AiPD: Autoinhibited Protein Database

B0I1T2

Gene name	MYO1G (HA2)
Protein name	Unconventional myosin-Ig
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:64005
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

463-534 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

463-534 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for B0I1T2

Entry ID	Method	Resolution	Chain	Position	Source
AF-B0I1T2-F1	Predicted				AlphaFoldDB

897 variants for B0I1T2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA4246736 rs762899403	2	E>D		No	ClinGen ExAC gnomAD
CA4246734 rs769523482	4	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	5	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367423430 rs1472879606	5	E>D		No	ClinGen gnomAD
rs374494970 CA4246733	5	E>K		No	ClinGen ESP ExAC gnomAD
rs1009219002 CA157961201	6	G>V		No	ClinGen TOPMed gnomAD
rs76849948 CA4246732	7	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768013797 CA4246731	8	E>V		No	ClinGen ExAC gnomAD
rs1282493620 CA367423410	9	Y>D		No	ClinGen TOPMed
rs1282493620 CA367423412	9	Y>N		No	ClinGen TOPMed
rs746381955 CA4246730	12	P>H		No	ClinGen ExAC gnomAD
CA367423373 rs1210365013	14	F>S		No	ClinGen TOPMed gnomAD
CA367423362 rs771418567	16	L>F		No	ClinGen ExAC gnomAD
rs1277428289 CA367423361	16	L>H		No	ClinGen TOPMed
CA4246728 rs771418567	16	L>V		No	ClinGen ExAC gnomAD
CA4246727 rs140641126	18	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1381479531 CA367423344	19	Q>E		No	ClinGen gnomAD
CA367423336 rs1282619821	20	V>M		No	ClinGen gnomAD
CA367423288 rs1456032916	26	M>K		No	ClinGen gnomAD
CA367423290 rs1322901689	26	M>V		No	ClinGen gnomAD
rs752816329 CA4246724	29	L>M		No	ClinGen ExAC TOPMed gnomAD
rs781334286 CA4246723	30	Q>R		No	ClinGen ExAC gnomAD
CA367423254 rs1415275728	31	L>F		No	ClinGen gnomAD
CA367423232 rs1221311302	32	R>S		No	ClinGen gnomAD
rs201659933 CA4246700	34	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs756945855 CA4246699	36	G>S		No	ClinGen ExAC gnomAD
rs1403760167 CA367423204	36	G>V		No	ClinGen gnomAD
CA4246698 rs370803021	37	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs763720788 COSM3412096 CA4246697	37	R>H	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs376133572 CA157960110	42	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs376133572 CA4246695	42	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA367423165 rs1434758148	43	G>S		No	ClinGen gnomAD
CA367423146 rs1198668372	45	V>G		No	ClinGen gnomAD
TCGA novel	48	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs61739531 VAR_044013 CA4246690	49	V>M	allele HA-2M; the HA-2V allele constitute the HA-2 epitope while HA-2M is not recognized by HA-2 cytotoxic T lymphocytes [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1583797810 CA367423120	50	N>T		No	ClinGen Ensembl
rs1460513424 CA367423113	51	P>S		No	ClinGen TOPMed
CA367423106 rs1583797801	52	Y>S		No	ClinGen Ensembl
rs201545083 CA4246688	53	Q>K		No	ClinGen ExAC gnomAD
CA4246687 rs769048455	55	L>R		No	ClinGen ExAC gnomAD
rs747178161 CA4246686	56	P>L		No	ClinGen ExAC gnomAD
rs200838066 CA157960082	56	P>S		No	ClinGen 1000Genomes
CA367423076 rs1352900250	57	L>P		No	ClinGen TOPMed gnomAD
rs148775890 CA367423077	57	L>V		No	ClinGen ESP ExAC gnomAD
CA367423062 rs1291223575	59	G>E		No	ClinGen TOPMed
CA4246683 rs201090665	60	P>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1395305645 CA367423050	61	E>G		No	ClinGen gnomAD
rs62461376 CA157960062	62	A>S		No	ClinGen Ensembl
rs757215110 CA367423033	64	A>S		No	ClinGen ExAC gnomAD
rs757215110 CA4246681	64	A>T		No	ClinGen ExAC gnomAD
rs1583797741 CA367423030	64	A>V		No	ClinGen Ensembl
CA4246680 rs753620320	66	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	68	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4246678 rs755789331	68	G>S		No	ClinGen ExAC TOPMed gnomAD
CA4246677 rs752308636	69	R>C		No	ClinGen ExAC TOPMed gnomAD
rs145958021 CA4246675	69	R>H		No	ClinGen 1000Genomes ESP TOPMed gnomAD
CA157960008 rs1025495092	71	L>P		No	ClinGen Ensembl
CA4246673 rs759102137	72	Y>S		No	ClinGen ExAC gnomAD
CA367422976 rs1183871224	73	E>K		No	ClinGen TOPMed gnomAD
CA4246671 rs144045009	74	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
COSM1090025 CA4246672 rs538169011	74	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA367422963 rs1255888194	75	P>L		No	ClinGen TOPMed
CA157959984 rs771794310	75	P>S		No	ClinGen Ensembl
rs1209756872 CA367422960	76	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	79	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs895308524 CA157959975	79	Y>C		No	ClinGen TOPMed
CA367422939 rs895308524	79	Y>F		No	ClinGen TOPMed
CA157959972 rs969917828	81	V>L		No	ClinGen TOPMed gnomAD
rs776880632 CA4246669	82	A>S		No	ClinGen ExAC gnomAD
CA367422916 rs1583797602	83	N>T		No	ClinGen Ensembl
CA4246668 rs769101475	84	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4246666 rs377581554	85	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA367422897 rs1446033272	86	Y>C		No	ClinGen Ensembl
rs746002482 CA4246664	87	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1461748486 CA367422886	88	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs779019726 CA4246662	89	M>I		No	ClinGen ExAC gnomAD
rs368929221 CA157959938	89	M>L		No	ClinGen ESP TOPMed
rs1269290300 CA367422873	90	K>Q		No	ClinGen TOPMed
CA4246661 rs770827963	91	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA4246659 rs139094604	92	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs199877330 CA4246660	92	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	93	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1278788997 CA367422849	94	R>G		No	ClinGen TOPMed
CA367422835 rs755842091	95	D>E		No	ClinGen ExAC TOPMed gnomAD
CA4246657 rs752474007	96	T>A		No	ClinGen ExAC gnomAD
CA4246656 rs146195000	96	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA4246655 rs146195000	96	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA4246654 rs146195000	96	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1395799151 CA367422829	97	C>Y		No	ClinGen TOPMed
rs1265444844 CA367422822	98	I>F		No	ClinGen gnomAD
CA4246651 rs773866590	99	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs764568895 CA4246650	102	G>W		No	ClinGen ExAC gnomAD
rs376285247 CA157959764	103	E>Q		No	ClinGen Ensembl
CA4246620 rs748025444	105	G>E		No	ClinGen ExAC TOPMed gnomAD
CA367422761 rs1270520109	106	A>T		No	ClinGen gnomAD
CA4246619 rs776440562	107	G>E		No	ClinGen ExAC gnomAD
rs779815381 CA4246616	109	T>K		No	ClinGen ExAC gnomAD
TCGA novel	110	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4246615 rs79603179	110	E>K		No	ClinGen ExAC gnomAD
CA367422719 rs1562834432	112	S>N		No	ClinGen Ensembl
CA367422717 rs1289002157	112	S>R		No	ClinGen gnomAD
rs541825395 CA157959749	114	H>Y		No	ClinGen TOPMed
CA4246613 rs778545686	117	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs778545686 CA367422684	117	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs915741324 CA157959743	120	A>G		No	ClinGen TOPMed
rs372361298 CA4246611	120	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs202131850 CA157959733	121	A>S		No	ClinGen Ensembl
rs369562485 CA4246610	124	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1413366209 CA367422635	125	P>S		No	ClinGen gnomAD
rs1470917691 CA367422594	130	E>D		No	ClinGen gnomAD
rs751862160 CA4246608	132	E>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	133	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4246607 rs766661597	133	R>T		No	ClinGen ExAC
CA367422558 rs1269762882	134	V>D		No	ClinGen TOPMed gnomAD
CA367422535 rs1460734918	137	V>G		No	ClinGen gnomAD
CA4246592 rs201682799	137	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367422510 rs1248541005	141	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA367422508 rs1170701280	142	T>A		No	ClinGen TOPMed
rs933845034 CA367422506	142	T>I		No	ClinGen TOPMed gnomAD
CA157959254 rs933845034	142	T>S		No	ClinGen TOPMed gnomAD
rs781753632 CA4246591	143	C>R		No	ClinGen ExAC gnomAD
