C0LGX1

PR
Gene name
At5g65240 (MQN23.19)
Protein name
Probable LRR receptor-like serine/threonine-protein kinase At5g65240
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G65240
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

168-301 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C0LGX1

Entry ID Method Resolution Chain Position Source
AF-C0LGX1-F1 Predicted AlphaFoldDB

26 variants for C0LGX1

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14649268 2 A>S No 1000Genomes
ENSVATH14649268 2 A>T No 1000Genomes
tmp_5_26077626_A_C 9 L>V No 1000Genomes
ENSVATH12938464 13 S>C No 1000Genomes
tmp_5_26077605_A_C 16 S>A No 1000Genomes
tmp_5_26077601_G_A 17 S>F No 1000Genomes
ENSVATH12938460 62 K>R No 1000Genomes
ENSVATH07482493 121 D>N No 1000Genomes
ENSVATH12938429 123 H>Q No 1000Genomes
ENSVATH00752639 126 D>G No 1000Genomes
ENSVATH03477851 144 S>R No 1000Genomes
tmp_5_26076841_A_C 146 N>K No 1000Genomes
tmp_5_26076673_T_A 175 E>V No 1000Genomes
tmp_5_26076668_G_A 177 P>S No 1000Genomes
tmp_5_26076662_T_C 179 S>G No 1000Genomes
ENSVATH07482484 216 R>K No 1000Genomes
tmp_5_26076360_G_C 220 I>M No 1000Genomes
ENSVATH00752638 248 Y>F No 1000Genomes
ENSVATH00752632 309 V>I No 1000Genomes
tmp_5_26075951_T_C 333 I>V No 1000Genomes
tmp_5_26075915_T_C 345 I>V No 1000Genomes
ENSVATH14649261 346 G>S No 1000Genomes
ENSVATH14649260 347 F>Y No 1000Genomes
ENSVATH12938371 523 E>G No 1000Genomes
tmp_5_26075090_T_C 572 N>D No 1000Genomes
ENSVATH07482475 579 E>K No 1000Genomes

No associated diseases with C0LGX1

3 regional properties for C0LGX1

Type Name Position InterPro Accession
domain Protein kinase domain 25 - 316 IPR000719
conserved_site Mitogen-activated protein (MAP) kinase, conserved site 60 - 163 IPR003527
binding_site Protein kinase, ATP binding site 31 - 55 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

22 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P0C0K6 EPHB6 Ephrin type-B receptor 6 Pan troglodytes (Chimpanzee) SS
O15146 MUSK Muscle, skeletal receptor tyrosine-protein kinase Homo sapiens (Human) EV
P04629 NTRK1 High affinity nerve growth factor receptor Homo sapiens (Human) EV
Q16288 NTRK3 NT-3 growth factor receptor Homo sapiens (Human) SS
Q16620 NTRK2 BDNF/NT-3 growth factors receptor Homo sapiens (Human) EV
P55144 Tyro3 Tyrosine-protein kinase receptor TYRO3 Mus musculus (Mouse) SS
Q61006 Musk Muscle, skeletal receptor tyrosine-protein kinase Mus musculus (Mouse) SS
Q00993 Axl Tyrosine-protein kinase receptor UFO Mus musculus (Mouse) PR
Q60805 Mertk Tyrosine-protein kinase Mer Mus musculus (Mouse) SS
Q3UFB7 Ntrk1 High affinity nerve growth factor receptor Mus musculus (Mouse) SS
P09581 Csf1r Macrophage colony-stimulating factor 1 receptor Mus musculus (Mouse) SS
P21803 Fgfr2 Fibroblast growth factor receptor 2 Mus musculus (Mouse) SS
P16092 Fgfr1 Fibroblast growth factor receptor 1 Mus musculus (Mouse) SS
Q03142 Fgfr4 Fibroblast growth factor receptor 4 Mus musculus (Mouse) PR
P05622 Pdgfrb Platelet-derived growth factor receptor beta Mus musculus (Mouse) SS
Q00342 Flt3 Receptor-type tyrosine-protein kinase FLT3 Mus musculus (Mouse) SS
Q61851 Fgfr3 Fibroblast growth factor receptor 3 Mus musculus (Mouse) PR
P24786 NTRK3 NT-3 growth factor receptor Sus scrofa (Pig) SS
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZS4 NIK3 Protein NSP-INTERACTING KINASE 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AG2 SERK1 Somatic embryogenesis receptor kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9XIC7 SERK2 Somatic embryogenesis receptor kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MALLIITALV FSSLWSSVSP DAQGDALFAL RSSLRASPEQ LSDWNQNQVD PCTWSQVICD
70 80 90 100 110 120
DKKHVTSVTL SYMNFSSGTL SSGIGILTTL KTLTLKGNGI MGGIPESIGN LSSLTSLDLE
130 140 150 160 170 180
DNHLTDRIPS TLGNLKNLQF LTLSRNNLNG SIPDSLTGLS KLINILLDSN NLSGEIPQSL
190 200 210 220 230 240
FKIPKYNFTA NNLSCGGTFP QPCVTESSPS GDSSSRKTGI IAGVVSGIAV ILLGFFFFFF
250 260 270 280 290 300
CKDKHKGYKR DVFVDVAGEV DRRIAFGQLR RFAWRELQLA TDEFSEKNVL GQGGFGKVYK
310 320 330 340 350 360
GLLSDGTKVA VKRLTDFERP GGDEAFQREV EMISVAVHRN LLRLIGFCTT QTERLLVYPF
370 380 390 400 410 420
MQNLSVAYCL REIKPGDPVL DWFRRKQIAL GAARGLEYLH EHCNPKIIHR DVKAANVLLD
430 440 450 460 470 480
EDFEAVVGDF GLAKLVDVRR TNVTTQVRGT MGHIAPECIS TGKSSEKTDV FGYGIMLLEL
490 500 510 520 530 540
VTGQRAIDFS RLEEEDDVLL LDHVKKLERE KRLEDIVDKK LDEDYIKEEV EMMIQVALLC
550 560 570 580 590 600
TQAAPEERPA MSEVVRMLEG EGLAERWEEW QNLEVTRQEE FQRLQRRFDW GEDSINNQDA
IELSGGR