E9Q5F9
SS
Gene name |
Setd2 (Kiaa1732, Kmt3a) |
Protein name |
Histone-lysine N-methyltransferase SETD2 |
Names |
EC 2.1.1.359 , Lysine N-methyltransferase 3A , Protein-lysine N-methyltransferase SETD2 , EC 2.1.1.- , SET domain-containing protein 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:235626 |
EC number |
2.1.1.359: Methyltransferases |
Protein Class |
|
Descriptions
Huntingtin(Htt) yeast two-hybrid protein B (HYPB, which is known as SETD2), a histone methyltransferase, directly interacts with Htt and is involved in Huntington's disease pathology. The WW domain (2383-2430) of HYPB specifically interacts with the preceding polyproline (polyP) stretch to form a structural entity and this autoinhibitory structure provides an arena for allosterically regulating its interaction with Htt proline-rich region (PRR). The polyP region can be divided into two peptide segments: PP1 and PP2. PP2WW is predominantly in the closed state, effectively inhibiting the WW domain from interacting with other PRRs, such as Htt PRR. Thus, the interaction between the WW domain of HYPB and PRR of Htt is finely modulated intramolecularly by the polyP stretch.
Autoinhibitory domains (AIDs)
Target domain |
2362-2395 (WW domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for E9Q5F9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-E9Q5F9-F1 | Predicted | AlphaFoldDB |
120 variants for E9Q5F9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389065783 | 41 | F>L | No | EVA | |
| rs3389065794 | 56 | L>M | No | EVA | |
| rs3389022415 | 77 | S>N | No | EVA | |
| rs3389080603 | 89 | F>C | No | EVA | |
| rs3400767801 | 92 | A>S | No | EVA | |
| rs3400128149 | 92 | A>V | No | EVA | |
| rs3400674279 | 94 | S>C | No | EVA | |
| rs3400812112 | 94 | S>I | No | EVA | |
| rs3400812084 | 95 | N>I | No | EVA | |
| rs3389022400 | 96 | E>A | No | EVA | |
| rs3400813088 | 96 | E>D | No | EVA | |
| rs3389022400 | 96 | E>G | No | EVA | |
| rs3399578637 | 98 | Q>H | No | EVA | |
| rs3400466256 | 98 | Q>R | No | EVA | |
| rs3389077480 | 104 | S>P | No | EVA | |
| rs3389080606 | 105 | P>Q | No | EVA | |
| rs236843517 | 201 | S>T | No | EVA | |
| rs3547520247 | 236 | V>G | No | EVA | |
| rs579701642 | 243 | P>L | No | EVA | |
| rs3389080524 | 362 | E>* | No | EVA | |
| rs3389065727 | 366 | K>T | No | EVA | |
| rs3389076556 | 368 | S>* | No | EVA | |
| rs3389087282 | 466 | Y>C | No | EVA | |
| rs3389053614 | 498 | E>* | No | EVA | |
| rs216993874 | 511 | T>S | No | EVA | |
| rs3389087215 | 528 | K>T | No | EVA | |
| rs33296450 | 646 | R>H | No | EVA | |
| rs3389079767 | 660 | D>V | No | EVA | |
| rs3389086618 | 664 | N>K | No | EVA | |
| rs236333626 | 693 | I>V | No | EVA | |
| rs262385961 | 697 | S>C | No | EVA | |
| rs248767446 | 714 | M>I | No | EVA | |
| rs3547543113 | 724 | G>D | No | EVA | |
| rs3389053549 | 753 | S>P | No | EVA | |
| rs254409620 | 778 | V>A | No | EVA | |
| rs33296452 | 792 | I>R | No | EVA | |
| rs221833345 | 805 | A>T | No | EVA | |
| rs243908498 | 809 | A>V | No | EVA | |
| rs265441172 | 811 | T>K | No | EVA | |
| rs265441172 | 811 | T>M | No | EVA | |
| rs33297304 | 813 | S>P | No | EVA | |
| rs258576191 | 815 | H>N | No | EVA | |
| rs242397952 | 828 | I>T | No | EVA | |
| rs212919228 | 837 | R>Q | No | EVA | |
| rs251711002 | 849 | S>N | No | EVA | |
| rs3400106701 | 920 | D>E | No | EVA | |
| rs3389086675 | 953 | E>V | No | EVA | |
| rs47670880 | 954 | R>G | No | EVA | |
| rs3400767866 | 992 | D>H | No | EVA | |
| rs3389073196 | 1001 | D>G | No | EVA | |
| rs3389045039 | 1023 | S>G | No | EVA | |
| rs3389070691 | 1030 | S>C | No | EVA | |
| rs246489985 | 1079 | R>H | No | EVA | |
| rs3400341182 | 1082 | D>E | No | EVA | |
| rs263079703 | 1094 | E>K | No | EVA | |
| rs3389053628 | 1112 | T>I | No | EVA | |
| rs224877194 | 1115 | S>N | No | EVA | |
| rs240325542 | 1118 | S>T | No | EVA | |
| rs3389082948 | 1122 | Q>H | No | EVA | |
| rs259289085 | 1137 | A>S | No | EVA | |
| rs3413128276 | 1139 | S>C | No | EVA | |
