C0LGT6

PR
Gene name
EFR
Protein name
LRR receptor-like serine/threonine-protein kinase EFR
Names
Elongation factor Tu receptor, EF-Tu receptor
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G20480
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

644-730 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C0LGT6

Entry ID Method Resolution Chain Position Source
AF-C0LGT6-F1 Predicted AlphaFoldDB

118 variants for C0LGT6

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_6922534_C_T 13 T>M No 1000Genomes
tmp_5_6922551_T_A 19 C>S No 1000Genomes
ENSVATH10883071 21 F>S No 1000Genomes
ENSVATH07001591 22 A>S No 1000Genomes
ENSVATH03085744 36 L>V No 1000Genomes
ENSVATH03085745 44 E>G No 1000Genomes
tmp_5_6922653_T_C 53 S>P No 1000Genomes
ENSVATH00634705 88 V>M No 1000Genomes
tmp_5_6922823_T_G 109 F>L No 1000Genomes
ENSVATH07001594 111 S>N No 1000Genomes
ENSVATH03085749 116 K>E No 1000Genomes
ENSVATH03085750 119 R>M No 1000Genomes
ENSVATH00634706 134 E>V No 1000Genomes
ENSVATH09576248 139 S>P No 1000Genomes
ENSVATH00634708 148 S>L No 1000Genomes
tmp_5_6922951_T_A 152 L>* No 1000Genomes
tmp_5_6922971_C_G 159 H>D No 1000Genomes
tmp_5_6923006_G_C 170 K>N No 1000Genomes
tmp_5_6923047_A_T 184 N>I No 1000Genomes
ENSVATH07001597 184 N>K No 1000Genomes
tmp_5_6923150_A_T 218 Q>H No 1000Genomes
tmp_5_6923178_A_T 228 S>C No 1000Genomes
ENSVATH07001601 235 P>L No 1000Genomes
tmp_5_6923229_T_A 245 S>T No 1000Genomes
tmp_5_6923255_T_G 253 F>L No 1000Genomes
tmp_5_6923271_G_C 259 A>P No 1000Genomes
tmp_5_6923287_T_A 264 L>H No 1000Genomes
ENSVATH09576258 270 R>K No 1000Genomes
ENSVATH07001602 270 R>S No 1000Genomes
tmp_5_6923332_C_G 279 T>S No 1000Genomes
ENSVATH07001603 284 K>I No 1000Genomes
tmp_5_6923350_C_T 285 T>I No 1000Genomes
ENSVATH07001604 285 T>S No 1000Genomes
ENSVATH10883072 296 D>Y No 1000Genomes
ENSVATH07001605 297 I>T No 1000Genomes
ENSVATH00634712 303 S>T No 1000Genomes
ENSVATH14106721 321 I>S No 1000Genomes
ENSVATH00634713 339 A>P No 1000Genomes
ENSVATH07001609 340 V>L No 1000Genomes
ENSVATH07001611 344 T>N No 1000Genomes
ENSVATH00634714 362 A>D No 1000Genomes
ENSVATH03085758 384 T>N No 1000Genomes
ENSVATH03085758 384 T>S No 1000Genomes
ENSVATH03085760 387 H>R No 1000Genomes
ENSVATH09576274 399 S>N No 1000Genomes
tmp_5_6923713_G_C 406 S>T No 1000Genomes
ENSVATH14106722 439 N>Y No 1000Genomes
tmp_5_6923833_T_G 446 L>R No 1000Genomes
ENSVATH00634718 472 M>I No 1000Genomes
ENSVATH08418700 474 T>A No 1000Genomes
tmp_5_6923935_C_G 480 T>S No 1000Genomes
ENSVATH00634719 483 Q>R No 1000Genomes
ENSVATH00634720 486 L>M No 1000Genomes
tmp_5_6923961_C_A 489 P>T No 1000Genomes
ENSVATH07001614 528 K>N No 1000Genomes
ENSVATH03085767 529 M>I No 1000Genomes
tmp_5_6924108_T_C 538 S>P No 1000Genomes
ENSVATH03085768 543 F>Y No 1000Genomes
ENSVATH07001615 545 Q>E No 1000Genomes
tmp_5_6924139_C_T 548 S>L No 1000Genomes
ENSVATH00634722 552 A>P No 1000Genomes
tmp_5_6924168_C_G 558 R>G No 1000Genomes
tmp_5_6924169_G_A 558 R>Q No 1000Genomes
tmp_5_6924183_A_G 563 K>E No 1000Genomes
tmp_5_6924190_T_G 565 V>G No 1000Genomes
tmp_5_6924210_C_T 572 L>F No 1000Genomes
tmp_5_6924220_G_T 575 R>L No 1000Genomes
tmp_5_6924225_C_T 577 P>S No 1000Genomes
ENSVATH00634723 585 S>L No 1000Genomes
ENSVATH03085769 591 L>I No 1000Genomes
ENSVATH00634724 599 R>M No 1000Genomes
tmp_5_6924322_C_G 609 A>G No 1000Genomes
ENSVATH07001617 624 V>I No 1000Genomes
ENSVATH07001618 625 R>L No 1000Genomes
tmp_5_6924440_G_T 648 K>N No 1000Genomes
ENSVATH07001621 651 V>A No 1000Genomes
tmp_5_6924457_T_C 654 I>T No 1000Genomes
tmp_5_6924472_C_G 659 A>G No 1000Genomes
ENSVATH07001624 677 K>R No 1000Genomes
ENSVATH14106724 690 S>F No 1000Genomes
ENSVATH07001627 692 T>I No 1000Genomes
ENSVATH00634726 698 E>K No 1000Genomes
ENSVATH10883074 706 H>L No 1000Genomes
tmp_5_6924617_T_G 707 S>R No 1000Genomes
ENSVATH07001629 711 R>G No 1000Genomes
tmp_5_6924628_G_A 711 R>H No 1000Genomes
tmp_5_6924699_A_G 735 N>D No 1000Genomes
tmp_5_6924855_A_G 787 R>G No 1000Genomes
ENSVATH14106785 796 K>N No 1000Genomes
tmp_5_6924886_G_A 797 G>E No 1000Genomes
tmp_5_6924899_G_T 801 M>I No 1000Genomes
ENSVATH07001637 805 L>P No 1000Genomes
ENSVATH07001638 808 L>Q No 1000Genomes
tmp_5_6924928_T_C 811 V>A No 1000Genomes
tmp_5_6924927_G_A 811 V>I No 1000Genomes
ENSVATH07001639 813 D>E No 1000Genomes
tmp_5_6924940_C_T 815 S>L No 1000Genomes
ENSVATH03085770 820 P>L No 1000Genomes
tmp_5_6924957_G_C 821 A>P No 1000Genomes
tmp_5_6925033_C_T 846 A>V No 1000Genomes
ENSVATH07001642 853 S>C No 1000Genomes
ENSVATH07001643 855 I>V No 1000Genomes
ENSVATH07001644 859 D>N No 1000Genomes
ENSVATH07001645 879 R>G No 1000Genomes
tmp_5_6925141_T_A 882 F>Y No 1000Genomes
ENSVATH14106786 928 K>N No 1000Genomes
tmp_5_6925417_C_T 945 T>I No 1000Genomes
tmp_5_6925441_C_T 953 T>M No 1000Genomes
tmp_5_6925444_G_A 954 S>N No 1000Genomes
ENSVATH07001663 964 G>W No 1000Genomes
tmp_5_6925490_G_T 969 L>F No 1000Genomes
ENSVATH07001664 973 I>V No 1000Genomes
tmp_5_6925522_C_T 980 P>L No 1000Genomes
ENSVATH03085773 993 L>I No 1000Genomes
tmp_5_6925590_T_C 1003 S>P No 1000Genomes
ENSVATH00634728 1014 A>V No 1000Genomes
ENSVATH07001667 1026 T>A No 1000Genomes
tmp_5_6925675_T_C 1031 M>T No 1000Genomes

