A8K0S8

PR
Gene name
MEIS3P2
Protein name
Putative homeobox protein Meis3-like 2
Names
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-149 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8K0S8

Entry ID Method Resolution Chain Position Source
AF-A8K0S8-F1 Predicted AlphaFoldDB

No variants for A8K0S8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8K0S8

No associated diseases with A8K0S8

7 regional properties for A8K0S8

Type Name Position InterPro Accession
domain Cyclic nucleotide-binding domain 152 - 272 IPR000595-1
domain Cyclic nucleotide-binding domain 274 - 400 IPR000595-2
domain cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain 7 - 44 IPR003117
conserved_site Cyclic nucleotide-binding, conserved site 179 - 195 IPR018488-1
conserved_site Cyclic nucleotide-binding, conserved site 219 - 236 IPR018488-2
conserved_site Cyclic nucleotide-binding, conserved site 301 - 317 IPR018488-3
conserved_site Cyclic nucleotide-binding, conserved site 348 - 365 IPR018488-4

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

7 GO annotations of biological process

Name Definition
animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
embryonic pattern specification The process that results in the patterns of cell differentiation that will arise in an embryo.
eye development The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P40424 PBX1 Pre-B-cell leukemia transcription factor 1 Homo sapiens (Human) PR
P40425 PBX2 Pre-B-cell leukemia transcription factor 2 Homo sapiens (Human) PR
Q8IUE1 TGIF2LX Homeobox protein TGIF2LX Homo sapiens (Human) PR
O14770 MEIS2 Homeobox protein Meis2 Homo sapiens (Human) EV
A6NDR6 MEIS3P1 Putative homeobox protein Meis3-like 1 Homo sapiens (Human) PR
Q99687 MEIS3 Homeobox protein Meis3 Homo sapiens (Human) SS
O00470 MEIS1 Homeobox protein Meis1 Homo sapiens (Human) SS
P97368 Meis3 Homeobox protein Meis3 Mus musculus (Mouse) PR
Q75LX7 OSH10 Homeobox protein knotted-1-like 4 Oryza sativa subsp japonica (Rice) PR
Q75LX9 Os03g0673500 Putative homeobox protein knotted-1-like 5 Oryza sativa subsp japonica (Rice) PR
Q1PFD1 BLH11 BEL1-like homeodomain protein 11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SIW1 BLH7 BEL1-like homeodomain protein 7 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MARRYDELPH YPSIADGPAA LAGFPEAVPA APGPYGPHRP PQPLPPGLDS DGLKRDKDEI
70 80 90 100 110 120
YGHPLFPLLA LVFEKCELAT CSPRDGAGAG LGTPRGGDVC SSDSFNEDNT AFAKQVRSER
130 140 150 160 170 180
PFFSSNPELD NLMIQAIQVL RFHLLELEKG KMPIDLVIED RDGGCREDFE DYPASCLSLP
190 200 210 220 230 240
DQNNIWIRDH EDSGSVHLGT PGPSSGGLAS QSGDNSSDQG VGLDTSVASP SSGGEDEDLD
250 260 270 280 290 300
QEPRRNKKRG IFPKVATNIM RAWLFQHLWH PYPSEEQKKQ LVQDTGLTIL QVNNWFINAR
310 320 330 340 350
RRMVQPMIDQ SNRIGQGAAF SPEGQPIGGY TETEPHVAFR PPASVGMSLN LEGEWHYL