C0LGI2

PR
Gene name
At1g67720 (F12A21.30)
Protein name
Probable LRR receptor-like serine/threonine-protein kinase At1g67720
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G67720
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

432-619 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

748-772 (Activation loop from InterPro)

Target domain

606-880 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for C0LGI2

Entry ID Method Resolution Chain Position Source
AF-C0LGI2-F1 Predicted AlphaFoldDB

77 variants for C0LGI2

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05094466 19 V>A No 1000Genomes
ENSVATH05094472 27 V>A No 1000Genomes
ENSVATH05094473 29 I>V No 1000Genomes
ENSVATH00129922 33 C>G No 1000Genomes
ENSVATH05094474 37 Y>N No 1000Genomes
ENSVATH05094475 43 G>R No 1000Genomes
tmp_1_25387003_A_T 69 M>L No 1000Genomes
ENSVATH13760887 78 P>S No 1000Genomes
ENSVATH05094477 89 S>G No 1000Genomes
tmp_1_25387097_C_T 100 T>I No 1000Genomes
ENSVATH05094478 103 L>R No 1000Genomes
ENSVATH05094480 119 Y>F No 1000Genomes
ENSVATH00129923 120 L>V No 1000Genomes
tmp_1_25387232_C_A 145 A>E No 1000Genomes
ENSVATH14441897 158 I>L No 1000Genomes
tmp_1_25387310_C_A 171 P>Q No 1000Genomes
tmp_1_25387369_G_T 191 A>S No 1000Genomes
ENSVATH05094483 233 T>R No 1000Genomes
tmp_1_25387616_C_A 243 T>K No 1000Genomes
tmp_1_25387644_A_T 252 K>N No 1000Genomes
ENSVATH01495454 259 V>I No 1000Genomes
ENSVATH05094484 261 T>K No 1000Genomes
tmp_1_25387672_C_G 262 Q>E No 1000Genomes
ENSVATH05094485 273 D>N No 1000Genomes
ENSVATH05094486 291 G>S No 1000Genomes
ENSVATH13760890 294 E>K No 1000Genomes
ENSVATH14441900 340 T>A No 1000Genomes
ENSVATH13760891 340 T>M No 1000Genomes
tmp_1_25387925_C_A 346 T>N No 1000Genomes
ENSVATH14441901 355 L>V No 1000Genomes
tmp_1_25388166_A_T 384 M>L No 1000Genomes
tmp_1_25388177_T_G 387 D>E No 1000Genomes
ENSVATH05094493 387 D>N No 1000Genomes
ENSVATH05094494 399 I>T No 1000Genomes
tmp_1_25388229_T_A 405 W>R No 1000Genomes
ENSVATH00129925 407 N>D No 1000Genomes
tmp_1_25388271_A_C 419 I>L No 1000Genomes
tmp_1_25388370_T_G 421 L>R No 1000Genomes
ENSVATH01495456 433 G>V No 1000Genomes
ENSVATH14441903 447 D>N No 1000Genomes
ENSVATH05094498 455 P>L No 1000Genomes
ENSVATH01495459 480 Y>C No 1000Genomes
ENSVATH14441905 480 Y>D No 1000Genomes
tmp_1_25388727_G_A 482 A>T No 1000Genomes
ENSVATH05094499 488 Q>K No 1000Genomes
tmp_1_25388862_T_A 501 I>N No 1000Genomes
ENSVATH05094501 509 K>Q No 1000Genomes
tmp_1_25388891_T_A 511 L>M No 1000Genomes
ENSVATH05094508 518 P>S No 1000Genomes
tmp_1_25389127_G_A 523 E>K No 1000Genomes
tmp_1_25389137_G_A 526 R>Q No 1000Genomes
ENSVATH05094509 529 F>C No 1000Genomes
tmp_1_25389161_G_A 534 G>E No 1000Genomes
ENSVATH05094510 539 A>T No 1000Genomes
tmp_1_25389212_T_C 551 L>P No 1000Genomes
tmp_1_25389214_G_A 552 V>I No 1000Genomes
tmp_1_25389235_A_G 559 K>E No 1000Genomes
ENSVATH13760895 583 R>Q No 1000Genomes
tmp_1_25389450_G_A 606 D>N No 1000Genomes
ENSVATH14441906 656 R>K No 1000Genomes
ENSVATH05094515 665 L>F No 1000Genomes
tmp_1_25389871_T_G 694 S>A No 1000Genomes
ENSVATH05094517 708 I>T No 1000Genomes
tmp_1_25389920_A_T 710 Q>L No 1000Genomes
ENSVATH00129931 711 D>N No 1000Genomes
ENSVATH13760899 743 M>I No 1000Genomes
ENSVATH14441909 765 S>N No 1000Genomes
ENSVATH00129935 770 T>A No 1000Genomes
ENSVATH14441910 780 A>G No 1000Genomes
tmp_1_25390531_C_T 822 A>V No 1000Genomes
tmp_1_25390546_G_A 827 R>H No 1000Genomes
tmp_1_25390692_A_T 876 I>L No 1000Genomes
ENSVATH13760901 887 E>K No 1000Genomes
ENSVATH13760902 900 A>T No 1000Genomes
ENSVATH13760903 915 E>* No 1000Genomes
tmp_1_25390815_C_T 917 P>S No 1000Genomes
ENSVATH13760904 926 P>T No 1000Genomes