CA4246590 rs149320563	143	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs780229491 CA4246588	144	V>M		No	ClinGen ExAC gnomAD
TCGA novel	145	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1386001080 CA367422479	147	A>T		No	ClinGen TOPMed
rs1318754883 CA367422456	150	N>S		No	ClinGen Ensembl
rs750576329 CA4246585	152	R>C		No	ClinGen ExAC TOPMed gnomAD
CA4246584 rs138665059	152	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA367422443 rs138665059	152	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1583796138 CA367422442	153	T>P		No	ClinGen Ensembl
rs1345130239 CA367422432	154	N>S		No	ClinGen gnomAD
CA4246582 rs761496818	155	R>C		No	ClinGen ExAC TOPMed gnomAD
CA4246581 rs764134145 COSM1450978	155	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA367422425 rs764134145	155	R>L		No	ClinGen ExAC gnomAD
rs760508039 CA4246580	156	N>S		No	ClinGen ExAC gnomAD
CA367422413 rs1443650788	157	H>R		No	ClinGen gnomAD
rs1419921255 CA367422406	158	N>T		No	ClinGen gnomAD
CA367422397 rs1583796068	159	S>F		No	ClinGen Ensembl
CA4246579 rs775378186	159	S>P		No	ClinGen ExAC gnomAD
CA157959199 rs983810090 COSM400676	161	R>C	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
rs771955737 CA4246578	161	R>H		No	ClinGen ExAC TOPMed gnomAD
CA4246576 rs774092283	163	G>R		No	ClinGen ExAC gnomAD
rs1224686153 CA367422368	164	K>R		No	ClinGen TOPMed
rs770696573 CA4246575	165	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs748844106 CA4246574	167	D>V		No	ClinGen ExAC
rs1305178170 CA367422329	169	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1583796011 CA367422325	170	F>V		No	ClinGen Ensembl
rs1468066992 CA367422291	174	G>A		No	ClinGen TOPMed
CA4246572 rs150595238	174	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA4246571 rs150595238	174	G>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1213236080 CA367422276	176	P>L		No	ClinGen gnomAD
rs1583795956 CA367422274	177	I>V		No	ClinGen Ensembl
CA4246569 rs758703751	178	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1366837300 CA367422264	178	G>V		No	ClinGen gnomAD
rs779172188 CA4246567	181	I>M		No	ClinGen ExAC TOPMed gnomAD
CA4246565 rs200185437	186	L>P		No	ClinGen 1000Genomes ExAC gnomAD
rs757493511 CA4246546	189	S>C		No	ClinGen ExAC TOPMed gnomAD
rs777917603 CA4246545	190	R>L		No	ClinGen ExAC TOPMed gnomAD
rs777917603 CA367422176	190	R>P		No	ClinGen ExAC TOPMed gnomAD
rs777917603 CA4246544 COSM1090021	190	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA367422177 rs1205985181	190	R>W		No	ClinGen gnomAD
TCGA novel	192	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367422159 rs1203998039	193	K>R		No	ClinGen gnomAD
CA367422153 rs1234875645	194	Q>*		No	ClinGen TOPMed
CA367422155 rs1234875645	194	Q>E		No	ClinGen TOPMed
rs535530112 CA4246542	195	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA4246541 COSM283059 rs767632037	196	V>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	197	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	201	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4246538 rs761378235	203	A>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4246539 rs761378235	203	A>S		No	ClinGen ExAC TOPMed gnomAD
CA157958893 rs761378235	203	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4246537 rs762667215	205	Y>*		No	ClinGen ExAC gnomAD
rs1337132547 CA367422068	206	Q>R		No	ClinGen gnomAD
CA367422037 rs1314998636	209	R>S		No	ClinGen TOPMed
TCGA novel	210	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774786191 CA4246512	211	S>N		No	ClinGen ExAC gnomAD
rs771458391 CA4246511	212	E>K		No	ClinGen ExAC gnomAD
CA367422010 rs1223524496	213	D>G		No	ClinGen TOPMed
CA367421990 rs1260341217	216	L>V		No	ClinGen gnomAD
rs1291897339 CA367421982	217	H>R		No	ClinGen gnomAD
CA367421984 rs1487704049	217	H>Y		No	ClinGen gnomAD
CA157954647 rs773599271	218	E>*		No	ClinGen ExAC gnomAD
CA4246507 rs145240682	218	E>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs145240682 CA4246508	218	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4246509 rs773599271	218	E>K		No	ClinGen ExAC gnomAD
rs371408293 CA367421960	220	H>Q		No	ClinGen ESP ExAC gnomAD
rs138286002 CA4246505	220	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1470198210 CA367421927	223	R>G		No	ClinGen TOPMed
rs779921725 CA367421920	223	R>I		No	ClinGen ExAC TOPMed gnomAD
rs779921725 CA4246503	223	R>K		No	ClinGen ExAC TOPMed gnomAD
CA367421899 rs1381701299	225	P>T		No	ClinGen gnomAD
rs778721252 CA4246501	226	A>P		No	ClinGen ExAC gnomAD
rs778721252 CA4246502	226	A>S		No	ClinGen ExAC gnomAD
rs778721252 CA4246500	226	A>T		No	ClinGen ExAC gnomAD
rs149988287 CA4246499	226	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1038376929 CA157954619	229	N>D		No	ClinGen TOPMed gnomAD
CA367421849 rs1165905258	229	N>S		No	ClinGen TOPMed
CA367421819 rs1365203672	231	T>I		No	ClinGen TOPMed gnomAD
rs753424886 CA4246498	232	H>N		No	ClinGen ExAC TOPMed gnomAD
CA367421791 rs1371823383	233	Q>H		No	ClinGen TOPMed gnomAD
CA367421781 rs1193038507	234	G>A		No	ClinGen TOPMed gnomAD
rs1193038507 CA367421783	234	G>E		No	ClinGen TOPMed gnomAD
CA367421788 rs1443039069	234	G>R		No	ClinGen TOPMed
CA157954612 rs1002575674	235	A>G		No	ClinGen TOPMed gnomAD
CA4246497 rs763609190	236	G>E		No	ClinGen ExAC gnomAD
rs1315533665 CA367421730	239	M>L		No	ClinGen TOPMed
CA4246496 rs565338681	239	M>T		No	ClinGen 1000Genomes ExAC gnomAD
CA4246495 rs752202083	240	T>I		No	ClinGen ExAC gnomAD
CA367421689 COSM50559 rs1341279319	242	H>Q	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1331079679 CA367421607	245	L>F		No	ClinGen TOPMed gnomAD
CA367421610 rs1334213413	245	L>S		No	ClinGen gnomAD
CA367421576 rs1408903947	247	S>R		No	ClinGen gnomAD
CA367421488 rs1487017478	254	A>E		No	ClinGen gnomAD
rs1158645708 COSM1239528 CA367421491	254	A>T	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
rs868581313 CA157954388	256	T>I		No	ClinGen TOPMed gnomAD
rs745778626 CA4246484	257	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1201645863 CA367421467	258	A>T		No	ClinGen gnomAD
rs1225589960 CA367421456	259	M>I		No	ClinGen gnomAD
rs145850475 CA4246482	259	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145850475 CA4246481	259	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs61742025 CA4246480	260	R>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200568970 CA367421445	261	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4246479 rs200568970	261	V>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367421442 rs1385380744	262	I>V		No	ClinGen gnomAD
CA4246478 rs752201322	263	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA367421429 rs1346321841	264	F>V		No	ClinGen gnomAD
rs1318392118 CA367421422	265	S>G		No	ClinGen gnomAD
rs1343084944 CA367421415	266	P>S		No	ClinGen TOPMed
CA157954339 rs199503090	267	E>K		No	ClinGen 1000Genomes
CA367421372 rs1583791929	269	V>G		No	ClinGen Ensembl
rs1402009966 CA367421380	269	V>M		No	ClinGen gnomAD
CA367421366 rs1231794549	270	E>*		No	ClinGen TOPMed
CA367421328 rs1157622831	273	H>D		No	ClinGen gnomAD
CA4246476 rs576547378	273	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367421312 rs1386789972	274	R>C		No	ClinGen gnomAD
rs750882648 CA4246475	274	R>H		No	ClinGen ExAC TOPMed gnomAD
rs149854663 CA4246474	275	I>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200523348 CA4246473	276	L>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367421283 rs1217998609	277	A>P		No	ClinGen gnomAD
rs1562831597 CA367421277	277	A>V		No	ClinGen Ensembl
CA367421273 rs1445403339	278	A>T		No	ClinGen gnomAD
rs777103562 CA4246472	278	A>V		No	ClinGen ExAC gnomAD
CA367421264 rs1223457342	279	I>L		No	ClinGen gnomAD
CA367421262 rs1223457342	279	I>V		No	ClinGen gnomAD
CA367421233 rs1268350673	281	H>P		No	ClinGen TOPMed
rs900047377 CA157954320	281	H>Y		No	ClinGen TOPMed
rs867736209 CA157954314	282	L>P		No	ClinGen Ensembl
rs1361872538 CA367421223	282	L>V		No	ClinGen gnomAD
CA4246462 rs755789533	286	E>K		No	ClinGen ExAC gnomAD
CA367421114 rs1374099795	286	E>V		No	ClinGen TOPMed
