C0LGE4

PR
Gene name
At1g12460 (F5O11.21, T12C24.1)
Protein name
Probable LRR receptor-like serine/threonine-protein kinase At1g12460
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G12460
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C0LGE4

Entry ID Method Resolution Chain Position Source
AF-C0LGE4-F1 Predicted AlphaFoldDB

52 variants for C0LGE4

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_4247715_C_A 5 H>N No 1000Genomes
tmp_1_4247718_C_A 6 L>I No 1000Genomes
ENSVATH11062041 13 F>L No 1000Genomes
ENSVATH11062042 22 D>N No 1000Genomes
ENSVATH04564983 23 S>F No 1000Genomes
ENSVATH00019885 38 S>C No 1000Genomes
ENSVATH04564984 43 N>S No 1000Genomes
tmp_1_4247856_G_A 52 G>S No 1000Genomes
tmp_1_4247996_G_C 98 L>F No 1000Genomes
tmp_1_4248019_A_T 106 N>I No 1000Genomes
tmp_1_4248024_C_G 108 P>A No 1000Genomes
tmp_1_4248087_G_T 129 G>C No 1000Genomes
tmp_1_4248121_G_T 140 S>I No 1000Genomes
tmp_1_4248128_G_T 142 R>S No 1000Genomes
ENSVATH11062043 143 F>L No 1000Genomes
tmp_1_4248156_A_T 152 T>S No 1000Genomes
ENSVATH04564988 179 S>A No 1000Genomes
tmp_1_4248269_C_A 189 N>K No 1000Genomes
ENSVATH00019886 206 P>L No 1000Genomes
ENSVATH11062044 208 I>F No 1000Genomes
tmp_1_4248361_G_A 220 R>K No 1000Genomes
tmp_1_4248447_C_G 249 H>D No 1000Genomes
tmp_1_4248466_C_T 255 A>V No 1000Genomes
tmp_1_4248487_T_C 262 I>T No 1000Genomes
tmp_1_4248592_C_G 297 T>S No 1000Genomes
ENSVATH00019887 329 G>V No 1000Genomes
ENSVATH11062115 357 F>Y No 1000Genomes
ENSVATH04564993 413 R>Q No 1000Genomes
tmp_1_4249111_C_T 439 S>L No 1000Genomes
tmp_1_4249123_C_T 443 P>L No 1000Genomes
ENSVATH04564994 449 G>R No 1000Genomes
ENSVATH04564994 449 G>W No 1000Genomes
ENSVATH11062118 455 T>M No 1000Genomes
ENSVATH11062118 455 T>R No 1000Genomes
tmp_1_4249161_C_T 456 H>Y No 1000Genomes
ENSVATH01041610 491 D>Y No 1000Genomes
tmp_1_4249287_A_G 498 N>D No 1000Genomes
ENSVATH01041611 510 D>N No 1000Genomes
ENSVATH11062119 520 I>V No 1000Genomes
ENSVATH04564996 543 R>M No 1000Genomes
tmp_1_4249495_T_G 567 I>R No 1000Genomes
ENSVATH13885855 610 A>T No 1000Genomes
ENSVATH00019888 616 V>I No 1000Genomes
ENSVATH11062122 683 I>F No 1000Genomes
ENSVATH00019889 748 L>I No 1000Genomes
ENSVATH11062124 756 D>G No 1000Genomes
ENSVATH04565002 777 Q>H No 1000Genomes
tmp_1_4250140_C_T 782 A>V No 1000Genomes
ENSVATH04565003 817 R>T No 1000Genomes
tmp_1_4250248_A_G 818 D>G No 1000Genomes
ENSVATH04565005 856 T>M No 1000Genomes
ENSVATH01041613 861 L>R No 1000Genomes

No associated diseases with C0LGE4

6 regional properties for C0LGE4

Type Name Position InterPro Accession
domain Protein kinase domain 593 - 876 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 595 - 873 IPR001245
repeat Leucine-rich repeat, typical subtype 138 - 162 IPR003591-1
repeat Leucine-rich repeat, typical subtype 355 - 379 IPR003591-2
repeat Leucine-rich repeat, typical subtype 403 - 427 IPR003591-3
domain Leucine-rich repeat-containing N-terminal, plant-type 25 - 64 IPR013210

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P0C0K6 EPHB6 Ephrin type-B receptor 6 Pan troglodytes (Chimpanzee) SS
Q38SD2 LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens (Human) EV
Q9TZM3 lrk-1 Leucine-rich repeat serine/threonine-protein kinase 1 Caenorhabditis elegans SS
C0LGT6 EFR LRR receptor-like serine/threonine-protein kinase EFR Arabidopsis thaliana (Mouse-ear cress) PR
Q9SHI4 RLP3 Receptor-like protein 3 Arabidopsis thaliana (Mouse-ear cress) SS
C0LGJ1 At1g74360 Probable LRR receptor-like serine/threonine-protein kinase At1g74360 Arabidopsis thaliana (Mouse-ear cress) PR
Q6XAT2 ERL2 LRR receptor-like serine/threonine-protein kinase ERL2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRKVHLFLVL VHFIYISTSR SDSISERDIL LQFKGSISDD PYNSLASWVS DGDLCNSFNG
70 80 90 100 110 120
ITCNPQGFVD KIVLWNTSLA GTLAPGLSNL KFIRVLNLFG NRFTGNLPLD YFKLQTLWTI
130 140 150 160 170 180
NVSSNALSGP IPEFISELSS LRFLDLSKNG FTGEIPVSLF KFCDKTKFVS LAHNNIFGSI
190 200 210 220 230 240
PASIVNCNNL VGFDFSYNNL KGVLPPRICD IPVLEYISVR NNLLSGDVSE EIQKCQRLIL
250 260 270 280 290 300
VDLGSNLFHG LAPFAVLTFK NITYFNVSWN RFGGEIGEIV DCSESLEFLD ASSNELTGRI
310 320 330 340 350 360
PTGVMGCKSL KLLDLESNKL NGSIPGSIGK MESLSVIRLG NNSIDGVIPR DIGSLEFLQV
370 380 390 400 410 420
LNLHNLNLIG EVPEDISNCR VLLELDVSGN DLEGKISKKL LNLTNIKILD LHRNRLNGSI
430 440 450 460 470 480
PPELGNLSKV QFLDLSQNSL SGPIPSSLGS LNTLTHFNVS YNNLSGVIPP VPMIQAFGSS
490 500 510 520 530 540
AFSNNPFLCG DPLVTPCNSR GAAAKSRNSD ALSISVIIVI IAAAVILFGV CIVLALNLRA
550 560 570 580 590 600
RKRRKDEEIL TVETTPLASS IDSSGVIIGK LVLFSKNLPS KYEDWEAGTK ALLDKENIIG
610 620 630 640 650 660
MGSIGSVYRA SFEGGVSIAV KKLETLGRIR NQEEFEQEIG RLGGLQHPNL SSFQGYYFSS
670 680 690 700 710 720
TMQLILSEFV PNGSLYDNLH LRIFPGTSSS YGNTDLNWHR RFQIALGTAK ALSFLHNDCK
730 740 750 760 770 780
PAILHLNVKS TNILLDERYE AKLSDYGLEK FLPVMDSFGL TKKFHNAVGY IAPELAQQSL
790 800 810 820 830 840
RASEKCDVYS YGVVLLELVT GRKPVESPSE NQVLILRDYV RDLLETGSAS DCFDRRLREF
850 860 870 880
EENELIQVMK LGLLCTSENP LKRPSMAEVV QVLESIRNGF GS