E1C4B0

SS
Gene name
MDM4
Protein name
Double minute 4 protein
Names
Mdm2-like p53-binding protein, Protein Mdm4, p53-binding protein Mdm4
Species
Gallus gallus (Chicken)
KEGG Pathway
EC number
Protein Class

Descriptions

MDM4 is a homologous protein that binds to p53 and regulates its activity. Residues 190-210 in that intrinsically disordered region constitute an inhibitory module. It competes with the p53TAD for binding to the NTD of MDM4, thus lowering the affinity of MDMX for p53. Efficient binding of MDM4 to p53 requires a mechanism to relieve the allosteric self-inhibition.

Autoinhibitory domains (AIDs)

275-295 (Tryptohpan-rich segment) SS

Target domain

25-108 (SWIB/MDM2 domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for E1C4B0

Entry ID Method Resolution Chain Position Source
No available structures

12 variants for E1C4B0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs735998286 2 M>T No Ensembl
rs737743020 15 P>L No Ensembl
rs313312373 146 L>R No Ensembl
rs737549927 152 V>G No Ensembl
rs740481684 235 M>V No Ensembl
rs314819986 255 E>G No Ensembl
rs316939361 335 N>S No Ensembl
rs736389738 345 C>W No Ensembl
rs316856937 360 C>R No Ensembl
rs15228767 428 T>A No Ensembl
rs732348167 455 K>E No Ensembl
rs314795248 493 H>R No Ensembl

No associated diseases with E1C4B0

No regional properties for E1C4B0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for E1C4B0

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription repressor complex A protein complex that possesses activity that prevents or downregulates transcription.

3 GO annotations of molecular function

Name Definition
enzyme binding Binding to an enzyme, a protein with catalytic activity.
metal ion binding Binding to a metal ion.
p53 binding Binding to one of the p53 family of proteins.

9 GO annotations of biological process

Name Definition
cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
DNA damage response, signal transduction by p53 class mediator A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
protein-containing complex assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2HJ21 MDM4 Protein Mdm4 Bos taurus (Bovine) SS
O15151 MDM4 Protein Mdm4 Homo sapiens (Human) EV
O35618 Mdm4 Protein Mdm4 Mus musculus (Mouse) SS
Q5XIN1 Mdm4 Protein Mdm4 Rattus norvegicus (Rat) SS
Q7ZUW7 mdm4 Protein Mdm4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MMRPRRAGRR TEAAPQPCWL RGEVAAEAPR RWRSAARGGC RGVSPQPGPP GPHGAAVGLH
70 80 90 100 110 120
LVIWGEACSS FSRFSPLEKA GLFHKQLITA TMTSSSSAQH PAAENACRIT LGQANQVRPK
130 140 150 160 170 180
LPLLKILQAA GAQGETFTLK EVMHYLGQYI MVRQLYDKRQ QHMVYCGGDQ LGELLGLESF
190 200 210 220 230 240
SVKDPSPVYE MLKRNLTSAA MTDAAQNLAK EQSVDKPSQD QLKFSPKEGS DTVIMGDESN
250 260 270 280 290 300
ASAVSTSEHK CENYEDKDLI ENLSKSKKPK LDLVFEEWDV AGLPWWFLGN LRSNYKSRSN
310 320 330 340 350 360
GSTDIQTNQD IDTAIVSDTT DDLWFLNESP LDQTNTAVKM ETADCEEVKE GDKKVTEDAC
370 380 390 400 410 420
LHDFEDSQCL SDDTDTEAAS EDCWQCTKCK KFNSPGKRYC YRCWALRKDW YSDCPKLTHS
430 440 450 460 470 480
LSLSNIDTMQ NENSDEGIDV PDCRRTISAP VGPPKDMYVV ENKSHVDPCG SIESLDLARE
490 500 510 520 530 540
CERRDSLLSF TEHKKEEEIQ SLESIKKLLN PCFLCHHRPR DGNIVHGRTA HLVACFKCAK
550 560
MLKKRRSPCP VCRKDIEMVI RIFMG