rs141019616 CA4246461	288	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs141019616 CA367421094	288	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA4246460 rs201309689	290	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
COSM313059 rs1172281136 CA367421047	291	E>D	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs202161315 CA157953859	292	E>K		No	ClinGen Ensembl
CA367421025 rs1463950578	293	G>C		No	ClinGen gnomAD
rs1481483839 CA367420967	298	E>K		No	ClinGen gnomAD
TCGA novel	299	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1202937495 CA367420927	301	A>E		No	ClinGen gnomAD
rs765884251 CA4246456	301	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1317833703 CA367420914	302	V>A		No	ClinGen gnomAD
CA4246454 rs144037510	304	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA367420881 rs760984092	305	E>D		No	ClinGen ExAC gnomAD
rs139240752 CA4246453	305	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA367420867 rs1218211374	306	A>V		No	ClinGen gnomAD
rs775723751 CA4246451	307	L>Q		No	ClinGen ExAC gnomAD
rs1399419760 CA367420851	308	V>A		No	ClinGen TOPMed gnomAD
CA4246449 rs759730175	308	V>L		No	ClinGen ExAC gnomAD
CA157953802 rs963986926	310	H>Y		No	ClinGen gnomAD
CA367420790 rs1419877433	313	E>K		No	ClinGen gnomAD
rs1410522053 CA367420784	313	E>V		No	ClinGen gnomAD
rs1272794251 CA367420773	314	L>Q		No	ClinGen TOPMed gnomAD
CA367420763 rs774267015	315	T>K		No	ClinGen ExAC TOPMed gnomAD
rs774267015 CA4246448 COSM1450975	315	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA367420761 rs774267015	315	T>R		No	ClinGen ExAC TOPMed gnomAD
CA367420735 rs1403430680	317	T>I		No	ClinGen TOPMed
CA367420714 rs201269538	319	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4246445 rs201269538	319	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367420720 rs1322760502	319	R>W		No	ClinGen TOPMed
CA4246443 rs529814356	322	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs754554734 CA4246441	324	R>C		No	ClinGen ExAC TOPMed gnomAD
rs762665139 COSM1450974 CA4246440	324	R>H	large_intestine haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs779661449 CA4246439	325	S>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	325	S>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs906770427 CA157953716	328	A>T		No	ClinGen gnomAD
rs142047672 CA4246437	328	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1302326073 CA367420614	329	R>C		No	ClinGen gnomAD
CA4246436 rs764567133	329	R>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	329	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA157953674 rs749976915	330	T>I		No	ClinGen ExAC gnomAD
rs749976915 CA4246435	330	T>R		No	ClinGen ExAC gnomAD
rs1583791040 CA367420584	332	A>S		No	ClinGen Ensembl
rs905570815 CA157953641	333	S>L		No	ClinGen TOPMed gnomAD
CA367420558 rs1386183561	334	G>E		No	ClinGen gnomAD
CA4246432 rs374832205	335	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs374832205 CA367420548	335	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs767824357 CA4246433	335	G>S		No	ClinGen ExAC gnomAD
rs374832205 CA4246431	335	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA367420504 rs1199362206	339	I>V		No	ClinGen gnomAD
rs532010528 CA4246429	340	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA367420431 rs1352540528	344	T>A		No	ClinGen gnomAD
CA157953596 rs757768100	350	Y>H		No	ClinGen Ensembl
CA367420364 rs1338594736	351	A>V		No	ClinGen gnomAD
rs768375129 CA4246424	352	R>P		No	ClinGen ExAC TOPMed gnomAD
rs768375129 CA367420359	352	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs776266211 CA4246425	352	R>W		No	ClinGen ExAC TOPMed gnomAD
CA4246423 rs558589142	353	D>N		No	ClinGen ExAC TOPMed gnomAD
rs868866517 CA157953567	354	A>V		No	ClinGen Ensembl
CA367420308 rs1470360384	356	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	357	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367419954 rs1350175797	358	A>G		No	ClinGen gnomAD
rs770358784 CA4246401	361	Q>L		No	ClinGen ExAC gnomAD
CA4246400 rs748567359	362	R>Q		No	ClinGen ExAC gnomAD
CA367419900 rs1324315404	364	F>S		No	ClinGen gnomAD
rs781626265 CA4246399	364	F>V		No	ClinGen ExAC gnomAD
TCGA novel	366	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA157953428 rs989561733	366	W>R		No	ClinGen gnomAD
rs370221955 CA4246397	367	V>A		No	ClinGen ESP ExAC
rs755351228 CA4246398	367	V>M		No	ClinGen ExAC gnomAD
rs1583790746 CA367419837	368	V>G		No	ClinGen Ensembl
CA4246396 rs780291110 CA367419820	369	N>K		No	ClinGen ExAC gnomAD
rs1400235540 CA367419828	369	N>S		No	ClinGen TOPMed
rs958128215 CA157953406	370	R>K		No	ClinGen TOPMed gnomAD
CA367419807 rs1319277384	370	R>S		No	ClinGen TOPMed
CA4246395 rs758593558	373	S>R		No	ClinGen ExAC TOPMed gnomAD
CA157953401 rs1031615007	373	S>T		No	ClinGen TOPMed
CA4246394 rs750522884	375	M>T		No	ClinGen ExAC gnomAD
rs1562830928 CA367419711	376	E>*		No	ClinGen Ensembl
rs1470606384 CA367419686	377	P>L		No	ClinGen gnomAD
rs377745166 CA4246393	377	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs377745166 CA367419698	377	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA4246391 rs546640885	378	R>G		No	ClinGen ExAC TOPMed gnomAD
rs374351000 CA367419681	378	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs374351000 CA4246390	378	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA4246392 rs546640885	378	R>W		No	ClinGen ExAC TOPMed gnomAD
rs200247779 CA4246388	380	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4246387 rs767329499	380	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4246389 rs200247779	380	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773946753 CA4246385	381	D>N		No	ClinGen ExAC TOPMed gnomAD
CA4246384 rs748813866	383	R>G		No	ClinGen ExAC TOPMed gnomAD
CA4246381 rs371241303	383	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4246382 rs371241303	383	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1450972 CA4246383 rs748813866	383	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4246380 rs747419960	384	R>C		No	ClinGen ExAC gnomAD
rs148616273 CA4246379	384	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1477759404 CA367419607	385	D>N		No	ClinGen TOPMed
CA4246378 rs758648715	386	G>S		No	ClinGen ExAC gnomAD
CA157953311 rs1022622791	386	G>V		No	ClinGen TOPMed
CA367419567 rs1344538725	387	K>R		No	ClinGen gnomAD
TCGA novel	388	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746021934 CA367419530	389	T>I		No	ClinGen ExAC gnomAD
CA4246377 rs746021934	389	T>K		No	ClinGen ExAC gnomAD
rs779062594 CA4246376	390	V>I		No	ClinGen ExAC TOPMed
rs1297967644 CA367419503	391	I>S		No	ClinGen TOPMed
rs763979006 CA4246373	393	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	395	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367419441 rs1335619193	396	I>N		No	ClinGen gnomAD
CA4246371 rs376644026	396	I>V		No	ClinGen ESP ExAC gnomAD
CA367419424 rs1412299151	397	Y>C		No	ClinGen gnomAD
CA4246369 rs759270351	400	E>K		No	ClinGen ExAC gnomAD
TCGA novel	400	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367419356 rs1583790572	401	V>G		No	ClinGen Ensembl
rs61740095 CA4246367	403	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA367419334 rs1231916019	403	P>S		No	ClinGen TOPMed
rs772753676 CA4246365	404	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1340702590 CA367419244	408	E>K		No	ClinGen gnomAD
rs1278266534 CA367419206	411	C>Y		No	ClinGen gnomAD
CA4246347 rs749930736	412	I>S		No	ClinGen ExAC TOPMed gnomAD
rs1401347682 CA367419196	412	I>V		No	ClinGen gnomAD
CA4246346 rs764660208	414	Y>H		No	ClinGen ExAC gnomAD
rs1425221749 CA367419146	415	C>R		No	ClinGen TOPMed
CA4246345 rs761183049	416	N>H		No	ClinGen ExAC gnomAD
rs1351334425 CA367419125	416	N>S		No	ClinGen gnomAD
CA157952734 rs893067745	417	E>K		No	ClinGen Ensembl
rs1404682476 CA367419102	418	K>E		No	ClinGen gnomAD
CA4246342 rs771068176	420	Q>*		No	ClinGen ExAC gnomAD
rs1054756115 CA157952675	423	F>L		No	ClinGen Ensembl
rs1423036709 CA367418982	426	L>I		No	ClinGen TOPMed gnomAD
CA4246341 rs774762623	426	L>P		No	ClinGen ExAC gnomAD
