B0S5N4

SS
Gene name
plxna3 (si:dkey-7i23.3)
Protein name
Plexin A3
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:567422
EC number
Protein Class

Descriptions

PlexA1 (NOV, PLXN1) plays a role in axon guidance, invasive growth and cell migration. Sema domain of PlexA1 restricts PlexA1 to a basal inactive state by binding to the remainder of the ectodomain. Deletion analysis of the PlexinA1 ectodomain demonstrates that the sema domain prevents PlexinA1 activation in the basal state. Sema-deleted PlexinA1 is constitutively active, producing cell contraction, growth cone collapse, and inhibition of neurite outgrowth. Plexin A1 is autoinhibited by its sema domain, and Sema3A/NP1 releases this inhibition. According to mouse Plexin-A3 (P70208), Plexin may possess a segment preceding C1 domain and an RDB domain as autoinhibitory elements.

Autoinhibitory domains (AIDs)

18-509 (Sema domain) SS

Target domain

1314-1862 (Plexin, cytoplasmic RasGAP domain)

Relief mechanism

Partner binding

Assay

1264-1344 (Segment preceding C1 domain) SS

Target domain

1314-1862 (Plexin, RasGAP domain)

Relief mechanism

Assay

1470-1670 (RBD domain) SS

Target domain

1314-1862 (Plexin, RasGAP domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0S5N4

Entry ID Method Resolution Chain Position Source
AF-B0S5N4-F1 Predicted AlphaFoldDB

No variants for B0S5N4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0S5N4

No associated diseases with B0S5N4

15 regional properties for B0S5N4

Type Name Position InterPro Accession
domain Sema domain 20 - 509 IPR001627
repeat Plexin repeat 511 - 552 IPR002165-1
repeat Plexin repeat 658 - 701 IPR002165-2
repeat Plexin repeat 807 - 851 IPR002165-3
domain IPT domain 860 - 955 IPR002909-1
domain IPT domain 956 - 1041 IPR002909-2
domain IPT domain 1043 - 1143 IPR002909-3
domain IPT domain 1145 - 1240 IPR002909-4
domain Plexin, cytoplasmic RasGAP domain 1315 - 1862 IPR013548
domain PSI domain 511 - 561 IPR016201-1
domain PSI domain 658 - 705 IPR016201-2
domain PSI domain 806 - 859 IPR016201-3
domain Plexin, TIG domain 1 566 - 657 IPR041019
domain Plexin, TIG domain 2 712 - 805 IPR041362
domain Plexin, cytoplasmic RhoGTPase-binding domain 1484 - 1596 IPR046800

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
semaphorin receptor complex A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