No associated diseases with C0LGT6

16 regional properties for C0LGT6

Type Name Position InterPro Accession
domain Protein kinase domain 712 - 1001 IPR000719
repeat Leucine-rich repeat 122 - 144 IPR001611-1
repeat Leucine-rich repeat 146 - 204 IPR001611-2
repeat Leucine-rich repeat 266 - 326 IPR001611-3
repeat Leucine-rich repeat 345 - 367 IPR001611-4
repeat Leucine-rich repeat, typical subtype 96 - 120 IPR003591-1
repeat Leucine-rich repeat, typical subtype 168 - 191 IPR003591-2
repeat Leucine-rich repeat, typical subtype 192 - 216 IPR003591-3
repeat Leucine-rich repeat, typical subtype 265 - 288 IPR003591-4
repeat Leucine-rich repeat, typical subtype 392 - 415 IPR003591-5
repeat Leucine-rich repeat, typical subtype 416 - 439 IPR003591-6
repeat Leucine-rich repeat, typical subtype 440 - 464 IPR003591-7
repeat Leucine-rich repeat, typical subtype 583 - 608 IPR003591-8
active_site Serine/threonine-protein kinase, active site 845 - 857 IPR008271
domain Leucine-rich repeat-containing N-terminal, plant-type 29 - 68 IPR013210
binding_site Protein kinase, ATP binding site 718 - 741 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane; Single-pass type I membrane protein
  • Endomembrane system; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
transmembrane receptor protein kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP.

