C0LGQ4

PR
Gene name
MDIS2 (MRH1)
Protein name
Protein MALE DISCOVERER 2
Names
AtMDIS2, Probable LRR receptor-like serine/threonine-protein kinase MRH1, Protein MORPHOGENESIS OF ROOT HAIR 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G18640
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

215-399 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C0LGQ4

Entry ID Method Resolution Chain Position Source
AF-C0LGQ4-F1 Predicted AlphaFoldDB

52 variants for C0LGQ4

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06717413 24 L>V No 1000Genomes
ENSVATH14248211 29 Q>K No 1000Genomes
ENSVATH06717417 41 N>K No 1000Genomes
tmp_4_10260706_G_T 46 G>W No 1000Genomes
ENSVATH06717418 55 G>V No 1000Genomes
ENSVATH06717419 58 D>Y No 1000Genomes
ENSVATH06717425 80 Y>C No 1000Genomes
tmp_4_10260927_C_T 90 L>F No 1000Genomes
ENSVATH00520326 100 I>T No 1000Genomes
ENSVATH06717433 110 I>V No 1000Genomes
tmp_4_10261114_C_A 123 L>M No 1000Genomes
ENSVATH06717434 129 D>N No 1000Genomes
tmp_4_10261149_T_G 134 I>M No 1000Genomes
tmp_4_10261164_C_G 139 S>R No 1000Genomes
ENSVATH00520327 142 L>F No 1000Genomes
ENSVATH00520328 147 L>F No 1000Genomes
tmp_4_10261302_A_G 153 K>E No 1000Genomes
ENSVATH06717435 153 K>N No 1000Genomes
tmp_4_10261341_C_A 166 Q>K No 1000Genomes
tmp_4_10261398_C_T 185 L>F No 1000Genomes
ENSVATH02875315 199 N>D No 1000Genomes
ENSVATH06717439 202 I>F No 1000Genomes
ENSVATH00520331 203 Q>L No 1000Genomes
ENSVATH00520331 203 Q>R No 1000Genomes
ENSVATH02875316 209 A>S No 1000Genomes
ENSVATH14248225 214 I>N No 1000Genomes
ENSVATH11982184 228 F>V No 1000Genomes
tmp_4_10261739_C_A 240 L>I No 1000Genomes
tmp_4_10261743_T_A 241 L>H No 1000Genomes
ENSVATH06717444 261 G>R No 1000Genomes
ENSVATH11982235 266 A>V No 1000Genomes
ENSVATH06717445 278 T>S No 1000Genomes
ENSVATH02875317 281 K>R No 1000Genomes
tmp_4_10261869_G_A 283 R>K No 1000Genomes
ENSVATH06717446 288 V>L No 1000Genomes
tmp_4_10261899_C_T 293 S>F No 1000Genomes
tmp_4_10261904_G_C 295 D>H No 1000Genomes
ENSVATH06717447 307 Q>R No 1000Genomes
ENSVATH14248226 310 D>N No 1000Genomes
ENSVATH06717448 332 V>A No 1000Genomes
tmp_4_10262039_G_A 340 V>I No 1000Genomes
ENSVATH06717451 396 Y>F No 1000Genomes
ENSVATH14248228 419 S>T No 1000Genomes
ENSVATH06717459 482 E>D No 1000Genomes
tmp_4_10262724_G_C 487 S>T No 1000Genomes
ENSVATH00520342 490 M>I No 1000Genomes
tmp_4_10262753_G_A 497 A>T No 1000Genomes
tmp_4_10262826_A_C 521 Y>S No 1000Genomes
ENSVATH14248231 573 M>I No 1000Genomes
ENSVATH02875341 614 F>V No 1000Genomes
tmp_4_10263390_A_G 617 E>G No 1000Genomes
ENSVATH00520350 644 A>S No 1000Genomes

