B2RXS4
SS
Gene name |
Plxnb2 |
Protein name |
Plexin-B2 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:140570 |
EC number |
|
Protein Class |
|
Descriptions
Plexins are a large family of cell surface receptors for the axon guidance molecules semaphorins. Semaphorin-plexin signaling is essential for the regulation of neuronal development and other processes. Dysfunction in plexin pathways has been implicated in various diseases including neurological disorders and cancer. <br> Plexins are transmembrane proteins with a multidomain extracellular region that contains an N-terminal Sema domain. Before semaphorin binding, Plexin is an inactive monomer or dimer in which the RapGAP activity is autoinhibited. Binding of semaphorin to the Sema domain of plexin leads to activation of its cytoplasmic region, which relays the signal to downstream pathways. Mouse Plexin-A3 (P70208) possesses a segment preceding C1 domain and RDB domain as autoinhibitory elements.
Autoinhibitory domains (AIDs)
Target domain |
1275-1809 (Plexin, cytoplasmic RasGAP domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
1275-1809 (Plexin, cytoplasmic RasGAP domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Wang Y et al. (2012) "Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization", Science signaling, 5, ra6
- He H et al. (2009) "Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration", Proceedings of the National Academy of Sciences of the United States of America, 106, 15610-5
Autoinhibited structure
Activated structure
3 structures for B2RXS4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5E6P | X-ray | 321 A | A | 1226-1842 | PDB |
| 7KDC | X-ray | 310 A | C/D | 1463-1565 | PDB |
| AF-B2RXS4-F1 | Predicted | AlphaFoldDB |
96 variants for B2RXS4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs252475511 | 14 | T>M | No | EVA | |
| rs864299025 | 26 | E>G | No | EVA | |
| rs1132540772 | 53 | A>E | No | EVA | |
| rs49880590 | 177 | H>N | No | EVA | |
| rs265917866 | 271 | D>V | No | EVA | |
| rs3389387900 | 289 | G>S | No | EVA | |
| rs242209047 | 290 | A>T | No | EVA | |
| rs3389387845 | 290 | A>V | No | EVA | |
| rs3389381213 | 307 | G>R | No | EVA | |
| rs3389332752 | 323 | K>T | No | EVA | |
| rs3389351777 | 345 | K>N | No | EVA | |
| rs252614717 | 383 | A>T | No | EVA | |
| rs3389391383 | 386 | V>A | No | EVA | |
| rs864284746 | 396 | A>P | No | EVA | |
| rs3389382067 | 412 | T>N | No | EVA | |
| rs3389380211 | 442 | I>F | No | EVA | |
| rs3389397328 | 442 | I>N | No | EVA | |
| rs3389381172 | 480 | C>Y | No | EVA | |
| rs3389381227 | 497 | C>S | No | EVA | |
| rs3389332692 | 498 | T>I | No | EVA | |
| rs3389380240 | 507 | E>* | No | EVA | |
| rs3389380240 | 507 | E>K | No | EVA | |
| rs3389376442 | 557 | C>W | No | EVA | |
| rs3389372729 | 557 | C>Y | No | EVA | |
| rs3389377526 | 562 | S>L | No | EVA | |
| rs3389372690 | 578 | S>P | No | EVA | |
| rs3389397376 | 600 | L>F | No | EVA | |
| rs3389387878 | 627 | L>P | No | EVA | |
| rs3389382097 | 637 | W>L | No | EVA | |
| rs3389397336 | 637 | W>R | No | EVA | |
| rs3389391346 | 655 | P>T | No | EVA | |
| rs3389362865 | 661 | R>C | No | EVA | |
| rs3389351699 | 688 | T>S | No | EVA | |
| rs3389300057 | 696 | T>N | No | EVA | |
| rs3389391353 | 711 | F>S | No | EVA | |
| rs3389375376 | 725 | F>Y | No | EVA | |
| rs3389351763 | 729 | K>N | No | EVA | |
| rs50813147 | 732 | H>Y | No | EVA | |
