D3ZLH5

SS
Gene name
Plxnb3
Protein name
Plexin-B3
Names
Protein Plxnb3
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:363517
EC number
Protein Class

Descriptions

Plexins are a large family of cell surface receptors for the axon guidance molecules semaphorins. Semaphorin-plexin signaling is essential for the regulation of neuronal development and other processes. Dysfunction in plexin pathways has been implicated in various diseases including neurological disorders and cancer. <br> Plexins are transmembrane proteins with a multidomain extracellular region that contains an N-terminal Sema domain. Before semaphorin binding, Plexin is an inactive monomer or dimer in which the RapGAP activity is autoinhibited. Binding of semaphorin to the Sema domain of plexin leads to activation of its cytoplasmic region, which relays the signal to downstream pathways. Mouse Plexin-A3 (P70208) possesses a segment preceding C1 domain and RDB domain as autoinhibitory elements.

Autoinhibitory domains (AIDs)

18-461 (Sema domain) SS

Target domain

1317-1869 (Plexin, cytoplasmic RasGAP domain)

Relief mechanism

Partner binding

Assay

1491-1610 (RBD domain) SS

Target domain

1317-1869 (Plexin, cytoplasmic RasGAP domain)

Relief mechanism

Partner binding

Assay

1267-1347 (Segment preceding C1 domain) SS

Target domain

1317-1869 (Plexin, RasGAP domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for D3ZLH5

Entry ID Method Resolution Chain Position Source
AF-D3ZLH5-F1 Predicted AlphaFoldDB

No variants for D3ZLH5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for D3ZLH5

No associated diseases with D3ZLH5

7 regional properties for D3ZLH5

Type Name Position InterPro Accession
domain Zinc finger, TRAF-type 151 - 192 IPR001293-1
domain Zinc finger, TRAF-type 204 - 261 IPR001293-2
domain MATH/TRAF domain 350 - 499 IPR002083
conserved_site Zinc finger, RING-type, conserved site 85 - 94 IPR017907
domain TNF receptor-associated factor 6, C3HC3D-type RING zinc finger 67 - 124 IPR027139
domain TNF receptor-associated factor 6, MATH domain 351 - 500 IPR037309
domain TNF receptor-associated factor 6, zinc finger 2 157 - 183 IPR041310

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Colocalizes with RIT2/RIN at the plasma membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
semaphorin receptor complex A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

4 GO annotations of molecular function

Name Definition
cell-cell adhesion mediator activity The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell.
protein domain specific binding Binding to a specific domain of a protein.
Rho GDP-dissociation inhibitor binding Binding to a Rho GDP-dissociation inhibitor protein.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