rs1048268186 CA157952642	427	I>V		No	ClinGen TOPMed gnomAD
CA367418919 rs1245292153	430	Q>P		No	ClinGen gnomAD
rs1562830447 CA367418893	432	Q>K		No	ClinGen Ensembl
rs374911863 CA4246340	432	Q>R		No	ClinGen ESP ExAC gnomAD
rs749457397 CA157952633	433	E>*		No	ClinGen ExAC TOPMed gnomAD
CA4246339 rs749457397	433	E>K		No	ClinGen ExAC TOPMed gnomAD
rs201604505 CA367418833	435	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201080539 CA157952630	435	Y>F		No	ClinGen 1000Genomes
CA367418825 rs545754641	436	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs545754641 CA4246336	436	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs545754641 CA4246337	436	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA4246335 rs781350023	437	R>C		No	ClinGen ExAC TOPMed gnomAD
CA4246334 rs199915467	437	R>H		No	ClinGen ExAC TOPMed gnomAD
rs138418256 CA4246332	438	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA367418777 rs1353491925	439	G>D		No	ClinGen TOPMed
TCGA novel	439	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4246330 rs199914832	441	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4246331 rs199914832	441	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758264063 CA4246310	445	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA367418599 rs1583789775	447	Y>D		No	ClinGen Ensembl
CA157952319 rs1042764007	451	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1562830271 CA367418446	457	V>A		No	ClinGen Ensembl
CA367418441 rs1286308862	458	E>Q		No	ClinGen TOPMed
rs753359428 CA4246306	459	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4246307 rs200348996	459	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA4246305 rs763526010	462	R>C		No	ClinGen ExAC TOPMed gnomAD
CA367418378 rs1353993162	462	R>H		No	ClinGen TOPMed gnomAD
CA367418374 rs1353993162	462	R>L		No	ClinGen TOPMed gnomAD
rs1353993162 CA367418376	462	R>P		No	ClinGen TOPMed gnomAD
rs1485581442 CA367418358	464	I>L		No	ClinGen gnomAD
CA367418310 rs1313276657	467	V>A		No	ClinGen gnomAD
CA367418305 rs1313276657	467	V>E		No	ClinGen gnomAD
rs150434835 CA4246300 COSM746769	467	V>M	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA4246299 rs367581527	468	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs909340605 CA157952298	469	D>A		No	ClinGen Ensembl
rs141395808 CA367418266	469	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA157952288 rs985097448	470	E>K		No	ClinGen Ensembl
CA4246296 rs768734596	472	C>*		No	ClinGen ExAC TOPMed gnomAD
CA157952275 rs951011944	472	C>F		No	ClinGen Ensembl
TCGA novel	474	S>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4246295 rs747038665	477	T>A		No	ClinGen ExAC
CA367418121 rs1400821857	477	T>N		No	ClinGen TOPMed gnomAD
rs1562830208 CA367418090	479	T>A		No	ClinGen Ensembl
rs199731003 CA157952229	480	D>G		No	ClinGen 1000Genomes
COSM1450969 CA4246293 rs771899380	481	R>*	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA367418045 rs745720343	481	R>P		No	ClinGen ExAC TOPMed gnomAD
CA4246292 rs745720343	481	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA367418037 rs1369432853	482	I>V		No	ClinGen gnomAD
rs201569078 CA157952185	485	Q>K		No	ClinGen TOPMed gnomAD
CA574227573 rs1253392273	485	Q>L		No	ClinGen gnomAD
CA367417895 rs1336442389	489	M>I		No	ClinGen TOPMed
VAR_044014 CA4246290 rs3735485	489	M>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA367417886 rs1583789510	490	H>P		No	ClinGen Ensembl
rs1265811290 CA367417872	491	H>D		No	ClinGen gnomAD
rs1357741526 CA367417863	491	H>P		No	ClinGen TOPMed
CA4246289 rs748898010	492	R>C		No	ClinGen ExAC TOPMed gnomAD
CA4246288 rs777168514	492	R>H		No	ClinGen ExAC gnomAD
CA367417853 rs748898010	492	R>S		No	ClinGen ExAC TOPMed gnomAD
CA367417830 rs1219370510	493	H>D		No	ClinGen gnomAD
CA4246285 rs766972278	495	L>V		No	ClinGen ExAC gnomAD
CA367417773 rs1456831932	496	H>R		No	ClinGen TOPMed gnomAD
rs758921531 CA4246284	496	H>Y		No	ClinGen ExAC gnomAD
rs750824729 CA4246283	497	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs750824729 CA367417753	497	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA4246282 rs765659912	498	T>P		No	ClinGen ExAC gnomAD
rs1477892136 CA367417703	499	S>R		No	ClinGen gnomAD
CA4246281 rs762149642	500	R>C		No	ClinGen ExAC TOPMed gnomAD
CA4246280 rs777044357	500	R>H		No	ClinGen ExAC TOPMed gnomAD
CA367417687 rs777044357	500	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA367417678 rs1446076912	501	Q>*		No	ClinGen gnomAD
TCGA novel	501	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4246264 rs757737951	502	L>H		No	ClinGen ExAC TOPMed gnomAD
CA157951697 rs985881592	506	D>N		No	ClinGen Ensembl
CA367417499 rs1258042505	507	K>N		No	ClinGen gnomAD
CA367417493 rs1240278479	508	T>P		No	ClinGen TOPMed
rs754150092 CA367417465	509	M>R		No	ClinGen ExAC TOPMed gnomAD
rs754150092 CA4246263	509	M>T		No	ClinGen ExAC TOPMed gnomAD
CA367417475 rs1256080545	509	M>V		No	ClinGen gnomAD
CA4246261 rs760750378	513	R>*		No	ClinGen ExAC TOPMed gnomAD
rs141469545 CA4246260	513	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs146602744 CA4246258	516	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA4246259 rs372731729	516	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA367417337 rs1326242797	517	I>F		No	ClinGen gnomAD
rs774318946 CA4246257	518	K>E		No	ClinGen ExAC gnomAD
rs1460482427 CA367417308	519	H>L		No	ClinGen TOPMed
rs1464235643 CA367417276	522	G>R		No	ClinGen gnomAD
TCGA novel	523	D>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762799551 CA4246255	523	D>Y		No	ClinGen ExAC gnomAD
CA367417251 rs1441462789	524	V>I		No	ClinGen gnomAD
CA4246253 rs769495251	525	T>M		No	ClinGen ExAC TOPMed gnomAD
CA367416007 rs1583787704	527	S>C		No	ClinGen Ensembl
CA4246229 rs533218684	528	V>M		No	ClinGen ExAC TOPMed gnomAD
CA4246228 rs749719081	530	G>R		No	ClinGen ExAC TOPMed gnomAD
CA367415953 rs1401499860	531	F>L		No	ClinGen gnomAD
rs1453161607 CA367415940	531	F>L		No	ClinGen TOPMed
CA157950527 rs201954673	531	F>Y		No	ClinGen Ensembl
COSM1450968 rs371871174 CA4246226	533	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA4246225 rs141050106	537	D>V		No	ClinGen 1000Genomes ExAC
CA4246223 rs200445653	545	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs201539357 COSM1090016 CA4246224	545	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA
CA4246221 rs766410449	548	Y>C		No	ClinGen ExAC gnomAD
rs1024637656 CA157950476	550	S>T		No	ClinGen TOPMed gnomAD
rs202090846 CA4246203	551	T>A		No	ClinGen ExAC TOPMed gnomAD
CA4246202 rs200200271	551	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs753691383 CA4246198	553	P>R		No	ClinGen ExAC gnomAD
CA367415524 rs1583787443	554	T>P		No	ClinGen Ensembl
CA157950308 rs760936897	554	T>S		No	ClinGen Ensembl
rs891772891 CA157950307	555	L>P		No	ClinGen TOPMed
rs552543010 CA4246196	556	R>P		No	ClinGen 1000Genomes ExAC gnomAD
rs552543010 CA4246195	556	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs763941323 CA4246197	556	R>W		No	ClinGen ExAC TOPMed gnomAD
rs145495335 CA4246194	557	A>S		No	ClinGen ESP ExAC gnomAD
CA157950281 rs761931000	558	M>T		No	ClinGen Ensembl
rs149694733 CA4246192	560	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs149694733 CA4246193	560	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1193470170 CA367415390	561	D>E		No	ClinGen TOPMed gnomAD
CA367415400 rs1168744426	561	D>G		No	ClinGen TOPMed
CA4246189 rs777006572	562	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4246187 rs747346222	565	D>N		No	ClinGen ExAC gnomAD
CA157950263 rs751701889	566	I>M		No	ClinGen Ensembl
CA4246186 rs61745695	567	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs772326969 CA4246185	567	T>I		No	ClinGen ExAC gnomAD
CA4246184 rs745949471	568	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1210310349 CA367415294	568	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1583787370 CA367415263	569	V>A		No	ClinGen Ensembl
rs200887711 CA157950254	572	R>C		No	ClinGen 1000Genomes
