C0LGJ1

PR
Gene name
At1g74360 (F1M20.4)
Protein name
Probable LRR receptor-like serine/threonine-protein kinase At1g74360
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G74360
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

739-831 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C0LGJ1

Entry ID Method Resolution Chain Position Source
AF-C0LGJ1-F1 Predicted AlphaFoldDB

69 variants for C0LGJ1

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_27954348_T_G 17 L>R No 1000Genomes
ENSVATH05144012 18 C>Y No 1000Genomes
ENSVATH05144013 21 C>Y No 1000Genomes
tmp_1_27954681_A_G 31 I>V No 1000Genomes
ENSVATH13807425 62 L>I No 1000Genomes
tmp_1_27954784_A_G 65 E>G No 1000Genomes
ENSVATH00142615 71 Q>E No 1000Genomes
ENSVATH01535334 124 E>Q No 1000Genomes
ENSVATH14478766 129 D>A No 1000Genomes
tmp_1_27954988_G_A 133 R>H No 1000Genomes
ENSVATH05144018 137 L>F No 1000Genomes
ENSVATH05144019 149 G>E No 1000Genomes
ENSVATH14478767 150 E>D No 1000Genomes
ENSVATH05144020 151 L>I No 1000Genomes
ENSVATH00142616 153 L>F No 1000Genomes
ENSVATH13807427 170 T>A No 1000Genomes
ENSVATH13807430 221 E>Q No 1000Genomes
ENSVATH05144021 256 M>V No 1000Genomes
ENSVATH01535335 267 E>K No 1000Genomes
tmp_1_27955404_G_A 272 V>I No 1000Genomes
ENSVATH05144022 322 N>T No 1000Genomes
ENSVATH13807438 391 T>A No 1000Genomes
tmp_1_27955782_A_G 398 S>G No 1000Genomes
ENSVATH05144026 416 E>D No 1000Genomes
ENSVATH05144025 416 E>K No 1000Genomes
tmp_1_27955847_C_A 419 N>K No 1000Genomes
tmp_1_27955848_A_T 420 M>L No 1000Genomes
tmp_1_27955896_T_C 436 S>P No 1000Genomes
ENSVATH14478768 441 F>L No 1000Genomes
tmp_1_27956020_C_G 477 A>G No 1000Genomes
ENSVATH13807450 495 N>D No 1000Genomes
tmp_1_27956112_G_T 508 D>Y No 1000Genomes
ENSVATH05144027 515 G>S No 1000Genomes
tmp_1_27956172_T_A 528 F>I No 1000Genomes
tmp_1_27956235_C_T 549 H>Y No 1000Genomes
tmp_1_27956272_C_T 561 S>F No 1000Genomes
ENSVATH13807459 616 Q>L No 1000Genomes
ENSVATH13807462 653 F>L No 1000Genomes
ENSVATH13807463 659 T>M No 1000Genomes
tmp_1_27956689_C_G 700 P>R No 1000Genomes
ENSVATH14478769 706 S>I No 1000Genomes
ENSVATH13807469 710 Q>H No 1000Genomes
ENSVATH13807468 710 Q>K No 1000Genomes
ENSVATH05144032 712 G>E No 1000Genomes
tmp_1_27956805_C_A 739 L>I No 1000Genomes
tmp_1_27956884_T_C 765 I>T No 1000Genomes
ENSVATH13807476 777 M>T No 1000Genomes
ENSVATH13807477 778 T>S No 1000Genomes
ENSVATH05144033 903 L>F No 1000Genomes
tmp_1_27957323_A_C 911 Q>H No 1000Genomes
ENSVATH13807488 913 K>R No 1000Genomes
ENSVATH01535338 966 L>V No 1000Genomes
ENSVATH00142618 1012 T>M No 1000Genomes
ENSVATH05144035 1031 V>A No 1000Genomes
ENSVATH05144034 1031 V>I No 1000Genomes
ENSVATH13807497 1034 G>D No 1000Genomes
ENSVATH13807497 1034 G>V No 1000Genomes
tmp_1_27957698_G_A 1036 M>I No 1000Genomes
tmp_1_27957700_C_G 1037 T>R No 1000Genomes
ENSVATH01535339 1038 A>T No 1000Genomes
ENSVATH13807498 1042 P>A No 1000Genomes
ENSVATH13807500 1043 I>L No 1000Genomes
tmp_1_27957727_C_T 1046 S>L No 1000Genomes
tmp_1_27957765_G_A 1059 E>K No 1000Genomes
tmp_1_27957780_G_A 1064 G>S No 1000Genomes
ENSVATH14478770 1067 C>S No 1000Genomes
ENSVATH14478771 1068 T>S No 1000Genomes
tmp_1_27957821_C_G 1077 N>K No 1000Genomes
ENSVATH05144036 1099 S>Y No 1000Genomes