7 GO annotations of biological process

Name Definition
detection of bacterium The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
hormone-mediated signaling pathway The series of molecular signals mediated by the detection of a hormone.
immune response-regulating signaling pathway The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response.
plant-type hypersensitive response The rapid, localized death of plant cells in response to invasion by a pathogen.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of anion channel activity Any process that modulates the frequency, rate or extent of anion channel activity.
response to molecule of bacterial origin Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
C0LGE4 At1g12460 Probable LRR receptor-like serine/threonine-protein kinase At1g12460 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGJ1 At1g74360 Probable LRR receptor-like serine/threonine-protein kinase At1g74360 Arabidopsis thaliana (Mouse-ear cress) PR
Q6XAT2 ERL2 LRR receptor-like serine/threonine-protein kinase ERL2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SHI4 RLP3 Receptor-like protein 3 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MKLSFSLVFN ALTLLLQVCI FAQARFSNET DMQALLEFKS QVSENNKREV LASWNHSSPF
70 80 90 100 110 120
CNWIGVTCGR RRERVISLNL GGFKLTGVIS PSIGNLSFLR LLNLADNSFG STIPQKVGRL
130 140 150 160 170 180
FRLQYLNMSY NLLEGRIPSS LSNCSRLSTV DLSSNHLGHG VPSELGSLSK LAILDLSKNN
190 200 210 220 230 240
LTGNFPASLG NLTSLQKLDF AYNQMRGEIP DEVARLTQMV FFQIALNSFS GGFPPALYNI
250 260 270 280 290 300
SSLESLSLAD NSFSGNLRAD FGYLLPNLRR LLLGTNQFTG AIPKTLANIS SLERFDISSN
310 320 330 340 350 360
YLSGSIPLSF GKLRNLWWLG IRNNSLGNNS SSGLEFIGAV ANCTQLEYLD VGYNRLGGEL
370 380 390 400 410 420
PASIANLSTT LTSLFLGQNL ISGTIPHDIG NLVSLQELSL ETNMLSGELP VSFGKLLNLQ
430 440 450 460 470 480
VVDLYSNAIS GEIPSYFGNM TRLQKLHLNS NSFHGRIPQS LGRCRYLLDL WMDTNRLNGT
490 500 510 520 530 540
IPQEILQIPS LAYIDLSNNF LTGHFPEEVG KLELLVGLGA SYNKLSGKMP QAIGGCLSME
550 560 570 580 590 600
FLFMQGNSFD GAIPDISRLV SLKNVDFSNN NLSGRIPRYL ASLPSLRNLN LSMNKFEGRV
610 620 630 640 650 660
PTTGVFRNAT AVSVFGNTNI CGGVREMQLK PCIVQASPRK RKPLSVRKKV VSGICIGIAS
670 680 690 700 710 720
LLLIIIVASL CWFMKRKKKN NASDGNPSDS TTLGMFHEKV SYEELHSATS RFSSTNLIGS
730 740 750 760 770 780
GNFGNVFKGL LGPENKLVAV KVLNLLKHGA TKSFMAECET FKGIRHRNLV KLITVCSSLD
790 800 810 820 830 840
SEGNDFRALV YEFMPKGSLD MWLQLEDLER VNDHSRSLTP AEKLNIAIDV ASALEYLHVH
850 860 870 880 890 900
CHDPVAHCDI KPSNILLDDD LTAHVSDFGL AQLLYKYDRE SFLNQFSSAG VRGTIGYAAP
910 920 930 940 950 960
EYGMGGQPSI QGDVYSFGIL LLEMFSGKKP TDESFAGDYN LHSYTKSILS GCTSSGGSNA
970 980 990 1000 1010 1020
IDEGLRLVLQ VGIKCSEEYP RDRMRTDEAV RELISIRSKF FSSKTTITES PRDAPQSSPQ
1030
EWMLNTDMHT M