Descriptions
KIF7 is a kinesin-4 family member that plays a critical role in Hedgehog signaling in vertebrates. It is regulated by an autoinhibition mechanism via its inhibitory coiled coil segment. Truncation of the coiled coil segment relieves the autoinhibition of microtubule binding. Loss of autoinhibition, as seen in certain mutations, leads to strong microtubule binding and can be pathogenic for human diseases such as Joubert syndrome and acrocallosal syndrome.
Autoinhibitory domains (AIDs)
Target domain |
1-558 (N-terminal motor domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B7ZNG0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B7ZNG0-F1 | Predicted | AlphaFoldDB |
No variants for B7ZNG0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B7ZNG0 | |||||
No associated diseases with B7ZNG0
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
| ciliary tip | Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| kinesin complex | Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction |
| identical protein binding | Binding to an identical protein or proteins. |
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
| microtubule motor activity | A motor activity that generates movement along a microtubule, driven by ATP hydrolysis. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| aorta development | The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. |
| cardiac septum development | The progression of a cardiac septum over time, from its initial formation to the mature structure. |
| coronary vasculature development | The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. |
| microtubule-based movement | A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. |
| mitotic spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. |
| negative regulation of smoothened signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling. |
| positive regulation of smoothened signaling pathway | Any process that activates or increases the frequency, rate or extent of smoothened signaling. |
| spindle elongation | The cell cycle process in which the distance is lengthened between poles of the spindle. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q86VH2 | KIF27 | Kinesin-like protein KIF27 | Homo sapiens (Human) | SS |
| Q7Z4S6 | KIF21A | Kinesin-like protein KIF21A | Homo sapiens (Human) | EV |
| O95239 | KIF4A | Chromosome-associated kinesin KIF4A | Homo sapiens (Human) | SS |
| Q2VIQ3 | KIF4B | Chromosome-associated kinesin KIF4B | Homo sapiens (Human) | SS |
| O75037 | KIF21B | Kinesin-like protein KIF21B | Homo sapiens (Human) | EV |
| Q2M1P5 | KIF7 | Kinesin-like protein KIF7 | Homo sapiens (Human) | EV |
| Q7M6Z4 | Kif27 | Kinesin-like protein KIF27 | Mus musculus (Mouse) | SS |
| Q9QXL1 | Kif21b | Kinesin-like protein KIF21B | Mus musculus (Mouse) | SS |
| Q9QXL2 | Kif21a | Kinesin-like protein KIF21A | Mus musculus (Mouse) | EV SS |
| Q61768 | Kif5b | Kinesin-1 heavy chain | Mus musculus (Mouse) | EV |
| P28738 | Kif5c | Kinesin heavy chain isoform 5C | Mus musculus (Mouse) | SS |
| Q99PW8 | Kif17 | Kinesin-like protein KIF17 | Mus musculus (Mouse) | SS |
| Q9EQW7 | Kif13a | Kinesin-like protein KIF13A | Mus musculus (Mouse) | SS |
| P33175 | Kif5a | Kinesin heavy chain isoform 5A | Mus musculus (Mouse) | SS |
| F1M5N7 | Kif21b | Kinesin-like protein KIF21B | Rattus norvegicus (Rat) | SS |
| Q7M6Z5 | Kif27 | Kinesin-like protein KIF27 | Rattus norvegicus (Rat) | SS |
| Q58G59 | kif7 | Kinesin-like protein kif7 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLEAQRLPG | AEEAPVRVAL | RVRPLLPKEL | LHGHQSCLRV | EPERGRITLG | RDRHFGFHVV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGEDTGQEAV | YQACVQPLLE | AFFEGFNATV | FAYGQTGSGK | TYTMGEASVA | SLHEDEQGII |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PRAMAEAFKL | IDENDLLDCL | VHVSYLELYK | EEFRDLLEVG | TASRDIQLRE | DDRGNVVLCG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VKEVDVEGLD | EVLSLLEMGN | AARHTGATHF | NRLSSRSHTV | FTVTLEQRGR | TPSRLPRPAA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GHLLVSKFHF | VDLAGSERVL | KTGSTGERLK | ESIQINSTLL | ALGNVISALG | DPQRRGSHIP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YRDSKITRIL | KDSLGGNAKT | VMIACVSPSS | SDFDETLNTL | NYASRAQNIR | NRATVNWHPE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AERVPEEQAA | GARGPPRHRS | ETRIIHRGRR | VPCPAVGSAA | VAAGLGAECA | RCRARTSAAY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SLLRELQAEP | GLPGAAARKV | RDWLCAVEGE | RSTLSSASGP | DSGIESAPAE | DQAAQGTSGR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KGDEGTQQLL | TLQSQVARLE | EENRDFLAAL | EDAMEQYKLQ | SDRLREQQEE | MVELRLRLEL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AQPGWGAPGL | LQGLPPGSFV | PRPHTAPLGG | AHTHMLGMMP | STCLPGEEVS | SEQQVVSGKE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VKAEVLAQAD | KLRSASSTTS | EEEGEEEEEE | EEEEEEPPRR | TLYLRRNGIS | NWSQRAGLSP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GSPPDRKGPE | VCPEEPAAAI | PAPQAVGSGK | VPVQTRQAPA | AMASEWRLAQ | AQQKIRELAI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NIRMKEELIG | ELVRTGKAAQ | ALNRQHSQRI | RELEQEAERV | RAELCEGQRQ | LRELEGREPQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DASERSRLQE | FRKRVAAAQS | QVQVLKEKKQ | ATERLVSLSA | QSETRLQELE | RNVQLMRRQQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GQLQRRLREE | TEQKRRLETE | MNKRQHRVKE | LELKHEQQQK | ILKIKTEEIA | AFQRKRRSGS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NGSVVSLEQQ | QKIEEQKKWL | DQEMEKVLQQ | RRALEELGEE | LRKREVILAK | KEALMQEKTG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LESKRLRSSQ | ALNEDIVRVS | SRLEHLEKEL | SEKSGQLRQG | SAQNQQQIRG | EIDTLRQEKD |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SLLKQRLEID | SKLRQGSLLS | PEEERTLFQL | DEAIEALDAA | IEYKNEAITC | RQRVLRASAS |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LLSQCEMNLM | AKLSYLSSSE | TRALLCKYFD | KVVTLREEQH | QQQIAFSELE | MQLEEQQRLV |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| YWLEVALERQ | RLEMDRQLTL | QQKEHEQNVQ | LLLQQGRDHL | GEGLADSKRQ | YEARIHALEK |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| ELGRHMWINQ | ELKQKLSAGS | TAGQSQGCER | RSLCLENRQC | LGNEDGLHPA | APEPLWQSSL |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| LEGVSRVWDE | SRDLVHAPLP | LTWKRSSLCS | EQGSSEESRV | RETTEPPVGR | VLPMGEVGLS |
| 1330 | 1340 | ||||
| WNFGPLPKPR | WEPRRTSPGM | IDVRKNPL |