No associated diseases with C0LGJ1

14 regional properties for C0LGJ1

Type Name Position InterPro Accession
domain Protein kinase domain 814 - 1095 IPR000719
repeat Leucine-rich repeat 105 - 172 IPR001611-1
repeat Leucine-rich repeat 277 - 336 IPR001611-2
repeat Leucine-rich repeat 421 - 481 IPR001611-3
repeat Leucine-rich repeat, typical subtype 110 - 134 IPR003591-1
repeat Leucine-rich repeat, typical subtype 156 - 182 IPR003591-2
repeat Leucine-rich repeat, typical subtype 299 - 323 IPR003591-3
repeat Leucine-rich repeat, typical subtype 372 - 396 IPR003591-4
repeat Leucine-rich repeat, typical subtype 420 - 443 IPR003591-5
repeat Leucine-rich repeat, typical subtype 444 - 468 IPR003591-6
repeat Leucine-rich repeat, typical subtype 593 - 617 IPR003591-7
active_site Serine/threonine-protein kinase, active site 937 - 949 IPR008271
domain Leucine-rich repeat-containing N-terminal, plant-type 39 - 82 IPR013210
binding_site Protein kinase, ATP binding site 820 - 843 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Mitochondrion membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
defense response to nematode A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
multidimensional cell growth The process in which a cell irreversibly increases in size in two or three
protein phosphorylation The process of introducing a phosphate group on to a protein.
seed germination The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P0C0K6 EPHB6 Ephrin type-B receptor 6 Pan troglodytes (Chimpanzee) SS
P09581 Csf1r Macrophage colony-stimulating factor 1 receptor Mus musculus (Mouse) SS
P21803 Fgfr2 Fibroblast growth factor receptor 2 Mus musculus (Mouse) SS
P16092 Fgfr1 Fibroblast growth factor receptor 1 Mus musculus (Mouse) SS
Q03142 Fgfr4 Fibroblast growth factor receptor 4 Mus musculus (Mouse) PR
P05622 Pdgfrb Platelet-derived growth factor receptor beta Mus musculus (Mouse) SS
Q00342 Flt3 Receptor-type tyrosine-protein kinase FLT3 Mus musculus (Mouse) SS
Q61006 Musk Muscle, skeletal receptor tyrosine-protein kinase Mus musculus (Mouse) SS
P55144 Tyro3 Tyrosine-protein kinase receptor TYRO3 Mus musculus (Mouse) SS
Q00993 Axl Tyrosine-protein kinase receptor UFO Mus musculus (Mouse) PR
Q60805 Mertk Tyrosine-protein kinase Mer Mus musculus (Mouse) SS
Q3UFB7 Ntrk1 High affinity nerve growth factor receptor Mus musculus (Mouse) SS
Q61851 Fgfr3 Fibroblast growth factor receptor 3 Mus musculus (Mouse) PR
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
Q9TZM3 lrk-1 Leucine-rich repeat serine/threonine-protein kinase 1 Caenorhabditis elegans SS
C0LGT6 EFR LRR receptor-like serine/threonine-protein kinase EFR Arabidopsis thaliana (Mouse-ear cress) PR
C0LGE4 At1g12460 Probable LRR receptor-like serine/threonine-protein kinase At1g12460 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SHI4 RLP3 Receptor-like protein 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q6XAT2 ERL2 LRR receptor-like serine/threonine-protein kinase ERL2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTMVTRVIMT DDDSQSLCFL CFLLFFFITA IAVAGDSLDS DREVLLSLKS YLESRNPQNR
70 80 90 100 110 120
GLYTEWKMEN QDVVCQWPGI ICTPQRSRVT GINLTDSTIS GPLFKNFSAL TELTYLDLSR
130 140 150 160 170 180
NTIEGEIPDD LSRCHNLKHL NLSHNILEGE LSLPGLSNLE VLDLSLNRIT GDIQSSFPLF
190 200 210 220 230 240
CNSLVVANLS TNNFTGRIDD IFNGCRNLKY VDFSSNRFSG EVWTGFGRLV EFSVADNHLS
250 260 270 280 290 300
GNISASMFRG NCTLQMLDLS GNAFGGEFPG QVSNCQNLNV LNLWGNKFTG NIPAEIGSIS
310 320 330 340 350 360
SLKGLYLGNN TFSRDIPETL LNLTNLVFLD LSRNKFGGDI QEIFGRFTQV KYLVLHANSY
370 380 390 400 410 420
VGGINSSNIL KLPNLSRLDL GYNNFSGQLP TEISQIQSLK FLILAYNNFS GDIPQEYGNM
430 440 450 460 470 480
PGLQALDLSF NKLTGSIPAS FGKLTSLLWL MLANNSLSGE IPREIGNCTS LLWFNVANNQ
490 500 510 520 530 540
LSGRFHPELT RMGSNPSPTF EVNRQNKDKI IAGSGECLAM KRWIPAEFPP FNFVYAILTK
550 560 570 580 590 600
KSCRSLWDHV LKGYGLFPVC SAGSTVRTLK ISAYLQLSGN KFSGEIPASI SQMDRLSTLH
610 620 630 640 650 660
LGFNEFEGKL PPEIGQLPLA FLNLTRNNFS GEIPQEIGNL KCLQNLDLSF NNFSGNFPTS
670 680 690 700 710 720
LNDLNELSKF NISYNPFISG AIPTTGQVAT FDKDSFLGNP LLRFPSFFNQ SGNNTRKISN
730 740 750 760 770 780
QVLGNRPRTL LLIWISLALA LAFIACLVVS GIVLMVVKAS REAEIDLLDG SKTRHDMTSS
790 800 810 820 830 840
SGGSSPWLSG KIKVIRLDKS TFTYADILKA TSNFSEERVV GRGGYGTVYR GVLPDGREVA
850 860 870 880 890 900
VKKLQREGTE AEKEFRAEME VLSANAFGDW AHPNLVRLYG WCLDGSEKIL VHEYMGGGSL
910 920 930 940 950 960
EELITDKTKL QWKKRIDIAT DVARGLVFLH HECYPSIVHR DVKASNVLLD KHGNARVTDF
970 980 990 1000 1010 1020
GLARLLNVGD SHVSTVIAGT IGYVAPEYGQ TWQATTRGDV YSYGVLTMEL ATGRRAVDGG
1030 1040 1050 1060 1070 1080
EECLVEWARR VMTGNMTAKG SPITLSGTKP GNGAEQMTEL LKIGVKCTAD HPQARPNMKE
1090 1100
VLAMLVKISG KAELFNGLSS QGYIEM