B0LT89

PR
Gene name
Stk24 (Mst3, Stk3)
Protein name
Serine/threonine-protein kinase 24
Names
Mammalian STE20-like protein kinase 3, MST-3, MST3b, STE20-like kinase MST3
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:361092
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

161-184 (Activation loop from InterPro)

Target domain

24-274 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for B0LT89

Entry ID Method Resolution Chain Position Source
AF-B0LT89-F1 Predicted AlphaFoldDB

1 variants for B0LT89

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3322869544 317 S>T No EVA

No associated diseases with B0LT89

3 regional properties for B0LT89

Type Name Position InterPro Accession
domain Protein kinase domain 50 - 316 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 54 - 310 IPR001245
active_site Serine/threonine-protein kinase, active site 167 - 179 IPR008271

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Membrane
  • The truncated form (MST3/N) translocates to the nucleus
  • Colocalizes with STK38L in the membrane (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

9 GO annotations of biological process

Name Definition
cellular response to starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
execution phase of apoptosis A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
intrinsic apoptotic signaling pathway in response to oxidative stress The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
negative regulation of cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
positive regulation of axon regeneration Any process that activates, maintains or increases the rate of axon regeneration.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of axon regeneration Any process that modulates the frequency, rate or extent of axon regeneration.
response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SWY6 STK25 Serine/threonine-protein kinase 25 Bos taurus (Bovine) PR
P41279 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Homo sapiens (Human) EV
O00506 STK25 Serine/threonine-protein kinase 25 Homo sapiens (Human) PR
Q9P289 STK26 Serine/threonine-protein kinase 26 Homo sapiens (Human) PR
Q9Y6E0 STK24 Serine/threonine-protein kinase 24 Homo sapiens (Human) PR
Q07174 Map3k8 Mitogen-activated protein kinase kinase kinase 8 Mus musculus (Mouse) SS
Q9Z2W1 Stk25 Serine/threonine-protein kinase 25 Mus musculus (Mouse) PR
Q99JT2 Stk26 Serine/threonine-protein kinase 26 Mus musculus (Mouse) PR
Q99KH8 Stk24 Serine/threonine-protein kinase 24 Mus musculus (Mouse) PR
Q63562 Map3k8 Mitogen-activated protein kinase kinase kinase 8 Rattus norvegicus (Rat) SS
O88506 Stk39 STE20/SPS1-related proline-alanine-rich protein kinase Rattus norvegicus (Rat) PR
Q924I2 Map4k3 Mitogen-activated protein kinase kinase kinase kinase 3 Rattus norvegicus (Rat) PR
E9PTG8 Stk10 Serine/threonine-protein kinase 10 Rattus norvegicus (Rat) PR
H2L099 gck-1 Germinal center kinase 1 Caenorhabditis elegans PR
10 20 30 40 50 60
MAHSPVQSGL PGMQTLKADP EELFTKLEKI GKGSFGEVFK GIDNRTQKVV AIKIIDLEEA
70 80 90 100 110 120
EDEIEDIQQE ITVLSQCDSP YVTKYYGSYL KDTKLWIIME YLGGGSALDL LEPGPLDEIQ
130 140 150 160 170 180
IATILREILK GLDYLHSEKK IHRDIKAANV LLSEHGEVKL ADFGVAGQLT DTQIKRNTFV
190 200 210 220 230 240
GTPFWMAPEV IKQSAYDSKA DIWSLGITAI ELAKGEPPHS ELHPMKVLFL IPKNNPPTLE
250 260 270 280 290 300
GSYSRPLKEF VEACLNKEPS FRPTAKELLK HKFIIRNAKK TSYLTELIDR YKRWKAEQSH
310 320 330 340 350 360
EDSSSEDSDV ETDSQASGGS DSGDWIFTIR EKDPKNLENG TLQPSDLERN KMKDFPKRPF
370 380 390 400 410 420
SQCLSTIISP LFAELKEKSQ ACGGNLGSIE ELRGAIYLAE EACPGISDTM VAQLVQRLQR
430
YSLSGGGASA H