B8XX90

SS
Gene name
STING1
Protein name
Stimulator of interferon genes protein
Names
poSTING, Transmembrane protein 173
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:100217389
EC number
Protein Class

Descriptions

Stimulator of interferon genes (STING) plays a role as a sensor to directly bind cyclic diguanylate monophosphate (c-di-GMP), the abacterial second message, facilitates innate immune signalling and promotes the production of type I interferon for the first line of defence immune. In human STRING1 (Q86WV6), the autoinhibitory conformation of cytosolic c-di-GMP binding domain (CBD) is formed via the intramolecular interaction with the C-terminal tail (CTT), which hinders the binding of c-di-GMP on STING.

Autoinhibitory domains (AIDs)

339-378 (C-terminal regulatory region) SS

Target domain

154-337 (Cytosolic c-di-GMP binding domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for B8XX90

Entry ID Method Resolution Chain Position Source
6A03 X-ray 260 A A/B 152-342 PDB
6A04 X-ray 190 A A/B 152-342 PDB
6A05 X-ray 220 A A/B 152-342 PDB
6A06 X-ray 179 A A/B 152-342 PDB
6IYF X-ray 176 A A/B 152-342 PDB
AF-B8XX90-F1 Predicted AlphaFoldDB

No variants for B8XX90

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B8XX90

No associated diseases with B8XX90

No regional properties for B8XX90

Type Name Position InterPro Accession
No domain, repeats, and functional sites for B8XX90

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Cytoplasm, perinuclear region
  • Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein
  • Golgi apparatus membrane ; Multi-pass membrane protein
  • Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein
  • Mitochondrion outer membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • In response to double-stranded DNA stimulation, translocates from the endoplasmic reticulum through the endoplasmic reticulum-Golgi intermediate compartment and Golgi to post-Golgi vesicles, where the kinase TBK1 is recruited
  • Upon cGAMP-binding, translocates to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) in a process that is dependent on COPII vesicles; STING1-containing ERGIC serves as a membrane source for LC3 lipidation, which is a key step in autophagosome biogenesis
  • Localizes in the lysosome membrane in a TMEM203-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
autophagosome membrane The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
endoplasmic reticulum-Golgi intermediate compartment membrane The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
2',3'-cyclic GMP-AMP binding Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages.
cyclic-di-GMP binding Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
protein homodimerization activity Binding to an identical protein to form a homodimer.

8 GO annotations of biological process

Name Definition
activation of innate immune response Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
autophagosome assembly The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
positive regulation of interferon-beta production Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
positive regulation of macroautophagy Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
positive regulation of type I interferon production Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
reticulophagy The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KI99 STING1 Stimulator of interferon genes protein Bos taurus (Bovine) SS
E1C7U0 STING1 Stimulator of interferon genes protein Gallus gallus (Chicken) SS
Q86WV6 STING1 Stimulator of interferon genes protein Homo sapiens (Human) EV
Q3TBT3 Sting1 Stimulator of interferon genes protein Mus musculus (Mouse) SS
F1M391 Sting1 Stimulator of interferon genes protein Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MPYSSLHPSI PQPRGLRAQV AALVLLGACL VALWGLGELP EYTLRWLVLH LASQQIGLLV
70 80 90 100 110 120
KGLCSLAEEL CHVHSRYQSS YWRAARACLG CPIRCGALLL LSCYFYFSIR DKAGLPLPWM
130 140 150 160 170 180
LALLGLSQAL NILLGLQHLA PAEVSAICEK RNFNVAHGLA WSYYIGYLRL ILPGLRARIQ
190 200 210 220 230 240
AYNQRHKNVL GGIGNHRLHI LFPLDCGVPD DLSVADPNIR FLHELPQQSA DRAGIKGRVY
250 260 270 280 290 300
TNSIYELLEN GQPAGVCVLG YATPLQTLFA MSQDGRAGFS REDRLEQAKL FCRTLEDILA
310 320 330 340 350 360
DAPEAQNNCR LIVYQEPTEG GSFSLSQEIL RHLRQEEREV TMGSAETSVV PTSSTLSQEP
370
ELLISGMEQP LPLRSDIF