| rs3389080549 | 1156 | G>D | No | EVA | |
| rs108875979 | 1161 | E>G | No | EVA | |
| rs3389076379 | 1187 | K>N | No | EVA | |
| rs3389045032 | 1224 | S>T | No | EVA | |
| rs3400577936 | 1232 | G>W | No | EVA | |
| rs1135201745 | 1289 | P>S | No | EVA | |
| rs3389053597 | 1291 | T>I | No | EVA | |
| rs215949324 | 1354 | A>S | No | EVA | |
| rs247879352 | 1405 | M>V | No | EVA | |
| rs3413120404 | 1412 | V>M | No | EVA | |
| rs3389076358 | 1413 | P>S | No | EVA | |
| rs3389087193 | 1453 | N>I | No | EVA | |
| rs3389082985 | 1455 | Y>* | No | EVA | |
| rs3389086667 | 1464 | S>T | No | EVA | |
| rs3400720286 | 1465 | H>Q | No | EVA | |
| rs3400664706 | 1465 | H>R | No | EVA | |
| rs3400577846 | 1466 | R>W | No | EVA | |
| rs3400813087 | 1468 | I>F | No | EVA | |
| rs3389065732 | 1495 | L>R | No | EVA | |
| rs3389057193 | 1610 | E>G | No | EVA | |
| rs3389057193 | 1610 | E>V | No | EVA | |
| rs3389079835 | 1626 | T>I | No | EVA | |
| rs3389073190 | 1639 | D>E | No | EVA | |
| rs3389076429 | 1734 | N>I | No | EVA | |
| rs3400577965 | 1737 | S>P | No | EVA | |
| rs3389087221 | 1835 | S>T | No | EVA | |
| rs226849286 | 1842 | M>V | No | EVA | |
| rs3400720219 | 1900 | Q>L | No | EVA | |
| rs3547586082 | 1912 | V>I | No | EVA | |
| rs255063098 | 1925 | T>I | No | EVA | |
| rs3389077444 | 1927 | E>Q | No | EVA | |
| rs212199488 | 1932 | T>M | No | EVA | |
| rs3389076361 | 2017 | D>Y | No | EVA | |
| rs33294109 | 2018 | A>P | No | EVA | |
| rs255243667 | 2042 | S>P | No | EVA | |
| rs3389073240 | 2067 | R>G | No | EVA | |
| rs3389080551 | 2093 | E>* | No | EVA | |
| rs3389045109 | 2114 | M>I | No | EVA | |
| rs3389076622 | 2167 | M>L | No | EVA | |
| rs262734318 | 2188 | E>D | No | EVA | |
| rs3389076377 | 2189 | S>Y | No | EVA | |
| rs586363929 | 2193 | P>A | No | EVA | |
| rs247244391 | 2199 | V>A | No | EVA | |
| rs3389087190 | 2201 | H>L | No | EVA | |
| rs235993875 | 2236 | G>A | No | EVA | |
| rs586117337 | 2247 | E>D | No | EVA | |
| rs33294955 | 2249 | N>S | No | EVA | |
| rs3389065799 | 2263 | Q>H | No | EVA | |
| rs3389057220 | 2265 | Q>L | No | EVA | |
| rs214690737 | 2280 | S>G | No | EVA | |
| rs3389065770 | 2311 | T>I | No | EVA | |
| rs3389065770 | 2311 | T>R | No | EVA | |
| rs13473703 | 2321 | P>L | No | EVA | |
| rs244780685 | 2322 | T>S | No | EVA | |
| rs3389080611 | 2329 | V>I | No | EVA | |
| rs3389077427 | 2335 | Q>R | No | EVA | |
| rs3547568382 | 2458 | C>S | No | EVA | |
| rs3547633153 | 2527 | V>I | No | EVA | |
| rs1134948792 | 2538 | E>C | No | EVA |
No associated diseases with E9Q5F9
6 regional properties for E9Q5F9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | WW domain | 2362 - 2395 | IPR001202 |
| domain | SET domain | 1524 - 1647 | IPR001214 |
| domain | Post-SET domain | 1648 - 1664 | IPR003616 |
| domain | AWS domain | 1468 - 1523 | IPR006560 |
| domain | Set2 Rpb1 interacting domain | 2448 - 2529 | IPR013257 |
| domain | SETD2/Set2, SET domain | 1523 - 1664 | IPR044437 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.359 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha-tubulin binding | Binding to the microtubule constituent protein alpha-tubulin. |
| histone H3K36 methyltransferase activity | Catalysis of the reaction |
| histone H3K36 trimethyltransferase activity | Catalysis of the reaction |
| metal ion binding | Binding to a metal ion. |
| protein-lysine N-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. |
34 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| cell migration involved in vasculogenesis | The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes. |
| coronary vasculature morphogenesis | The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood. |
| defense response to virus | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
| embryonic cranial skeleton morphogenesis | The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. |
| embryonic organ development | Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. |