| rs3389382028 | 735 | N>K | No | EVA | |
| rs864281592 | 749 | K>E | No | EVA | |
| rs3389362836 | 791 | V>L | No | EVA | |
| rs31808964 | 798 | N>S | No | EVA | |
| rs3389397341 | 801 | S>Y | No | EVA | |
| rs3406382563 | 817 | P>A | No | EVA | |
| rs3406524078 | 818 | L>* | No | EVA | |
| rs3389377575 | 830 | N>K | No | EVA | |
| rs3389381203 | 842 | T>I | No | EVA | |
| rs3389372664 | 905 | P>S | No | EVA | |
| rs3389387848 | 909 | P>S | No | EVA | |
| rs3389385976 | 935 | L>V | No | EVA | |
| rs3551929684 | 970 | G>S | No | EVA | |
| rs3389385939 | 1041 | R>L | No | EVA | |
| rs3389381195 | 1053 | N>I | No | EVA | |
| rs3389332696 | 1055 | T>N | No | EVA | |
| rs3389397381 | 1187 | V>M | No | EVA | |
| rs3389377562 | 1200 | V>M | No | EVA | |
| rs3389379828 | 1218 | V>A | No | EVA | |
| rs3389375436 | 1230 | Q>* | No | EVA | |
| rs3389397371 | 1266 | D>Y | No | EVA | |
| rs3389375392 | 1293 | S>T | No | EVA | |
| rs3389351712 | 1307 | D>N | No | EVA | |
| rs3552050949 | 1315 | I>M | No | EVA | |
| rs3551881103 | 1315 | I>V | No | EVA | |
| rs3389397346 | 1356 | S>T | No | EVA | |
| rs3389397389 | 1360 | V>A | No | EVA | |
| rs3389344942 | 1441 | V>M | No | EVA | |
| rs3389385893 | 1450 | Y>C | No | EVA | |
| rs3389332709 | 1464 | Y>C | No | EVA | |
| rs3389344925 | 1465 | A>T | No | EVA | |
| rs3389391370 | 1483 | V>D | No | EVA | |
| rs3389379866 | 1483 | V>I | No | EVA | |
| rs3389382032 | 1486 | L>F | No | EVA | |
| rs3389377533 | 1500 | D>A | No | EVA | |
| rs3389387841 | 1501 | Q>H | No | EVA | |
| rs3389332700 | 1525 | S>C | No | EVA | |
| rs3389332700 | 1525 | S>F | No | EVA | |
| rs3404834559 | 1536 | T>P | No | EVA | |
| rs3389379874 | 1539 | R>W | No | EVA | |
| rs3389332779 | 1540 | E>D | No | EVA | |
| rs3389385964 | 1541 | G>S | No | EVA | |
| rs3389344853 | 1549 | L>Q | No | EVA | |
| rs3389376445 | 1595 | L>S | No | EVA | |
| rs3389351727 | 1597 | R>W | No | EVA | |
| rs3406382565 | 1613 | K>T | No | EVA | |
| rs3389376490 | 1615 | K>I | No | EVA | |
| rs3389387846 | 1656 | P>A | No | EVA | |
| rs3389332758 | 1684 | K>N | No | EVA | |
| rs3389375433 | 1712 | V>L | No | EVA | |
| rs3406382589 | 1724 | M>V | No | EVA | |
| rs3389377485 | 1739 | P>S | No | EVA | |
| rs3389387816 | 1751 | T>I | No | EVA | |
| rs3389377501 | 1767 | V>L | No | EVA | |
| rs3389376436 | 1793 | V>A | No | EVA | |
| rs3389300088 | 1806 | Y>* | No | EVA | |
| rs3404834551 | 1814 | E>V | No | EVA | |
| rs3389377511 | 1826 | F>V | No | EVA |
No associated diseases with B2RXS4
8 regional properties for B2RXS4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Dbl homology (DH) domain | 23 - 214 | IPR000219 |
| domain | DEP domain | 390 - 464 | IPR000591-1 |
| domain | DEP domain | 492 - 566 | IPR000591-2 |
| conserved_site | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | 162 - 187 | IPR001331 |
| domain | PDZ domain | 592 - 674 | IPR001478-1 |
| domain | PDZ domain | 677 - 749 | IPR001478-2 |
| domain | Pleckstrin homology domain | 245 - 363 | IPR001849 |
| domain | PREX2, DEP domain 1 | 382 - 462 | IPR037367 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| collagen-containing extracellular matrix | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| semaphorin receptor complex | A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| semaphorin receptor activity | Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| excitatory synapse assembly | The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| negative regulation of cell adhesion | Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. |