CA4246183 rs200123999	572	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA4246182 COSM1736693 rs370788368	575	T>M	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA157950250 rs866120405	576	A>S		No	ClinGen TOPMed
rs943989631 CA157950249	577	G>D		No	ClinGen Ensembl
CA367415102 rs1311308515	581	K>E		No	ClinGen gnomAD
rs777829367 CA4246180	583	S>C		No	ClinGen ExAC gnomAD
rs777829367 CA367415065	583	S>F		No	ClinGen ExAC gnomAD
rs756012247 CA4246179	585	V>M		No	ClinGen ExAC gnomAD
CA157950232 rs150942992	586	A>V		No	ClinGen ESP TOPMed
CA367415018 rs1583787319	588	V>G		No	ClinGen Ensembl
CA4246178 rs752533714	589	E>K		No	ClinGen ExAC gnomAD
rs911328610 CA157950229	590	N>K		No	ClinGen TOPMed
TCGA novel	590	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767130263 CA4246177	590	N>T		No	ClinGen ExAC gnomAD
rs759166174 CA4246176	592	A>V		No	ClinGen ExAC gnomAD
CA367414986 rs1438844982	594	K>E		No	ClinGen TOPMed gnomAD
rs757972664 CA4246156	595	E>G		No	ClinGen ExAC gnomAD
CA367414966 rs765921852	595	E>K		No	ClinGen ExAC gnomAD
CA4246157 rs765921852	595	E>Q		No	ClinGen ExAC gnomAD
CA4246154 rs764599025	596	P>L		No	ClinGen ExAC gnomAD
CA4246155 rs369047872	596	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs373796173 CA4246151	599	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs373796173 CA367414941	599	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs139803425 CA4246150	600	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774674442 CA4246149	600	R>H		No	ClinGen ExAC TOPMed gnomAD
rs774674442 CA367414934	600	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1336583811 CA367414923	602	I>V		No	ClinGen TOPMed
CA367414913 rs1219097435	603	K>R		No	ClinGen TOPMed
rs1215495179 CA367414904	604	P>L		No	ClinGen TOPMed gnomAD
rs147398930 CA4246147	605	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773363436 CA4246146	607	D>N		No	ClinGen ExAC gnomAD
rs769857146 CA4246145	609	V>G		No	ClinGen ExAC gnomAD
CA157949751 rs879939174	611	G>E		No	ClinGen TOPMed gnomAD
rs748075919 CA4246144	614	D>E		No	ClinGen ExAC gnomAD
TCGA novel CA157949748 rs908201402	615	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen gnomAD
rs989352151 CA157949739	617	H>D		No	ClinGen TOPMed gnomAD
CA367414820 rs1562828257	617	H>P		No	ClinGen Ensembl
rs754844310 CA4246142	619	R>C		No	ClinGen ExAC gnomAD
rs142790224 CA4246141	619	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA367414799 rs779817442	620	H>L		No	ClinGen ExAC gnomAD
CA4246140 rs779817442	620	H>P		No	ClinGen ExAC gnomAD
CA4246139 rs757988932	621	Q>*		No	ClinGen ExAC gnomAD
CA367414795 rs757988932	621	Q>E		No	ClinGen ExAC gnomAD
CA157949722 rs377158095	621	Q>L		No	ClinGen ESP TOPMed gnomAD
CA4246138 rs749940574	622	V>I		No	ClinGen ExAC gnomAD
rs374130084 CA4246136	623	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs753295216 CA4246135	625	L>V		No	ClinGen ExAC gnomAD
CA4246134 rs140521361	627	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA
CA367414737 rs1272594233	631	V>M		No	ClinGen gnomAD
CA367414728 rs1385843364	632	R>T		No	ClinGen gnomAD
rs1583786379 CA367414719	633	V>G		No	ClinGen Ensembl
rs774564779 CA4246132	634	R>C		No	ClinGen ExAC TOPMed gnomAD
CA4246131 rs534900639	634	R>H		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	637	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367414696 rs1297786909	637	G>V		No	ClinGen gnomAD
rs773455064 CA4246129	639	A>T		No	ClinGen ExAC TOPMed gnomAD
rs769943053 COSM85037 CA4246128	641	R>C	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs748148561 CA4246127	641	R>H		No	ClinGen ExAC TOPMed gnomAD
rs776700926 CA4246126	642	Q>H		No	ClinGen ExAC gnomAD
CA367414668 rs1380864406	642	Q>P		No	ClinGen TOPMed
TCGA novel	644	Y>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA157949688 rs61745627	646	R>G		No	ClinGen TOPMed
TCGA novel	647	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1446811882 CA367414627	649	L>V		No	ClinGen gnomAD
rs774073573 CA4246082	650	R>S		No	ClinGen ExAC gnomAD
rs1002875673 CA157949437	651	Y>C		No	ClinGen gnomAD
CA367414144 rs1583785810	653	M>K		No	ClinGen Ensembl
rs149389953 CA4246081	655	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA367414104 rs748847640	656	E>G		No	ClinGen ExAC gnomAD
CA367414110 rs1323959118	656	E>K		No	ClinGen gnomAD
rs748847640 CA4246080	656	E>V		No	ClinGen ExAC gnomAD
rs1172750599 CA367414059	659	W>*		No	ClinGen gnomAD
CA4246077 rs747660390	661	N>S		No	ClinGen ExAC gnomAD
rs1583785756 CA367414014	662	H>P		No	ClinGen Ensembl
CA4246075 rs758921507	662	H>Y		No	ClinGen ExAC gnomAD
rs1232979723 CA367413981	665	G>D		No	ClinGen TOPMed gnomAD
rs1232979723 CA367413983	665	G>V		No	ClinGen TOPMed gnomAD
CA4246073 rs779107157	666	S>Y		No	ClinGen ExAC gnomAD
rs1562827791 CA367413963	667	D>E		No	ClinGen Ensembl
CA4246070 rs199839026	667	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1583785714 CA367413954	668	K>R		No	ClinGen Ensembl
CA157949385 rs907176490	669	A>T		No	ClinGen Ensembl
CA367413942 rs1349806459	669	A>V		No	ClinGen gnomAD
CA4246069 rs756251983	670	A>T		No	ClinGen ExAC gnomAD
rs759400828 CA4246066	671	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs150202121 CA367413909	672	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs762785346 CA4246064	673	A>S		No	ClinGen ExAC TOPMed gnomAD
CA4246063 rs762785346	673	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	674	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367413878 rs1287875226	676	E>*		No	ClinGen TOPMed
CA4246062 rs141505221	678	H>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4246060 rs145905005	679	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA367413838 rs145905005	679	G>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140643676 CA367413797	683	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs140643676 CA4246059	683	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs867414113 CA157949320	684	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA157949315 rs372082507	685	A>V		No	ClinGen ESP TOPMed gnomAD
rs1486507372 CA367413758	686	F>L		No	ClinGen gnomAD
CA367413745 rs1583785590	687	G>A		No	ClinGen Ensembl
rs779453122 CA4246056	688	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1366444364 CA367413718	689	S>R		No	ClinGen TOPMed
TCGA novel	692	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367413697 rs1339633300	692	F>V		No	ClinGen gnomAD
CA4246055 rs576689841	694	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA4246054 rs555267455	694	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367413658 rs1372711574	695	S>L		No	ClinGen gnomAD
rs777914591 CA4246053	695	S>T		No	ClinGen ExAC TOPMed gnomAD
CA367413654 rs1307454172	696	P>A		No	ClinGen TOPMed
CA367413652 rs1376164203	696	P>L		No	ClinGen TOPMed
rs767541462 CA4246050	697	R>L		No	ClinGen ExAC TOPMed gnomAD
CA4246051 rs767541462	697	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4246052 rs374399060	697	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs754927435 CA4246049	698	T>I		No	ClinGen ExAC gnomAD
rs370683756 CA4246048	699	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1300322799 CA367413628	701	T>I		No	ClinGen TOPMed
rs566058703 CA4246044	702	L>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1583785472 CA367413622	702	L>Q		No	ClinGen Ensembl
rs554354933 COSM1090014 CA4246043	706	R>*	Variant assessed as Somatic; 0.0 impact. pancreas endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs776303594 CA367413577	706	R>P		No	ClinGen ExAC gnomAD
rs776303594 CA4246042	706	R>Q		No	ClinGen ExAC gnomAD
rs1476010542 CA367413567	707	A>V		No	ClinGen gnomAD
CA4246041 rs768331568	708	R>C		No	ClinGen ExAC TOPMed gnomAD
CA4246040 rs746489100	708	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA157949256 rs761781014	709	L>F		No	ClinGen gnomAD
CA367413551 rs1583785449	709	L>R		No	ClinGen Ensembl
CA4246039 rs774789469	711	P>A		No	ClinGen ExAC
CA4246012 rs747067198	721	W>R		No	ClinGen ExAC gnomAD
CA367413379 rs1195429620	722	R>Q		No	ClinGen gnomAD
CA157949115 rs1015562480	723	G>S		No	ClinGen TOPMed
CA157949110 rs776426213	723	G>V		No	ClinGen Ensembl