| embryonic placenta morphogenesis | The process in which the embryonic placenta is generated and organized. |
| endodermal cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. |
| forebrain development | The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). |
| mesoderm morphogenesis | The process in which the anatomical structures of the mesoderm are generated and organized. |
| microtubule cytoskeleton organization involved in mitosis | Any microtubule cytoskeleton organization that is involved in mitosis. |
| mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. |
| morphogenesis of a branching structure | The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. |
| neural tube closure | The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. |
| nucleosome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes. |
| peptidyl-lysine trimethylation | The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. |
| pericardium development | The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. |
| positive regulation of autophagy | Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| positive regulation of interferon-alpha production | Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. |
| positive regulation of ossification | Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. |
| regulation of cytokinesis | Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of double-strand break repair via homologous recombination | Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| regulation of mRNA export from nucleus | Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm. |
| regulation of protein localization to chromatin | Any process that modulates the frequency, rate or extent of protein localization to chromatin. |
| response to alkaloid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. |
| response to metal ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. |
| response to organic cyclic compound | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. |
| response to type I interferon | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. |
| stem cell development | The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. |
| stem cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. |
| transcription elongation by RNA polymerase II | The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. |
| vasculogenesis | The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BYW2 | SETD2 | Histone-lysine N-methyltransferase SETD2 | Homo sapiens (Human) | EV |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKPLPSQQPP | PKMGDFYDPE | HPTPEEEENE | AKIENVQKTG | FIKGPVFKGV | ASSRFLPKGT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KTKVNLEEQG | RQKVSFSFSF | TKKTLQNRFL | TALSNEKQSD | SPNSPAPPLQ | VDSNPKVKMD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AGDTFPATEE | SSPPKSRVEL | GRIHFKKHLL | HVTSRPQLAA | STTAASPLPP | TTQLPAVLAE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SMIDSPPSSP | PPPPPPPQAS | SPSPPAQISE | PVALPQPPAT | ALMTSPPGPL | PGDVAVRAQK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ESPVKSGPEV | LEVDTKQDIV | SNSLEEHTVQ | TLKEQADHLL | QKEDSHIGKE | EEVSDGSKIS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSSKKASSKK | KSSQFEGTFL | GSESDEDSVR | TSSSQRSHDL | KSSTSIDKER | DFKKSSAPSK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SEDLGKSSRS | KTERDDRYCS | YSKLERDTRY | VSSRCRSERD | RRRSRSRSRS | DRASRTSLSY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SRSERSHYYD | SERRYHRSSP | YRERTRYSRP | YTDNRARESS | DSEDEYKKTY | PRRTSAHSYR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DLRTSSSYSK | FDRDCKTETS | YLEMERRGKY | TSKLERESKR | TSEHETIKRC | CSPPNELGFR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RGSSYSKHDN | STSRYKSALS | KSISKNDKFK | NSFCCTELNE | ENKQSHSFSL | QTPCSKGSEL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RTINKISERE | KTGSPTPSNQ | LNDSPTFKKL | DESPVLKPEF | IGHDGRESIK | ELELSKVKND |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QLRNFCSIEL | NVNGSPETEA | DVATFCTSKT | DAISMTSDDS | VTGSEVSPLI | KACMLSSNGF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QNVGRCRERD | SDDTCRQHNT | SKSPFREMEP | LLSPHHDKLM | SLPVKTIDYP | KTLIKEPVDK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RHSCCKTKDS | DIYCSPNENP | EAENAEPSAM | TISSHSFVNV | HLESKTVICD | NREPTDRHSE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| NTCDEYKQSI | GSTSSASHNH | FDGLYEPIGS | SGISSLQSPP | SGIRCEENTS | PTLDAVESKK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GIDFLKYARK | ETDVGSALPD | SGKGFSWENR | HNNVLSGQSL | QEAQEEGNSI | LHERRGRPEI |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| PLDEEQRGHT | HISDDSEVVF | PYDLNLTMED | SDGITYTLKC | DSSGNAPEIV | STVHEDYSGS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SASSSDESDS | EDTESDDSSI | PRNRLQSVVV | VPKNSTLPME | ETSPCSSRSS | QSYKHYSDRW |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| EDGLETRRHA | YEEEYESKGC | SQTEKYFLHK | GTERSAESCY | SQFGRKADNH | LPDIAHAQSD |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| GVDSTSQTDS | RSDHLGHLNP | EDTLRAKTSR | PQELPVYSDD | FEDLPNKSRQ | QMIFSNRPDS |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SRLGKTELSF | SSSCDISRMD | GLHSSEELRN | LGWDFSQQER | PTTTYQQPDS | SYGTCGTHKY |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| QQSTEHYGGT | HNYWQGNGYW | DPRSAGRPPG | TGLAYDRIQG | QVPDSLTDDR | EEEEHWDQRS |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| GSHFSSPSNK | FFFHQKDKGS | VQAPEISSNS | IKDALVMNER | KDFSKNFEKN | DIKERGPPKK |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| RRQELESDSE | SDGELQARKK | VRVEMEQGES | SVPQHSELMG | PSCAMDDFRD | PQRWKEFAKL |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| GKMPCYFDLI | EENVYLTERK | KNKSHRDIKR | MQCECTPLSK | DERAQGEVAC | GEDCLNRLLM |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| IECSSRCPNG | DYCSNRRFQR | KQHADVEVIL | TEKKGWGLRA | AKDLPSNTFV | LEYCGEVLDH |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| KEFKARVKEY | ARNKNIHYYF | MALKNDEIID | ATQKGNCSRF | MNHSCEPNCE | TQKWTVNGQL |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| RVGFFTTKLV | PSGSELTFDY | QFQRYGKEAQ | KCFCGSANCR | GYLGGENRVS | IRAAGGKMKK |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| ERSRKKDSVD | GELEALMENG | EGLSDKNQVL | SLSRLMVRIE | TLEQKLTCLK | LIQNTHSQSC |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| LKSFLERHGL | SLLWIWMAEL | GDGRESNQKL | QEEIIKTLEH | LPIPTKNMLE | ESKVLPIIQR |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| WSQTKTAVPQ | LSEGDGYSSE | NTSRAHTPLN | TPDPSAKPST | EMDTDTPKKL | IFRRLKIISE |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| NSMDSAVSDV | TSELECKDGK | EDLDQLETVT | VEEDEELQSQ | QLLPQQLCES | KVESEATIEV |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| SKLPTSEPEA | DTETEPKDSN | GTKLEETIAE | ETPSQDEEEG | VSDVESERSQ | EPPDKTVDIS |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| DLATKLLDSW | KDLKEVYRIP | KKSQTEKEST | VAERGRDAAA | FRDQTAPKTP | NRSRERDPDK |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| QSQNKEKRKR | RGSLSPPSSA | YERGTKRPDD | RYDTPTSKKK | VRIKDRNKLS | TEERRKLFEQ |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| EVAQREAQKQ | QQQMQNLGMT | SPLPFDSLGY | NASHHPFAGY | PPGYPMQAYV | DPSNPNAGKV |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| LLPTPSMDPV | CSPAPYDHAQ | PLVGHSTESL | AAPPSVPVVP | HVAASVEVSS | SQYVAQNESV |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| VHQDSNVPVM | PVQAPGPVQG | QNYNVWESNQ | QSVSVQQQYS | PAQSQTTIYY | QGQTCSTVYS |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| VTSPYSQTTP | PIVQSYAQPS | LQYIQGQQIF | TAHPQGVVVQ | PTAAVTSIVA | PGQPQSLQPP |
| 2350 | 2360 | 2370 | 2380 | 2390 | 2400 |
| EMVVTNNLLD | LPPPSPPKPK | TIVLPPNWKT | ARDPEGKIYY | YHVITRQTQW | DPPTWESPGD |
| 2410 | 2420 | 2430 | 2440 | 2450 | 2460 |
| DASLEHEAEM | DLGTPTYDEN | PMKTSKKPKT | AEADTSSELA | KKSKEVFRKE | MSQFIVQCLN |
| 2470 | 2480 | 2490 | 2500 | 2510 | 2520 |
| PYRKPDCKVG | RITTTEDFKH | LARKLTHGVM | NKELKYCKNP | EDLECNENVK | HKTKEYIKKY |
| 2530 | |||||
| MQKFGAVYKP | KEDTELE |