E9Q5R7
SS
Gene name |
Nlrp12 (NALP12) |
Protein name |
NACHT, LRR and PYD domains-containing protein 12 |
Names |
Monarch-1 , PYRIN-containing APAF1-like protein 7 , PYPAF7 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:378425 |
EC number |
|
Protein Class |
|
Descriptions
PYPAF1 (PYRIN-containing Apaf1-like protein 1) is a novel PYRIN-containing signaling protein that belongs to the nucleotide-binding site/leucine-rich repeat (NBS/LRR) family of signaling proteins. C-terminal leucine-rich repeats (LRRs) may function as a negative regulator of PYPAF1 activity. PYPAF1 and ASC function to regulate the activation of NF-B.
Autoinhibitory domains (AIDs)
Target domain |
4-90 (PYRIN domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for E9Q5R7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-E9Q5R7-F1 | Predicted | AlphaFoldDB |
54 variants for E9Q5R7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3545489128 | 4 | S>A | No | EVA | |
| rs3397187666 | 35 | A>P | No | EVA | |
| rs3388862134 | 68 | E>K | No | EVA | |
| rs3388870899 | 90 | Q>* | No | EVA | |
| rs3388873315 | 95 | V>M | No | EVA | |
| rs3545489008 | 179 | V>I | No | EVA | |
| rs3397629220 | 218 | A>P | No | EVA | |
| rs3545106164 | 227 | A>S | No | EVA | |
| rs3545389387 | 278 | S>F | No | EVA | |
| rs3545105772 | 289 | L>P | No | EVA | |
| rs3388856200 | 310 | W>S | No | EVA | |
| rs3545256207 | 329 | R>Q | No | EVA | |
| rs3545107434 | 352 | G>S | No | EVA | |
| rs3388846910 | 354 | L>I | No | EVA | |
| rs3388853605 | 396 | P>T | No | EVA | |
| rs3388870715 | 420 | S>N | No | EVA | |
| rs3388856169 | 421 | G>W | No | EVA | |
| rs3545233452 | 456 | A>G | No | EVA | |
| rs3545097310 | 529 | N>H | No | EVA | |
| rs3545228378 | 537 | A>V | No | EVA | |
| rs3406028603 | 553 | V>G | No | EVA | |
| rs3545104997 | 635 | S>A | No | EVA | |
| rs3545133910 | 678 | Q>H | No | EVA | |
| rs3388862142 | 688 | N>D | No | EVA | |
| rs3397563838 | 689 | M>L | No | EVA | |
| rs3545233918 | 702 | V>I | No | EVA | |
| rs3388856156 | 705 | N>S | No | EVA | |
| rs3388856116 | 713 | L>S | No | EVA | |
| rs3397592893 | 744 | R>I | No | EVA | |
| rs3388873404 | 764 | N>T | No | EVA | |
| rs3397640762 | 772 | D>G | No | EVA | |
| rs3397573097 | 781 | E>A | No | EVA | |
| rs3397592920 | 867 | E>K | No | EVA | |
| rs3388870891 | 877 | Q>H | No | EVA | |
| rs3388865352 | 894 | V>L | No | EVA | |
| rs3545389665 | 902 | S>R | No | EVA | |
| rs3388856211 | 922 | A>E | No | EVA | |
| rs3388853533 | 924 | V>A | No | EVA | |
| rs3545196964 | 925 | G>E | No | EVA | |
| rs3388846949 | 928 | S>G | No | EVA | |
| rs3545300941 | 934 | T>K | No | EVA | |
| rs3397573108 | 955 | G>E | No | EVA | |
| rs3397629250 | 956 | E>A | No | EVA | |
| rs3397744363 | 959 | R>G | No | EVA | |
| rs3397182873 | 959 | R>M | No | EVA | |
| rs3412997737 | 960 | H>P | No | EVA | |
| rs3397573012 | 962 | T>A | No | EVA | |
| rs3397640845 | 963 | C>F | No | EVA | |
| rs3397563856 | 972 | N>S | No | EVA | |
| rs3388875207 | 1032 | L>M | No | EVA | |
| rs3397501776 | 1034 | K>R | No | EVA | |
| rs3412946427 | 1050 | L>P | No | EVA | |
| rs3388869595 | 1053 | G>E* | No | EVA | |
| rs3388856149 | 1055 | C>G | No | EVA |
No associated diseases with E9Q5R7
10 regional properties for E9Q5R7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Leucine-rich repeat | 762 - 784 | IPR001611-1 |
| repeat | Leucine-rich repeat | 818 - 841 | IPR001611-2 |
| repeat | Leucine-rich repeat | 876 - 898 | IPR001611-3 |
| repeat | Leucine-rich repeat | 932 - 954 | IPR001611-4 |
| repeat | Leucine-rich repeat | 990 - 1008 | IPR001611-5 |
| domain | DAPIN domain | 1 - 95 | IPR004020 |
| domain | NACHT nucleoside triphosphatase | 211 - 528 | IPR007111 |
| domain | NACHT-associated domain | 128 - 201 | IPR029495 |
| domain | NOD1/2, winged helix domain | 460 - 512 | IPR041075 |
| domain | NACHT, LRR and PYD domains-containing protein, helical domain HD2 | 514 - 621 | IPR041267 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to cytokine stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. |
| dendritic cell migration | The movement of a dendritic cell within or between different tissues and organs of the body. |
| ERK1 and ERK2 cascade | An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier |
