D3ZD32

PR
Gene name
Chd5
Protein name
Chromodomain-helicase-DNA-binding protein 5
Names
CHD-5, ATP-dependent helicase CHD5
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-155 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for D3ZD32

Entry ID Method Resolution Chain Position Source
AF-D3ZD32-F1 Predicted AlphaFoldDB

No variants for D3ZD32

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for D3ZD32

No associated diseases with D3ZD32

17 regional properties for D3ZD32

Type Name Position InterPro Accession
domain SNF2, N-terminal 717 - 996 IPR000330
domain Chromo/chromo shadow domain 464 - 552 IPR000953-1
domain Chromo/chromo shadow domain 588 - 644 IPR000953-2
domain Helicase, C-terminal 1024 - 1191 IPR001650
domain Zinc finger, PHD-type 343 - 386 IPR001965-1
domain Zinc finger, PHD-type 416 - 459 IPR001965-2
conserved_site DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site 840 - 849 IPR002464
domain CHD subfamily II, SANT-like domain 1370 - 1529 IPR009462
domain Domain of unknown function DUF1087 1293 - 1357 IPR009463
domain CHD, C-terminal 2 1727 - 1872 IPR012957
domain CHD, N-terminal 149 - 199 IPR012958
domain Helicase superfamily 1/2, ATP-binding domain 694 - 906 IPR014001
conserved_site Zinc finger, PHD-type, conserved site 344 - 385 IPR019786
domain Zinc finger, PHD-finger 341 - 388 IPR019787-1
domain Zinc finger, PHD-finger 414 - 461 IPR019787-2
domain Chromo domain 591 - 630 IPR023780
domain Chromodomain-helicase-DNA-binding protein 5, DEAH-box helicase domain 698 - 929 IPR028727

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
  • Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
heterochromatin A compact and highly condensed form of chromatin that is refractory to transcription.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
NuRD complex An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.

10 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent chromatin remodeler activity An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
H3K27me3 modified histone binding Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
histone deacetylase binding Binding to histone deacetylase.
metal ion binding Binding to a metal ion.