13 GO annotations of biological process

Name Definition
cell chemotaxis The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
homophilic cell adhesion via plasma membrane adhesion molecules The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
negative regulation of cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of GTPase activity Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
negative regulation of lamellipodium assembly Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
positive chemotaxis The directed movement of a motile cell or organism towards a higher concentration of a chemical.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
positive regulation of endothelial cell proliferation Any process that activates or increases the rate or extent of endothelial cell proliferation.
positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
regulation of cell shape Any process that modulates the surface configuration of a cell.
semaphorin-plexin signaling pathway The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
semaphorin-plexin signaling pathway involved in axon guidance Any semaphorin-plexin signaling pathway that is involved in axon guidance.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
A0M8S8 MET Hepatocyte growth factor receptor Felis catus (Cat) (Felis silvestris catus) PR
Q04912 MST1R Macrophage-stimulating protein receptor Homo sapiens (Human) EV
P08581 MET Hepatocyte growth factor receptor Homo sapiens (Human) EV
O43157 PLXNB1 Plexin-B1 Homo sapiens (Human) EV SS
Q9HCM2 PLXNA4 Plexin-A4 Homo sapiens (Human) SS
O75051 PLXNA2 Plexin-A2 Homo sapiens (Human) SS
P51805 PLXNA3 Plexin-A3 Homo sapiens (Human) SS
Q9UIW2 PLXNA1 Plexin-A1 Homo sapiens (Human) EV SS
O15031 PLXNB2 Plexin-B2 Homo sapiens (Human) SS
Q9ULL4 PLXNB3 Plexin-B3 Homo sapiens (Human) SS
P70208 Plxna3 Plexin-A3 Mus musculus (Mouse) EV SS
Q3UH93 Plxnd1 Plexin-D1 Mus musculus (Mouse) SS
P70207 Plxna2 Plexin-A2 Mus musculus (Mouse) SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
B2RXS4 Plxnb2 Plexin-B2 Mus musculus (Mouse) SS
Q8CJH3 Plxnb1 Plexin-B1 Mus musculus (Mouse) SS
Q9QZC2 Plxnc1 Plexin-C1 Mus musculus (Mouse) SS
Q80UG2 Plxna4 Plexin-A4 Mus musculus (Mouse) SS
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
P70206 Plxna1 Plexin-A1 Mus musculus (Mouse) EV SS
Q9QY40 Plxnb3 Plexin-B3 Mus musculus (Mouse) SS
Q2QLE0 MET Hepatocyte growth factor receptor Sus scrofa (Pig) PR
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
D3ZPX4 Plxna3 Plexin-A3 Rattus norvegicus (Rat) SS
Q6BEA0 plxna4 Plexin-A4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
B0S5N4 plxna3 Plexin A3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MLTDFLQAPV MAPWSPFSLH LLLLFLLLLP LTRAHRFSVP NASFNHLVLA PDQGKLYVGA
70 80 90 100 110 120
VNHLFQLSPE LEMESVAITG PVIDSPDCVP FRDLAECPQA QLTDNANQLL LVSSRAQELV
130 140 150 160 170 180
ACGQVRQGVC EKRRLGDVTQ VLYQAEDPGD GQFVAANTLG VTTVGLVVPL PGRDLLLVAR
190 200 210 220 230 240
GLAGKLSAGV PPLTVRQLAG PQPFSSEGLG RLVVGDFSDY NNSYVGAFSD AHSAYFVFRR
250 260 270 280 290 300
RGARAQTEYR SYVARVCLGD VNLYSYVEVP LTCHGQGLIQ AAFLAPDTLL GAFSAGTSQA
310 320 330 340 350 360
QAALCAFPLA DLDGSMEQAR RLCYTTGGQG PNGMEEATVE YGVTSRCVTL PPDSPESYPC
370 380 390 400 410 420
GDEHTPSPIA GRQPLEAQPL LQLGQPISAV AALQTDGHTI AFLGDTEGQL HKVFLNSSHG
430 440 450 460 470 480
QVYHSQQVGP PGSAISPDLL VDNSGDYLYV LTAQQVDRIL VAACPQFPNC TTCLQARDPL
490 500 510 520 530 540
CGWCILQGRC TRRAECGRAV QPNQWLWSYE DNHCLHIQSL LPAQHPRQEH GQITLSVPGL
550 560 570 580 590 600
PNLAMDEYFY CAFGDYNSLA QVEEHHVVCA TPPQDRMPPN PPGSDHVTLP LALMFEDVVL
610 620 630 640 650 660
AATTFSFYDC SAIQALEVAA PCRTCVSSLW RCHWCPQSSH CVYGERCPEG EKAVYSAQEV
670 680 690 700 710 720
DILVRGPEAC PQVKGLASPQ LVPVGWESHV TLHIENLHYF RGLPALYYCW LELPGKLRKL
730 740 750 760 770 780
PAFLEETSRN SGLIHCQAQQ FHPSMSQWEL PVPIYVTRGE IQRLDNTGDL HVTLYDCAMG
790 800 810 820 830 840
HPDCSHCQAA NGSLSCLWCG DGQPACRYGP LCPPGAVEQL CPIPSIDVIE PLTGPPEGGL
850 860 870 880 890 900
AITILGSNLG QAFNDVRNAV TVAGQPCNPD PSLYRISARI VCVTSPAPNG TSGPVQVAIK
910 920 930 940 950 960
SRPPGISAQH FTYQDPVLLS LNPQWGPQAG GTQLTIHGQY LQTGGNVSAF VGDQPCPIQE
970 980 990 1000 1010 1020
PVCPEAIICH TMPQMEPGEA VVFVVFGHVE RKLLTTPFRY TANPQLVEAE PSVSFRGGGR
1030 1040 1050 1060 1070 1080
VIRVRGTGLD VVWQPLLSVW LEDEFQVKAL GVQAQDVNPR RSCGAPAADP QACIHLESGL
1090 1100 1110 1120 1130 1140
LQCSTLCSVN SSSLLLCHSP AVPDGALPKR VFFALDNMQV DFASASGGQG FLYQPNPRLA
1150 1160 1170 1180 1190 1200
PLSHEGITHP YRLKPGHVLD VEGEGLNLGI SKEEVQVHIG DGKCLVKTLT LTHLYCEPPQ
1210 1220 1230 1240 1250 1260
QAPQPTNGSG TLPQFVVQMG NVRLALGPVQ YEAEPMISTF PVEAQVGLGM GAAMLIAAVL
1270 1280 1290 1300 1310 1320
LLTLMYRHKS KQALRDYQKV LVQLENLETG VGDQCRKEFT DLMTEMTDLT SDLEASGIPF
1330 1340 1350 1360 1370 1380
LDYRTYAERA FFPGHVGCPL QPGLEGPGEE GRRVTVCQGL TQLSNLLNSK LFLLTLIHTL
1390 1400 1410 1420 1430 1440
EEQPSFSQRD RCHVASLLSL ALHSKLEYLT DIMRTLLGDL AAHYVHKNPK LMLRRTETMV
1450 1460 1470 1480 1490 1500
EKLLTNWLSI CLYAFLKEVA GEPLYMLFRA IKYQVDKGPV DAVTGKAKRT LNDSHLLRED
1510 1520 1530 1540 1550 1560
VEFRPLTLMA LVGPGAGGAA GNSEVHRVPA RVLDTDTITQ VKEKVLDQIY KGTPFSQRPS
1570 1580 1590 1600 1610 1620
VHSLDLEWRS GLAGHLTLSD EDLTSVTQNH WKRLNTLQHY KVPDGATVVL IPQLHNGGTV
1630 1640 1650 1660 1670 1680
SQSLEQTGCH SGENTPMLED GEEGGVRLWH LVKATEETEG AKVRRSSLRE RERERARAKA
1690 1700 1710 1720 1730 1740
IPEIYLTRLL SMKGTLQKFV DDTFQAILSM NRPVPIAVKY LFDFLDELAE KHGIEDPETL
1750 1760 1770 1780 1790 1800
HIWKTNSLLL RFWVNALKNP QLIFDVRVSD NEDAILAVIA QTFIDSCMVS EHKVGRDSPV
1810 1820 1830 1840 1850 1860
NKLLYAREIP RYKQMVEKYY ADIRQSSPAS YQEMNSALAE LSGNYTSAPN CLEALRELYN
1870 1880 1890 1900
HIHRYYDQII SALEEDPVAQ KMQLACRLQQ VAALVEYKVT DL