No associated diseases with C0LGQ4

3 regional properties for C0LGQ4

Type Name Position InterPro Accession
domain HECT domain 549 - 904 IPR000569
repeat Ankyrin repeat 68 - 199 IPR002110-1
repeat Ankyrin repeat 200 - 261 IPR002110-2

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Endomembrane system ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
pollen tube A tubular cell projection that is part of a pollen tube cell and extends from a pollen grain.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.
root hair cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a root hair cell.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P09581 Csf1r Macrophage colony-stimulating factor 1 receptor Mus musculus (Mouse) SS
P21803 Fgfr2 Fibroblast growth factor receptor 2 Mus musculus (Mouse) SS
P16092 Fgfr1 Fibroblast growth factor receptor 1 Mus musculus (Mouse) SS
Q03142 Fgfr4 Fibroblast growth factor receptor 4 Mus musculus (Mouse) PR
P05622 Pdgfrb Platelet-derived growth factor receptor beta Mus musculus (Mouse) SS
Q00342 Flt3 Receptor-type tyrosine-protein kinase FLT3 Mus musculus (Mouse) SS
Q61006 Musk Muscle, skeletal receptor tyrosine-protein kinase Mus musculus (Mouse) SS
P55144 Tyro3 Tyrosine-protein kinase receptor TYRO3 Mus musculus (Mouse) SS
Q00993 Axl Tyrosine-protein kinase receptor UFO Mus musculus (Mouse) PR
Q60805 Mertk Tyrosine-protein kinase Mer Mus musculus (Mouse) SS
Q3UFB7 Ntrk1 High affinity nerve growth factor receptor Mus musculus (Mouse) SS
Q61851 Fgfr3 Fibroblast growth factor receptor 3 Mus musculus (Mouse) PR
Q9LYN6 At3g56050 Probable inactive receptor-like protein kinase At3g56050 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FG33 LECRKS5 Probable L-type lectin-domain containing receptor kinase S.5 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E991 PRK6 Pollen receptor-like kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
O12990 jak1 Tyrosine-protein kinase JAK1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MMGCGFHFPW FFFLIIGLQA PLSLSLTSQG SALLKFRARV NSDPHGTLAN WNVSGINDLC
70 80 90 100 110 120
YWSGVTCVDG KVQILDLSGY SLEGTLAPEL SQLSDLRSLI LSRNHFSGGI PKEYGSFENL
130 140 150 160 170 180
EVLDLRENDL SGQIPPELSN GLSLKHLLLS GNKFSDDMRI KIVRLQSSYE VRLKKSPKLS
190 200 210 220 230 240
PLAVLGCINR KLGHCVSRNR IIQVKKVEAI VFRIKATSRR FLKAFPSFLE ETDIYKRREL
250 260 270 280 290 300
LEETSNLAAE PAPSAPSPSP GIITEASPRS SGSFPAVTNA KKRRPPLVPP VPSPDKGSTS
310 320 330 340 350 360
PDISKNQPQD NKQSKGSKHV WLYVVIAVAS FVGLLIIVAV IFFCRKRAVK SIGPWKTGLS
370 380 390 400 410 420
GQLQKAFVTG VPKLNRSELE TACEDFSNII ETFDGYTVYK GTLSSGVEIA VASTAIAESK
430 440 450 460 470 480
EWTRAMEMAY RRKIDTLSRI NHKNFVNLIG YCEEDDPFNR MMVFEYAPNG TLFEHLHDKE
490 500 510 520 530 540
TEHLDWSARM RIIMGTAYCL QHMHGMNPPM AHTDFNSSEI YLTDDYAAKV SEIPFNLEAR
550 560 570 580 590 600
LNPKKHVSGD LEQTSLLLPP EPEANVHSFG VLMLEIISGK LSFSDEYGSI EQWASKYLEK
610 620 630 640 650 660
DDLGEMIDPS LKTFKEEELE VICDVIRECL KTEQRQRPSM KDVAEQLKQV INITPEKATP
670
RSSPLWWAEL EILSSEAT