E1BK52

PR
Gene name
STK10
Protein name
Serine/threonine-protein kinase 10
Names
Species
Bos taurus (Bovine)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

174-197 (Activation loop from InterPro)

Target domain

23-314 (Catalytic domain of the Serine/Threonine Kinase, STK10, also called Lymphocyte-Oriented Kinase or LOK)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for E1BK52

Entry ID Method Resolution Chain Position Source
AF-E1BK52-F1 Predicted AlphaFoldDB

No variants for E1BK52

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for E1BK52

No associated diseases with E1BK52

3 regional properties for E1BK52

Type Name Position InterPro Accession
domain Interferon regulatory factor, DNA-binding domain 3 - 115 IPR001346
domain Interferon regulatory factor-3 204 - 384 IPR019471
conserved_site Interferon regulatory factor, conserved site 28 - 61 IPR019817

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
regulation of lymphocyte migration Any process that modulates the frequency, rate or extent of lymphocyte migration.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H2G2 SLK STE20-like serine/threonine-protein kinase Homo sapiens (Human) PR
O94804 STK10 Serine/threonine-protein kinase 10 Homo sapiens (Human) PR
O54988 Slk STE20-like serine/threonine-protein kinase Mus musculus (Mouse) PR
O55098 Stk10 Serine/threonine-protein kinase 10 Mus musculus (Mouse) PR
E9PTG8 Stk10 Serine/threonine-protein kinase 10 Rattus norvegicus (Rat) PR
Q0IHQ8 stk10 Serine/threonine-protein kinase 10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MAFANFRRIL RLSTFEKRKS REYEHVRRDL DPNEVWEIVG ELGDGAFGKV YKAKNKETGA
70 80 90 100 110 120
LAAAKVIETN SEEELEDYIV EIEILATCDH PYIVKLLGAY YYDGKLWIMI EFCPGGAVDA
130 140 150 160 170 180
IMLELDRGLT EPQIQVVCRQ MLEALTFLHG KKIIHRDLKA GNVLMTLEGD IRLADFGVSA
190 200 210 220 230 240
KNLKTLQKRD SFIGTPYWMA PEVVMCETMK DTPYDYKADI WSLGITLIEM AQIEPPHHEL
250 260 270 280 290 300
NPMRVLLKIA KSDPPTLLSP SKWSAEFRDF LKTALDKNPE TRPSAAQLLE HPFVSSVTSN
310 320 330 340 350 360
KALRELVAEA KAEVMEEIED GRDEGDEEDA VEAASPLENH TRDSSEVSQL SIDADKLLKE
370 380 390 400 410 420
SPFTPPPPSQ PQDGANGPSE PPGHGALPAT SPLDVAPGNE NGQAVPVPLR KFRPVSMGAR
430 440 450 460 470 480
IQVSEEKQAA DQGGDLSPAA SRSQKASQSR PNSSALETLR SELTNGSLEL PTPGAQSLSK
490 500 510 520 530 540
RDSDCGSVST SGSTDFGTSL SADMSVNKES GSLSIKDSRL HNKTLKRTRK FVVDGVEVSI
550 560 570 580 590 600
TTSKIISEDE KKDEEMRFLR RQELRELRLL QKEEHRNQTQ LSSKHELQLE QMHKRFEQEI
610 620 630 640 650 660
NAKKKFFDIE LENLERQQKQ QVEKMEQDHA VRRREEAKRI RLEQERDYAK FQEQLKLMKK
670 680 690 700 710 720
EVKNEVEKLP RQQRKESMKQ KMEEHTQKKQ LLDRDFLAKQ KEDLELAMKR ITADNRREIC
730 740 750 760 770 780
DKERECLTRK QELLRDREAA LWEMEEHHLQ ERHQLVKQQL KDQYFLQRHE LLRKHEKERE
790 800 810 820 830 840
QMQRYNQRMI EQLKVRQQQE KARLPKIQRS EGKTRMAMYK KSLHINGGGS AAEQREKIKQ
850 860 870 880 890 900
FSQQEEKRQK AERLQQQQKH ENQMRDMLAQ CESNMSELQQ LQNEKCHLLI EHETQKLKAL
910 920 930 940 950 960
DESHNQNLKE WRDKLRPRKK ALEEDLNQKK REQEMFFKMN EESECANPTS PNKVTKFFPY
SSADAA