A8WIP6
Gene name |
cdk20 (ccrk, si:dkeyp-77f7.1, zgc:101530) |
Protein name |
Cyclin-dependent kinase 20 |
Names |
Cell cycle-related kinase, Cell division protein kinase 20 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:494112 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
144-168 (Activation loop from InterPro)
Target domain |
4-288 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for A8WIP6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A8WIP6-F1 | Predicted | AlphaFoldDB |
No variants for A8WIP6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A8WIP6 | |||||
No associated diseases with A8WIP6
4 regional properties for A8WIP6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 4 - 288 | IPR000719 |
| active_site | Serine/threonine-protein kinase, active site | 123 - 135 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 10 - 33 | IPR017441 |
| domain | Cyclin-dependent kinase 20-like, catalytic domain | 3 - 289 | IPR048002 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8IZL9 | CDK20 | Cyclin-dependent kinase 20 | Homo sapiens (Human) | PR |
| Q9JHU3 | Cdk20 | Cyclin-dependent kinase 20 | Mus musculus (Mouse) | PR |
| Q4KM34 | Cdk20 | Cyclin-dependent kinase 20 | Rattus norvegicus (Rat) | PR |
| P29620 | CDKD-1 | Cyclin-dependent kinase D-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q5Z754 | CDKF-1 | Cyclin-dependent kinase F-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q9LMT0 | CDKD-3 | Cyclin-dependent kinase D-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C9U2 | CDKD-1 | Cyclin-dependent kinase D-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1RLU9 | cdk15 | Cyclin-dependent kinase 15 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q6AXJ9 | cdkl1 | Cyclin-dependent kinase-like 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8JH47 | cdk8 | Cyclin-dependent kinase 8 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDQYSILGRI | GEGAHGIVFK | AKHIETGETV | ALKKVALRRL | EDGIPNQALR | EIKALQEIED |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NQYVVKLKDV | FPHGTGFVLV | FEYMLSDLSE | VIRNSQRPLT | ASQVKSYMMM | LLKGVAFCHE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NSIMHRDLKP | ANLLISSTGH | LKIADFGLAR | LFSNEGDRLY | SHQVATRWYR | APELLYGARK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YDEGVDLWAV | GCIFGELLNN | SPLFPGENDI | EQLCCVLRVL | GTPNQKVWPE | ITELPDYNKI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TFKENPPIPL | EEIVPDTSPQ | AVDLLKKFLV | YPSKQRISAR | QALLHPYFFT | DPLPAHHSEL |
| 310 | 320 | 330 | 340 | ||
| PIPQRGGKHS | RQRMQPPHEF | TVDRPLHESV | VDPSLIQKHA | MSCS |