Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for C0SUW7

Entry ID Method Resolution Chain Position Source
AF-C0SUW7-F1 Predicted AlphaFoldDB

20 variants for C0SUW7

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_7280629_C_G 3 D>H No 1000Genomes
tmp_1_7280532_G_C 35 P>R No 1000Genomes
tmp_1_7280521_G_A 39 P>S No 1000Genomes
ENSVATH04612495 44 L>H No 1000Genomes
ENSVATH00034829 57 G>D No 1000Genomes
tmp_1_7280452_C_A 62 V>F No 1000Genomes
ENSVATH04612494 70 T>I No 1000Genomes
tmp_1_7280409_A_G 76 L>S No 1000Genomes
ENSVATH13935142 80 T>S No 1000Genomes
ENSVATH01078623 94 D>N No 1000Genomes
ENSVATH00034827 100 T>A No 1000Genomes
ENSVATH04612491 106 P>Q No 1000Genomes
tmp_1_7280122_A_C 127 F>L No 1000Genomes
tmp_1_7278597_G_A 219 P>L No 1000Genomes
ENSVATH04612470 255 A>V No 1000Genomes
tmp_1_7278153_C_T 290 V>I No 1000Genomes
ENSVATH13935135 293 E>K No 1000Genomes
ENSVATH11664385 302 V>I No 1000Genomes
tmp_1_7277944_C_A 303 V>F No 1000Genomes
tmp_1_7277467_G_T 344 A>E No 1000Genomes

No associated diseases with C0SUW7

2 regional properties for C0SUW7

Type Name Position InterPro Accession
domain ARID DNA-binding domain 106 - 198 IPR001606
domain Alpha crystallin/Hsp20 domain 305 - 398 IPR002068

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
histone deacetylase complex A protein complex that possesses histone deacetylase activity.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
minor groove of adenine-thymine-rich DNA binding Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

2 GO annotations of biological process

Name Definition
glucosinolate metabolic process The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q99856 ARID3A AT-rich interactive domain-containing protein 3A Homo sapiens (Human) SS
Q8BM75 Arid5b AT-rich interactive domain-containing protein 5B Mus musculus (Mouse) PR
Q62431 Arid3a AT-rich interactive domain-containing protein 3A Mus musculus (Mouse) PR
O02326 cfi-1 AT-rich interactive domain-containing protein cfi-1 Caenorhabditis elegans PR
Q0WNR6 ARID5 AT-rich interactive domain-containing protein 5 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVDTEMQEQD VTFGALVETK YLEEEPLEPE NDHNPSEIPQ PLLLGDGQAN NGHGMNGGAV
70 80 90 100 110 120
GVVDHSERKT RRVQMLSPKT EGENAKKRKT WLLDSEAQGT DEAGTPVEQV AFLREVEAFY
130 140 150 160 170 180
KESFLEFKPP KFYGQPLNIL KLWRAVVNLG GYEVVTTNKL WRQVGESFNP PKTCTTVSYT
190 200 210 220 230 240
FRNFYEKALL EYEKCLRNNG ELNLPGSTLI LSSSVEKEPS SHQGSGSGRA RRDSAARAMQ
250 260 270 280 290 300
GWHAQRLVGS GEVTAPAVKD KGLISTPKHK KLKSIGLQKH KQQTSMDHVV TNEADKQLAA
310 320 330 340 350 360
EVVDVGPVAD WVKINVKESK DSFEIFALVP GLLRKEVRIQ SDPAGKVVIT GQPEQLDNPW
370 380 390
GITPFKKIVD LSARIDPLHT SAVMSMHGRL FIRVPFEQ