C5AP93
Gene name |
meaB (MexAM1_META1p0188) |
Protein name |
Methylmalonyl-CoA mutase accessory protein |
Names |
|
Species |
Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (Methylobacterium extorquens) |
KEGG Pathway |
mea:Mex_1p0188 |
EC number |
|
Protein Class |
METHYLMALONYL-COA MUTASE (PTHR23408) |
Descriptions
MeaB is an accessory GTPase protein involved in the assembly, protection, and reactivation of 5’-deoxyadenosyl cobalamin-dependent methylmalonyl-CoA mutase (MCM). MeaB's autoinhibition involves the switch II motif, which suppresses intrinsic GTPase activity by stabilizing the GDP-bound state and preventing assembly of the active site with MCM. The motif plays a crucial role in regulating nucleotide-sensitive conformational changes in switch III, which are essential for its chaperone function.
Autoinhibitory domains (AIDs)
Target domain |
178-188 (Switch III motif) |
Relief mechanism |
Partner binding |
Assay |
Mutagenesis experiment, Structural analysis |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for C5AP93
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4JYB | X-ray | 210 A | A/B | 1-329 | PDB |
| 4JYC | X-ray | 220 A | A/B/C/D | 1-329 | PDB |
| 4LC1 | X-ray | 180 A | A/B | 1-329 | PDB |
| 8DPB | X-ray | 272 A | A/B | 1-329 | PDB |
| AF-C5AP93-F1 | Predicted | AlphaFoldDB |
No variants for C5AP93
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for C5AP93 | |||||
No associated diseases with C5AP93
No regional properties for C5AP93
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for C5AP93 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR23408 | METHYLMALONYL-COA MUTASE |
| PANTHER Subfamily | PTHR23408:SF3 | METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL |
| PANTHER Protein Class | mutase | |
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSATLPDMDT | LRERLLAGDR | AALARAITLA | ESRRADHRAA | VRDLIDAVLP | QTGRAIRVGI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TGVPGVGKST | TIDALGSLLT | AAGHKVAVLA | VDPSSTRTGG | SILGDKTRMA | RLAIDRNAFI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RPSPSSGTLG | GVAAKTRETM | LLCEAAGFDV | ILVETVGVGQ | SETAVADLTD | FFLVLMLPGA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GDELQGIKKG | ILELADMIAV | NKADDGDGER | RASAAASEYR | AALHILTPPS | ATWTPPVVTI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SGLHGKGLDS | LWSRIEDHRS | KLTATGEIAG | KRREQDVKWM | WALVHERLHQ | RLVGSAEVRQ |
| 310 | 320 | ||||
| ATAEAERAVA | GGEHSPAAGA | DAIATLIGL |