No associated diseases with C0LGI2

6 regional properties for C0LGI2

Type Name Position InterPro Accession
domain Protein kinase domain 606 - 880 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 608 - 873 IPR001245
repeat Leucine-rich repeat 439 - 496 IPR001611
active_site Serine/threonine-protein kinase, active site 727 - 739 IPR008271
binding_site Protein kinase, ATP binding site 612 - 634 IPR017441
domain Malectin-like domain 29 - 362 IPR024788

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

45 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q91044 NTRK3 NT-3 growth factor receptor Gallus gallus (Chicken) SS
Q91987 NTRK2 BDNF/NT-3 growth factors receptor Gallus gallus (Chicken) SS
Q91009 NTRK1 High affinity nerve growth factor receptor Gallus gallus (Chicken) SS
P0C0K6 EPHB6 Ephrin type-B receptor 6 Pan troglodytes (Chimpanzee) SS
P20594 NPR2 Atrial natriuretic peptide receptor 2 Homo sapiens (Human) PR
P55144 Tyro3 Tyrosine-protein kinase receptor TYRO3 Mus musculus (Mouse) SS
Q61006 Musk Muscle, skeletal receptor tyrosine-protein kinase Mus musculus (Mouse) SS
Q00993 Axl Tyrosine-protein kinase receptor UFO Mus musculus (Mouse) PR
Q60805 Mertk Tyrosine-protein kinase Mer Mus musculus (Mouse) SS
Q3UFB7 Ntrk1 High affinity nerve growth factor receptor Mus musculus (Mouse) SS
P09581 Csf1r Macrophage colony-stimulating factor 1 receptor Mus musculus (Mouse) SS
P21803 Fgfr2 Fibroblast growth factor receptor 2 Mus musculus (Mouse) SS
P16092 Fgfr1 Fibroblast growth factor receptor 1 Mus musculus (Mouse) SS
Q03142 Fgfr4 Fibroblast growth factor receptor 4 Mus musculus (Mouse) PR
P05622 Pdgfrb Platelet-derived growth factor receptor beta Mus musculus (Mouse) SS
Q00342 Flt3 Receptor-type tyrosine-protein kinase FLT3 Mus musculus (Mouse) SS
Q61851 Fgfr3 Fibroblast growth factor receptor 3 Mus musculus (Mouse) PR
P24786 NTRK3 NT-3 growth factor receptor Sus scrofa (Pig) SS
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
P43293 PBL11 Probable serine/threonine-protein kinase PBL11 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E8W4 ANX2 Receptor-like protein kinase ANXUR2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LPZ9 SD113 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 Arabidopsis thaliana (Mouse-ear cress) SS
C0LGG3 At1g51820 Probable LRR receptor-like serine/threonine-protein kinase At1g51820 Arabidopsis thaliana (Mouse-ear cress) PR