2 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

11 GO annotations of biological process

Name Definition
axon extension Long distance growth of a single axon process involved in cellular development.
branching morphogenesis of a nerve The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).
cardiac chamber development The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.
embryonic skeletal joint morphogenesis The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton.
motor neuron axon guidance The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of collateral sprouting in absence of injury Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury.
semaphorin-plexin signaling pathway involved in axon guidance Any semaphorin-plexin signaling pathway that is involved in axon guidance.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
A0M8S8 MET Hepatocyte growth factor receptor Felis catus (Cat) (Felis silvestris catus) PR
Q04912 MST1R Macrophage-stimulating protein receptor Homo sapiens (Human) EV
P08581 MET Hepatocyte growth factor receptor Homo sapiens (Human) EV
O43157 PLXNB1 Plexin-B1 Homo sapiens (Human) EV SS
Q9HCM2 PLXNA4 Plexin-A4 Homo sapiens (Human) SS
O75051 PLXNA2 Plexin-A2 Homo sapiens (Human) SS
Q9UIW2 PLXNA1 Plexin-A1 Homo sapiens (Human) EV SS
O15031 PLXNB2 Plexin-B2 Homo sapiens (Human) SS
Q9ULL4 PLXNB3 Plexin-B3 Homo sapiens (Human) SS
P51805 PLXNA3 Plexin-A3 Homo sapiens (Human) SS
Q9QY40 Plxnb3 Plexin-B3 Mus musculus (Mouse) SS
Q3UH93 Plxnd1 Plexin-D1 Mus musculus (Mouse) SS
P70207 Plxna2 Plexin-A2 Mus musculus (Mouse) SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
B2RXS4 Plxnb2 Plexin-B2 Mus musculus (Mouse) SS
Q8CJH3 Plxnb1 Plexin-B1 Mus musculus (Mouse) SS
Q9QZC2 Plxnc1 Plexin-C1 Mus musculus (Mouse) SS
Q80UG2 Plxna4 Plexin-A4 Mus musculus (Mouse) SS
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
P70206 Plxna1 Plexin-A1 Mus musculus (Mouse) EV SS
P70208 Plxna3 Plexin-A3 Mus musculus (Mouse) EV SS
Q2QLE0 MET Hepatocyte growth factor receptor Sus scrofa (Pig) PR
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
D3ZLH5 Plxnb3 Plexin-B3 Rattus norvegicus (Rat) SS
D3ZPX4 Plxna3 Plexin-A3 Rattus norvegicus (Rat) SS
Q6BEA0 plxna4 Plexin-A4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MRSLWLLVFS FSVLTGTNMA FPMILSERPE VTGSFKVKDT SLTHLTVHRK TGEVFVGAIN
70 80 90 100 110 120
RVYKLSANLT ETRSHQTGPV EDNAKCYPPP SVRACTQKLE STDNVNKLLL VDYAGNRLVA
130 140 150 160 170 180
CGSIWQGVCQ FLRLEDLFKL GEPHHRKEHY LSGAKESDGM AGVVVGDDDG DLKKKKKGGS
190 200 210 220 230 240
RLFIGAAIDG KSEYFPTLSS RKLVADEESV NMFSLVYQDE FVSSQIKIPS DTLSQYPAFD
250 260 270 280 290 300
IYYVYGFSSR TYIYFLTLQL DTQLTQVDVT GEKFFTSKIV RMCSNDTEFY SYVEFPLGCT
310 320 330 340 350 360
KDGVEYRLVQ AAYKHRPGKI LAQALGLSED EDVLFVIFSQ GQKNRANPPR ETVLCLFTLH
370 380 390 400 410 420
QINLAMRERI KSCYRGEGKL SLPWLLNKEL PCINTPKQIG DDFCGLVLNQ PLGGLMVIEG
430 440 450 460 470 480
IPLFDDRTDG MASVAAYTYG DHSVVFVGTR SGHLKKIRVN GVPPPSENAL LYETVTVVEG
490 500 510 520 530 540
SPILRDMVFS PDYQYIYLLS DKQVSRLPVE SCSQYSSCKT CLGSGDPHCG WCVLHNKCSR
550 560 570 580 590 600
KEACEKWAEP LHFSTELKQC VDITVTPDNM SVTSVSTQLS VKVANVPNLS AGVTCVFEEL
610 620 630 640 650 660
TESPGEVLAE GQILCMSPSL RDVPSVTQGY GDKRVVKLSL KSKETGLKFI TTDFVFYNCS
670 680 690 700 710 720
VLQSCSSCVS SPFPCNWCKY RHICTNNVAE CSFQEGRVSS AEGCPQILPS SDILVPAGIV
730 740 750 760 770 780
RPITLRARNL PQPQSGQKNY ECVFNIQGKV QRIPAVRFNS SCIQCQNTSY WYEGNEMGDL
790 800 810 820 830 840
PVDFSIVWDG DFPIDKPSSM RALLYKCEAQ RDSCGLCLKA DSTFECGWCL ADKKCLLKQH
850 860 870 880 890 900
CPSAEHNWMH QGRRNIRCSH PRITKIRPLT GPKEGGTRVT IEGENLGLQV REITHVRVAG
910 920 930 940 950 960
VRCNPAAAEY ISAERIVCDM EESLMSSPPG GPVELCIGDC SAEYRTQSTQ TYSFVMPSFS
970 980 990 1000 1010 1020
RVRPEKGPVS GGTRLTISGR HLDAGSAVTV FLAQEECLFV RRTVREIVCV TPPSASGSGP
1030 1040 1050 1060 1070 1080
SSVKLFIDKA EITSDTRYIY TEDPNISTIE PNWSIINGST SLTVTGTNLL TIQEPKVRAK
1090 1100 1110 1120 1130 1140
YGGVETTNIC SLVNDSVMTC LAPGIIYTKR EAPESGVHPD EFGFILDHVS ALLILNGTPF
1150 1160 1170 1180 1190 1200
TYYPNPTFEP LGNAGILEVK PGSPIILKGK NLIPPAPGNI RLNYSVTIGE TPCLLTVSES
1210 1220 1230 1240 1250 1260
QLLCDSPDLT GEQRVMILVG GLEYSPGMLH IYSDSTLTLP AIIGIGAGGG VLLIAIIAVL
1270 1280 1290 1300 1310 1320
IAYKRKTRDA DRTLKRLQLQ MDNLESRVAL ECKEAFAELQ TDIQELTNDM DGVKIPFLEY
1330 1340 1350 1360 1370 1380
RTYTMRVMFP GIEEHPVLKE LDSPANVEKA LRLFSQLLHN KMFLLTFIHT LEAQRSFSMR
1390 1400 1410 1420 1430 1440
DRGNVASLLM AALQGRMEYA TVVLKQLLAD LIEKNLENRN HPKLLLRRTE SVAEKMLTNW
1450 1460 1470 1480 1490 1500
FTFLLHRFLK ECAGEPLFML YCAIKQQMEK GPIDAITGEA RYSLSEDKLI RQQIDYKQLT
1510 1520 1530 1540 1550 1560
LMCIPPEGEA GTEIPVKVLN CDTITQVKDK LLDAVYKGIP YSQRPQADDM DLEWRQGRLT
1570 1580 1590 1600 1610 1620
RIILQDEDVT TKIESDWKRL NTLAHYQVTD GSLVALVQKQ VSAYNIANSF TFTRSLSRYE
1630 1640 1650 1660 1670 1680
SLLRTSSSPD SLRSRAPMIT PDQETGTKLW HLVKNHEHAD QREGDRGSKM VSEIYLTRLL
1690 1700 1710 1720 1730 1740
ATKGTLQKFV DDLFETVFST AHRGSALPLA IKYMFDFLDE QADKRQITDP DVRHTWKSNC
1750 1760 1770 1780 1790 1800
LPLRFWVNVI KNPQFVFDIH KNSITDACLS VVAQTFMDSC STSEHRLGKD SPSNKLLYAK
1810 1820 1830 1840 1850 1860
DIPNYKSWVE RYYRDISKMP SISDQDMDAY LVEQSRLHGN EFNTLSALSE LYFYINKYKE
1870 1880 1890
EILTALDRDG YCRKHKLRHK LEQAINLMSG SS