CA157949101 rs1017395724	724	T>N		No	ClinGen Ensembl
rs750424358 CA367413349	725	L>F		No	ClinGen ExAC gnomAD
CA4246008 rs371874192	726	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs753674854 CA4246006	728	W>G		No	ClinGen ExAC gnomAD
CA367413310 rs1349062821	729	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1349062821 CA367413311	729	R>G		No	ClinGen gnomAD
rs763849651 CA4246005	729	R>H		No	ClinGen ExAC TOPMed gnomAD
CA367413308 rs763849651	729	R>P		No	ClinGen ExAC TOPMed gnomAD
CA157949086 rs1035079745	730	C>Y		No	ClinGen TOPMed
CA4246004 rs367655783	731	R>G		No	ClinGen ExAC TOPMed gnomAD
CA367413291 rs760385721	731	R>L		No	ClinGen ExAC TOPMed gnomAD
CA4246003 rs760385721	731	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA157949075 rs367655783	731	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1583785040 CA367413289	732	R>G		No	ClinGen Ensembl
rs1002272536 CA157949069	732	R>S		No	ClinGen TOPMed gnomAD
rs1398260523 CA367413254	735	A>V		No	ClinGen gnomAD
CA367413251 rs1296111346	736	I>V		No	ClinGen gnomAD
CA157949064 rs899535059	739	I>V		No	ClinGen TOPMed gnomAD
rs905006130 CA157949058	740	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
COSM292787 rs767004739 CA4246002	741	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs773745075 CA4246000	741	R>H		No	ClinGen ExAC TOPMed gnomAD
rs773745075 CA4246001	741	R>L		No	ClinGen ExAC TOPMed gnomAD
rs767004739 CA367413196	741	R>S		No	ClinGen ExAC TOPMed gnomAD
CA4245999 rs200693120	742	W>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4245997 rs529667295	744	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs149069497 CA4245998	744	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768794653 CA4245996	746	H>Q		No	ClinGen ExAC gnomAD
rs1421091899 CA367413147	746	H>Y		No	ClinGen gnomAD
rs745931480 CA4245992	749	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs772234800 CA4245993	749	R>W		No	ClinGen ExAC TOPMed gnomAD
CA367413108 rs1410016931	750	A>T		No	ClinGen TOPMed
CA4245991 rs779052877	750	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	752	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA157949030 rs890157132	753	A>G		No	ClinGen TOPMed
CA367413076 rs1444089465	753	A>S		No	ClinGen gnomAD
rs879093489 CA157949028	754	E>A		No	ClinGen Ensembl
rs749098280 CA4245989	755	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA4245987 rs201003622	757	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs558918192 CA4245988	757	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA4245986 rs752438917	758	R>*		No	ClinGen ExAC TOPMed gnomAD
rs781147464 CA157949009	758	R>P		No	ClinGen TOPMed gnomAD
CA157949012 rs781147464	758	R>Q		No	ClinGen TOPMed gnomAD
CA367413038 rs1159086719	759	F>L		No	ClinGen gnomAD
CA367413023 rs1222879941	762	A>T		No	ClinGen TOPMed
rs1455351826 CA367413018	762	A>V		No	ClinGen TOPMed gnomAD
CA367413015 rs1181665721	763	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs201440829 CA4245984	764	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4245983 rs751052723	765	P>L		No	ClinGen ExAC gnomAD
CA367412994 rs1264792809	766	P>Q		No	ClinGen TOPMed
CA367412993 rs1264792809	766	P>R		No	ClinGen TOPMed
rs201481844 CA157949000	767	L>P		No	ClinGen 1000Genomes TOPMed
CA367412982 rs1285492084	768	Y>C		No	ClinGen TOPMed gnomAD
rs764573392 CA4245979	769	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	769	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760917700 CA4245978	770	R>C		No	ClinGen ExAC gnomAD
rs145057132 CA4245977	770	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs760917700 CA367412972	770	R>S		No	ClinGen ExAC gnomAD
CA4245976 rs772172953	772	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	773	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1090013 CA4245975 rs745961199	775	P>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA367412931 rs1294886757	775	P>S		No	ClinGen gnomAD
CA367412893 rs1318844733	779	A>V		No	ClinGen TOPMed gnomAD
CA367412868 rs1386511556	782	Q>*		No	ClinGen gnomAD
rs1303072361 CA367412831	785	Q>*		No	ClinGen TOPMed
CA4245974 rs774503919	786	D>G		No	ClinGen ExAC gnomAD
rs1583784732 CA367412806	787	T>A		No	ClinGen Ensembl
rs1583784732 CA367412807	787	T>P		No	ClinGen Ensembl
rs755972612 CA4245971	790	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs755972612 CA4245970	790	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4245969 rs375304069	790	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1562827158 CA367412757	791	L>V		No	ClinGen Ensembl
rs1468506073 CA367412661	794	R>S		No	ClinGen TOPMed gnomAD
CA367412638 rs371969345	796	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371969345 CA4245951	796	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs769604336 CA4245952	796	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA367412636 rs1450719753	797	A>T		No	ClinGen gnomAD
CA4245950 rs2107737 VAR_050212	798	R>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA157948765 rs922704991	798	R>W		No	ClinGen gnomAD
rs61739437 CA157948760	801	V>E		No	ClinGen Ensembl
rs61739437 CA367412584	801	V>G		No	ClinGen Ensembl
rs768320893 CA4245949	801	V>M		No	ClinGen ExAC TOPMed gnomAD
CA367412552 rs1460527341	803	N>S		No	ClinGen TOPMed
rs1562826853 CA367412514	805	P>L		No	ClinGen Ensembl
CA4245947 rs779650578	806	P>A		No	ClinGen ExAC TOPMed gnomAD
CA367412512 rs779650578	806	P>S		No	ClinGen ExAC TOPMed gnomAD
CA367412508 rs779650578	806	P>T		No	ClinGen ExAC TOPMed gnomAD
rs368207989 CA4245944	808	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	810	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367412393 rs1428144697	814	A>V		No	ClinGen TOPMed gnomAD
rs753134009 CA4245941	818	A>T		No	ClinGen ExAC gnomAD
CA4245940 rs767722811	819	M>I		No	ClinGen ExAC gnomAD
rs1018838361 CA157948750	819	M>T		No	ClinGen Ensembl
CA4245939 rs147841026	820	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA367412327 rs1157193899	821	A>T		No	ClinGen gnomAD
rs1477482958 CA367412319	821	A>V		No	ClinGen gnomAD
rs1481924599 CA367412285	824	G>E		No	ClinGen gnomAD
rs1201850845 CA367412270	826	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA4245937 rs751867377	826	R>H		No	ClinGen ExAC TOPMed gnomAD
CA4245936 rs766703139	827	Q>K		No	ClinGen ExAC gnomAD
CA4245935 rs199820812	828	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1477062526 CA367412255	828	D>N		No	ClinGen gnomAD
rs1189053185 CA367412239	829	W>*		No	ClinGen TOPMed
rs958286103 CA157948729	832	R>*		No	ClinGen TOPMed
rs572778883 CA4245934	832	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs769773795 CA367412199	833	R>G		No	ClinGen ExAC gnomAD
rs761609063 CA4245932	833	R>Q		No	ClinGen ExAC gnomAD
rs769773795 CA4245933	833	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1313909453 CA367412186	834	A>D		No	ClinGen gnomAD
rs1350229971 CA367412191	834	A>T		No	ClinGen gnomAD
rs1408107500 CA573821578	835	W>*		No	ClinGen gnomAD
rs768480261 CA4245931	837	R>*		No	ClinGen ExAC TOPMed gnomAD
CA4245930 rs768480261	837	R>G		No	ClinGen ExAC TOPMed gnomAD
CA4245929 rs751614152	837	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4245928 rs779744480	838	D>N		No	ClinGen ExAC gnomAD
CA367412127 rs1471428885	839	Y>*		No	ClinGen gnomAD
rs906170459 CA157948715	840	L>V		No	ClinGen TOPMed
rs1250794799 CA367412110	841	S>Y		No	ClinGen gnomAD
rs144525470 CA4245908	846	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA4245907 rs745459946	848	T>A		No	ClinGen ExAC gnomAD
rs774029585 CA4245906	848	T>I		No	ClinGen ExAC TOPMed gnomAD
CA367411540 rs1450276600	849	A>V		No	ClinGen TOPMed
rs1215666929 CA367411519	851	S>R		No	ClinGen TOPMed gnomAD
rs770384569 CA4245905	853	F>S		No	ClinGen ExAC TOPMed gnomAD
CA157946664 rs753768198	854	A>T		No	ClinGen Ensembl
rs1216383376 CA367411485	855	Q>E		No	ClinGen TOPMed
CA157946662 rs1016309315	856	R>*		No	ClinGen TOPMed
CA367411469 rs1387314884	856	R>L		No	ClinGen gnomAD
rs1326102385 CA367411467	857	L>V		No	ClinGen gnomAD
rs1366463453 CA367411437	860	L>V		No	ClinGen gnomAD