| negative regulation of canonical NF-kappaB signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. |
| negative regulation of ERK1 and ERK2 cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| negative regulation of inflammatory response | Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. |
| negative regulation of interleukin-1 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. |
| negative regulation of interleukin-6 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. |
| negative regulation of non-canonical NF-kappaB signal transduction | Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling. |
| negative regulation of protein autophosphorylation | Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. |
| negative regulation of Toll signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway. |
| positive regulation of MHC class I biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I. |
| positive regulation of non-canonical NF-kappaB signal transduction | Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling. |
| regulation of canonical NF-kappaB signal transduction | Any process that modulates I-kappaB kinase/NF-kappaB signaling. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A6QLE5 | NLRP3 | NACHT, LRR and PYD domains-containing protein 3 | Bos taurus (Bovine) | SS |
| Q96P20 | NLRP3 | NACHT, LRR and PYD domains-containing protein 3 | Homo sapiens (Human) | EV |
| P59046 | NLRP12 | NACHT, LRR and PYD domains-containing protein 12 | Homo sapiens (Human) | SS |
| Q66X01 | Nlrp9c | NACHT, LRR and PYD domains-containing protein 9C | Mus musculus (Mouse) | PR |
| Q8CCN1 | Nlrp10 | NACHT, LRR and PYD domains-containing protein 10 | Mus musculus (Mouse) | PR |
| Q8R4B8 | Nlrp3 | NACHT, LRR and PYD domains-containing protein 3 | Mus musculus (Mouse) | SS |
| D4A523 | Nlrp3 | NACHT, LRR and PYD domains-containing protein 3 | Rattus norvegicus (Rat) | SS |
| B0FPE9 | NLRP3 | NACHT, LRR and PYD domains-containing protein 3 | Macaca mulatta (Rhesus macaque) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLPSTARDGL | YRLSTYLEEL | EAGELKKFKL | FLGIAEDLSQ | DKIPWGRMEK | AGPLEMAQLM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VAHMGTREAW | LLALSTFQRI | HRKDLWERGQ | GEDLVRVTPN | NGLCLFESQS | ACPLDVSPNA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PRKDLQTTYK | DYVRRKFQLM | EDRNARLGEC | VNLSNRYTRL | LLVKEHSNPI | WTQQKFVDVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WERSRTRRHQ | TSPIQMETLF | EPDEERPEPP | HTVVLQGAAG | MGKSMLAHKV | MLDWADGRLF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QGRFDYVFYI | SCRELNRSHT | QCSVQDLISS | CWPERGISLE | DLMQAPDRLL | FIIDGFDKLH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PSFHDAQGPW | CLCWEEKQPT | EVLLGSLIRR | LLLPQVSLLI | TTRPCALEKL | HGLLEHPRHV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EILGFSEEAR | KEYFYRYFHN | TGQASRVLSF | LMDYEPLFTM | CFVPMVSWVV | CTCLKQQLES |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GELLRQTPRT | TTAVYMFYLL | SLMQPKPGTP | TFKVPANQRG | LVSLAAEGLW | NQKILFDEQD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LGKHGLDGAD | VSTFLNVNIF | QKGIKCEKFY | SFIHLSFQEF | FAAMYCALNG | REAVRRALAE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YGFSERNFLA | LTVHFLFGLL | NEEMRCYLER | NLGWSISPQV | KEEVLAWIQN | KAGSEGSTLQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HGSLELLSCL | YEVQEEDFIQ | QALSHFQVVV | VRSISTKMEH | MVCSFCARYC | RSTEVLHLHG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SAYSTGMEDD | PPEPSGVQTQ | STYLQERNML | PDVYSAYLSA | AVCTNSNLIE | LALYRNALGS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QGVRLLCQGL | RHASCKLQNL | RLKRCQISGS | ACQDLAAAVI | ANRNLIRLDL | SDNSIGVPGL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ELLCEGLQHP | RCRLQMIQLR | KCLLEAAAGR | SLASVLSNNS | YLVELDLTGN | PLEDSGLKLL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| CQGLRHPVCR | LRTLWLKICH | LGQASCEDLA | STLKMNQSLL | ELDLGLNDLG | DSGVLLLCEG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LSHPDCKLQT | LRLGICRLGS | VACVGIASVL | QVNTCLQELD | LSFNDLGDRG | LQLLGEGLRH |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| QTCRLQKLWL | DNCGLTSKAC | EDLSSILGIS | QTLHELYLTN | NALGDTGVCL | LCKRLRHPGC |
| 1030 | 1040 | 1050 | |||
| KLRVLWLFGM | DLNKKTHRRM | AALRVTKPYL | DIGC |