D3ZPX4

SS
Gene name
Plxna3
Protein name
Plexin-A3
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:309280
EC number
Protein Class

Descriptions

Plexin cell surface receptors bind to semaphorin ligands and transduce signals for regulating neuronal axon guidance. The autoinhibitory regions including an Rho GTPase-binding domain (RBD) and a segment preceding C1 domain make extensive interactions with the GAP domain (C1 and C2 domains), which may enable it to regulate the GAP conformation in response to semaphorin binding. According to human Plexin-A1 (Q9UIW2) study, the Sema domain in Plexin-A3 may be also involved in autoinhibition.

Autoinhibitory domains (AIDs)

36-470 (Sema domain) SS

Target domain

1294-1842 (Plexin, RasGAP domain)

Relief mechanism

Partner binding

Assay

1244-1324 (Segment preceding C1 domain) SS

Target domain

1294-1842 (Plexin, RasGAP domain)

Relief mechanism

Assay

1450-1650 (RBD domain) SS

Target domain

1294-1842 (Plexin, RasGAP domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for D3ZPX4

Entry ID Method Resolution Chain Position Source
AF-D3ZPX4-F1 Predicted AlphaFoldDB

No variants for D3ZPX4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for D3ZPX4

No associated diseases with D3ZPX4

12 regional properties for D3ZPX4

Type Name Position InterPro Accession
domain Sema domain 6 - 489 IPR001627
repeat Plexin repeat 491 - 531 IPR002165-1
repeat Plexin repeat 638 - 678 IPR002165-2
domain IPT domain 840 - 934 IPR002909-1
domain IPT domain 935 - 1021 IPR002909-2
domain IPT domain 1023 - 1123 IPR002909-3
domain IPT domain 1125 - 1220 IPR002909-4
domain PSI domain 491 - 541 IPR016201-1
domain PSI domain 638 - 685 IPR016201-2
domain PSI domain 786 - 839 IPR016201-3
domain Plexin, TIG domain 2 692 - 785 IPR041362
domain Plexin, cytoplasmic RhoGTPase-binding domain 1464 - 1576 IPR046800

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
semaphorin receptor complex A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