rs139568291 CA4245903	861	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA367411429 rs139568291	861	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA367411422 rs7792760	861	Q>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA367411425 rs7792760	861	Q>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_044015 CA4245902 rs7792760	861	Q>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs747380693 CA4245901	862	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	862	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4245899 rs142328697	864	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757339463 COSM3950548 CA4245897	866	F>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA4245894 rs148751315 COSM1090009 CA4245895	867	G>R	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs752108220 CA157946652	868	A>P		No	ClinGen gnomAD
rs1363795702 CA367411306	872	S>*		No	ClinGen gnomAD
CA367411312 rs1228340465	872	S>T		No	ClinGen gnomAD
rs775289616 CA4245892	874	H>Q		No	ClinGen ExAC gnomAD
CA4245893 rs760569666	874	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1562826388 CA367411275	875	V>I		No	ClinGen Ensembl
CA4245891 rs767347183	876	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4245890 rs759342282	876	R>H		No	ClinGen ExAC gnomAD
rs777783175 CA4245877	880	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM1450965 CA4245876 rs199620741	880	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
TCGA novel	881	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367411124 rs1583783239	882	H>R		No	ClinGen Ensembl
CA367411108 rs1181978067	883	K>R		No	ClinGen gnomAD
CA367411074 rs1284165978	885	R>Q		No	ClinGen TOPMed
CA367411079 COSM1450964 rs1486210938	885	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs867877691 CA157946586	887	R>L		No	ClinGen Ensembl
rs773744055 CA157946587	887	R>W		No	ClinGen Ensembl
CA4245874 rs767481349	889	L>F		No	ClinGen ExAC gnomAD
rs1254946866 CA367411006	890	L>M		No	ClinGen gnomAD
TCGA novel	891	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4245872 rs751310560	893	D>E		No	ClinGen ExAC gnomAD
CA4245873 rs144298882	893	D>N		No	ClinGen ESP ExAC gnomAD
CA4245871 rs765950897	894	Q>K		No	ClinGen ExAC gnomAD
CA367410946 rs1340881232	895	H>Y		No	ClinGen gnomAD
rs1336041844 CA367410904	897	Y>*		No	ClinGen gnomAD
CA157946585 rs1038872506	899	L>M		No	ClinGen TOPMed gnomAD
rs1038872506 CA367410871	899	L>V		No	ClinGen TOPMed gnomAD
rs1401543677 CA367410863	900	D>H		No	ClinGen TOPMed gnomAD
TCGA novel	901	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367410845 rs1159284144	901	P>T		No	ClinGen gnomAD
rs201502354 CA4245869	903	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs762624367 CA367410810	903	R>W		No	ClinGen ExAC TOPMed gnomAD
rs142730861 CA367410745	906	R>G		No	ClinGen ESP TOPMed gnomAD
CA157946577 rs138226470	906	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs138226470 CA4245867	906	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs142730861 CA157946581	906	R>W		No	ClinGen ESP TOPMed gnomAD
CA367410728 rs1186009627	907	V>L		No	ClinGen gnomAD
CA367410689 rs776197319	909	R>G		No	ClinGen ExAC TOPMed gnomAD
CA4245865 rs370778515	909	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs776197319 CA4245866	909	R>W		No	ClinGen ExAC TOPMed gnomAD
CA367410681 rs1562826166	910	A>T		No	ClinGen Ensembl
rs1208746512 CA367410671	910	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM1450963 rs376350486 CA4245863	911	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA367410643 rs1356765158	913	L>F		No	ClinGen TOPMed gnomAD
rs1356765158 CA367410644	913	L>V		No	ClinGen TOPMed gnomAD
CA157946568 rs77923458	914	E>D		No	ClinGen gnomAD
rs1242509039 CA367410624	914	E>G		No	ClinGen gnomAD
CA4245862 rs771083602	914	E>Q		No	ClinGen ExAC gnomAD
CA367410613 rs1321152441	915	A>T		No	ClinGen gnomAD
rs368999334 CA4245861	915	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367410542 rs1351776427	916	V>L		No	ClinGen gnomAD
CA367410512 rs1405102020	917	T>M		No	ClinGen gnomAD
rs764970920 CA4245850	917	T>P		No	ClinGen ExAC gnomAD
CA4245847 rs772491166	921	V>M		No	ClinGen ExAC TOPMed gnomAD
CA367410438 rs1387776613	922	T>I		No	ClinGen gnomAD
CA367410434 rs1353746152	923	S>G		No	ClinGen TOPMed
CA367410414 rs1185486091	924	G>*		No	ClinGen gnomAD
rs1478075228 CA367410407	924	G>V		No	ClinGen gnomAD
CA157946250 rs977371992	929	V>M		No	ClinGen Ensembl
rs1181024277 CA367410277	932	H>Q		No	ClinGen TOPMed gnomAD
rs1482164079 CA367410260	933	A>G		No	ClinGen gnomAD
CA367410257 rs774701688	934	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1207172570 CA367410251	934	R>H		No	ClinGen gnomAD
CA4245845 rs774701688	934	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1340040142 CA367410220	936	Q>L		No	ClinGen TOPMed gnomAD
CA4245844 rs771364309	937	D>N		No	ClinGen ExAC gnomAD
CA367410176 rs1369859906	938	D>E		No	ClinGen TOPMed gnomAD
CA367410151 rs749646679	940	V>L		No	ClinGen ExAC TOPMed gnomAD
CA4245843 rs749646679	940	V>M		No	ClinGen ExAC TOPMed gnomAD
rs910515874 CA157946248	945	R>S		No	ClinGen TOPMed gnomAD
CA4245842 rs778023178	946	S>F		No	ClinGen ExAC
CA367410012 rs1370419817	948	P>S		No	ClinGen gnomAD
rs748229958 CA4245840	950	L>*		No	ClinGen ExAC TOPMed
rs748229958 CA367409981	950	L>S		No	ClinGen ExAC TOPMed
CA367409938 rs1246359058	952	N>K		No	ClinGen gnomAD
rs1177427572 CA367409943	952	N>S		No	ClinGen gnomAD
rs1562825544 CA367409931	953	R>H		No	ClinGen Ensembl
CA367409920 rs1414502760	954	V>A		No	ClinGen TOPMed gnomAD
CA367409918 rs1414502760	954	V>G		No	ClinGen TOPMed gnomAD
TCGA novel	956	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1562825522 CA367409862	960	V>M		No	ClinGen Ensembl
rs1407433110 CA367409831	963	A>T		No	ClinGen TOPMed
rs1252259218 CA367409803	964	H>Q		No	ClinGen gnomAD
CA367409812 rs1479928529	964	H>R		No	ClinGen gnomAD
CA367409790 rs1455063471	965	C>Y		No	ClinGen TOPMed
CA157946246 rs952104150	966	Q>R		No	ClinGen TOPMed gnomAD
rs1250935031 CA367409753	967	G>E		No	ClinGen TOPMed gnomAD
CA4245837 rs754892218	967	G>R		No	ClinGen ExAC gnomAD
CA367409686 rs1230522419	969	G>S		No	ClinGen TOPMed gnomAD
CA4245827 rs774987012	970	R>C		No	ClinGen ExAC TOPMed gnomAD
CA367409663 rs1302781130	970	R>L		No	ClinGen gnomAD
rs1451229061 CA367409652	971	T>S		No	ClinGen gnomAD
rs1388762320 CA367409604	975	R>P		No	ClinGen gnomAD
CA367409471 rs1425346013	984	H>L		No	ClinGen TOPMed gnomAD
CA367409473 rs1425346013	984	H>R		No	ClinGen TOPMed gnomAD
CA4245825 rs763316184	984	H>Y		No	ClinGen ExAC gnomAD
CA367409455 rs1344279544	986	G>E		No	ClinGen TOPMed
rs865914185 CA367409458	986	G>R		No	ClinGen gnomAD
rs865914185 CA157946240	986	G>W		No	ClinGen gnomAD
CA4245823 rs770033987	988	R>P		No	ClinGen ExAC TOPMed gnomAD
CA367409423 rs1207021393	989	R>G		No	ClinGen gnomAD
CA367409400 rs1485703100	990	L>F		No	ClinGen gnomAD
CA367409379 rs1487400233	991	I>M		No	ClinGen TOPMed
CA4245821 rs776693838	994	E>D		No	ClinGen ExAC TOPMed gnomAD
CA367409281 rs1236319681	997	P>R		No	ClinGen TOPMed gnomAD
CA4245819 rs577889210	1000	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs768849060 CA367409230	1000	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs768849060 CA4245820	1000	P>T		No	ClinGen ExAC TOPMed gnomAD
rs112599733 CA157946239	1001	E>G		No	ClinGen Ensembl
rs758345029 CA4245817	1002	P>S		No	ClinGen ExAC TOPMed gnomAD
rs200958914 CA367409184	1003	D>N		No	ClinGen ESP ExAC TOPMed
CA4245816 rs200958914	1003	D>Y		No	ClinGen ESP ExAC TOPMed
TCGA novel	1004	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757098246 CA4245814	1008	R>G		No	ClinGen ExAC TOPMed gnomAD
rs753570242 CA4245813	1009	G>D		No	ClinGen ExAC gnomAD
CA367409082 rs1293753063	1009	G>S		No	ClinGen TOPMed gnomAD
rs1388269566 CA367409045	1011	F>Y		No	ClinGen TOPMed
CA157946238 rs888765654	1012	T>S		No	ClinGen gnomAD
CA367409019 rs1330404740	1013	L>V		No	ClinGen TOPMed
rs766872839 CA4245809	1017	S>G		No	ClinGen ExAC TOPMed gnomAD
CA367408911 rs1428001335	1018	R>C		No	ClinGen gnomAD
rs1351598742 CA367408902	1018	R>L		No	ClinGen TOPMed