10 GO annotations of biological process

Name Definition
cerebral cortex neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.
chromatin remodeling A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
histone H3-K27 trimethylation The modification of histone H3 by addition of three methyl groups to lysine at position 27 of the histone.
histone H4 acetylation The modification of histone H4 by the addition of an acetyl group.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of signal transduction by p53 class mediator Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator.
regulation of cell differentiation Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O16102 Chd3 Chromodomain-helicase-DNA-binding protein 3 Drosophila melanogaster (Fruit fly) PR
Q14839 CHD4 Chromodomain-helicase-DNA-binding protein 4 Homo sapiens (Human) PR
Q12873 CHD3 Chromodomain-helicase-DNA-binding protein 3 Homo sapiens (Human) PR
Q8TDI0 CHD5 Chromodomain-helicase-DNA-binding protein 5 Homo sapiens (Human) PR
Q6PDQ2 Chd4 Chromodomain-helicase-DNA-binding protein 4 Mus musculus (Mouse) PR
A2A8L1 Chd5 Chromodomain-helicase-DNA-binding protein 5 Mus musculus (Mouse) PR
Q22516 chd-3 Chromodomain-helicase-DNA-binding protein 3 homolog Caenorhabditis elegans PR
10 20 30 40 50 60
MRGPLGTEEE LPRLFAEEME NEEEMSEEED GGLEGFEDFF PAEPVSLPKK KPKKLKESKS
70 80 90 100 110 120
KGKRKKKEGS NDELSENEED LEEKSESEGS DYSPTKKKKK KLKEKKEKKA KRKKRDEDEE
130 140 150 160 170 180
DNEDGGLKEP KSSGQLMAEW GLDDVDYLFS EDDYHTLTNY KAFSQFLRPL IAKKNPKIPM
190 200 210 220 230 240
SKMMTVLGAK WREFSANNPF KGSSAAAAAA AVAAAVETVT IAPPLAISPQ QVPQPLPVRK
250 260 270 280 290 300
AKTKEGKGPG VRKKNKGAKD SKKKGRGKRV AGLKFRFGGI SKRKKGSSSE EDEPEDSDLD
310 320 330 340 350 360
NASIHSSSVR SECSAALGKK NKRRRKKKRI DDGDGYETDH QDYCEVCQQG GEIILCDTCP
370 380 390 400 410 420
RAYHLVCLDP ELEKAPEGKW SCPHCEKEGI QWEPKDDDEE EEEGGCEEEE DDHMEFCRVC
430 440 450 460 470 480
KDGGELLCCD ACPSSYHLHC LNPPLPEIPN GEWLCPRCTC PPLKGKVQRI LHWRWTEPPA
490 500 510 520 530 540
PFMVGLPGPE VEPGMPPPRP LEGIPEREFF VKWAGLSYWH CSWVKELQLE LYHTVMYRNY
550 560 570 580 590 600
QRKNDMDEPP PFDYGSGDED GKSEKRKNKD PLYAKMEERF YRYGIKPEWM MVHRILNHSF
610 620 630 640 650 660
DKKGDVHYLI KWKDLPYDQC TWEIDEIDIP YYDNLKQTYW GHRELMLGED ARLPKRLVKK
670 680 690 700 710 720
GKKLKDDKQE KPPDTPIVDP TVKFDKQPWY IDSTGGTLHP YQLEGLNWLR FSWAQGTDTI
730 740 750 760 770 780
LADEMGLGKT VQTIVFLYSL YKEGHSKGPY LVSAPLSTII NWEREFEMWA PDFYVVTYTG
790 800 810 820 830 840
DKESRSVIRE NEFSFEDNAI RGGKKVFRMK KEVQIKFHVL LTSYELITID QAILGSIEWA
850 860 870 880 890 900
CLVVDEAHRL KNNQSKFFRV LNSYKIDYKL LLTGTPLQNN LEELFHLLNF LTPERFNNLE
910 920 930 940 950 960
GFLEEFADIS KEDQIKKLHD LLGPHMLRRL KADVFKNMPA KTELIVRVEL SQMQKKYYKF
970 980 990 1000 1010 1020
ILTRNFEALN SKGGGNQVSL LNIMMDLKKC CNHPYLFPVA AVEAPMLPNG SYDGSSLVKS
1030 1040 1050 1060 1070 1080
SGKLMLLQKM LKKLRDEGHR VLIFSQMTKM LDLLEDFLEY EGYKYERIDG GITGGLRQEA
1090 1100 1110 1120 1130 1140
IDRFNAPGAQ QFCFLLSTRA GGLGINLATA DTVIIYDSDW NPHNDIQAFS RAHRIGQNKK
1150 1160 1170 1180 1190 1200
VMIYRFVTRA SVEERITQVA KRKMMLTHLV VRPGLGSKSG SMTKQELDDI LKFGTEELFK
1210 1220 1230 1240 1250 1260
DDVEGMMSQG QRPTTPIPDV QSTKGGSLAA GAKKKHGGTP PGDNKDVEDS SVIHYDDAAI
1270 1280 1290 1300 1310 1320
SKLLDRNQDA TDDTELQNMN EYLSSFKVAQ YVVREEDGVE EVEREVIKQE ENVDPDYWEK
1330 1340 1350 1360 1370 1380
LLRHHYEQQQ EDLARNLGKG KRIRKQVNYN DASQEDQEWQ DELSDNQSEY SIGSEDEDED
1390 1400 1410 1420 1430 1440
FEERPEGQSG RRQSRRQLKS DRDKPLPPLL ARVGGNIEVL GFNARQRKAF LNAIMRWGMP
1450 1460 1470 1480 1490 1500
PQDAFNSHWL VRDLRGKSEK EFRAYVSLFM RHLCEPGADG AETFADGVPR EGLSRQHVLT
1510 1520 1530 1540 1550 1560
RIGVMSLVRK KVQEFEHVNG KYSTPDLVPE GPEGKKPGEV ISSDPNTPVP ASPAQLPPAP
1570 1580 1590 1600 1610 1620
LGLPDKMEAQ LGYTDEKESG TQKPKKSLEI QALPTALDRV EAEDKHQSSD SKDRAREERM
1630 1640 1650 1660 1670 1680
EEVEKAQGSP EQPLKEETLP DKEPVPDKLE LSLSHSNDFR PDDPKAEEKE PTETQQNGDR
1690 1700 1710 1720 1730 1740
EEDEEGKKED KNGKFKFMFN IADGGFTELH TLWQNEERAA VSSGKIYEIW HRRHDYWLLA
1750 1760 1770 1780 1790 1800
GIVTHGYARW QDIQNDPRYM ILNEPFKSEV HKGNYLEMKN KFLARRFKLL EQALVIEEQL
1810 1820 1830 1840 1850 1860
RRAAYLNMTQ DPNHPAMALN ARLAEVECLA ESHQHLSKES LAGNKPANAV LHKVLNQLEE
1870 1880 1890 1900 1910 1920
LLSDMKADVT RLPSMLSRIP PVAARLQMSE RSILSRLTNR AGDPTIQQGA FGSSQMYNNS
1930 1940
FGPNFRGPGP GGIVNYNQMP LGPYVTGR