA | |
| rs3389036027 | 866 | Q>E | No | EVA | |
| rs3389003319 | 872 | K>N | No | EVA | |
| rs37761940 | 936 | V>I | No | EVA | |
| rs3389051831 | 938 | S>C | No | EVA | |
| rs3389036021 | 943 | G>S | No | EVA | |
| rs3389055342 | 946 | K>* | No | EVA | |
| rs3389035999 | 957 | P>L | No | EVA | |
| rs3389031866 | 961 | H>Q | No | EVA | |
| rs3389024112 | 973 | P>R | No | EVA | |
| rs244523702 | 977 | F>L | No | EVA | |
| rs3389003312 | 980 | Q>R | No | EVA | |
| rs3389024134 | 1010 | T>M | No | EVA | |
| rs230969679 | 1056 | K>R | No | EVA | |
| rs3389035992 | 1063 | A>V | No | EVA |
No associated diseases with E9Q634
6 regional properties for E9Q634
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| binding_site | IQ motif, EF-hand binding site | 695 - 724 | IPR000048 |
| domain | SH3 domain | 1050 - 1107 | IPR001452 |
| domain | Myosin head, motor domain | 13 - 693 | IPR001609 |
| domain | Class I myosin tail homology domain | 719 - 922 | IPR010926 |
| domain | Unconventional myosin-Ie/If, SH3 domain | 1055 - 1106 | IPR035507 |
| domain | Class I myosin, motor domain | 33 - 679 | IPR036072 |
Functions
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| brush border | The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. |
| clathrin-coated endocytic vesicle | A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. |
| cuticular plate | A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| microvillus | Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. |
| myosin complex | A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| microfilament motor activity | A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. |
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| protein-containing complex binding | Binding to a macromolecular complex. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| glomerular basement membrane development | The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration. |
| glomerular filtration | The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein. |
| hemopoiesis | The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| kidney development | The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. |
| nitrogen compound metabolic process | The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. |
| platelet-derived growth factor receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| podocyte development | The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. |
| post-embryonic hemopoiesis | The stages of blood cell formation that take place after completion of embryonic development. |
| vasculogenesis | The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. |
| vesicle transport along actin filament | Movement of a vesicle along an actin filament, mediated by motor proteins. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P36006 | MYO3 | Myosin-3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| O00160 | MYO1F | Unconventional myosin-If | Homo sapiens (Human) | PR |
| Q12965 | MYO1E | Unconventional myosin-Ie | Homo sapiens (Human) | PR |
| Q99104 | Myo5a | Unconventional myosin-Va | Mus musculus (Mouse) | EV |
| Q64331 | Myo6 | Unconventional myosin-VI | Mus musculus (Mouse) | SS |
| P21271 | Myo5b | Unconventional myosin-Vb | Mus musculus (Mouse) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGSKGAYRYH | WQSHNVKHSG | VDDMVLLSKI | TESSIVENLK | KRYMDDYIFT | YIGSVLISVN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PFKQMPYFGE | KEVEMYQGAA | QYENPPHIYA | LADSMYRNMI | IDRENQCVII | SGESGAGKTV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AAKYIMSYVS | RVSGGGPKVQ | HVKDIILQSN | PLLEAFGNAK | TVRNNNSSRF | GKYFEIQFSP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GGEPDGGKIS | NFLLEKSRVV | MRNPGERSFH | IFYQLIEGAS | PEQKQSLGIT | SMDYYYYLSL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SGSYKVDDID | DKRDFQETLH | AMNVIGIFSE | EQTLVLQIVA | GILHLGNISF | KEVGNYAAVE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SEEFLAFPAY | LLGINQDRLK | EKLTSRQMDS | KWGGKSESIH | VTLNVEQACY | TRDALAKALH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ARVFDFLVDS | INKAMEKDHE | EYNIGVLDIY | GFEIFQKNGF | EQFCINFVNE | KLQQIFIELT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LKAEQEEYVQ | EGIRWTPIEY | FNNKIVCDLI | ESKVNPPGIM | SILDDVCATM | HAVGEGADQT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLQKLQMQIG | SHEHFNSWNQ | GFIIHHYAGK | VSYDMDGFCE | RNRDVLFMDL | IELMQSSELP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FIKSLFPENL | QADKKGRPTT | AGSKIKKQAN | DLVSTLMKCT | PHYIRCIKPN | ETKKPKDWEE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SRVKHQVEYL | GLKENIRVRR | AGYAYRRVFQ | KFLQRYAILT | KATWPVWRGD | EKQGVLHLLQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SVNMDSDQFQ | LGRSKVFIKA | PESLFLLEEM | RERKYDGYAR | VIQKTWRKFV | ARKKYVQMRE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EASDLLLNKK | ERRRNSINRN | FIGDYIGMEE | RPELQQFVGK | REKIDFADTV | TKYDRRFKGV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KRDLLLTPKC | LYLIGREKVK | QGPDKGVVKE | VLKRRIEVER | ILSVSLSTMQ | DDIFILHEQE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| YDSLLESVFK | TEFLSLLAKR | YEEKTQKQLP | LKFSNTLELK | LKKENWGPWS | AGGSRQVQFH |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QGFGDLAILK | PSNKVLQVSI | GPGLPKNSRP | TRRNTVTSRG | YPGGTKNNYP | MRAAPAPPGC |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| HQNGVIRNQF | VPPPHAFGNQ | RSNQKSLYTS | MARPPLPRQQ | STGSDRLSQT | PESLDFLKVP |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| DQGVAGVRRQ | TSSRPPPAGG | RPKPQPKPKP | QVPQCKALYA | YDAQDTDELS | FNANDIIDII |
| 1090 | 1100 | ||||
| KEDPSGWWTG | RLRGKQGLFP | NNYVTKI |