No associated diseases with B0I1T2

2 regional properties for B0I1T2

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	68 - 361	IPR000719
binding_site	Protein kinase, ATP binding site	74 - 97	IPR017441

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Peripheral membrane protein Cell projection, phagocytic cup	Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating cells or when membranes are deformed (By similarity) Localization at the membrane is not highly dependent on phosphatidylinositol 4,5-bisphosphate levels Released from the membrane in the presence of ATP May be enriched in peripheral processes, such as microvilli or ruffles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
filopodium	Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
leading edge membrane	The portion of the plasma membrane surrounding the leading edge of a motile cell.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
microvillus	Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
myosin complex	A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
phagocytic cup	An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

7 GO annotations of molecular function

Name	Definition
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
microfilament motor activity	A motor activity that generates movement along a microfilament, driven by ATP hydrolysis.
phosphatidylinositol-3,4,5-trisphosphate binding	Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
phosphatidylinositol-3,4-bisphosphate binding	Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
phosphatidylinositol-4,5-bisphosphate binding	Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.

9 GO annotations of biological process

Name	Definition
actin filament organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
cell gliding	Cell motility that results in the smooth movement of a cell along a solid surface.
cell-substrate adhesion	The attachment of a cell to the underlying substrate via adhesion molecules.
exocytosis	A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
Fc-gamma receptor signaling pathway involved in phagocytosis	An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
T cell meandering migration	The random-like motility observed for T cells in lymph nodes which enhances surveillance of antigens presented by major histocompatibility complex (MHC) molecules on antigen presenting cells (APCs).
T cell mediated immunity	Any process involved in the carrying out of an immune response by a T cell.
T cell migration	The movement of a T cell within or between different tissues and organs of the body.
vesicle transport along actin filament	Movement of a vesicle along an actin filament, mediated by motor proteins.

17 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q27991	MYH10	Myosin-10	Bos taurus (Bovine)	SS
Q02440	MYO5A	Unconventional myosin-Va	Gallus gallus (Chicken)	SS
Q5U651	RASIP1	Ras-interacting protein 1	Homo sapiens (Human)	PR
P35580	MYH10	Myosin-10	Homo sapiens (Human)	SS
Q12965	MYO1E	Unconventional myosin-Ie	Homo sapiens (Human)	PR
O00160	MYO1F	Unconventional myosin-If	Homo sapiens (Human)	PR
Q9UM54	MYO6	Unconventional myosin-VI	Homo sapiens (Human)	EV
Q9Y4I1	MYO5A	Unconventional myosin-Va	Homo sapiens (Human)	SS
Q9NQX4	MYO5C	Unconventional myosin-Vc	Homo sapiens (Human)	SS
Q9ULV0	MYO5B	Unconventional myosin-Vb	Homo sapiens (Human)	SS
Q3U0S6	Rasip1	Ras-interacting protein 1	Mus musculus (Mouse)	PR
P21271	Myo5b	Unconventional myosin-Vb	Mus musculus (Mouse)	SS
Q61879	Myh10	Myosin-10	Mus musculus (Mouse)	SS
Q99104	Myo5a	Unconventional myosin-Va	Mus musculus (Mouse)	EV
P70569	Myo5b	Unconventional myosin-Vb	Rattus norvegicus (Rat)	SS
Q9JLT0	Myh10	Myosin-10	Rattus norvegicus (Rat)	SS
Q9M2K0	XI-J	Myosin-16	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MEDEEGPEYG	KPDFVLLDQV	TMEDFMRNLQ	LRFEKGRIYT	YIGEVLVSVN	PYQELPLYGP
70	80	90	100	110	120
EAIARYQGRE	LYERPPHLYA	VANAAYKAMK	HRSRDTCIVI	SGESGAGKTE	ASKHIMQYIA
130	140	150	160	170	180
AVTNPSQRAE	VERVKDVLLK	STCVLEAFGN	ARTNRNHNSS	RFGKYMDINF	DFKGDPIGGH
190	200	210	220	230	240
IHSYLLEKSR	VLKQHVGERN	FHAFYQLLRG	SEDKQLHELH	LERNPAVYNF	THQGAGLNMT
250	260	270	280	290	300
VHSALDSDEQ	SHQAVTEAMR	VIGFSPEEVE	SVHRILAAIL	HLGNIEFVET	EEGGLQKEGL
310	320	330	340	350	360
AVAEEALVDH	VAELTATPRD	LVLRSLLART	VASGGRELIE	KGHTAAEASY	ARDACAKAVY
370	380	390	400	410	420
QRLFEWVVNR	INSVMEPRGR	DPRRDGKDTV	IGVLDIYGFE	VFPVNSFEQF	CINYCNEKLQ
430	440	450	460	470	480
QLFIQLILKQ	EQEEYEREGI	TWQSVEYFNN	ATIVDLVERP	HRGILAVLDE	ACSSAGTITD
490	500	510	520	530	540
RIFLQTLDMH	HRHHLHYTSR	QLCPTDKTME	FGRDFRIKHY	AGDVTYSVEG	FIDKNRDFLF
550	560	570	580	590	600
QDFKRLLYNS	TDPTLRAMWP	DGQQDITEVT	KRPLTAGTLF	KNSMVALVEN	LASKEPFYVR
610	620	630	640	650	660
CIKPNEDKVA	GKLDENHCRH	QVAYLGLLEN	VRVRRAGFAS	RQPYSRFLLR	YKMTCEYTWP
670	680	690	700	710	720
NHLLGSDKAA	VSALLEQHGL	QGDVAFGHSK	LFIRSPRTLV	TLEQSRARLI	PIIVLLLQKA
730	740	750	760	770	780
WRGTLARWRC	RRLRAIYTIM	RWFRRHKVRA	HLAELQRRFQ	AARQPPLYGR	DLVWPLPPAV
790	800	810	820	830	840
LQPFQDTCHA	LFCRWRARQL	VKNIPPSDMP	QIKAKVAAMG	ALQGLRQDWG	CRRAWARDYL
850	860	870	880	890	900
SSATDNPTAS	SLFAQRLKTL	QDKDGFGAVL	FSSHVRKVNR	FHKIRNRALL	LTDQHLYKLD
910	920	930	940	950	960
PDRQYRVMRA	VPLEAVTGLS	VTSGGDQLVV	LHARGQDDLV	VCLHRSRPPL	DNRVGELVGV
970	980	990	1000	1010
LAAHCQGEGR	TLEVRVSDCI	PLSHRGVRRL	ISVEPRPEQP	EPDFRCARGS	FTLLWPSR