E9PTG8

PR
Gene name
Stk10
Protein name
Serine/threonine-protein kinase 10
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

174-197 (Activation loop from InterPro)

Target domain

23-314 (Catalytic domain of the Serine/Threonine Kinase, STK10, also called Lymphocyte-Oriented Kinase or LOK)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for E9PTG8

Entry ID Method Resolution Chain Position Source
AF-E9PTG8-F1 Predicted AlphaFoldDB

No variants for E9PTG8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for E9PTG8

No associated diseases with E9PTG8

4 regional properties for E9PTG8

Type Name Position InterPro Accession
domain Protein kinase domain 36 - 294 IPR000719
active_site Serine/threonine-protein kinase, active site 153 - 165 IPR008271
binding_site Protein kinase, ATP binding site 42 - 65 IPR017441
domain Serine/threonine-protein kinase 10, catalytic domain 23 - 314 IPR042743

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding Binding to an identical protein or proteins.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

5 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
lymphocyte aggregation The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of lymphocyte migration Any process that modulates the frequency, rate or extent of lymphocyte migration.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
E1BK52 STK10 Serine/threonine-protein kinase 10 Bos taurus (Bovine) PR
Q9H2G2 SLK STE20-like serine/threonine-protein kinase Homo sapiens (Human) PR
O94804 STK10 Serine/threonine-protein kinase 10 Homo sapiens (Human) PR
O54988 Slk STE20-like serine/threonine-protein kinase Mus musculus (Mouse) PR
O55098 Stk10 Serine/threonine-protein kinase 10 Mus musculus (Mouse) PR
O88506 Stk39 STE20/SPS1-related proline-alanine-rich protein kinase Rattus norvegicus (Rat) PR
Q924I2 Map4k3 Mitogen-activated protein kinase kinase kinase kinase 3 Rattus norvegicus (Rat) PR
B0LT89 Stk24 Serine/threonine-protein kinase 24 Rattus norvegicus (Rat) PR
Q8LST2 WNK7 Probable serine/threonine-protein kinase WNK7 Arabidopsis thaliana (Mouse-ear cress) PR
Q944Q0 WNK8 Serine/threonine-protein kinase WNK8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVL5 WNK4 Probable serine/threonine-protein kinase WNK4 Arabidopsis thaliana (Mouse-ear cress) PR
Q0IHQ8 stk10 Serine/threonine-protein kinase 10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MAFANFRRIL RLSTFEKRKS REYEHVRRDL DPNDVWEILG ELGDGAFGKV YKAKNKETGA
70 80 90 100 110 120
LAAAKVIETK SEEELEDYIV EIEILATCDH PYIVKLLGAY YYDGKLWIMI EFCPGGAVDA
130 140 150 160 170 180
IMLELDRGLT EPQIQVVCRQ MLEALNFLHG KRIIHRDLKA GNVLMTLEGD IRLADFGVSA
190 200 210 220 230 240
KNLKTLQKRD SFIGTPYWMA PEVVLCETMK DAPYDYKADI WSLGITLIEM AQIEPPHHEL
250 260 270 280 290 300
NPMRVLLKIA KSDPPTLLTP SKWSTEFRDF LKIALDKNPE TRPSAAQLLQ HPFVSTVTSN
310 320 330 340 350 360
KALRELVAEA KAEVMEEIED GKEDGSEKDA VSAVPPPVNH TQDSSANGTQ PSLNSDKLLQ
370 380 390 400 410 420
DSSTPLPPSQ PQEPVNGPCN QPSGDGSPQN TSPADEVSKN DNGLKVPVPL RKSRPLSVDA
430 440 450 460 470 480
RIQVTEEKQI TDQAENPSSA ASKPPKVNQS RPNSSALETL GVETLANGGL ELPGSVTPNH
490 500 510 520 530 540
SKRASDCSNL STSESMDYGT SLSADLSLNK ETGSLSLKGS KLHNKTLKRT RRFVVDGVEV
550 560 570 580 590 600
SITTSKIISE DEKKDEEMRF LRRQELRELR LLQKEEHRNQ TQLSTKHELQ LEQMHRRFEQ
610 620 630 640 650 660
EINAKKKFYD VELENLERQQ KQQVEKMEQD HSVRRREEAK RIRLEQDRDY ARFQEQLKQM
670 680 690 700 710 720
KKEVKRSIEK ALRKQRQESM RMGQDSHTQK KQRLDRDFVA KQKEDLELAM KKLTAENRRE
730 740 750 760 770 780
ICDKERDCLN KKQELLRDRE AALWEMEEHQ LQERHQLVKQ QLKDQYFLQR HDLLRKHEKE
790 800 810 820 830 840
REQMQRYNQR MMEQLKVRQQ QEKARLPKIQ RSDGKTRMAM YKKSLHINGA GSASEQREKV
850 860 870 880 890 900
KQFSQQEEKR QKAERLQQQQ KHENQMRDMV AQCESNMNEL QQLQNEKCHL LVEHETQKLK
910 920 930 940 950 960
ALDESHNQSL KEWRDKLRPR KKALEEDLNQ KKREQEMFFR LSEEAETRPT TPNRASKFFP
YSSGDAS