| neural tube closure | The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. |
| neuroblast proliferation | The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. |
| positive regulation of axonogenesis | Any process that activates or increases the frequency, rate or extent of axonogenesis. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| positive regulation of translation | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
| regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. |
| regulation of neuron migration | Any process that modulates the frequency, rate or extent of neuron migration. |
| regulation of protein phosphorylation | Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. |
| semaphorin-plexin signaling pathway | The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. |
| semaphorin-plexin signaling pathway involved in axon guidance | Any semaphorin-plexin signaling pathway that is involved in axon guidance. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q769I5 | MET | Hepatocyte growth factor receptor | Bos taurus (Bovine) | PR |
| A0M8S8 | MET | Hepatocyte growth factor receptor | Felis catus (Cat) (Felis silvestris catus) | PR |
| Q04912 | MST1R | Macrophage-stimulating protein receptor | Homo sapiens (Human) | EV |
| P08581 | MET | Hepatocyte growth factor receptor | Homo sapiens (Human) | EV |
| O43157 | PLXNB1 | Plexin-B1 | Homo sapiens (Human) | EV SS |
| Q9HCM2 | PLXNA4 | Plexin-A4 | Homo sapiens (Human) | SS |
| O75051 | PLXNA2 | Plexin-A2 | Homo sapiens (Human) | SS |
| P51805 | PLXNA3 | Plexin-A3 | Homo sapiens (Human) | SS |
| Q9UIW2 | PLXNA1 | Plexin-A1 | Homo sapiens (Human) | EV SS |
| Q9ULL4 | PLXNB3 | Plexin-B3 | Homo sapiens (Human) | SS |
| O15031 | PLXNB2 | Plexin-B2 | Homo sapiens (Human) | SS |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| P70206 | Plxna1 | Plexin-A1 | Mus musculus (Mouse) | EV SS |
| P70207 | Plxna2 | Plexin-A2 | Mus musculus (Mouse) | SS |
| Q3UH93 | Plxnd1 | Plexin-D1 | Mus musculus (Mouse) | SS |
| Q80UG2 | Plxna4 | Plexin-A4 | Mus musculus (Mouse) | SS |
| Q8CJH3 | Plxnb1 | Plexin-B1 | Mus musculus (Mouse) | SS |
| Q9QY40 | Plxnb3 | Plexin-B3 | Mus musculus (Mouse) | SS |
| Q9QZC2 | Plxnc1 | Plexin-C1 | Mus musculus (Mouse) | SS |
| P70208 | Plxna3 | Plexin-A3 | Mus musculus (Mouse) | EV SS |
| Q2QLE0 | MET | Hepatocyte growth factor receptor | Sus scrofa (Pig) | PR |
| P97523 | Met | Hepatocyte growth factor receptor | Rattus norvegicus (Rat) | PR |
| D3ZPX4 | Plxna3 | Plexin-A3 | Rattus norvegicus (Rat) | SS |
| D3ZLH5 | Plxnb3 | Plexin-B3 | Rattus norvegicus (Rat) | SS |
| Q6BEA0 | plxna4 | Plexin-A4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| B0S5N4 | plxna3 | Plexin A3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALPLWALTF | LGLTGLGLSL | RSRKPESFRS | ETELNHLAVD | EVTGVVYVGA | VNALYQLSAD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LHVQQHVVTG | PFMDNKKCTP | PIEASQCHEA | VLTDNFNQLL | LLDPPGKRLV | ECGSLFKGIC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALRAMSNISV | RLFYEDGSGE | KSFVASNDER | VATVGLVTST | RPDGERVLFV | GKGNGPHDNG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IIVSTRLLDR | AEGREAFEAY | SDHTTFKAGY | LSTNTQQFVA | AFEDDFYVFF | VFNHQDKHPA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KNRTLLARMC | KDDPSYYSYV | EMDLQCQDPS | DPQDSAFGTC | LAASVATSGA | GRALYAVFSR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DGRSTGGPGA | GLCVFPLDKV | REKIEANRNA | CYTGAREAGR | TIFYKPFHGE | IQCGGHLIGA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SESFPCGSEH | LPYPLGSRDG | LVATAVLHRG | GLNLTAVTVT | AENDHTVAFL | GTSDGRILKV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YLAPDGTSAE | YGSIPVDINK | KIKQDLALSG | NLSSLYAMTQ | DKVFRLPVQE | CLSYVTCAQC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RDSQDPYCGW | CVIEGRCTRK | SECSRAEETG | HWLWSREKSC | VAITDAFPQN | MSRRAQGEVR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LSVSPLPTLT | EDDELLCLFG | DSPPHPARVE | DDTVICNSPS | SIPSTPPGQD | HVDVSIQLLL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KSGSVFLTSH | QYPFYDCREA | MSLVENLPCI | SCASNRWTCQ | WDLQYYECRE | ASPNPEEGII |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RAHMEDNCPQ | FLAPDPLVIP | MNHETEVTFQ | GKNLETVKVS | SLYVGSELLN | FEETVTMHES |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DTFSFRTPKL | SHDGNETLPL | HLYVKSFGKN | IDSKLQVTLY | NCSFGRSDCS | LCLAADPAYR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| CVWCRGQNRC | VYEALCSNVT | SECPPPVITR | IQPETGPLGG | GILVTIHGSN | LGVKADDVKK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ITVAGQNCAF | EPRGYSVSTR | IVCAIEASEM | PFTGGIEVDV | NGKLGHSPPH | VQFTYQQPQP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LSVEPRQGPQ | AGGTTLTING | THLDTGSKED | VRVTLNDVPC | EVTKFGAQLQ | CVTGQQLAPG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| QVTLEIYYGG | SRVPSPGISF | TYCENPMIRA | FEPLRSFVSG | GRSINVTGQG | FSLIQKFAMV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VIAEPLRSWR | RRRREAGALE | RVTVEGMEYV | FYNDTKVVFL | SPAVPEEPEA | YNLTVLIRMD |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| GHCAPLRTEA | GVFEYVADPT | FENFTGGVKK | QVNKLIHARG | TNLNKAMTLE | EAEAFVGAER |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| CIMKTLTETD | LYCEPPEVQP | PPKRRQKRDT | AHNLPEFIVK | FGSREWVLGR | VEYDTRASDV |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| PLSLILPLVM | VPMVFIIVVS | IYCYWRKSQQ | AEREYEKIKS | QLEGLEESVR | DRCKKEFTDL |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| MIEMEDQTND | VHEAGIPTLD | YKTYTDRVFF | LPSKDGDKDV | MITGKLDIPE | SRRPIVEQAL |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| YQFSNLLNSK | SFLINFIHTL | ENQREFSARA | KVYFASLLTV | ALHGKLEYYT | DIMRTLFLEL |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| MEQYVVAKNP | KLMLRRSETV | VERMLSNWMS | ICLYQYLKDS | AGEPLYKLFK | AIKHQVEKGP |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| VDAVQKKAKY | TLNDTGLLGD | DVEYAPLTVS | VIVQDEGIDA | IPVKVLNCDT | ISQVKEKIID |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| QVYRTQPCSC | WPKPDSVVLE | WRPGSTAQIL | SDLDLTSQRE | GRWKRINTLM | HYNVRDGATL |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| ILSKVGVSQQ | PEDSQQDLPG | ERHALLEEEN | RVWHLVRPTD | EVDEGKSKRG | SMKEKERTKA |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| ITEIYLTRLL | SVKGTLQQFV | DNFFQSVLAP | GHAVPPAVKY | FFDFLDEQAE | KHDIRDEDTI |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| HIWKTNSLPL | RFWVNILKNP | HFIFDVHVHE | VVDASLSVIA | QTFMDACTRT | EHKLSRDSPS |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| NKLLYAKEIS | TYKKMVEDYY | KGIRQMVQVS | DQDMNTHLAE | ISRAHTDSLN | TLVALHQLYQ |
| 1810 | 1820 | 1830 | 1840 | ||
| YTQKYYDEII | NALEEDPAAQ | KMQLAFRLQQ | IAAALENKVT | DL |