C5YUK3
Gene name |
FEN1-A |
Protein name |
Flap endonuclease 1-A |
Names |
FEN-1-A, Flap structure-specific endonuclease 1-A |
Species |
Sorghum bicolor (Sorghum) (Sorghum vulgare) |
KEGG Pathway |
sbi:8061074 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for C5YUK3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-C5YUK3-F1 | Predicted | AlphaFoldDB |
No variants for C5YUK3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for C5YUK3 | |||||
No associated diseases with C5YUK3
6 regional properties for C5YUK3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | 5'-3' exonuclease | 29 - 299 | IPR002421 |
| domain | XPG, N-terminal | 1 - 108 | IPR006085 |
| domain | XPG-I domain | 147 - 234 | IPR006086 |
| conserved_site | Helix-hairpin-helix motif, class 2 | 221 - 254 | IPR008918 |
| conserved_site | XPG conserved site | 80 - 94 | IPR019974-1 |
| conserved_site | XPG conserved site | 150 - 164 | IPR019974-2 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5'-3' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. |
| 5'-flap endonuclease activity | Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| base-excision repair | In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. |
| DNA replication, removal of RNA primer | Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q58DH8 | FEN1 | Flap endonuclease 1 | Bos taurus (Bovine) | PR |
| Q5ZLN4 | FEN1 | Flap endonuclease 1 | Gallus gallus (Chicken) | PR |
| Q9VRJ0 | Gen | Flap endonuclease GEN | Drosophila melanogaster (Fruit fly) | PR |
| P39748 | FEN1 | Flap endonuclease 1 | Homo sapiens (Human) | PR |
| Q5XIP6 | Fen1 | Flap endonuclease 1 | Rattus norvegicus (Rat) | PR |
| Q75LI2 | FEN1B | Flap endonuclease 1-B | Oryza sativa subsp japonica (Rice) | PR |
| Q9SXQ6 | FEN1A | Flap endonuclease 1-A | Oryza sativa subsp japonica (Rice) | PR |
| Q9M2Z3 | SEND1 | Single-strand DNA endonuclease 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGIKGLTKLL | ADNAPKAMKE | QKFESYFGRK | IAIDASMSIY | QFLIVVGRTG | METLTNEAGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VTSHLQGMFN | RTIRLLEAGI | KPVYVFDGKP | PDMKKEELAK | RFSKREDATN | DLKEAVEAGD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KDAVEKLSKR | TVKVTAQHND | DCKRLLRLMG | VPVVEAPSEA | EAECAALCKN | DKVFAVASED |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MDSLTFGAPR | FLRHLMDPSS | KKIPVMEFDV | AKVLEELELT | MDQFIDLCIL | CGCDYCDSIK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GIGGQTALKL | IRQHGSIESI | LENLNKDRYQ | IPEDWPYQEA | RRLFKEPNVT | LDVPELKWTP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PDEEGLISFL | VKDNGFNEDR | VTKAIEKIKS | AKNKSSQGRL | ESFFKPVATT | SAPLKRKETS |
| 370 | |||||
| DKTSKAAAAN | KKTKAGGKKK |