P43298 TMK1 Receptor protein kinase TMK1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR3 At2g14510 Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWW0 ALE2 Receptor-like serine/threonine-protein kinase ALE2 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LIG2 At3g21340 Receptor-like protein kinase At3g21340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SNA3 At3g46340 Putative receptor-like protein kinase At3g46340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M2S4 LECRKS4 L-type lectin-domain containing receptor kinase S.4 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWZ5 SD25 G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGW2 PAM74 Probable LRR receptor-like serine/threonine-protein kinase PAM74 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN94 At5g59670 Receptor-like protein kinase At5g59670 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN93 At5g59680 Probable LRR receptor-like serine/threonine-protein kinase At5g59680 Arabidopsis thaliana (Mouse-ear cress) PR
O64556 At2g19230 Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXB4 At1g11300 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JQ4 PRK2 Pollen receptor-like kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZS4 NIK3 Protein NSP-INTERACTING KINASE 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AG2 SERK1 Somatic embryogenesis receptor kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
O64477 At2g19130 G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 Arabidopsis thaliana (Mouse-ear cress) SS
Q9XIC7 SERK2 Somatic embryogenesis receptor kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGLCLAQLAV TCLFLVPFVL SQVTEFVSID CGCSSNYTDP RTGLGWVSDS EIIKQGKPVT
70 80 90 100 110 120
LANTNWNSMQ YRRRRDFPTD NKKYCYRLST KERRRYIVRT TFLYGGLGSE EAYPKFQLYL
130 140 150 160 170 180
DATKWATVTI QEVSRVYVEE LIVRATSSYV DVCVCCAITG SPFMSTLELR PLNLSMYATD
190 200 210 220 230 240
YEDNFFLKVA ARVNFGAPNM DALRYPDDPY DRIWESDINK RPNYLVGVAP GTTRINTSKT
250 260 270 280 290 300
INTLTREYPP MKVMQTAVVG TQGLISYRLN LEDFPANARA YAYFAEIEEL GANETRKFKL
310 320 330 340 350 360
VQPYFPDYSN AVVNIAENAN GSYTLYEPSY MNVTLDFVLT FSFGKTKDST QGPLLNAIEI
370 380 390 400 410 420
SKYLPISVKT DRSDVSVLDA IRSMSPDSDW ASEGGDPCIP VLWSWVNCSS TSPPRVTKIA
430 440 450 460 470 480
LSRKNLRGEI PPGINYMEAL TELWLDDNEL TGTLPDMSKL VNLKIMHLEN NQLSGSLPPY
490 500 510 520 530 540
LAHLPNLQEL SIENNSFKGK IPSALLKGKV LFKYNNNPEL QNEAQRKHFW QILGISIAAV
550 560 570 580 590 600
AILLLLVGGS LVLLCALRKT KRADKGDSTE TKKKGLVAYS AVRGGHLLDE GVAYFISLPV
610 620 630 640 650 660
LEEATDNFSK KVGRGSFGSV YYGRMKDGKE VAVKITADPS SHLNRQFVTE VALLSRIHHR
670 680 690 700 710 720
NLVPLIGYCE EADRRILVYE YMHNGSLGDH LHGSSDYKPL DWLTRLQIAQ DAAKGLEYLH
730 740 750 760 770 780
TGCNPSIIHR DVKSSNILLD INMRAKVSDF GLSRQTEEDL THVSSVAKGT VGYLDPEYYA
790 800 810 820 830 840
SQQLTEKSDV YSFGVVLFEL LSGKKPVSAE DFGPELNIVH WARSLIRKGD VCGIIDPCIA
850 860 870 880 890 900
SNVKIESVWR VAEVANQCVE QRGHNRPRMQ EVIVAIQDAI RIERGNENGL KSSSSSSSKA
910 920
QSSRKTLLTS FLELESPDIS RNSLAPAAR