C8ZE58

EV
Gene name
EC1118_1L7_3389g
Protein name
Leu3p
Names
Species
Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's yeast)
KEGG Pathway
EC number
Protein Class
FINGER DOMAIN PROTEIN, PUTATIVE-RELATED (PTHR31845)

Descriptions

Leu3p belongs to a family of proteins characterized by an N-terminal DNA binding domain of the Zn(II)2Cys6 binuclear cluster type. The mutations within the autoinhibitory region (604-741) are found to make Leu3p constitutively active.

Autoinhibitory domains (AIDs)

604-741 (Autoinhibitory region) EV

Target domain

855-886 (Transactivation domain)

Relief mechanism

Ligand binding

Assay

Deletion assay, Mutagenesis experiment

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C8ZE58

Entry ID Method Resolution Chain Position Source
AF-C8ZE58-F1 Predicted AlphaFoldDB

No variants for C8ZE58

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C8ZE58

No associated diseases with C8ZE58

7 regional properties for C8ZE58

Type Name Position InterPro Accession
domain CDC48, N-terminal subdomain 5 - 86 IPR003338
domain AAA+ ATPase domain 252 - 399 IPR003593-1
domain AAA+ ATPase domain 535 - 671 IPR003593-2
domain ATPase, AAA-type, core 256 - 396 IPR003959-1
domain ATPase, AAA-type, core 539 - 668 IPR003959-2
conserved_site ATPase, AAA-type, conserved site 367 - 385 IPR003960
domain CDC48, domain 2 111 - 183 IPR004201

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family PTHR31845 FINGER DOMAIN PROTEIN, PUTATIVE-RELATED
PANTHER Subfamily PTHR31845:SF21 REGULATORY PROTEIN LEU3
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
zinc ion binding Binding to a zinc ion (Zn).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEGRSDSVAT SQSGSEMSHS ETRNRTGMNA RKRKFACVEC RQQKSKCDAH ERAPEPCTKC
70 80 90 100 110 120
AKKNVPCILK RDFRRTYKRA RNEAIEKRFK ELTRTLTNLT SDEILKKIEE EQEIVLDNSN
130 140 150 160 170 180
FTKEKVKQLR KSAFETTEIE PRSYKTLRGE PISYSTNRKH TDSSPLTLLS SSTNFDPVHS
190 200 210 220 230 240
TNVMTDDQLK CLPKSLGDVY LSSSDIAELF QEFATKYHQF LPVVDLSKGA ERIYHLSPCL
250 260 270 280 290 300
FWVILLIGLR RKFWATDLMT RLSVLVKSVL SEITISPIIR YTPSDKDEPV LNVASVYSVQ
310 320 330 340 350 360
AFLLYTFWPP LTSSLSADTS WNTIGTAMFQ ALRVGLNCAG FSKEYASANS ELVNEQIRTW
370 380 390 400 410 420
ICCNVVSQTV ASSFGFPAYV SFDYLVISSI RVPNSKSQVD IPNELRQMAQ IARFENQIVN
430 440 450 460 470 480
TMNSTPASVT GMVSQEEKQP LLHVLNQQLS QLEISLEENN LDDIRKFLLL VAKVHLLTYY
490 500 510 520 530 540
FTDVTSQSAG KSNGNIYEGS YSIMELDTSF ETKRGLVKVY NAAVNFLIHA NSMWEHDPTI
550 560 570 580 590 600
IKYFPGLFVL NIWQSACIIS KLIHSSLHSM LDVNSGKKAY NNAISLTFNA SVLKYDMAYR
610 620 630 640 650 660
SSGIMRSIWS LFANMYDAWK NDQKEGGGRL NNDFNLGITI KSRMSVNVFF DCLYILKEKC
670 680 690 700 710 720
GMAKLERETK VSTAYNVDEE EEEDEDEEGE EEEEEEELSS KVLENMDSQQ LRTRKFTNVR
730 740 750 760 770 780
HPEKKARKII ETIPLDPNPI NAGSTSSGSS LTTPNSQVAN TISYRGILNK MSPREQLNHA
790 800 810 820 830 840
NLDSSVSTDI KDTEAVNEPL PIGRNAEHPA NQPPLSITQM QENTLPATQA NSSLLETYPI
850 860 870 880
VQSNPVTTTI KESPNSIMAG WDNWESDMVW RDVDILMNEF AFNPKV