1 GO annotations of molecular function

Name Definition
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

17 GO annotations of biological process

Name Definition
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
branchiomotor neuron axon guidance The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
facial nerve structural organization The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
hippocampus development The progression of the hippocampus over time from its initial formation until its mature state.
negative chemotaxis The directed movement of a motile cell or organism towards a lower concentration of a chemical.
negative regulation of axon extension involved in axon guidance Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance.
negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
neuron projection extension Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuron projection guidance The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
positive regulation of cytoskeleton organization Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
pyramidal neuron development The progression of a pyramidal neuron from its initial formation to its mature state.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
semaphorin-plexin signaling pathway involved in axon guidance Any semaphorin-plexin signaling pathway that is involved in axon guidance.
trigeminal nerve structural organization The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
A0M8S8 MET Hepatocyte growth factor receptor Felis catus (Cat) (Felis silvestris catus) PR
Q04912 MST1R Macrophage-stimulating protein receptor Homo sapiens (Human) EV
P08581 MET Hepatocyte growth factor receptor Homo sapiens (Human) EV
O43157 PLXNB1 Plexin-B1 Homo sapiens (Human) EV SS
Q9HCM2 PLXNA4 Plexin-A4 Homo sapiens (Human) SS
O75051 PLXNA2 Plexin-A2 Homo sapiens (Human) SS
Q9UIW2 PLXNA1 Plexin-A1 Homo sapiens (Human) EV SS
O15031 PLXNB2 Plexin-B2 Homo sapiens (Human) SS
Q9ULL4 PLXNB3 Plexin-B3 Homo sapiens (Human) SS
P51805 PLXNA3 Plexin-A3 Homo sapiens (Human) SS
Q9QY40 Plxnb3 Plexin-B3 Mus musculus (Mouse) SS
Q3UH93 Plxnd1 Plexin-D1 Mus musculus (Mouse) SS
P70207 Plxna2 Plexin-A2 Mus musculus (Mouse) SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
B2RXS4 Plxnb2 Plexin-B2 Mus musculus (Mouse) SS
Q8CJH3 Plxnb1 Plexin-B1 Mus musculus (Mouse) SS
Q9QZC2 Plxnc1 Plexin-C1 Mus musculus (Mouse) SS
Q80UG2 Plxna4 Plexin-A4 Mus musculus (Mouse) SS
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
P70206 Plxna1 Plexin-A1 Mus musculus (Mouse) EV SS
P70208 Plxna3 Plexin-A3 Mus musculus (Mouse) EV SS
Q2QLE0 MET Hepatocyte growth factor receptor Sus scrofa (Pig) PR
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
D3ZLH5 Plxnb3 Plexin-B3 Rattus norvegicus (Rat) SS
Q6BEA0 plxna4 Plexin-A4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
B0S5N4 plxna3 Plexin A3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MHTVCLLPLL FFTIGGCLGS SRPFRTFVVT DTTLTHLAVH RVTGEVFVGA VNRVFKLASN
70 80 90 100 110 120
LTELRAHVTG PIEDNARCYP PPSMRVCSHR LVPVDNVNKL LLIDYAARRL VACGSIWQGI
130 140 150 160 170 180
CQFLRLDDLF KLGEPHHRKE HYLSGAQEPD SMAGVIVEQG QGPSKLFVGT AVDGKSEYFP
190 200 210 220 230 240
TLSSRKLIDD EDSGDMFSLV YQDEFVSSQI KIPSDTLSLY PAFDIYYIYG FVSASFVYFL
250 260 270 280 290 300
TLQLDTQQTL LDTAGEKFFT SKIVRMCAGD SEFYSYVEFP IGCSWRGVEY RLVQSAHLAK
310 320 330 340 350 360
PGLLLAQALG VPADEDVLFT IFSQGQKNRA NPPRQTILCL FTLSSINAHI RRRIQSCYRG
370 380 390 400 410 420
EGTLALPWLL NKELPCINTP MQINGNFCGL VLNQPLGGLH VIEGLPLLAD STDGMASVAA
430 440 450 460 470 480
YTYHQHSVVF IGTRSGNLKK VRVDGSQDAQ LYETVSVVQG TPILRDLLFS PDHRHIYLLS
490 500 510 520 530 540
EKQVSQLPVE TCEQYLSCAA CLGSGDPHCG WCVLQHRCCR EGACPGASAP HGFAEELNKC
550 560 570 580 590 600
IQVRVRPNNV SVTSSGVQLT VAMRNVPDLS LGVSCSFEEV TESEAILLPS GELRCPSPSL
610 620 630 640 650 660
QELQTLTRGH GATHTVRLQL LSMETGVRFA GVDFVFYNCS ALQSCMSCVG SPYPCHWCKY
670 680 690 700 710 720
RHVCTSHPHE CSFQEGRVHS PEGCPEILPR GDLLIPVGVM QPLTLRAKNL PQPQSGQKNY
730 740 750 760 770 780
ECVVRVQGRQ HRVPAVRFNS SSVQCQNASY FYEGDEFGDT ELDFSVVWDG DFPIDKPPSF
790 800 810 820 830 840
RALLYKCWAQ RPSCGLCLKA DPRFNCGWCI SEHRCQLRVH CPAPKSNWMH PSQKGARCSH
850 860 870 880 890 900
PRITQIHPLT GPKEGGTRVT IVGENLGLTS REVGLRVAGV RCNSIPTEYV SAERIVCEME
910 920 930 940 950 960
ESLVPSPPPG PAELCVGDCS ADFRTQSQQL YSFVTPTLDR VSPTRGPASG GTRLTISGTS
970 980 990 1000 1010 1020
LDAGSRVTVI IRDGECQFVR RDAEAIVCIS PISTLGPSQA PIILAIDHAN ISSTGVIYTY
1030 1040 1050 1060 1070 1080
TQDPTVTHLE PTWSIINGST SITVSGTHLL TVQEPRVRAK YRGIETTNTC QVINDTAMLC
1090 1100 1110 1120 1130 1140
KAPGIFLGHP QPRAQGEHPD EFGFLLDHVQ AARSLNRSSF TYYPDPSFEP LGPSGVLDVK
1150 1160 1170 1180 1190 1200
PGSHVVLKGK NLIPAAAGSS RLNYTVLIGG QPCALTVSDT QLLCDSPSQT GRQPVMVLVG
1210 1220 1230 1240 1250 1260
GLEFWLGTLH ITADRALTLP AMVGLAAGGG LLLLAITVVL VAYKRKTQDA DRTLKRLQLQ
1270 1280 1290 1300 1310 1320
MDNLESRVAL ECKEAFAELQ TDINELTNHM DGVQIPFLDY RTYAVRVLFP GIEAHPVLKE
1330 1340 1350 1360 1370 1380
LDTPPNVEKA LRLFGQLLHS RAFLLTFIHT LEAQSSFSMR DRGTVASLTM VALQSRLDYA
1390 1400 1410 1420 1430 1440
TGLLKQLLAD LIEKNLESKN HPKLLLRRTE SVAEKMLTNW FTFLLHKFLK ECAGEPLFLL
1450 1460 1470 1480 1490 1500
YCAIKQQMEK GPIDAITGEA RYSLSEDKLI RQQIDYKTLT LHCVCPESEG SAQVPVKVLN
1510 1520 1530 1540 1550 1560
CDSITQAKDK LLDTVYKGIP YSQRPKAEDM DLEWRQGRMA RIILQDEDIT TKIECDWKRI
1570 1580 1590 1600 1610 1620
NSLAHYQVTD GSLVALVPKQ VSAYNMANSF TFTRSLSRYE SLLRAASSPD SLRSRAPMLT
1630 1640 1650 1660 1670 1680
PDQEAGTKLW HLVKNHDHAD HREGDRGSKM VSEIYLTRLL ATKGTLQKFV DDLFETVFST
1690 1700 1710 1720 1730 1740
AHRGSALPLA IKYMFDFLDE QADQRQISDP DVRHTWKSNC LPLRFWVNVI KNPQFVFDIH
1750 1760 1770 1780 1790 1800
KNSITDACLS VVAQTFMDSC STSEHRLGKD SPSNKLLYAK DIPNYKSWVE RYYRDIAKMA
1810 1820 1830 1840 1850 1860
SISDQDMDAY LVEQSRLHAN DFNVLSALSE LYFYVTKYRQ EILTSLDRDA SCRKHKLRQK
1870
LEQIITLVSS SS